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Search results 301 to 400 out of 661 for Tec

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Type Details Score
Publication
19290923 | -
First Author: Readinger JA
Year: 2009
Journal: Immunol Rev
Title: Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk.
Volume: 228
Issue: 1
Pages: 93-114
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Publication
10823839 | -
First Author: Yoshida K
Year: 2000
Journal: J Biol Chem
Title: Mediation by the protein-tyrosine kinase Tec of signaling between the B cell antigen receptor and Dok-1.
Volume: 275
Issue: 32
Pages: 24945-52
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Allele
Tg(Tec-BCR/ABL1)3Hhi | MGI:3039032
Name: transgene insertion 3, Hisamaru Hirai
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Tec-BCR/ABL1)5Hhi | MGI:3039034
Name: transgene insertion 5, Hisamaru Hirai
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Tec-BCR/ABL1)#Hhi | MGI:3527269
Name: transgene insertion, Hisamaru Hirai
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Tec-BCR/ABL1)1Hhi | MGI:7507535
Name: transgene insertion 1, Hisamaru Hirai
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
11340625 | -
First Author: Smith CI
Year: 2001
Journal: Bioessays
Title: The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species.
Volume: 23
Issue: 5
Pages: 436-46
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Publication
19234145 | J:148525
First Author: Miyazaki K
Year: 2009
Journal: Blood
Title: Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia.
Volume: 113
Issue: 19
Pages: 4702-10
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Publication
30167087 | J:346826
First Author: Takita M
Year: 2018
Journal: Oncotarget
Title: Paradoxical counteraction by imatinib against cell death in myeloid progenitor 32D cells expressing p210BCR-ABL.
Volume: 9
Issue: 60
Pages: 31682-31696
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Publication
18193087 | J:135601
First Author: Mizuno T
Year: 2008
Journal: Oncogene
Title: Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice.
Volume: 27
Issue: 24
Pages: 3465-74
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Strain
MGI:6145075 | B6.Cg-Tg(Tec-BCR/ABL1)1Hhi/HomyRbrc
Attribute String: mutant strain, congenic, transgenic
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Publication
24833663 | J:258718
First Author: Sánchez-Sánchez B
Year: 2014
Journal: Clin Cancer Res
Title: NADPH oxidases as therapeutic targets in chronic myelogenous leukemia.
Volume: 20
Issue: 15
Pages: 4014-25
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HT Experiment
GSE53110 | Gene expression in thymic epithelial cells [RNA-seq]
Series Id: E-GEOD-53110
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
15489910 | -
First Author: Boggon TJ
Year: 2004
Journal: Oncogene
Title: Structure and regulation of Src family kinases.
Volume: 23
Issue: 48
Pages: 7918-27
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Publication
15803148 | -
First Author: Schwartzberg PL
Year: 2005
Journal: Nat Rev Immunol
Title: TEC-family kinases: regulators of T-helper-cell differentiation.
Volume: 5
Issue: 4
Pages: 284-95
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Protein Domain
IPR035572 | Tec_SH3
Type: Domain
Description: This entry represents the SH3 domain of Tec [, ]. Tec is a cytoplasmic (or nonreceptor) tyrosine kinase containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain []. It also contains an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation, and the Tec homology (TH) domain, which contains proline-rich and zinc-binding regions []. It is more widely-expressed than other Tec subfamily kinases. Tec is found in endothelial cells, both B- and T-cells, and a variety of myeloid cells including mast cells, erythroid cells, platelets, macrophages and neutrophils [, ]. Tec is a key component of T-cell receptor (TCR) signaling, and is important in TCR-stimulated proliferation and phospholipase C-gamma1 activation [].
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Publication
7524075 | -
First Author: August A
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.
Volume: 91
Issue: 20
Pages: 9347-51
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HT Experiment
GSE100314 | RNA-sequencing of fetal thymic epithelial cells (TECs), in control, loss-of-function and gain-of-function Notch mutants
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Kit<W-bd> | MGI:1856258
 
Name: KIT proto-oncogene receptor tyrosine kinase; banded
Allele Type: Spontaneous
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Publication
24270545 | J:206884
First Author: Jain N
Year: 2013
Journal: Nat Med
Title: CD28 and ITK signals regulate autoreactive T cell trafficking.
Volume: 19
Issue: 12
Pages: 1632-7
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Publication
9006068 | J:38382
First Author: Klüppel M
Year: 1997
Journal: Development
Title: Long-range genomic rearrangements upstream of Kit dysregulate the developmental pattern of Kit expression in W57 and Wbanded mice and interfere with distinct steps in melanocyte development.
Volume: 124
Issue: 1
Pages: 65-77
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HT Experiment
GSE65617 | Differential features of Aire-induced and Aire-independent promiscuous gene expression in thymic epithelial cells
Series Id: E-GEOD-65617
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein Domain
IPR039111 | STAP1/STAP2
Type: Family
Description: STAP1 and STAP2 are signal-transducing adaptor proteins. They contain Pleckstrin Homology (PH) and SH2 domains along with several tyrosine phosphorylation sites.STAP1 functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. It is phosphorylated by Tec and participates in a positive feedback loop, increasing Tec activity []. STAP-1 has been shown to interact with STAT5 []. STAP2 is a substrate of breast tumour kinase, an Src-type non-receptor tyrosine kinase that mediates the interactions linking proteins involved in signal transduction pathways [].
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Publication
9490692 | J:46392
First Author: Honda H
Year: 1998
Journal: Blood
Title: Development of acute lymphoblastic leukemia and myeloproliferative disorder in transgenic mice expressing p210bcr/abl: a novel transgenic model for human Ph1-positive leukemias.
Volume: 91
Issue: 6
Pages: 2067-75
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Publication
15611091 | J:97253
First Author: Sekine Y
Year: 2005
Journal: J Biol Chem
Title: Physical and functional interactions between STAP-2/BKS and STAT5.
Volume: 280
Issue: 9
Pages: 8188-96
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HT Experiment
GSE226128 | Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells - tuft and non-tuft cells
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Protein Domain
IPR035870 | Txk_SH2
Type: Domain
Description: Txk is a member of the Tec protein tyrosine kinase family. It plays a role in TCR signal transduction, T cell development, and selection which is analogous to the function of Itk. Txk has been shown to interact with IFN-gamma [, ]. Unlike most of the Tec family members Txk lacks a PH domain. Instead Txk has a unique region containing a palmitoylated cysteine string which has a similar membrane tethering function as the PH domain []. This entry includes the SH2 domain of Txk.The Tec protein tyrosine kinase family includes Tec,Btk, Itk, Bmx, and Txk. They contain an NH2-terminal pleckstrin homology (PH) domain (absent in Txk), a proline-rich region, Src-homology 3 (SH3) and SH2 domains, and a COOH-terminal PTK domain. The TH domain consists of a Zn2+-binding Btk motif and a proline-rich region. The Btk motif is found in Tec kinases, Ras GAP, and IGBP and crucial to the function of the PH domain. It is not present in Txk which is not surprising since it lacks a PH domain. The type 1 splice form of the Drosophila homologue also lacks both the PH domain and the Btk motif. The proline-rich regions are highly conserved for the most part with the exception of Bmx whose residues surrounding the PXXP motif are not conserved (TH-like) and Btk29A which is entirely unique with large numbers of glycine residues (TH-extended). Tec family members all lack a C-terminal tyrosine having an autoinhibitory function in its phosphorylated state [, ].
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Publication
17207856 | J:118704
First Author: Contreras CM
Year: 2007
Journal: Mol Immunol
Title: Btk regulates multiple stages in the development and survival of B-1 cells.
Volume: 44
Issue: 10
Pages: 2719-28
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Strain
MGI:3579315 | STOCK Kit<W-bd>/H
Attribute String: spontaneous mutation, inversion, mutant stock
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Publication
9438424 | J:45208
First Author: Klüppel M
Year: 1998
Journal: Dev Dyn
Title: Developmental origin and Kit-dependent development of the interstitial cells of cajal in the mammalian small intestine.
Volume: 211
Issue: 1
Pages: 60-71
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Publication
- | J:14074
 
First Author: Beechey CV
Year: 1986
Journal: Mouse News Lett
Title: Banded - a new W allele
Volume: 74
Pages: 92
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Publication
- | J:20782
First Author: Beechey CV
Year: 1994
Journal: Mouse Genome
Title: A new spontaneous W allele, W36H
Volume: 92
Issue: 3
Pages: 502
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Publication
- | J:13934
 
First Author: Beechey CV
Year: 1983
Journal: Mouse News Lett
Title: Two new W mutations
Volume: 68
Pages: 70
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Publication
19620960 | J:151543
First Author: Sanada M
Year: 2009
Journal: Nature
Title: Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
Volume: 460
Issue: 7257
Pages: 904-8
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Publication
11489947 | J:95640
First Author: Di Cristofano A
Year: 2001
Journal: J Exp Med
Title: p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl).
Volume: 194
Issue: 3
Pages: 275-84
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Publication
21848808 | J:309066
First Author: Seo S
Year: 2011
Journal: Cancer Sci
Title: Crk-associated substrate lymphocyte type regulates myeloid cell motility and suppresses the progression of leukemia induced by p210Bcr/Abl.
Volume: 102
Issue: 12
Pages: 2109-17
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Genotype
Genotype
Symbol: Dok1/Dok1 Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dok2/Dok2 Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dok1/Dok1<+> Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: 129S1/Sv
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dok2/Dok2<+> Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: 129S1/Sv
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dok1/Dok1 Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: 129S1/Sv
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dok2/Dok2 Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: 129S1/Sv
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kit/Kit<+>
Background: involves: STOCK Rw Fgf5 Vps33a
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kit/Kit
Background: involves: STOCK Rw Fgf5 Vps33a
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kit/Kit
Background: involves: 101/H * C3H/HeH * STOCK Rw Fgf5 Vps33a
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cbl/Cbl<+> Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cbl/Cbl Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
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Protein Domain
IPR035877 | STAP1_SH2
Type: Domain
Description: STAP1 is a signal-transducing adaptor protein. It is composed of a Pleckstrin Homology (PH) and SH2 domains along with several tyrosine phosphorylation sites. STAP-1 is an orthologue of BRDG1 (also known as BCR downstream signaling 1). STAP1 protein functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is phosphorylated by Tec and participates in a positive feedback loop, increasing Tec activity []. STAP-1 has been shown to interact with STAT5 []. This entry represents the SH2 domain of STAP1.In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites [, , ].
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Protein Domain
IPR035579 | TXK_SH3
Type: Domain
Description: TXK is a member of the Tec family, which is a group of nonreceptor tyrosine kinases containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. It also contains an N-terminal cysteine-rich region. TXK forms a complex with EF-1alpha and PARP1 that regulates interferon-gamma gene transcription in Th1 cells []. This entry represents the SH3 domain of TXK.
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HT Experiment
GSE215418 | Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE192480 | Single-cell RNA sequencing of non-hematopoietic cells from mouse thymus spanning embryonic and adult stages
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
37165001 | J:335559
First Author: Hiroki H
Year: 2023
Journal: Sci Rep
Title: Targeting Poly(ADP)ribose polymerase in BCR/ABL1-positive cells.
Volume: 13
Issue: 1
Pages: 7588
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Publication
10666183 | J:60817
First Author: Honda H
Year: 2000
Journal: Blood
Title: Acquired loss of p53 induces blastic transformation in p210(bcr/abl)-expressing hematopoietic cells: a transgenic study for blast crisis of human CML.
Volume: 95
Issue: 4
Pages: 1144-50
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Publication
15611294 | J:95335
First Author: Yasuda T
Year: 2004
Journal: J Exp Med
Title: Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia.
Volume: 200
Issue: 12
Pages: 1681-7
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Genotype
Genotype
Symbol: Dok1/Dok1 Dok2/Dok2 Tg(Tec-BCR/ABL1)5Hhi/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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HT Experiment
GSE240015 | Age-related epithelial defects limit thymic function and regeneration [visium]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
16931156 | -
First Author: Kosaka Y
Year: 2006
Journal: Trends Immunol
Title: Itk and Th2 responses: action but no reaction.
Volume: 27
Issue: 10
Pages: 453-60
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Publication
17412921 | J:121632
First Author: Huang YH
Year: 2007
Journal: Science
Title: Positive regulation of Itk PH domain function by soluble IP4.
Volume: 316
Issue: 5826
Pages: 886-9
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Publication
9701039 | -
First Author: King PD
Year: 1998
Journal: Int Immunol
Title: CD2-mediated activation of the Tec-family tyrosine kinase ITK is controlled by proline-rich stretch-4 of the CD2 cytoplasmic tail.
Volume: 10
Issue: 7
Pages: 1009-16
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Publication
21205088 | -
First Author: Ikeda O
Year: 2011
Journal: Cancer Sci
Title: Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells.
Volume: 102
Issue: 4
Pages: 756-61
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Publication
14766749 | -
First Author: Brown K
Year: 2004
Journal: J Biol Chem
Title: Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors.
Volume: 279
Issue: 18
Pages: 18727-32
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Publication
16802597 | -
 
First Author: Tsoukas CD
Year: 2006
Journal: Adv Exp Med Biol
Title: Inducible T cell tyrosine kinase (ITK): structural requirements and actin polymerization.
Volume: 584
Pages: 29-41
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Publication
20545945 | -
First Author: Kutach AK
Year: 2010
Journal: Chem Biol Drug Des
Title: Crystal structures of IL-2-inducible T cell kinase complexed with inhibitors: insights into rational drug design and activity regulation.
Volume: 76
Issue: 2
Pages: 154-63
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Protein Domain
IPR042785 | ITK_PTKc
Type: Domain
Description: PTKs catalyse the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Itk, also known as Tsk or Emt, is a member of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, Itk contains the Tec homology (TH) domain containing one proline-rich region and a zinc-binding region [, ].Itk is expressed in T-cells and mast cells, and is important in their development and differentiation []. Of the three Tec kinases expressed in T-cells, Itk plays the predominant role in T-cell receptor (TCR) signalling. It is activated by phosphorylation upon TCR crosslinking and is involved in the pathway resulting in phospholipase C-gamma1 activation and actin polymerization []. It also plays a role in the downstream signalling of the T-cell costimulatory receptor CD28, the T-cell surface receptor CD2, and the chemokine receptor CXCR4 [, ]. In addition, Itk is crucial for the development of T-helper(Th)2 effector responses [].
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Protein Domain
IPR035583 | ITK_SH3
Type: Domain
Description: ITK (also known as Tsk or Emt) is a member of the Tec family, which is a group of nonreceptor tyrosine kinases containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. It also contains an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation [], and the Tec homology (TH) domain, which contains proline-rich and zinc-binding regions. ITK is expressed in T-cells and mast cells, and is important in their development and differentiation [, ]. Of the three Tec kinases expressed in T-cells, ITK plays the predominant role in T-cell receptor (TCR) signaling. It is activated by phosphorylation upon TCR crosslinking and is involved in the pathway resulting in phospholipase C-gamma1 activation and actin polymerization []. It also plays a role in the downstream signaling of the T-cell costimulatory receptor CD28 [], the T-cell surface receptor CD2 [], and the chemokine receptor CXCR4 []. In addition, ITK is crucial for the development of T-helper(Th)2 effector responses []. This entry represents the SH3 domain of ITK.
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HT Experiment
GSE44945 | Transcriptome sequencing of neonatal thymic epithelial cells.
Series Id: E-GEOD-44945
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
10640270 | J:95641
First Author: Yamanashi Y
Year: 2000
Journal: Genes Dev
Title: Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling.
Volume: 14
Issue: 1
Pages: 11-6
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Publication
36010887 | J:327859
 
First Author: Gómez C
Year: 2022
Journal: Cancers (Basel)
Title: Critical Requirement of SOS1 for Development of BCR/ABL-Driven Chronic Myelogenous Leukemia.
Volume: 14
Issue: 16
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HT Experiment
GSE193456 | Single-cell RNA-seq analysis of WT and Furin KO TECs
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE71268 | Transcriptome sequencing of Wild-type and psmb11-/- thymic epithelial cells
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
8893810 | J:36084
First Author: Tate G
Year: 1996
Journal: Cytogenet Cell Genet
Title: Localization of the human IL-2-inducible T-cell kinase gene (ITK) to chromosome band 5q34 and the mouse gene (Itk) to chromosome 15 by fluorescence in situ hybridization.
Volume: 74
Issue: 1-2
Pages: 96-8
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Publication
9218782 | -
First Author: Hyvönen M
Year: 1997
Journal: EMBO J
Title: Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia.
Volume: 16
Issue: 12
Pages: 3396-404
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Publication
9280283 | -
First Author: Vihinen M
Year: 1997
Journal: FEBS Lett
Title: Missense mutations affecting a conserved cysteine pair in the TH domain of Btk.
Volume: 413
Issue: 2
Pages: 205-10
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Publication
9796816 | -
First Author: Jiang Y
Year: 1998
Journal: Nature
Title: The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain.
Volume: 395
Issue: 6704
Pages: 808-13
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Publication
15661031 | -
 
First Author: Lindvall JM
Year: 2005
Journal: Immunol Rev
Title: Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling.
Volume: 203
Pages: 200-15
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Protein Domain
IPR001562 | Znf_Btk_motif
Type: Conserved_site
Description: The Btk-type zinc finger or Btk motif (BM) is a conserved zinc-binding motif containing conserved cysteines and a histidine that is present in certain eukaryotic signalling proteins. The motif is named after Bruton's tyrosine kinase (Btk), an enzyme which is essential for B cell maturation in humans and mice [, ]. Btk is a member of the Tec family of protein tyrosine kinases (PTK). These kinases contain a conserved Tec homology (TH) domain between the N-terminal pleckstrin homology (PH) domain () and the Src homology 3 (SH3) domain (). The N-terminal of the TH domain is highly conserved and known as the Btf motif, while the C-terminal region of the TH domain contains a proline-rich region (PRR). The Btk motif contains a conserved His and three Cys residues that form a zinc finger (although these differ from known zinc finger topologies), while PRRs are commonly involved in protein-protein interactions, including interactions with G proteins [, ]. The TH domain may be of functional importance in various signalling pathways in different species []. A complete TH domain, containing both the Btk and PRR regions, has not been found outside the Tec family; however, the Btk motif on its own does occur in other proteins, usually C-terminal to a PH domain (note that although a Btk motif always occurs C-terminal to a PH domain, not all PH domains are followed by a Btk motif).The crystal structures of Btk show that the Btk-type zinc finger has a globular core, formed by a long loop which is held together by a zinc ion, and that the Btk motif is packed against the PH domain []. The zinc-binding residues are a histidine and three cysteines, which are fully conserved in the Btk motif []. Proteins known to contain a Btk-type zinc finger include:Mammalian Bruton's tyrosine kinase (Btk), a protein tyrosine kinase involved in modulation of diverse cellular processes. Mutations affecting Btk are the cause of X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency in mice. Mammalian Tec, Bmx, and Itk proteins, which are tyrosine protein kinases of the Tec subfamily. Drosophila tyrosine-protein kinase Btk29A, which is required for the development of proper ring canals and of male genitalia and required for adult survival. Mammalian Ras GTPase-activating proteins (RasGAP), which regulate the activation of inactive GDP-bound Ras by converting GDP to GTP.
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Publication
17290574 | -
First Author: Mesci L
Year: 2006
Journal: Turk J Pediatr
Title: A novel mutation leading to a deletion in the SH3 domain of Bruton's tyrosine kinase.
Volume: 48
Issue: 4
Pages: 362-4
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Publication
11102316 | -
 
First Author: Vihinen M
Year: 2000
Journal: Front Biosci
Title: Bruton tyrosine kinase (BTK) in X-linked agammaglobulinemia (XLA).
Volume: 5
Pages: D917-28
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Publication
15944945 | -
First Author: Brunner C
Year: 2005
Journal: Histol Histopathol
Title: Bruton's Tyrosine Kinase is involved in innate and adaptive immunity.
Volume: 20
Issue: 3
Pages: 945-55
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Publication
11598012 | -
First Author: Kang SW
Year: 2001
Journal: EMBO J
Title: PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.
Volume: 20
Issue: 20
Pages: 5692-702
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Protein Domain
IPR035574 | BTK_SH3
Type: Domain
Description: Btk (Bruton tyrosine kinase) is a member of the Tec family, which is a group of nonreceptor tyrosine kinases containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Btk also contains an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation, and the Tec homology (TH) domain with proline-rich and zinc-binding regions [].Btk is expressed in B-cells, and a variety of myeloid cells including mast cells, platelets, neutrophils, and dendrictic cells [, ]. It interacts with a variety of partners, from cytosolic proteins to nuclear transcription factors, suggesting a diversity of functions. Stimulation of a diverse array of cell surface receptors, including antigen engagement of the B-cell receptor (BCR), leads to PH-mediated membrane translocation of Btk and subsequent phosphorylation by Src kinase and activation []. Btk plays an important role in the life cycle of B-cells including their development, differentiation, proliferation, survival, and apoptosis []. Mutations in Btk cause the primary immunodeficiency disease, X-linked agammaglobulinaemia (XLA) in humans [, ]. This entry represents the SH3 domain of Btk.
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Publication
24747972 | J:216528
First Author: Sato T
Year: 2014
Journal: Oncogene
Title: Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia.
Volume: 33
Issue: 42
Pages: 5028-38
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Publication
9551546 | -
First Author: Barford D
Year: 1998
Journal: Structure
Title: Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.
Volume: 6
Issue: 3
Pages: 249-54
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Protein
Q3TQ19
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: true
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Protein
B7ZP01
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: false
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Protein
A0A0H2UKC0
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: false
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Publication
11520461 | J:110427
First Author: Sano S
Year: 2001
Journal: Immunity
Title: Stat3 in thymic epithelial cells is essential for postnatal maintenance of thymic architecture and thymocyte survival.
Volume: 15
Issue: 2
Pages: 261-73
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Publication
14528302 | J:86255
First Author: Su DM
Year: 2003
Journal: Nat Immunol
Title: A domain of Foxn1 required for crosstalk-dependent thymic epithelial cell differentiation.
Volume: 4
Issue: 11
Pages: 1128-35
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HT Experiment
GSE66873 | Sex hormones have pervasive effects on thymic epithelial cells
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
10587356 | J:64938
First Author: Rajagopal K
Year: 1999
Journal: J Exp Med
Title: RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation.
Volume: 190
Issue: 11
Pages: 1657-68
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Publication
7935409 | J:20410
First Author: Kohmura N
Year: 1994
Journal: Mol Cell Biol
Title: A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption.
Volume: 14
Issue: 10
Pages: 6915-25
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Publication
30961932 | J:291672
First Author: Tian H
Year: 2019
Journal: Biochem Biophys Res Commun
Title: SHP-1 inhibits renal ischemia reperfusion injury via dephosphorylating ASK1 and suppressing apoptosis.
Volume: 513
Issue: 2
Pages: 360-367
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Publication
12626529 | J:126271
First Author: Mizuno T
Year: 2003
Journal: J Immunol
Title: Cutting edge: CD40 engagement eliminates the need for Bruton's tyrosine kinase in B cell receptor signaling for NF-kappa B.
Volume: 170
Issue: 6
Pages: 2806-10
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Publication
20439914 | J:161220
First Author: Alves NL
Year: 2010
Journal: J Immunol
Title: Cutting Edge: a thymocyte-thymic epithelial cell cross-talk dynamically regulates intrathymic IL-7 expression in vivo.
Volume: 184
Issue: 11
Pages: 5949-53
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Publication
27173733 | J:345185
 
First Author: Ciornei RT
Year: 2016
Journal: Cell Immunol
Title: Mechanisms and kinetics of proliferation and fibrosis development in a mouse model of thyrocyte hyperplasia.
Volume: 304-305
Pages: 16-26
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Publication
22291096 | J:181695
First Author: Block H
Year: 2012
Journal: J Exp Med
Title: Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.
Volume: 209
Issue: 2
Pages: 407-21
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Publication
24135055 | J:206056
First Author: Kayes TD
Year: 2013
Journal: Cell Immunol
Title: Culture promotes transfer of thyroid epithelial cell hyperplasia and proliferation by reducing regulatory T cell numbers.
Volume: 285
Issue: 1-2
Pages: 84-91
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Publication
28406139 | J:275129
 
First Author: Kannan AK
Year: 2017
Journal: Sci Rep
Title: T-Bet independent development of IFNγ secreting natural T helper 1 cell population in the absence of Itk.
Volume: 7
Pages: 45935
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Publication
18641364 | J:139224
First Author: Yu S
Year: 2008
Journal: J Immunol
Title: TGF-beta promotes thyroid epithelial cell hyperplasia and fibrosis in IFN-gamma-deficient NOD.H-2h4 mice.
Volume: 181
Issue: 3
Pages: 2238-45
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Publication
28455312 | J:270980
First Author: Lopes N
Year: 2017
Journal: EMBO Mol Med
Title: Administration of RANKL boosts thymic regeneration upon bone marrow transplantation.
Volume: 9
Issue: 6
Pages: 835-851
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