Type |
Details |
Score |
Publication |
First Author: |
Pandithage R |
Year: |
2008 |
Journal: |
J Cell Biol |
Title: |
The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility. |
Volume: |
180 |
Issue: |
5 |
Pages: |
915-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park SH |
Year: |
2012 |
Journal: |
Transl Cancer Res |
Title: |
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis. |
Volume: |
1 |
Issue: |
1 |
Pages: |
15-21 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion GK6, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
785
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
180
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
47
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
120
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
108
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
758
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
585
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Zou L |
Year: |
2003 |
Journal: |
Science |
Title: |
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. |
Volume: |
300 |
Issue: |
5625 |
Pages: |
1542-8 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The function of the ATR-ATRIP (ATR-interacting protein) protein kinase complex is crucial for the cellular response to replication stress and DNA damage. ATRIP is a regulatory partner of ATR. The binding of ATRIP to replication protein A-coated ssDNA at sites of DNA damage drives ATR activation and enables the ATR-ATRIP complex to stimulate phosphorylation of substrates, such as Rad17 or Chk1, and the initiation of checkpoint signalling []. ATRIP deacetylation by SIRT2 promotes ATR-ATRIP bindingto RPA-ssDNA []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Bhaskar A |
Year: |
2020 |
Journal: |
Elife |
Title: |
Host sirtuin 2 as an immunotherapeutic target against tuberculosis. |
Volume: |
9 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Chen X |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia. |
Volume: |
10 |
Issue: |
1 |
Pages: |
e0116919 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roy S |
Year: |
2024 |
Journal: |
Commun Biol |
Title: |
Dab2 (Disabled-2), an adaptor protein, regulates self-renewal of hair follicle stem cells. |
Volume: |
7 |
Issue: |
1 |
Pages: |
525 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jing H |
Year: |
2016 |
Journal: |
Cancer Cell |
Title: |
A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity. |
Volume: |
29 |
Issue: |
3 |
Pages: |
297-310 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun L |
Year: |
2022 |
Journal: |
Sci Adv |
Title: |
Deacetylation of ATG4B promotes autophagy initiation under starvation. |
Volume: |
8 |
Issue: |
31 |
Pages: |
eabo0412 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suzuki K |
Year: |
2007 |
Journal: |
Neuroscience |
Title: |
Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: a crucial role of tubulin deacetylation. |
Volume: |
147 |
Issue: |
3 |
Pages: |
599-612 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo L |
Year: |
2019 |
Journal: |
J Biol Chem |
Title: |
Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease. |
Volume: |
294 |
Issue: |
31 |
Pages: |
11805-11816 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo Q |
Year: |
2019 |
Journal: |
Am J Transl Res |
Title: |
Inhibition of SIRT1 promotes taste bud stem cell survival and mitigates radiation-induced oral mucositis in mice. |
Volume: |
11 |
Issue: |
8 |
Pages: |
4789-4799 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun W |
Year: |
2021 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
MYO1F regulates antifungal immunity by regulating acetylation of microtubules. |
Volume: |
118 |
Issue: |
30 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Binker MG |
Year: |
2015 |
Journal: |
Biochem Biophys Res Commun |
Title: |
ER stress-associated CTRC mutants decrease stimulated pancreatic zymogen secretion through SIRT2-mediated microtubule dysregulation. |
Volume: |
463 |
Issue: |
3 |
Pages: |
329-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gaur U |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Molecular evolutionary patterns of NAD+/Sirtuin aging signaling pathway across taxa. |
Volume: |
12 |
Issue: |
8 |
Pages: |
e0182306 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fonseca Costa SS |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Normalisation against Circadian and Age-Related Disturbances Enables Robust Detection of Gene Expression Changes in Liver of Aged Mice. |
Volume: |
12 |
Issue: |
1 |
Pages: |
e0169615 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roy Chowdhury S |
Year: |
2018 |
Journal: |
Mol Cell Neurosci |
Title: |
Depressed mitochondrial function and electron transport Complex II-mediated H2O2 production in the cortex of type 1 diabetic rodents. |
Volume: |
90 |
|
Pages: |
49-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu J |
Year: |
2016 |
Journal: |
J Neurochem |
Title: |
High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects. |
Volume: |
137 |
Issue: |
3 |
Pages: |
371-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang Q |
Year: |
2018 |
Journal: |
Reproduction |
Title: |
Melatonin attenuates postovulatory oocyte dysfunction by regulating SIRT1 expression. |
Volume: |
156 |
Issue: |
1 |
Pages: |
81-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
|
|
|
|
•
•
•
•
•
|