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Search results 301 to 400 out of 427 for Tiam1

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:4422222
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828714
Age: embryonic day 14.5
Image: euxassay_006321_16
Specimen Label: euxassay_006321_16
Detected: true
Specimen Num: 16
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Publication
14550769 | J:85971
First Author: Matsuo N
Year: 2003
Journal: Mol Cell Neurosci
Title: Roles of STEF/Tiam1, guanine nucleotide exchange factors for Rac1, in regulation of growth cone morphology.
Volume: 24
Issue: 1
Pages: 69-81
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Publication
22427969 | J:186916
First Author: Hart SP
Year: 2012
Journal: PLoS One
Title: Characterization of the effects of cross-linking of macrophage CD44 associated with increased phagocytosis of apoptotic PMN.
Volume: 7
Issue: 3
Pages: e33142
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Publication
9204476 | J:41286
First Author: Ehler E
Year: 1997
Journal: Mol Cell Neurosci
Title: Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth.
Volume: 9
Issue: 1
Pages: 1-12
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Publication
12525493 | J:82578
First Author: Baumeister MA
Year: 2003
Journal: J Biol Chem
Title: Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting.
Volume: 278
Issue: 13
Pages: 11457-64
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Publication
9070862 | J:38630
First Author: Song WJ
Year: 1997
Journal: Biochem Biophys Res Commun
Title: The murine Dyrk protein maps to chromosome 16, localizes to the nucleus, and can form multimers.
Volume: 231
Issue: 3
Pages: 640-4
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Publication
10662544 | J:60651
First Author: Gardner HP
Year: 2000
Journal: Genomics
Title: Cloning and characterization of Hunk, a novel mammalian SNF1-related protein kinase.
Volume: 63
Issue: 1
Pages: 46-59
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Publication
19367791 | J:149489
First Author: Minobe S
Year: 2009
Journal: Neurosci Res
Title: Rac is involved in the interkinetic nuclear migration of cortical progenitor cells.
Volume: 63
Issue: 4
Pages: 294-301
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Publication
11290294 | J:68213
First Author: Tkatchenko AV
Year: 2001
Journal: Development
Title: Overexpression of Hoxc13 in differentiating keratinocytes results in downregulation of a novel hair keratin gene cluster and alopecia.
Volume: 128
Issue: 9
Pages: 1547-58
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Publication
8692692 | J:34150
First Author: Schmidt T
Year: 1996
Journal: Nucleic Acids Res
Title: MoMuLV proviral integrations identified by Sup-F selection in tumors from infected myc/pim bitransgenic mice correlate with activation of the gfi-1 gene.
Volume: 24
Issue: 13
Pages: 2528-34
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Publication
8858343 | J:34963
First Author: Wei J
Year: 1996
Journal: Genome Res
Title: Direct cDNA selection with DNA microdissected from mouse chromosome 16: isolation of novel clones and construction of a partial transcription map of the C3-C4 region.
Volume: 6
Issue: 8
Pages: 678-87
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Publication
- | J:71237
     
First Author: Akeson EC
Year: 2001
Journal: MGI Direct Data Submission
Title: FISH mapping of the mouse orthologs of genes on human Chromosome 21
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Publication
22750946 | J:193444
First Author: Galic M
Year: 2012
Journal: Nat Cell Biol
Title: External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane.
Volume: 14
Issue: 8
Pages: 874-81
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Publication
8812055 | J:31897
First Author: Fan CM
Year: 1996
Journal: Mol Cell Neurosci
Title: Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome.
Volume: 7
Issue: 1
Pages: 1-16
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Publication
38077328 | J:343684
 
First Author: Hornigold K
Year: 2023
Journal: Front Immunol
Title: The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses.
Volume: 14
Pages: 1223653
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Publication
25956904 | J:222249
First Author: Tu HC
Year: 2015
Journal: Genes Dev
Title: LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans.
Volume: 29
Issue: 10
Pages: 1074-86
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Publication
23533177 | J:195272
First Author: Sipe CW
Year: 2013
Journal: Development
Title: Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization.
Volume: 140
Issue: 8
Pages: 1785-95
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Publication
12466855 | J:80501
First Author: Gitton Y
Year: 2002
Journal: Nature
Title: A gene expression map of human chromosome 21 orthologues in the mouse.
Volume: 420
Issue: 6915
Pages: 586-90
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Publication
12466854 | J:80502
First Author: Reymond A
Year: 2002
Journal: Nature
Title: Human chromosome 21 gene expression atlas in the mouse.
Volume: 420
Issue: 6915
Pages: 582-6
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
10512203 | J:93290
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
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Publication
15840001 | J:110088
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
17339315 | -
First Author: Ceccarelli DF
Year: 2007
Journal: J Biol Chem
Title: Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9.
Volume: 282
Issue: 18
Pages: 13864-74
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UniProt Feature
UniProt Feature
Begin: 2
Description: Rho guanine nucleotide exchange factor TIAM1
Type: chain
End: 1591
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Publication
17440041 | J:248221
First Author: Tolias KF
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development.
Volume: 104
Issue: 17
Pages: 7265-70
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Publication
24069171 | J:207539
First Author: Yu LN
Year: 2013
Journal: PLoS One
Title: Tiam1 transgenic mice display increased tumor invasive and metastatic potential of colorectal cancer after 1,2-dimethylhydrazine treatment.
Volume: 8
Issue: 9
Pages: e73077
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Interaction Experiment
Tanaka M (2004)
Description: Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2.
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Publication
11130063 | -
First Author: Worthylake DK
Year: 2000
Journal: Nature
Title: Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1.
Volume: 408
Issue: 6813
Pages: 682-8
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Publication
21192692 | -
First Author: Shepherd TR
Year: 2011
Journal: Biochemistry
Title: Distinct ligand specificity of the Tiam1 and Tiam2 PDZ domains.
Volume: 50
Issue: 8
Pages: 1296-308
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Allele
Tiam1<em1Smoc> | MGI:7292787
Name: T cell lymphoma invasion and metastasis 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
20496116 | -
First Author: Yoo S
Year: 2010
Journal: Mol Cells
Title: EphA8-ephrinA5 signaling and clathrin-mediated endocytosis is regulated by Tiam-1, a Rac-specific guanine nucleotide exchange factor.
Volume: 29
Issue: 6
Pages: 603-9
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Strain
MGI:6429666 | C57BL/6JSmoc-Tiam1<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
19899799 | -
First Author: Woodcock SA
Year: 2009
Journal: J Proteome Res
Title: A modified tandem affinity purification technique identifies that 14-3-3 proteins interact with Tiam1, an interaction which controls Tiam1 stability.
Volume: 8
Issue: 12
Pages: 5629-41
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DO Term
DOID:0070444 | neurodevelopmental disorder with language delay and seizures
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Allele
Dp(16Tiam1-Kcnj6)6Yey | MGI:5305765
 
Name: duplication, Chr 16, Y Eugene Yu 6
Allele Type: Targeted
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Allele
Del(16Tiam1-Kcnj6)7Yey | MGI:5305766
Name: deletion, Chr 16, Y Eugene Yu 7
Allele Type: Targeted
Attribute String: Null/knockout
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Protein Domain
IPR040655 | TIAM1_CC-Ex
Type: Domain
Description: Tiam1 is a guanine exchange factor (GEF) for CDC42 and the Rho-family GTPase Rac1, which plays an important role in cell-matrix adhesion and in cell migration [, ]. Tiam1 is involved in multiple steps of tumorigenesis [].This entry represents the CC and Ex subdomain found in the PH-CC-Ex globular domain of the Tiam1 and Tiam2 proteins (T-lymphoma invasion and metastasis). The CC subdomain forms an antiparallel coiled coil with two long α-helices, together with the C-terminal Ex subdomain they form a small globular domain comprising three α-helices. The CC subdomain of the Tiam2 PHCCEx domain follows the C-terminal alpha1 helix of the PH subdomain through a four-residue linker [].
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Strain
MGI:5428041 | 129-Dp(16Tiam1-Kcnj6)6Yey/J
Attribute String: targeted mutation, coisogenic, duplication, mutant strain
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Genotype
Genotype
Symbol: Del(16Tiam1-Kcnj6)7Yey/+
Background: involves: 129S7/SvEvBrd
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dp(16Tiam1-Kcnj6)6Yey/+
Background: involves: 129S7/SvEvBrd
Zygosity: ht
Has Mutant Allele: true
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Strain
MGI:5428040 | 129-Del(16Tiam1-Kcnj6)7Yey/Dp(16Tiam1-Kcnj6)6Yey/J
Attribute String: coisogenic, mutant strain, duplication, deletion, targeted mutation
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Genotype
Genotype
Symbol: Dp(16Lipi-Zbtb21)1Yey/? Del(16Tiam1-Kcnj6)7Yey/?
Background: involves: 129S7/SvEvBrd
Zygosity: cx
Has Mutant Allele: true
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Publication
21763699 | -
First Author: Stafford RL
Year: 2011
Journal: J Mol Biol
Title: The molecular basis of the Caskin1 and Mint1 interaction with CASK.
Volume: 412
Issue: 1
Pages: 3-13
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Protein Domain
IPR032232 | Caskin1-CID
Type: Domain
Description: The Caskin1 protein interacts with the CASK protein via this region []. CASK and Caskin1 are synaptic scaffolding proteins. The binding motif on human Caskin1 is EEIWVLRK. A similar motif is found on protein MINT1 and protein TIAM1, both shown to be able to bind to CASK though the motif. However, MINT1 and TIAM1 are not included in this entry []. This region is predicted to be natively unstructured.This entry also matches Caskin2, a Caskin1 homologue deprived of the CASK interaction domain (CID) []. Caskin1 and caskin2 consist of multiple ankyrin repeats, two SAM domains and one SH3 domain. In Caskin1 the CID is located between the SH3 and SAM domains [].
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Publication
9662423 | J:48454
First Author: Fleming IN
Year: 1998
Journal: FEBS Lett
Title: Phospholipase C-gamma, protein kinase C and Ca2+/calmodulin-dependent protein kinase II are involved in platelet-derived growth factor-induced phosphorylation of Tiam1.
Volume: 429
Issue: 3
Pages: 229-33
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Protein
A0A2I3BRI9
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: true
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Publication
30817801 | J:273736
First Author: Charron Y
Year: 2019
Journal: PLoS Genet
Title: Two isoforms of the RAC-specific guanine nucleotide exchange factor TIAM2 act oppositely on transmission ratio distortion by the mouse t-haplotype.
Volume: 15
Issue: 2
Pages: e1007964
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Publication
8999801 | -
First Author: Sone M
Year: 1997
Journal: Science
Title: Still life, a protein in synaptic terminals of Drosophila homologous to GDP-GTP exchangers.
Volume: 275
Issue: 5299
Pages: 543-7
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Publication
29844364 | J:262990
First Author: Woroniuk A
Year: 2018
Journal: Nat Commun
Title: STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap.
Volume: 9
Issue: 1
Pages: 2124
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Publication
24377522 | -
First Author: Zhao ZY
Year: 2013
Journal: Asian Pac J Cancer Prev
Title: TIAM2 enhances non-small cell lung cancer cell invasion and motility.
Volume: 14
Issue: 11
Pages: 6305-9
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Publication
21469146 | -
First Author: Chen JS
Year: 2012
Journal: Int J Cancer
Title: Expression of T-cell lymphoma invasion and metastasis 2 (TIAM2) promotes proliferation and invasion of liver cancer.
Volume: 130
Issue: 6
Pages: 1302-13
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Protein Domain
IPR043537 | Tiam1/Tiam2/Sif
Type: Family
Description: T-lymphoma invasion and metastasis-inducing protein 1 (Tiam1) is a guanine exchange factor (GEF) for CDC42 and the Rho-family GTPase Rac1, which plays an important role in cell-matrix adhesion and in cell migration [, ]. Tiam1 is involved in multiple steps of tumorigenesis [].Tiam2 has been shown to localise to the nuclear envelope and to regulate Rac1 activity at the nuclear envelope which regulates the perinuclear actin cap []. It has been shown to promote invasion and motility of non-small cell lung cancer cells []. It has also been shown to promote epithelial-to-mesenchymal transition and results in proliferation and invasion in liver cancer cells []. This entry includes a group of guanine nucleotide exchange factors, including Tiam1/2 from humans and Sif from Drosophila [, , ]. Tiam1/2 are activators of the Rho GTPase Rac1 and critical for cell morphology, adhesion, migration, and polarity [].
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Publication
20719958 | J:182832
First Author: Montenegro-Venegas C
Year: 2010
Journal: Mol Biol Cell
Title: MAP1B regulates axonal development by modulating Rho-GTPase Rac1 activity.
Volume: 21
Issue: 20
Pages: 3518-28
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Publication
23733346 | J:201471
First Author: Liu Y
Year: 2013
Journal: J Cell Biol
Title: A novel pathway spatiotemporally activates Rac1 and redox signaling in response to fluid shear stress.
Volume: 201
Issue: 6
Pages: 863-73
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Publication
33397922 | J:300957
First Author: Pickering KA
Year: 2021
Journal: Nat Commun
Title: A RAC-GEF network critical for early intestinal tumourigenesis.
Volume: 12
Issue: 1
Pages: 56
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Publication
27549312 | -
First Author: Smirnova E
Year: 2016
Journal: Cell Commun Signal
Title: A new mode of SAM domain mediated oligomerization observed in the CASKIN2 neuronal scaffolding protein.
Volume: 14
Issue: 1
Pages: 17
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Publication
27619958 | -
 
First Author: Kwan JJ
Year: 2016
Journal: BMC Struct Biol
Title: A lack of peptide binding and decreased thermostability suggests that the CASKIN2 scaffolding protein SH3 domain may be vestigial.
Volume: 16
Pages: 14
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Protein Domain
IPR043453 | Slm1_PH
Type: Domain
Description: Slm1 is a component of the target of rapamycin complex 2 (TORC2) signaling pathway. It plays a role in the regulation of actin organization and is a target of sphingolipid signaling during the heat shock response []. Slm1 contains a single PH domain that binds PtdIns(4,5)P2, PtdIns(4)P, and dihydrosphingosine 1-phosphate (DHS-1P). Slm1 possesses two binding sites for anionic lipids. The non-canonical binding site of the PH domain of Slm1 is used for ligand binding, and it is proposed that beta-spectrin, Tiam1 and ArhGAP9 also have this type of phosphoinositide binding site []. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner []. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity []. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane []. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes [].
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Publication
23595754 | J:196966
First Author: Duman JG
Year: 2013
Journal: J Neurosci
Title: The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites.
Volume: 33
Issue: 16
Pages: 6964-78
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Publication
10364228 | J:55621
First Author: Hoshino M
Year: 1999
Journal: J Biol Chem
Title: Identification of the stef gene that encodes a novel guanine nucleotide exchange factor specific for Rac1.
Volume: 274
Issue: 25
Pages: 17837-44
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Publication
24046447 | J:211218
First Author: Di Lorenzo A
Year: 2013
Journal: J Cell Sci
Title: eNOS-derived nitric oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases.
Volume: 126
Issue: Pt 24
Pages: 5541-52
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Publication
29254825 | J:261682
 
First Author: Wijayatunge R
Year: 2018
Journal: Mol Cell Neurosci
Title: The histone demethylase Kdm6b regulates a mature gene expression program in differentiating cerebellar granule neurons.
Volume: 87
Pages: 4-17
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