Type |
Details |
Score |
Publication |
First Author: |
Lin W |
Year: |
2022 |
Journal: |
Lab Invest |
Title: |
Deletion of Smurf1 attenuates liver steatosis via stabilization of p53. |
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Interaction Experiment |
Description: |
The E3 ligase Smurf1 regulates Wolfram syndrome protein stability at the endoplasmic reticulum. |
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Interaction Experiment |
Description: |
Phosphorylation of E3 ligase Smurf1 switches its substrate preference in support of axon development. |
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•
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Interaction Experiment |
Description: |
Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. |
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Interaction Experiment |
Description: |
Non-proteolytic ubiquitin modification of PPAR by Smurf1 protects the liver from steatosis. |
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Interaction Experiment |
Description: |
Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth. |
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•
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Interaction Experiment |
Description: |
Neddylation modification of the U3 snoRNA-binding protein RRP9 by Smurf1 promotes tumorigenesis. |
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Interaction Experiment |
Description: |
The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy. |
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Publication |
First Author: |
Li S |
Year: |
2010 |
Journal: |
Mol Cell Biochem |
Title: |
Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation. |
Volume: |
338 |
Issue: |
1-2 |
Pages: |
11-7 |
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•
•
•
•
•
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Publication |
First Author: |
Guo X |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
The E3 ligase Smurf1 regulates Wolfram syndrome protein stability at the endoplasmic reticulum. |
Volume: |
286 |
Issue: |
20 |
Pages: |
18037-47 |
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•
•
•
•
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Publication |
First Author: |
Feng X |
Year: |
2019 |
Journal: |
Autophagy |
Title: |
Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth. |
Volume: |
15 |
Issue: |
7 |
Pages: |
1130-1149 |
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•
•
•
•
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Publication |
First Author: |
Du MG |
Year: |
2021 |
Journal: |
J Biol Chem |
Title: |
Neddylation modification of the U3 snoRNA-binding protein RRP9 by Smurf1 promotes tumorigenesis. |
Volume: |
297 |
Issue: |
5 |
Pages: |
101307 |
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•
•
•
•
•
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Publication |
First Author: |
Wang Y |
Year: |
2012 |
Journal: |
EMBO Rep |
Title: |
CKIP-1 couples Smurf1 ubiquitin ligase with Rpt6 subunit of proteasome to promote substrate degradation. |
Volume: |
13 |
Issue: |
11 |
Pages: |
1004-11 |
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•
•
•
•
|
Interaction Experiment |
Description: |
The E3 ligase Cdh1-anaphase promoting complex operates upstream of the E3 ligase Smurf1 in the control of axon growth. |
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•
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•
|
Interaction Experiment |
Description: |
E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation. |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
751
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
787
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
835
 |
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
855
 |
Fragment?: |
false |
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•
•
•
•
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Publication |
First Author: |
Kannan M |
Year: |
2012 |
Journal: |
Development |
Title: |
The E3 ligase Cdh1-anaphase promoting complex operates upstream of the E3 ligase Smurf1 in the control of axon growth. |
Volume: |
139 |
Issue: |
19 |
Pages: |
3600-12 |
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•
•
•
•
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Publication |
First Author: |
Zhao M |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation. |
Volume: |
278 |
Issue: |
30 |
Pages: |
27939-44 |
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•
•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
887
 |
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
864
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
870
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
918
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
748
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1004
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
918
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
976
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
887
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
956
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
824
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
806
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
896
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
912
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
918
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
824
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1004
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
872
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
876
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
728
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
875
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
870
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
757
 |
Fragment?: |
false |
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•
•
•
•
•
|
Publication |
First Author: |
Singh PNP |
Year: |
2018 |
Journal: |
Development |
Title: |
Precise spatial restriction of BMP signaling in developing joints is perturbed upon loss of embryo movement. |
Volume: |
145 |
Issue: |
5 |
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•
•
•
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•
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Publication |
First Author: |
Zhang F |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice. |
Volume: |
12 |
Issue: |
1 |
Pages: |
3997 |
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•
•
•
•
•
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Publication |
First Author: |
Guo YC |
Year: |
2018 |
Journal: |
EMBO J |
Title: |
Ubiquitin-specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling. |
Volume: |
37 |
Issue: |
20 |
|
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•
•
•
•
•
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Publication |
First Author: |
Zhang L |
Year: |
2018 |
Journal: |
PLoS Pathog |
Title: |
Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome. |
Volume: |
14 |
Issue: |
5 |
Pages: |
e1007067 |
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•
•
•
•
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Publication |
First Author: |
Kim P |
Year: |
2022 |
Journal: |
Nat Commun |
Title: |
Mast4 determines the cell fate of MSCs for bone and cartilage development. |
Volume: |
13 |
Issue: |
1 |
Pages: |
3960 |
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•
•
•
•
•
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Publication |
First Author: |
Sapkota G |
Year: |
2007 |
Journal: |
Mol Cell |
Title: |
Balancing BMP signaling through integrated inputs into the Smad1 linker. |
Volume: |
25 |
Issue: |
3 |
Pages: |
441-54 |
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•
•
•
•
•
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Publication |
First Author: |
Li X |
Year: |
2008 |
Journal: |
J Cell Biol |
Title: |
CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation. |
Volume: |
181 |
Issue: |
6 |
Pages: |
959-72 |
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•
•
•
•
•
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Publication |
First Author: |
Zhu J |
Year: |
2021 |
Journal: |
Mol Cell |
Title: |
Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity. |
Volume: |
81 |
Issue: |
15 |
Pages: |
3171-3186.e8 |
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•
•
•
•
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Publication |
First Author: |
Chen Z |
Year: |
2020 |
Journal: |
Br J Pharmacol |
Title: |
Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked NADPH oxidase 4 polyubiquitination and degradation. |
Volume: |
177 |
Issue: |
1 |
Pages: |
145-160 |
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•
•
•
•
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Publication |
First Author: |
Yoon WJ |
Year: |
2015 |
Journal: |
J Cell Physiol |
Title: |
Pin1 plays a critical role as a molecular switch in canonical BMP signaling. |
Volume: |
230 |
Issue: |
3 |
Pages: |
640-7 |
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•
•
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•
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Publication |
First Author: |
Liu J |
Year: |
2017 |
Journal: |
Aging Cell |
Title: |
Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP signaling to inhibit bone formation during aging. |
Volume: |
16 |
Issue: |
2 |
Pages: |
360-376 |
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•
•
•
•
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Publication |
First Author: |
Chang J |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
NF-κB inhibits osteogenic differentiation of mesenchymal stem cells by promoting β-catenin degradation. |
Volume: |
110 |
Issue: |
23 |
Pages: |
9469-74 |
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•
•
•
•
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Publication |
First Author: |
Shu L |
Year: |
2013 |
Journal: |
J Bone Miner Res |
Title: |
Ubiquitin E3 ligase Wwp1 negatively regulates osteoblast function by inhibiting osteoblast differentiation and migration. |
Volume: |
28 |
Issue: |
9 |
Pages: |
1925-35 |
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•
•
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•
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Publication |
First Author: |
Sato Y |
Year: |
2008 |
Journal: |
Dev Biol |
Title: |
Retinoic acid regulates murine enteric nervous system precursor proliferation, enhances neuronal precursor differentiation, and reduces neurite growth in vitro. |
Volume: |
320 |
Issue: |
1 |
Pages: |
185-98 |
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•
•
•
•
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Publication |
First Author: |
Xu J |
Year: |
2012 |
Journal: |
Stem Cells |
Title: |
ZO-1 regulates Erk, Smad1/5/8, Smad2, and RhoA activities to modulate self-renewal and differentiation of mouse embryonic stem cells. |
Volume: |
30 |
Issue: |
9 |
Pages: |
1885-900 |
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•
•
•
•
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Publication |
First Author: |
Tang Y |
Year: |
2018 |
Journal: |
Int J Biol Sci |
Title: |
Generation of Smurf2 Conditional Knockout Mice. |
Volume: |
14 |
Issue: |
5 |
Pages: |
542-548 |
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•
•
•
•
|
Publication |
First Author: |
Li Z |
Year: |
2020 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Short AIP1 (ASK1-Interacting Protein-1) Isoform Localizes to the Mitochondria and Promotes Vascular Dysfunction. |
Volume: |
40 |
Issue: |
1 |
Pages: |
112-127 |
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•
•
•
•
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Publication |
First Author: |
Huang H |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
Skeletal Characterization of Smurf2-Deficient Mice and In Vitro Analysis of Smurf2-Deficient Chondrocytes. |
Volume: |
11 |
Issue: |
1 |
Pages: |
e0148088 |
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•
•
•
•
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Publication |
First Author: |
Kamalakar A |
Year: |
2021 |
Journal: |
Bone |
Title: |
JAGGED1 stimulates cranial neural crest cell osteoblast commitment pathways and bone regeneration independent of canonical NOTCH signaling. |
Volume: |
143 |
|
Pages: |
115657 |
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•
•
•
•
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Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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