| Type |
Details |
Score |
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
313
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
313
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
105
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lim J |
| Year: |
2002 |
| Journal: |
Mol Cell Biol |
| Title: |
The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes. |
| Volume: |
22 |
| Issue: |
22 |
| Pages: |
7953-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
King JA |
| Year: |
2005 |
| Journal: |
Biochem J |
| Title: |
Distinct requirements for the Sprouty domain for functional activity of Spred proteins. |
| Volume: |
388 |
| Issue: |
Pt 2 |
| Pages: |
445-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lim J |
| Year: |
2000 |
| Journal: |
J Biol Chem |
| Title: |
Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain. |
| Volume: |
275 |
| Issue: |
42 |
| Pages: |
32837-45 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Sprouty (Spry) and Spred (Sprouty related EVH1 domain) proteins have been identified as inhibitors of the Ras/mitogen-activated protein kinase(MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases [, ]. These proteins share a conserved, C-terminal cysteine-rich region, the SPR domain. This domain has been defined as a novel cytosol to membrane translocation domain [, , , ]. It has been found to be a PtdIns(4,5)P2-binding domain that targets the proteins to a cellular localization that maximizes their inhibitory potential [, ]. It also mediates homodimer formation of these proteins [, ].The SPR domain can occur in association with the WH1 domain (see ) (located in the N-terminal part of the proteins) in the Spred proteins. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Harmer NJ |
| Year: |
2005 |
| Journal: |
FEBS Lett |
| Title: |
1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family. |
| Volume: |
579 |
| Issue: |
5 |
| Pages: |
1161-6 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
300
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
315
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
288
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
315
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hanafusa H |
| Year: |
2002 |
| Journal: |
Nat Cell Biol |
| Title: |
Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway. |
| Volume: |
4 |
| Issue: |
11 |
| Pages: |
850-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yap BK |
| Year: |
2016 |
| Journal: |
FEBS Lett |
| Title: |
Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction. |
| Volume: |
590 |
| Issue: |
6 |
| Pages: |
696-704 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
410
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
408
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
444
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
408
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
437
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jin HK |
| Year: |
1999 |
| Journal: |
J Virol |
| Title: |
Identification of the murine Mx2 gene: interferon-induced expression of the Mx2 protein from the feral mouse gene confers resistance to vesicular stomatitis virus. |
| Volume: |
73 |
| Issue: |
6 |
| Pages: |
4925-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Goulding M |
| Year: |
1993 |
| Journal: |
Genomics |
| Title: |
Analysis of the Pax-3 gene in the mouse mutant splotch. |
| Volume: |
17 |
| Issue: |
2 |
| Pages: |
355-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Epstein DJ |
| Year: |
1991 |
| Journal: |
Genomics |
| Title: |
Molecular characterization of a deletion encompassing the splotch mutation on mouse chromosome 1. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
89-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Latremoliere A |
| Year: |
2015 |
| Journal: |
Neuron |
| Title: |
Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. |
| Volume: |
86 |
| Issue: |
6 |
| Pages: |
1393-406 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
229
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wilkie TM |
| Year: |
1993 |
| Journal: |
Genomics |
| Title: |
Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. |
| Volume: |
18 |
| Issue: |
2 |
| Pages: |
175-84 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vogan KJ |
| Year: |
1993 |
| Journal: |
Genomics |
| Title: |
The splotch-delayed (Spd) mouse mutant carries a point mutation within the paired box of the Pax-3 gene. |
| Volume: |
17 |
| Issue: |
2 |
| Pages: |
364-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Miyagi Y |
| Year: |
2002 |
| Journal: |
J Neurosci |
| Title: |
Delphilin: a novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor delta 2 subunit. |
| Volume: |
22 |
| Issue: |
3 |
| Pages: |
803-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kato R |
| Year: |
2003 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation. |
| Volume: |
302 |
| Issue: |
4 |
| Pages: |
767-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Epstein DJ |
| Year: |
1993 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant. |
| Volume: |
90 |
| Issue: |
2 |
| Pages: |
532-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Luo J |
| Year: |
2020 |
| Journal: |
Br J Pharmacol |
| Title: |
Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, from Rhodomela confervoides. |
| Volume: |
177 |
| Issue: |
19 |
| Pages: |
4464-4480 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Blum AM |
| Year: |
1999 |
| Journal: |
J Immunol |
| Title: |
The substance P receptor is necessary for a normal granulomatous response in murine schistosomiasis mansoni. |
| Volume: |
162 |
| Issue: |
10 |
| Pages: |
6080-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cronin SJF |
| Year: |
2018 |
| Journal: |
Nature |
| Title: |
The metabolite BH4 controls TÂ cell proliferation in autoimmunity and cancer. |
| Volume: |
563 |
| Issue: |
7732 |
| Pages: |
564-568 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Boren J |
| Year: |
2001 |
| Journal: |
J Biol Chem |
| Title: |
Binding of low density lipoproteins to lipoprotein lipase is dependent on lipids but not on apolipoprotein B. |
| Volume: |
276 |
| Issue: |
29 |
| Pages: |
26916-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
el-Shazly S |
| Year: |
2001 |
| Journal: |
Biochem Genet |
| Title: |
Male hybrid sterility of mice with the genomic region of the KitW mutation and the KitS allele from Mus spretus. |
| Volume: |
39 |
| Issue: |
3-4 |
| Pages: |
127-37 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Epstein DJ |
| Year: |
1994 |
| Journal: |
Genomics |
| Title: |
Characterization of a region-specific library of microclones in the vicinity of the Bcg and splotch loci on mouse chromosome 1. |
| Volume: |
19 |
| Issue: |
1 |
| Pages: |
163-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Matsumura K |
| Year: |
2007 |
| Journal: |
J Biol Chem |
| Title: |
Carbohydrate binding specificity of a fucose-specific lectin from Aspergillus oryzae: a novel probe for core fucose. |
| Volume: |
282 |
| Issue: |
21 |
| Pages: |
15700-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ling J |
| Year: |
2008 |
| Journal: |
J Biol Chem |
| Title: |
Structural constraints for the binding of short peptides to claudin-4 revealed by surface plasmon resonance. |
| Volume: |
283 |
| Issue: |
45 |
| Pages: |
30585-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lund-Katz S |
| Year: |
2010 |
| Journal: |
J Lipid Res |
| Title: |
Surface plasmon resonance analysis of the mechanism of binding of apoA-I to high density lipoprotein particles. |
| Volume: |
51 |
| Issue: |
3 |
| Pages: |
606-17 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wegener H |
| Year: |
2013 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
The vWFA2 domain of type VII collagen is responsible for collagen binding. |
| Volume: |
430 |
| Issue: |
2 |
| Pages: |
449-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chehboun S |
| Year: |
2017 |
| Journal: |
J Biol Chem |
| Title: |
Epstein-Barr virus-induced gene 3 (EBI3) can mediate IL-6 trans-signaling. |
| Volume: |
292 |
| Issue: |
16 |
| Pages: |
6644-6656 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Callebaut I |
| Year: |
1998 |
| Journal: |
FEBS Lett |
| Title: |
EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family. |
| Volume: |
441 |
| Issue: |
2 |
| Pages: |
181-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Makino CL |
| Year: |
2012 |
| Journal: |
PLoS One |
| Title: |
Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice. |
| Volume: |
7 |
| Issue: |
10 |
| Pages: |
e47637 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pankonien I |
| Year: |
2012 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Ahnak1 interaction is affected by phosphorylation of Ser-296 on Cavβ₂. |
| Volume: |
421 |
| Issue: |
2 |
| Pages: |
184-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ozawa T |
| Year: |
2012 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
The binding affinity of a soluble TCR-Fc fusion protein is significantly improved by crosslinkage with an anti-Cβ antibody. |
| Volume: |
422 |
| Issue: |
2 |
| Pages: |
245-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ni T |
| Year: |
2017 |
| Journal: |
Biochem J |
| Title: |
Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain. |
| Volume: |
474 |
| Issue: |
4 |
| Pages: |
539-556 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Malerba F |
| Year: |
2016 |
| Journal: |
Front Mol Neurosci |
| Title: |
NGF and proNGF Reciprocal Interference in Immunoassays: Open Questions, Criticalities, and Ways Forward. |
| Volume: |
9 |
|
| Pages: |
63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cattanach BM |
| Year: |
1993 |
| Journal: |
Mouse Genome |
| Title: |
A further mutation at the splotch locus |
| Volume: |
91 |
| Issue: |
1 |
| Pages: |
115-16 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hamer RD |
| Year: |
2003 |
| Journal: |
J Gen Physiol |
| Title: |
Multiple steps of phosphorylation of activated rhodopsin can account for the reproducibility of vertebrate rod single-photon responses. |
| Volume: |
122 |
| Issue: |
4 |
| Pages: |
419-44 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Peters J |
| Year: |
1995 |
| Journal: |
Mouse Genome |
| Title: |
Genetic and phenotypic analysis of Del(1)Spr3H and Pax3Sp-4H |
| Volume: |
93 |
| Issue: |
4 |
| Pages: |
1041-3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Malas S |
| Year: |
1995 |
| Journal: |
Mouse Genome |
| Title: |
PCR Markers associated with the mouse nicotinic-acetylcholine-receptor-subunit genes alpha-4, alpha-7 and beta-4 on mouse Chromosomes 2, 7, and 9 |
| Volume: |
93 |
| Issue: |
2 |
| Pages: |
433-5 |
|
•
•
•
•
•
|