Type |
Details |
Score |
Publication |
First Author: |
Nicholson SE |
Year: |
1999 |
Journal: |
EMBO J |
Title: |
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. |
Volume: |
18 |
Issue: |
2 |
Pages: |
375-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marine JC |
Year: |
1999 |
Journal: |
Cell |
Title: |
SOCS3 is essential in the regulation of fetal liver erythropoiesis. |
Volume: |
98 |
Issue: |
5 |
Pages: |
617-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Polizzotto MN |
Year: |
2000 |
Journal: |
J Comp Neurol |
Title: |
Expression of "suppressor of cytokine signalling" (SOCS) genes in the developing and adult mouse nervous system. |
Volume: |
423 |
Issue: |
2 |
Pages: |
348-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hilton DJ |
Year: |
1998 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Twenty proteins containing a C-terminal SOCS box form five structural classes. |
Volume: |
95 |
Issue: |
1 |
Pages: |
114-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mann-Chandler MN |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
IFN-gamma induces apoptosis in developing mast cells. |
Volume: |
175 |
Issue: |
5 |
Pages: |
3000-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Delconte RB |
Year: |
2016 |
Journal: |
Immunity |
Title: |
The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15. |
Volume: |
44 |
Issue: |
1 |
Pages: |
103-115 |
|
•
•
•
•
•
|
Publication |
First Author: |
Davey GM |
Year: |
2005 |
Journal: |
J Exp Med |
Title: |
SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential. |
Volume: |
202 |
Issue: |
8 |
Pages: |
1099-108 |
|
•
•
•
•
•
|
Publication |
First Author: |
Naka T |
Year: |
2001 |
Journal: |
Immunity |
Title: |
SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo. |
Volume: |
14 |
Issue: |
5 |
Pages: |
535-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baguet A |
Year: |
2004 |
Journal: |
J Exp Med |
Title: |
A Leishmania major response locus identified by interval-specific congenic mapping of a T helper type 2 cell bias-controlling quantitative trait locus. |
Volume: |
200 |
Issue: |
12 |
Pages: |
1605-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sato T |
Year: |
2004 |
Journal: |
Biochem Biophys Res Commun |
Title: |
IFN-gamma-induced SOCS-1 regulates STAT6-dependent eotaxin production triggered by IL-4 and TNF-alpha. |
Volume: |
314 |
Issue: |
2 |
Pages: |
468-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vuong BQ |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome. |
Volume: |
24 |
Issue: |
20 |
Pages: |
9092-101 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohtani M |
Year: |
2012 |
Journal: |
Cell Microbiol |
Title: |
Involvement of suppressor of cytokine signalling-1-mediated degradation of MyD88-adaptor-like protein in the suppression of Toll-like receptor 2-mediated signalling by the murine C-type lectin SIGNR1-mediated signalling. |
Volume: |
14 |
Issue: |
1 |
Pages: |
40-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Babon JJ |
Year: |
2014 |
Journal: |
Biochem J |
Title: |
The molecular regulation of Janus kinase (JAK) activation. |
Volume: |
462 |
Issue: |
1 |
Pages: |
1-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ueki K |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. |
Volume: |
24 |
Issue: |
12 |
Pages: |
5434-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kamura T |
Year: |
2004 |
Journal: |
Genes Dev |
Title: |
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. |
Volume: |
18 |
Issue: |
24 |
Pages: |
3055-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park JH |
Year: |
2010 |
Journal: |
Nat Immunol |
Title: |
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells. |
Volume: |
11 |
Issue: |
3 |
Pages: |
257-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
El Kasmi KC |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
General nature of the STAT3-activated anti-inflammatory response. |
Volume: |
177 |
Issue: |
11 |
Pages: |
7880-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ozawa Y |
Year: |
2007 |
Journal: |
Dev Biol |
Title: |
SOCS3 is required to temporally fine-tune photoreceptor cell differentiation. |
Volume: |
303 |
Issue: |
2 |
Pages: |
591-600 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aringer M |
Year: |
1999 |
Journal: |
Life Sci |
Title: |
Janus kinases and their role in growth and disease. |
Volume: |
64 |
Issue: |
24 |
Pages: |
2173-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lv N |
Year: |
2009 |
Journal: |
Exp Cell Res |
Title: |
JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. |
Volume: |
315 |
Issue: |
12 |
Pages: |
2064-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Torre S |
Year: |
2017 |
Journal: |
Nat Immunol |
Title: |
USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation. |
Volume: |
18 |
Issue: |
1 |
Pages: |
54-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Masuhara M |
Year: |
2000 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains. |
Volume: |
268 |
Issue: |
3 |
Pages: |
697-703 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fairchild CL |
Year: |
2018 |
Journal: |
Development |
Title: |
RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. |
Volume: |
145 |
Issue: |
3 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Simó S |
Year: |
2013 |
Journal: |
Dev Cell |
Title: |
Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors. |
Volume: |
27 |
Issue: |
4 |
Pages: |
399-411 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pogribny IP |
Year: |
2010 |
Journal: |
Lab Invest |
Title: |
Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. |
Volume: |
90 |
Issue: |
10 |
Pages: |
1437-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniPathway vocabulary mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Dickinson ME |
Year: |
2016 |
Journal: |
Nature |
Title: |
High-throughput discovery of novel developmental phenotypes. |
Volume: |
537 |
Issue: |
7621 |
Pages: |
508-514 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koscielny G |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Volume: |
42 |
Issue: |
Database issue |
Pages: |
D802-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
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•
•
•
•
•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
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|
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
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|
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•
•
•
•
•
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Publication |
First Author: |
Wu QY |
Year: |
2018 |
Journal: |
Cell Death Dis |
Title: |
CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia. |
Volume: |
9 |
Issue: |
7 |
Pages: |
774 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ripley BJ |
Year: |
2010 |
Journal: |
Int Immunol |
Title: |
Green tea polyphenol epigallocatechin gallate inhibits cell signaling by inducing SOCS1 gene expression. |
Volume: |
22 |
Issue: |
5 |
Pages: |
359-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin L |
Year: |
2021 |
Journal: |
Theranostics |
Title: |
SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma. |
Volume: |
11 |
Issue: |
9 |
Pages: |
4232-4250 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway. |
|
•
•
•
•
•
|
Publication |
First Author: |
De Sepulveda P |
Year: |
1999 |
Journal: |
EMBO J |
Title: |
Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. |
Volume: |
18 |
Issue: |
4 |
Pages: |
904-15 |
|
•
•
•
•
•
|
Allele |
Name: |
suppressor of cytokine signaling 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Publication |
First Author: |
Maruoka M |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway. |
Volume: |
292 |
Issue: |
17 |
Pages: |
6895-6909 |
|
•
•
•
•
•
|
Allele |
Name: |
interferon gamma receptor 1; targeted mutation 1.1, Robyn Starr |
Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ifngr1/Ifngr1 |
Background: |
involves: BALB/cJ * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
170
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
106
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
72
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Dey BR |
Year: |
1998 |
Journal: |
J Biol Chem |
Title: |
Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor. |
Volume: |
273 |
Issue: |
37 |
Pages: |
24095-101 |
|
•
•
•
•
•
|
Publication |
First Author: |
Leung KC |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2. |
Volume: |
100 |
Issue: |
3 |
Pages: |
1016-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Man J |
Year: |
2011 |
Journal: |
Protein Cell |
Title: |
CUEDC2: an emerging key player in inflammation and tumorigenesis. |
Volume: |
2 |
Issue: |
9 |
Pages: |
699-703 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
CUE domain containing 2 (CUEDC2) is involved in the regulation of the cell cycle, inflammation, and tumorigenesis []. It interacts with progesterone receptor (PR) and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway []. It also interacts with SOCS1 to to suppress SOCS1's ubiquitin-mediated degradation []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
62
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Cytokine signaling mediated by the JAK-STAT pathway plays essential roles in differentiation, maturation, proliferation and apoptosis of a various types of cells. Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of the JAK-STAT signaling pathway. SOCS1 and SOCS3 are potent inhibitors of JAKs and can play pivotal roles in inflammation, as well as in the development and progression of cancers []. All SOCS share a central SH2 domain and a C-terminal SOCS box, but only SOCS1 and SOCS3 possess a kinase inhibitory region immediately upstream of the central SH2 [].SOCS3 interacts with gp130, a common cytokine receptor for interleukin (IL)-6, leukemia inhibitory factor (LIF) and other members of the IL-6 family of cytokines. SOCS3 has been reported also to interact with the leptin receptor, erythropoietin receptor, insulin receptor, IL-12beta receptor and granulocyte-colony stimulating factor receptor []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Cytokine signaling mediated by the JAK-STAT pathway plays essential roles in differentiation, maturation, proliferation and apoptosis of a various types of cells. Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of the JAK-STAT signaling pathway. SOCS1 and SOCS3 are potent inhibitors of JAKs and can play pivotal roles in inflammation, as well as in the development and progression of cancers []. All SOCS share a central SH2 domain and a C-terminal SOCS box, but only SOCS1 and SOCS3 possess a kinase inhibitory region immediately upstream of the central SH2 [].SOCS2 is necessary for normal growth regulation []. It appears to be a negative regulator in the growth hormone/IGF1 signaling pathway [, ]. |
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the SH2 domain of SOCS3.Cytokine signaling mediated by the JAK-STAT pathway plays essential roles in differentiation, maturation, proliferation and apoptosis of a various types of cells. Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of the JAK-STAT signaling pathway. SOCS1 and SOCS3 are potent inhibitors of JAKs and can play pivotal roles in inflammation, as well as in the development and progression of cancers []. All SOCS share a central SH2 domain and a C-terminal SOCS box, but only SOCS1 and SOCS3 possess a kinase inhibitory region immediately upstream of the central SH2 [].SOCS3 interacts with gp130, a common cytokine receptor for interleukin (IL)-6, leukemia inhibitory factor (LIF) and other members of the IL-6 family of cytokines. SOCS3 has been reported also to interact with the leptin receptor, erythropoietin receptor, insulin receptor, IL-12beta receptor and granulocyte-colony stimulating factor receptor []. |
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the SH2 domain of SOCS1.Cytokine signaling mediated by the JAK-STAT pathway plays essential roles in differentiation, maturation, proliferation and apoptosis of a various types of cells. Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of the JAK-STAT signaling pathway. SOCS1 and SOCS3 are potent inhibitors of JAKs and can play pivotal roles in inflammation, as well as in the development and progression of cancers []. All SOCS share a central SH2 domain and a C-terminal SOCS box, but only SOCS1 and SOCS3 possess a kinase inhibitory region immediately upstream of the central SH2 [].SOCS1 plays a key role in the negative regulation of interferon-gamma signaling and in T cell differentiation [, , ]. |
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the SH2 domain of SOCS2.Cytokine signaling mediated by the JAK-STAT pathway plays essential roles in differentiation, maturation, proliferation and apoptosis of a various types of cells. Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of the JAK-STAT signaling pathway. SOCS1 and SOCS3 are potent inhibitors of JAKs and can play pivotal roles in inflammation, as well as in the development and progression of cancers []. All SOCS share a central SH2 domain and a C-terminal SOCS box, but only SOCS1 and SOCS3 possess a kinase inhibitory region immediately upstream of the central SH2 [].SOCS2 is necessary for normal growth regulation []. It appears to be a negative regulator in the growth hormone/IGF1 signaling pathway [, ]. |
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Publication |
First Author: |
Boyle K |
Year: |
2008 |
Journal: |
J Reprod Immunol |
Title: |
The role of SOCS3 in modulating leukaemia inhibitory factor signalling during murine placental development. |
Volume: |
77 |
Issue: |
1 |
Pages: |
1-6 |
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Publication |
First Author: |
Zhang PJ |
Year: |
2007 |
Journal: |
EMBO J |
Title: |
CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome. |
Volume: |
26 |
Issue: |
7 |
Pages: |
1831-42 |
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HT Experiment |
Series Id: |
GSE19675 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
273
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
195
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
266
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
246
 |
Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
70
 |
Fragment?: |
true |
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Publication |
First Author: |
Croker BA |
Year: |
2003 |
Journal: |
Nat Immunol |
Title: |
SOCS3 negatively regulates IL-6 signaling in vivo. |
Volume: |
4 |
Issue: |
6 |
Pages: |
540-5 |
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Publication |
First Author: |
Bergamin E |
Year: |
2006 |
Journal: |
Structure |
Title: |
Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3. |
Volume: |
14 |
Issue: |
8 |
Pages: |
1285-92 |
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Publication |
First Author: |
Zhang Y |
Year: |
2014 |
Journal: |
Immunity |
Title: |
Activation of vascular endothelial growth factor receptor-3 in macrophages restrains TLR4-NF-κB signaling and protects against endotoxin shock. |
Volume: |
40 |
Issue: |
4 |
Pages: |
501-14 |
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Publication |
First Author: |
Wroblewska A |
Year: |
2018 |
Journal: |
Cell |
Title: |
Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens. |
Volume: |
175 |
Issue: |
4 |
Pages: |
1141-1155.e16 |
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Publication |
First Author: |
Yu X |
Year: |
2016 |
Journal: |
Immunity |
Title: |
Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality. |
Volume: |
45 |
Issue: |
5 |
Pages: |
1093-1107 |
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Publication |
First Author: |
Moffitt AB |
Year: |
2017 |
Journal: |
J Exp Med |
Title: |
Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2. |
Volume: |
214 |
Issue: |
5 |
Pages: |
1371-1386 |
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Publication |
First Author: |
Hsieh WC |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells. |
Volume: |
9 |
Issue: |
1 |
Pages: |
463 |
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•
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Publication |
First Author: |
Russell RC |
Year: |
2011 |
Journal: |
Nat Med |
Title: |
Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia. |
Volume: |
17 |
Issue: |
7 |
Pages: |
845-53 |
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Publication |
First Author: |
Liu Q |
Year: |
2006 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation. |
Volume: |
345 |
Issue: |
3 |
Pages: |
1122-30 |
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