| Type |
Details |
Score |
| Allele |
| Name: |
Sp2 transcription factor; gene trap IST14503D8, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
Sp2 transcription factor; gene trap IST14546C5, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
Sp2 transcription factor; gene trap IST14580B2, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
Sp2 transcription factor; gene trap IST14588E4, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
Sp2 transcription factor; gene trap IST14586D6, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
Sp2 transcription factor; gene trap IST14675B8, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
Sp2 transcription factor; gene trap IST14658E8, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
Sp2 transcription factor; gene trap IST14708D1, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
Sp2 transcription factor; gene trap IST14846A11, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
Sp2 transcription factor; gene trap IST14914F4, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
Sp2 transcription factor; gene trap IST14855B12, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
Sp2 transcription factor; gene trap IST14860B10, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
Sp2 transcription factor; gene trap IST14935E5, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
Sp2 transcription factor; gene trap IST15030G9, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
Sp2 transcription factor; gene trap IST15044F10, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Sp2/Sp2 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Sp2/Sp2 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Sp2/Sp2 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Sp2/Sp2 |
| Background: |
involves: 129 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
428
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Sp2/Sp2 Tg(Nes-cre)1Kln/? |
| Background: |
involves: 129 * C57BL/6 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Sp2/Sp2<+> Tg(Nes-cre)1Kln/? |
| Background: |
involves: 129 * C57BL/6 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Sp2/Sp2 Emx1/Emx1<+> |
| Background: |
involves: 129S2/SvPas |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Pseudogene |
| Type: |
pseudogene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Martin BM |
| Year: |
1994 |
| Journal: |
Biochem J |
| Title: |
Novel K(+)-channel-blocking toxins from the venom of the scorpion Centruroides limpidus limpidus Karsch. |
| Volume: |
304 ( Pt 1) |
|
| Pages: |
51-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang N |
| Year: |
2004 |
| Journal: |
Proteins |
| Title: |
Solution structure of BmKK2, a new potassium channel blocker from the venom of chinese scorpion Buthus martensi Karsch. |
| Volume: |
55 |
| Issue: |
4 |
| Pages: |
835-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang Y |
| Year: |
2019 |
| Journal: |
Cell Biosci |
| Title: |
Immunosuppressive effects of a novel potassium channel toxin Ktx-Sp2 from Scorpiops Pocoki. |
| Volume: |
9 |
|
| Pages: |
99 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Reynaud S |
| Year: |
2020 |
| Journal: |
J Med Chem |
| Title: |
A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists. |
| Volume: |
63 |
| Issue: |
15 |
| Pages: |
8250-8264 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhao F |
| Year: |
2021 |
| Journal: |
Toxins (Basel) |
| Title: |
BmK NSPK, a Potent Potassium Channel Inhibitor from Scorpion Buthus martensii Karsch, Promotes Neurite Outgrowth via NGF/TrkA Signaling Pathway. |
| Volume: |
13 |
| Issue: |
1 |
|
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Scorpion venoms contain a variety of peptides toxic to mammals, insects and crustaceans. Among these peptides there is a family of short toxins (30 to 40 residues) [, ]. This entry represents members of this family with potassium channel blocking activity []. KTX 12 Sp2 toxin from Scorpiops pococki has shown a strong immunosuppressant effect, being an interesting therapeutic agent for autoimmune disease treatment []. This entry also includes NU-buthitoxin-Ptr1a, a toxin that acts as an agonist on melanocortin receptors and does not show activity on mammalian sodium or potassium channels []. Toxin BmK NSPK from Manchurian scorpion, is a voltage-gated potassium (Kv) channel inhibitor that augments neurite extension via NGF/TrkA signaling pathway. As Kv channels may represent molecular targets to modulate spinal cord neurons development and regeneration, they become interesting targets to develop treatments for spinal cord injury []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lippens G |
| Year: |
1995 |
| Journal: |
Biochemistry |
| Title: |
NMR sequential assignments and solution structure of chlorotoxin, a small scorpion toxin that blocks chloride channels. |
| Volume: |
34 |
| Issue: |
1 |
| Pages: |
13-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen J |
| Year: |
2009 |
| Journal: |
J Biol Chem |
| Title: |
A new isoform of interleukin-3 receptor {alpha} with novel differentiation activity and high affinity binding mode. |
| Volume: |
284 |
| Issue: |
9 |
| Pages: |
5763-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kurosawa Y |
| Year: |
1982 |
| Journal: |
J Exp Med |
| Title: |
Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments. |
| Volume: |
155 |
| Issue: |
1 |
| Pages: |
201-18 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Reininger L |
| Year: |
1987 |
| Journal: |
J Immunol |
| Title: |
Novel V genes encode virtually identical variable regions of six murine monoclonal anti-bromelain-treated red blood cell autoantibodies. |
| Volume: |
138 |
| Issue: |
1 |
| Pages: |
316-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Suzow J |
| Year: |
1993 |
| Journal: |
Mol Cell Biol |
| Title: |
The murine myeloperoxidase promoter contains several functional elements, one of which binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1). |
| Volume: |
13 |
| Issue: |
4 |
| Pages: |
2141-51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Berberich S |
| Year: |
1994 |
| Journal: |
Oncogene |
| Title: |
The mdm-2 oncogene is translocated and overexpressed in a murine plasmacytoma cell line expressing wild-type p53. |
| Volume: |
9 |
| Issue: |
5 |
| Pages: |
1469-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Asakura K |
| Year: |
1995 |
| Journal: |
Brain Res Mol Brain Res |
| Title: |
Oligodendrocyte-reactive O1, O4, and HNK-1 monoclonal antibodies are encoded by germline immunoglobulin genes. |
| Volume: |
34 |
| Issue: |
2 |
| Pages: |
283-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tsai YT |
| Year: |
2014 |
| Journal: |
J Neurochem |
| Title: |
Epigenetic activation of mouse ganglioside synthase genes: implications for neurogenesis. |
| Volume: |
128 |
| Issue: |
1 |
| Pages: |
101-10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Suske G |
| Year: |
2017 |
| Journal: |
Biochim Biophys Acta |
| Title: |
NF-Y and SP transcription factors - New insights in a long-standing liaison. |
| Volume: |
1860 |
| Issue: |
5 |
| Pages: |
590-597 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mirza S |
| Year: |
2010 |
| Journal: |
J Biol Chem |
| Title: |
Two modes of beta-receptor recognition are mediated by distinct epitopes on mouse and human interleukin-3. |
| Volume: |
285 |
| Issue: |
29 |
| Pages: |
22370-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fitzgerald CT |
| Year: |
1998 |
| Journal: |
DNA Cell Biol |
| Title: |
Regulation of mouse Ah receptor (Ahr) gene basal expression by members of the Sp family of transcription factors. |
| Volume: |
17 |
| Issue: |
9 |
| Pages: |
811-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki N |
| Year: |
2004 |
| Journal: |
DNA Res |
| Title: |
Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. |
| Volume: |
11 |
| Issue: |
3 |
| Pages: |
205-18 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2000 |
| Journal: |
Genome Res |
| Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
| Volume: |
10 |
| Issue: |
10 |
| Pages: |
1617-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
1999 |
| Journal: |
Methods Enzymol |
| Title: |
High-efficiency full-length cDNA cloning. |
| Volume: |
303 |
|
| Pages: |
19-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shibata K |
| Year: |
2000 |
| Journal: |
Genome Res |
| Title: |
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
| Volume: |
10 |
| Issue: |
11 |
| Pages: |
1757-71 |
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•
•
•
•
|
| Publication |
| First Author: |
Katayama S |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
Antisense transcription in the mammalian transcriptome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1564-6 |
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•
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| Publication |
| First Author: |
Gerhard DS |
| Year: |
2004 |
| Journal: |
Genome Res |
| Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| Volume: |
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10B |
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•
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| Publication |
| First Author: |
Church DM |
| Year: |
2009 |
| Journal: |
PLoS Biol |
| Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
| Volume: |
7 |
| Issue: |
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e1000112 |
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