| Type |
Details |
Score |
| Allele |
| Name: |
STIP1 homology and U-Box containing protein 1; endonuclease-mediated mutation 2, Jonathan Schisler |
| Allele Type: |
Endonuclease-mediated |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
STIP1 homology and U-Box containing protein 1; targeted mutation 1, Shigeo Murata |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
STIP1 homology and U-Box containing protein 1; endonuclease-mediated mutation 2, Cyagen Biosciences |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
304
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ronnebaum SM |
| Year: |
2013 |
| Journal: |
Mol Cell Biol |
| Title: |
The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination. |
| Volume: |
33 |
| Issue: |
22 |
| Pages: |
4461-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sha Y |
| Year: |
2017 |
| Journal: |
EMBO J |
| Title: |
STUB1 regulates TFEB-induced autophagy-lysosome pathway. |
| Volume: |
36 |
| Issue: |
17 |
| Pages: |
2544-2552 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hu Z |
| Year: |
2021 |
| Journal: |
Aging (Albany NY) |
| Title: |
CHIP protects against MPP(+)/MPTP-induced damage by regulating Drp1 in two models of Parkinson's disease. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
1458-1472 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant strain |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
| Allele |
| Name: |
STIP1 homology and U-Box containing protein 1; targeted mutation 1, Mouse Biology Program, UC Davis |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, congenic, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Stub1/Stub1 |
| Background: |
involves: 129S/SvEv * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Stub1/Stub1 |
| Background: |
involves: 129S5/SvEvBrd * C57BL/6J |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Stub1/Stub1 |
| Background: |
B6.Cg-Stub1 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Stub1/Stub1 |
| Background: |
involves: 129S/SvEv |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Stub1/Stub1 |
| Background: |
C57BL/6J-Stub1 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Scaglione KM |
| Year: |
2011 |
| Journal: |
Mol Cell |
| Title: |
Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP. |
| Volume: |
43 |
| Issue: |
4 |
| Pages: |
599-612 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shan Y |
| Year: |
2004 |
| Journal: |
Cytogenet Genome Res |
| Title: |
Cloning and characterization of the mouse Arht2 gene which encodes a putative atypical GTPase. |
| Volume: |
106 |
| Issue: |
1 |
| Pages: |
91-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sane S |
| Year: |
2018 |
| Journal: |
Mol Oncol |
| Title: |
UBXN2A enhances CHIP-mediated proteasomal degradation of oncoprotein mortalin-2 in cancer cells. |
| Volume: |
12 |
| Issue: |
10 |
| Pages: |
1753-1777 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Le NT |
| Year: |
2012 |
| Journal: |
Circ Res |
| Title: |
p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction. |
| Volume: |
110 |
| Issue: |
4 |
| Pages: |
536-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhou P |
| Year: |
2018 |
| Journal: |
Nat Commun |
| Title: |
MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
1243 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ko HS |
| Year: |
2009 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity. |
| Volume: |
106 |
| Issue: |
8 |
| Pages: |
2897-902 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fukunishi Y |
| Year: |
1999 |
| Journal: |
FEBS Lett |
| Title: |
Prediction of human cDNA from its homologous mouse full-length cDNA and human shotgun database. |
| Volume: |
464 |
| Issue: |
3 |
| Pages: |
129-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jiang J |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Chaperone-dependent regulation of endothelial nitric-oxide synthase intracellular trafficking by the co-chaperone/ubiquitin ligase CHIP. |
| Volume: |
278 |
| Issue: |
49 |
| Pages: |
49332-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Petrucelli L |
| Year: |
2004 |
| Journal: |
Hum Mol Genet |
| Title: |
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. |
| Volume: |
13 |
| Issue: |
7 |
| Pages: |
703-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li X |
| Year: |
2008 |
| Journal: |
J Cell Biol |
| Title: |
CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation. |
| Volume: |
181 |
| Issue: |
6 |
| Pages: |
959-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cook C |
| Year: |
2012 |
| Journal: |
Hum Mol Genet |
| Title: |
Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation. |
| Volume: |
21 |
| Issue: |
13 |
| Pages: |
2936-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Su CH |
| Year: |
2013 |
| Journal: |
Arch Biochem Biophys |
| Title: |
Phosphorylation accelerates geldanamycin-induced Akt degradation. |
| Volume: |
536 |
| Issue: |
1 |
| Pages: |
6-11 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yoo L |
| Year: |
2018 |
| Journal: |
J Biol Chem |
| Title: |
The ubiquitin E3 ligase CHIP promotes proteasomal degradation of the serine/threonine protein kinase PINK1 during staurosporine-induced cell death. |
| Volume: |
293 |
| Issue: |
4 |
| Pages: |
1286-1297 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jeong DH |
| Year: |
2018 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Ubiquitin-proteasome dependent regulation of Profilin2 (Pfn2) by a cellular inhibitor of apoptotic protein 1 (cIAP1). |
| Volume: |
506 |
| Issue: |
3 |
| Pages: |
423-428 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Choi YN |
| Year: |
2014 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Regulation of fragile X mental retardation 1 protein by C-terminus of Hsc70-interacting protein depends on its phosphorylation status. |
| Volume: |
453 |
| Issue: |
1 |
| Pages: |
192-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nucifora FC Jr |
| Year: |
2016 |
| Journal: |
Nat Commun |
| Title: |
Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1. |
| Volume: |
7 |
|
| Pages: |
11792 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Qiu J |
| Year: |
2022 |
| Journal: |
Lab Invest |
| Title: |
PAQR3 depletion accelerates diabetic wound healing by promoting angiogenesis through inhibiting STUB1-mediated PPARγ degradation. |
| Volume: |
102 |
| Issue: |
10 |
| Pages: |
1121-1131 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Maruyama T |
| Year: |
2010 |
| Journal: |
EMBO J |
| Title: |
CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response. |
| Volume: |
29 |
| Issue: |
15 |
| Pages: |
2501-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang M |
| Year: |
2011 |
| Journal: |
J Exp Med |
| Title: |
E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKC{zeta}. |
| Volume: |
208 |
| Issue: |
10 |
| Pages: |
2099-112 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, coisogenic, targeted mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Stub1/Stub1<+> |
| Background: |
involves: 129S/SvEv |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen Z |
| Year: |
2013 |
| Journal: |
Immunity |
| Title: |
The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. |
| Volume: |
39 |
| Issue: |
2 |
| Pages: |
272-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Arndt V |
| Year: |
2010 |
| Journal: |
Curr Biol |
| Title: |
Chaperone-assisted selective autophagy is essential for muscle maintenance. |
| Volume: |
20 |
| Issue: |
2 |
| Pages: |
143-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ko HR |
| Year: |
2014 |
| Journal: |
Cell Death Dis |
| Title: |
P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP. |
| Volume: |
5 |
|
| Pages: |
e1131 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Beilina A |
| Year: |
2014 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. |
| Volume: |
111 |
| Issue: |
7 |
| Pages: |
2626-31 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hatakeyama S |
| Year: |
2001 |
| Journal: |
J Biol Chem |
| Title: |
U box proteins as a new family of ubiquitin-protein ligases. |
| Volume: |
276 |
| Issue: |
35 |
| Pages: |
33111-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Reventun P |
| Year: |
2017 |
| Journal: |
Arterioscler Thromb Vasc Biol |
| Title: |
iNOS-Derived Nitric Oxide Induces Integrin-Linked Kinase Endocytic Lysosome-Mediated Degradation in the Vascular Endothelium. |
| Volume: |
37 |
| Issue: |
7 |
| Pages: |
1272-1281 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang H |
| Year: |
2013 |
| Journal: |
J Immunol |
| Title: |
Enhanced endoplasmic reticulum entry of tumor antigen is crucial for cross-presentation induced by dendritic cell-targeted vaccination. |
| Volume: |
191 |
| Issue: |
12 |
| Pages: |
6010-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Radovanac K |
| Year: |
2013 |
| Journal: |
EMBO J |
| Title: |
Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response. |
| Volume: |
32 |
| Issue: |
10 |
| Pages: |
1409-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lim ST |
| Year: |
2012 |
| Journal: |
J Cell Biol |
| Title: |
Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression. |
| Volume: |
197 |
| Issue: |
7 |
| Pages: |
907-19 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Collum RG |
| Year: |
2000 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
A Stat3-interacting protein (StIP1) regulates cytokine signal transduction. |
| Volume: |
97 |
| Issue: |
18 |
| Pages: |
10120-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hawkes NA |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
Purification and characterization of the human elongator complex. |
| Volume: |
277 |
| Issue: |
4 |
| Pages: |
3047-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ariza J |
| Year: |
2017 |
| Journal: |
PLoS One |
| Title: |
Maternal autoimmune antibodies alter the dendritic arbor and spine numbers in the infragranular layers of the cortex. |
| Volume: |
12 |
| Issue: |
8 |
| Pages: |
e0183443 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lexicon Genetics Inc |
| Year: |
2005 |
| Journal: |
MGI Direct Data Submission |
| Title: |
NIH initiative supporting placement of Lexicon Genetics, Inc. mice into public repositories |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The RIKEN BioResource Center |
| Year: |
2006 |
| Journal: |
Unpublished |
| Title: |
Information obtained from The RIKEN BioResource Center |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
University of California, Davis |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by the University of California, Davis |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Velocigene |
| Year: |
2008 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2001 |
|
| Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2001 |
|
| Title: |
RIKEN Data Curation in Mouse Genome Informatics |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
International Mouse Strain Resource |
| Year: |
2014 |
| Journal: |
Database Download |
| Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Helmholtz Zentrum Muenchen GmbH |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kawai J |
| Year: |
2001 |
| Journal: |
Nature |
| Title: |
Functional annotation of a full-length mouse cDNA collection. |
| Volume: |
409 |
| Issue: |
6821 |
| Pages: |
685-90 |
|
•
•
•
•
•
|