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Search results 301 to 309 out of 309 for Sgo1

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0.016s

Type

Details

Score

Protein Domain

IPR026706 | SGO2

Type:

Family

Description:

This family consists of shugoshin-like 2 protein (SGOL2, also known as Sgo2 and TRIPIN) from chordates. Shugoshin (which is Japanese for guardian spirit) was first identified in Drosophila melanogaster (originally named Mei-S322) as a protein that is required for sister chromatid cohesion []. Later, a few shugoshin orthologs from yeast to human were identified through similarities in their sequence architectures []. Flies and budding yeast have only one known shugoshin (Mei-S322 and Sgo1, respectively), fission yeast, Xenopus laevis and mammals have two shugoshin-like proteins (Sgo1 and Sgo2 in yeast and SGOL1 and SGOL2 in vertebrates) [].The functions of Sgo1 from different species can vary. For instance, in S. cevervisiae and D. melanogaster, Sgo1 protects cohesion at meiosis but not mitosis. In humans and X. laevis, SGOL1 protect centromeric cohesion during mitosis [].SGOL2 is required for protecting centromeric cohesin during meiosis but is dispensable for mitosis. Loss of SGOL2 in humans and mice causes infertility in both males and females [, ].

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Protein Domain

IPR044693 | SGO_plant

Type:

Family

Description:

The Shugoshin (SGO) protein family plays a major role in the protection of centromeric cohesion in Drosophila and yeast. This entry represents plant shugoshins, including SGO1 and SGO2 from Arabidopsis [, ]. SGO1 is required for the maintenance of centromeric cohesion of sister chromatids in meiosis I, but not through the control of AtSYN1/AtREC8 localisation. Together with SGO2, it is required for protection of centromeric cohesion during anaphase I []. However, SGO2 is dispensable for meiosis. In rice, OsSGO1 is also involved in the assembly and maintenance of the synaptonemal complex (SC) during early prophase I []. In maize, ZmSGO1 is required for maintenance of centromeric cohesion before prophase II and correct segregation of chromatids during meiosis II [].

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Protein

Q7TSY8

Organism:	Mus musculus/domesticus
Length:	1164
Fragment?:	false

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Protein

E2IUN6

Organism:	Mus musculus/domesticus
Length:	1166
Fragment?:	false

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Protein

J3QMK1

Organism:	Mus musculus/domesticus
Length:	1167
Fragment?:	false

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Publication

24206843 | -

First Author:	Cromer L
Year:	2013
Journal:	Curr Biol
Title:	Centromeric cohesion is protected twice at meiosis, by SHUGOSHINs at anaphase I and by PATRONUS at interkinesis.
Volume:	23
Issue:	21
Pages:	2090-9

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Publication

24506176 | -

First Author:	Zamariola L
Year:	2014
Journal:	Plant J
Title:	SHUGOSHINs and PATRONUS protect meiotic centromere cohesion in Arabidopsis thaliana.
Volume:	77
Issue:	5
Pages:	782-94

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Publication

17205076 | J:159144

First Author:	Gómez R
Year:	2007
Journal:	EMBO Rep
Title:	Mammalian SGO2 appears at the inner centromere domain and redistributes depending on tension across centromeres during meiosis II and mitosis.
Volume:	8
Issue:	2
Pages:	173-80

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Publication

20889715 | J:164642

First Author:	Tanno Y
Year:	2010
Journal:	Genes Dev
Title:	Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres.
Volume:	24
Issue:	19
Pages:	2169-79

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