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Search results 301 to 400 out of 405 for Tfpi

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Allele
Adtrp<tm1e(KOMP)Wtsi> | MGI:5426569
Name: androgen dependent TFPI regulating protein; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Adtrp<em1(IMPC)Bay> | MGI:6257443
Name: androgen dependent TFPI regulating protein; endonuclease-mediated mutation 1, Baylor College of Medicine
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Adtrp<em1Smoc> | MGI:7288170
Name: androgen dependent TFPI regulating protein; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7590792 | C57BL/6J-Adtrp<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Adtrp/Adtrp
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Adtrp/Adtrp
Background: involves: 129S4/SvJaeSor * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Protein
O54819-2
Organism: Mus musculus/domesticus
Length: 253  
Fragment?: false
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Heritable Phenotypic Marker
MGI:6119616 | MF5L6
Type: heritable_phenotypic_marker
Organism: mouse, laboratory
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Strain
MGI:6345312 | C57BL/6N-Adtrp<em1(IMPC)Bay>/Mmucd
Attribute String: mutant strain, coisogenic, endonuclease-mediated mutation
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Strain
MGI:6408126 | C57BL/6N-Adtrp<em1(IMPC)Bay>/BayMmucd
Attribute String: coisogenic, targeted mutation
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Strain
MGI:6428128 | C57BL/6JSmoc-Adtrp<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Adtrp/Adtrp
Background: C57BL/6N-Adtrp/BayMmucd
Zygosity: hm
Has Mutant Allele: true
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Allele
Tfpi<tm2Smoc> | MGI:7786942
Name: tissue factor pathway inhibitor; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Adtrp/Adtrp Aig1/Aig1
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
15351845 | J:180949
First Author: Pan S
Year: 2004
Journal: Thromb Haemost
Title: The effect of vascular smooth muscle cell-targeted expression of tissue factor pathway inhibitor in a murine model of arterial thrombosis.
Volume: 92
Issue: 3
Pages: 495-502
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Allele
Tg(Tagln-Tfpi)1661Rdsi | MGI:5308413
Name: transgene insertion 1661, Robert D Simari
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:7788790 | C57BL/6JSmoc-Tfpi<tm2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Publication
16689766 | -
First Author: Maroney SA
Year: 2006
Journal: J Thromb Haemost
Title: A GPI-anchored co-receptor for tissue factor pathway inhibitor controls its intracellular trafficking and cell surface expression.
Volume: 4
Issue: 5
Pages: 1114-24
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Publication
23746805 | -
First Author: Alonso del Rivero M
Year: 2013
Journal: Structure
Title: A noncanonical mechanism of carboxypeptidase inhibition revealed by the crystal structure of the Tri-Kunitz SmCI in complex with human CPA4.
Volume: 21
Issue: 7
Pages: 1118-26
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Protein Domain
IPR008296 | TFPI-like
Type: Family
Description: Tissue factor pathway inhibitor (TFPI or TFPI1), also called lipoprotein-associated coagulation inhibitor (LACI) or extrinsic pathway inhibitor, is an anti-coagulation plasma protein that acts as a Kunitz-type serine protease inhibitor. Though TFPI lacks a membrane attachment signal, it remains associated with the endothelial surface through its association with a GPI-anchored co-receptor, which acts as a molecular chaperone to move TFPI to the cell surface []. TFPI is a dual inhibitor, binding directly to factor Xa (FXa), and to tissue factor/factor VIIa (TF/FVIIa) in a FXa-dependent way, presumably by forming a quaternary FXa/TFPI/FVIIa/TF complex, thereby blocking the continuation of the coagulation pathway. TFPI is thought to be important in modulating tissue factor-induced thrombogenesis []. The sequence of TFPI contains three Kunitz/Bovine pancreatic trypsin inhibitor domains. Inhibitor domains 1 and 2 belong to MEROPS protease inhibitor family I2 (aprotinin, clan IB). Domains 1 and 2 are required for the inhibition of TF/FVIIa activity, while domain 2 is required for binding and inhibition of FXa. Alteration of the inhibitory-site residue of the third domain has no significant effect on either function.The homologous tissue factor pathway inhibitor 2 (TFPI-2) has a similar structure and is thought to play a role in the regulation of extracellular matrix digestion and remodelling []. This entry also includes SmCI from Sabellastarte magnifica. SmCI is a bifunctional inhibitor of metallo carboxypeptidase and serine proteinase [].
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Strain
MGI:5308421 | C57BL/6-Tg(Tagln-Tfpi)1661Rdsi/J
Attribute String: coisogenic, mutant strain, transgenic
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Allele
Tfpi<tm1.1Madu> | MGI:7437558
Name: tissue factor pathway inhibitor; targeted mutation 1.1, Duan Ma
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Publication
16411383 | -
First Author: Chand HS
Year: 2005
Journal: Thromb Haemost
Title: Structure, function and biology of tissue factor pathway inhibitor-2.
Volume: 94
Issue: 6
Pages: 1122-30
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Publication
16261634 | -
First Author: Lwaleed BA
Year: 2006
Journal: J Pathol
Title: Tissue factor pathway inhibitor: structure, biology and involvement in disease.
Volume: 208
Issue: 3
Pages: 327-39
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Protein
O35536
Organism: Mus musculus/domesticus
Length: 230  
Fragment?: false
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Protein
Q8CI80
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
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Protein
A2ARA0
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: false
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Protein
Q3V1S9
Organism: Mus musculus/domesticus
Length: 230  
Fragment?: false
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Protein
A2ARA3
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: false
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Protein
A2ARA4
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: true
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Protein
Q8BSB7
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
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Protein Coding Gene
MGI:1913963 | Actr2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0016114 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0018063 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0018036 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0018000 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0018004 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0017818 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1913963 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018456 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0017379 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0017792 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017902 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017894 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017973 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017920 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0018497 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0017159 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0017433 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0016777 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0016957 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:7506851
Assay Type: RT-PCR
Annotation Date: 2023-07-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:7506973
Age: postnatal day 30
Image: 6
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7506851
Assay Type: RT-PCR
Annotation Date: 2023-07-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:7506973
Age: postnatal day 30
Image: 6
Specimen Label: DKO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6455453
Assay Type: Immunohistochemistry
Annotation Date: 2020-09-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6455477
Age: postnatal adult
Note: No difference in distribution or intensity of expression between wild type and mildly affected mutant mice.
Specimen Label: S6 Arp2/3 MIM+-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6455453
Assay Type: Immunohistochemistry
Annotation Date: 2020-09-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6455477
Age: postnatal adult
Specimen Label: S6 Arp2/3 MIM+/+
Detected: true
Specimen Num: 1
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Publication
29317453 | J:261558
First Author: Prince R
Year: 2018
Journal: Blood
Title: Targeting anticoagulant protein S to improve hemostasis in hemophilia.
Volume: 131
Issue: 12
Pages: 1360-1371
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Publication
23327927 | J:195867
First Author: Khurana S
Year: 2013
Journal: Blood
Title: Glypican-3-mediated inhibition of CD26 by TFPI: a novel mechanism in hematopoietic stem cell homing and maintenance.
Volume: 121
Issue: 14
Pages: 2587-95
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Publication
31351019 | J:294292
First Author: Crawley JTB
Year: 2019
Journal: J Thromb Haemost
Title: Defective fibrin deposition and thrombus stability in Bambi-/- mice are mediated by elevated anticoagulant function.
Volume: 17
Issue: 11
Pages: 1935-1949
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Publication
22492716 | J:188091
First Author: Higuchi Y
Year: 2012
Journal: Am J Physiol Heart Circ Physiol
Title: Upregulation of anticoagulant proteins, protein S and tissue factor pathway inhibitor, in the mouse myocardium with cardio-specific TNF-α overexpression.
Volume: 302
Issue: 11
Pages: H2352-62
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Publication
25427855 | J:234973
First Author: Subramaniam S
Year: 2015
Journal: Thromb Haemost
Title: Defective thrombus formation in mice lacking endogenous factor VII activating protease (FSAP).
Volume: 113
Issue: 4
Pages: 870-80
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Publication
18276908 | J:149035
First Author: Wu J
Year: 2008
Journal: Arterioscler Thromb Vasc Biol
Title: C-reactive protein enhances tissue factor expression by vascular smooth muscle cells: mechanisms and in vivo significance.
Volume: 28
Issue: 4
Pages: 698-704
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Publication
25071150 | J:224345
First Author: Ueda J
Year: 2014
Journal: Mol Cell Biol
Title: The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.
Volume: 34
Issue: 19
Pages: 3702-20
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Publication
31157616 | J:277319
   
First Author: Bolger-Munro M
Year: 2019
Journal: Elife
Title: Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation.
Volume: 8
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Publication
32079655 | J:288882
 
First Author: Ma W
Year: 2020
Journal: J Cell Sci
Title: Arp2/3 nucleates F-actin coating of fusing insulin granules in pancreatic β cells to control insulin secretion.
Volume: 133
Issue: 6
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Publication
21494665 | J:172280
First Author: Sun SC
Year: 2011
Journal: PLoS One
Title: Arp2/3 complex regulates asymmetric division and cytokinesis in mouse oocytes.
Volume: 6
Issue: 4
Pages: e18392
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Publication
25220164 | J:217819
First Author: Yang W
Year: 2014
Journal: Biochem J
Title: Arp2/3 complex regulates adipogenesis by controlling cortical actin remodelling.
Volume: 464
Issue: 2
Pages: 179-92
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Publication
26028144 | J:223041
 
First Author: Poulter NS
Year: 2015
Journal: Nat Commun
Title: Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.
Volume: 6
Pages: 7254
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Publication
27181356 | J:235760
First Author: Tang Y
Year: 2016
Journal: Biochem Biophys Res Commun
Title: ox-LDL induces endothelial dysfunction by promoting Arp2/3 complex expression.
Volume: 475
Issue: 2
Pages: 182-8
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Publication
22684256 | J:193447
First Author: Cao J
Year: 2012
Journal: Nat Cell Biol
Title: miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics.
Volume: 14
Issue: 7
Pages: 697-706
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Publication
21874009 | J:176957
First Author: Yi K
Year: 2011
Journal: Nat Cell Biol
Title: Dynamic maintenance of asymmetric meiotic spindle position through Arp2/3-complex-driven cytoplasmic streaming in mouse oocytes.
Volume: 13
Issue: 10
Pages: 1252-8
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Publication
23495010 | J:250041
First Author: Ritterson Lew C
Year: 2013
Journal: J Cell Biochem
Title: Aldolase sequesters WASP and affects WASP/Arp2/3-stimulated actin dynamics.
Volume: 114
Issue: 8
Pages: 1928-39
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Publication
24998208 | J:217315
 
First Author: Wang F
Year: 2014
Journal: Sci Rep
Title: WASH complex regulates Arp2/3 complex for actin-based polar body extrusion in mouse oocytes.
Volume: 4
Pages: 5596
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Publication
23439682 | J:195195
First Author: Yi K
Year: 2013
Journal: J Cell Biol
Title: Sequential actin-based pushing forces drive meiosis I chromosome migration and symmetry breaking in oocytes.
Volume: 200
Issue: 5
Pages: 567-76
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Publication
15247266 | J:93351
First Author: Guilherme A
Year: 2004
Journal: J Biol Chem
Title: Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes.
Volume: 279
Issue: 38
Pages: 40062-75
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Publication
19922875 | J:155753
First Author: Derivery E
Year: 2009
Journal: Dev Cell
Title: The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.
Volume: 17
Issue: 5
Pages: 712-23
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Publication
27927957 | J:237336
First Author: Gokhale A
Year: 2016
Journal: J Neurosci
Title: The Proteome of BLOC-1 Genetic Defects Identifies the Arp2/3 Actin Polymerization Complex to Function Downstream of the Schizophrenia Susceptibility Factor Dysbindin at the Synapse.
Volume: 36
Issue: 49
Pages: 12393-12411
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Publication
15331365 | J:94767
First Author: Perlegas D
Year: 2005
Journal: Am J Physiol Heart Circ Physiol
Title: ANG II type 2 receptor regulates smooth muscle growth and force generation in late fetal mouse development.
Volume: 288
Issue: 1
Pages: H96-102
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Publication
26975831 | J:236555
 
First Author: Thiam HR
Year: 2016
Journal: Nat Commun
Title: Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments.
Volume: 7
Pages: 10997
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Publication
33903241 | J:309471
 
First Author: Figueiredo AM
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Endothelial cell invasion is controlled by dactylopodia.
Volume: 118
Issue: 18
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Publication
25926623 | J:223805
First Author: Moehle MS
Year: 2015
Journal: Hum Mol Genet
Title: The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins.
Volume: 24
Issue: 15
Pages: 4250-67
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Publication
31146259 | J:285722
First Author: Liu Y
Year: 2019
Journal: Reproduction
Title: The sperm-associated antigen 6 interactome and its role in spermatogenesis.
Volume: 158
Issue: 2
Pages: 181-197
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Publication
21406566 | J:182970
First Author: Saarikangas J
Year: 2011
Journal: J Cell Sci
Title: Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia.
Volume: 124
Issue: Pt 8
Pages: 1245-55
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Publication
31961823 | J:309484
 
First Author: Tessier S
Year: 2020
Journal: JCI Insight
Title: Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation.
Volume: 5
Issue: 4
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
14566948 | J:86254
First Author: Vyas A
Year: 2003
Journal: J Comp Neurol
Title: Paleocortex is specified in mice in which dorsal telencephalic patterning is severely disrupted.
Volume: 466
Issue: 4
Pages: 545-53
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Publication
25315346 | J:315097
First Author: Leung C
Year: 2014
Journal: J Am Heart Assoc
Title: Rac1 signaling is critical to cardiomyocyte polarity and embryonic heart development.
Volume: 3
Issue: 5
Pages: e001271
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Publication
30833597 | J:276652
First Author: Fang Q
Year: 2019
Journal: Sci Rep
Title: Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function.
Volume: 9
Issue: 1
Pages: 3357
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Publication
19144319 | J:143718
First Author: Trost M
Year: 2009
Journal: Immunity
Title: The phagosomal proteome in interferon-gamma-activated macrophages.
Volume: 30
Issue: 1
Pages: 143-54
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Publication
34455539 | J:322355
First Author: Longatti A
Year: 2021
Journal: Mol Neurobiol
Title: Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice.
Volume: 58
Issue: 12
Pages: 6092-6110
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Publication
31577955 | J:300786
First Author: Zhang Z
Year: 2019
Journal: Cell Rep
Title: The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling.
Volume: 29
Issue: 1
Pages: 49-61.e7
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:24194
     
First Author: The Jackson Laboratory Backcross DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX BSS Panel Mapping Data
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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