Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:5641904 |
Assay Type: |
Western blot |
Annotation Date: |
2015-06-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737328 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5641991 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Kidney SUMO3 wild type |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5641904 |
Assay Type: |
Western blot |
Annotation Date: |
2015-06-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737328 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5641991 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Kidney SUMO3 wild type |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5641904 |
Assay Type: |
Western blot |
Annotation Date: |
2015-06-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737328 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5641991 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Kidney SUMO3 mutant (-/-) |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5641904 |
Assay Type: |
Western blot |
Annotation Date: |
2015-06-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737328 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5641991 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Kidney SUMO3 mutant (-/-) |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5641904 |
Assay Type: |
Western blot |
Annotation Date: |
2015-06-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737328 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5641991 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Kidney SUMO3 mutant (-/-) |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5641904 |
Assay Type: |
Western blot |
Annotation Date: |
2015-06-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737328 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5641991 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Kidney SUMO3 mutant (-/-) |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5641904 |
Assay Type: |
Western blot |
Annotation Date: |
2015-06-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737328 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5641991 |
Age: |
postnatal adult |
|
|
Specimen Label: |
Kidney SUMO3 mutant (-/-) |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
Allele |
Name: |
small ubiquitin-like modifier 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Publication |
First Author: |
Grégoire S |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors. |
Volume: |
25 |
Issue: |
6 |
Pages: |
2273-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Klein UR |
Year: |
2009 |
Journal: |
Mol Biol Cell |
Title: |
RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin. |
Volume: |
20 |
Issue: |
1 |
Pages: |
410-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang C |
Year: |
2009 |
Journal: |
EMBO J |
Title: |
SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. |
Volume: |
28 |
Issue: |
18 |
Pages: |
2748-62 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Sentrin-specific protease 3 (SENP3, MEROPS identifier C48.003) is an isopeptidase that releases SUMO2 and SUMO3 monomers from sumoylated substrates by hydrolysing the isopeptide bond []. SENP3 is a cysteine peptidase with a fold similar to that of adenain, and has the catalytic triad His, Asp, Cys, the reverse of the order in papain. Among the proteins that are deconjugated by SENP3 are MEF2D [], CDCA8 [], EP300 [], and nucleophosmin []. SENP3 is a component of the 5FMC []and MLL1/MLL complexes []. |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 10, Wei Yang |
Allele Type: |
Transgenic |
Attribute String: |
Conditional ready, Epitope tag, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, mutant strain, congenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Qin Y |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation. |
Volume: |
12 |
Issue: |
1 |
Pages: |
4794 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
SENP3 Suppresses Osteoclastogenesis by De-conjugating SUMO2/3 from IRF8 in Bone Marrow-Derived Monocytes. |
Volume: |
30 |
Issue: |
6 |
Pages: |
1951-1963.e4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gong L |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. |
Volume: |
281 |
Issue: |
23 |
Pages: |
15869-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chang TH |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
The small ubiquitin-like modifier-deconjugating enzyme sentrin-specific peptidase 1 switches IFN regulatory factor 8 from a repressor to an activator during macrophage activation. |
Volume: |
189 |
Issue: |
7 |
Pages: |
3548-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barbeito P |
Year: |
2023 |
Journal: |
Front Cell Dev Biol |
Title: |
EVC-EVC2 complex stability and ciliary targeting are regulated by modification with ubiquitin and SUMO. |
Volume: |
11 |
|
Pages: |
1190258 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ripamonti S |
Year: |
2020 |
Journal: |
J Neurochem |
Title: |
SUMOylation controls the neurodevelopmental function of the transcription factor Zbtb20. |
Volume: |
154 |
Issue: |
6 |
Pages: |
647-661 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brantis-de-Carvalho CE |
Year: |
2015 |
Journal: |
Exp Cell Res |
Title: |
MxA interacts with and is modified by the SUMOylation machinery. |
Volume: |
330 |
Issue: |
1 |
Pages: |
151-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fanis P |
Year: |
2012 |
Journal: |
Mol Cell Proteomics |
Title: |
Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. |
Volume: |
11 |
Issue: |
11 |
Pages: |
1263-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haindl M |
Year: |
2008 |
Journal: |
EMBO Rep |
Title: |
The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing. |
Volume: |
9 |
Issue: |
3 |
Pages: |
273-9 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
568
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
169
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Dou Y |
Year: |
2005 |
Journal: |
Cell |
Title: |
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. |
Volume: |
121 |
Issue: |
6 |
Pages: |
873-85 |
|
•
•
•
•
•
|