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Search results 301 to 342 out of 342 for Tmod1

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Type Details Score
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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GXD Expression
GXD Expression
Probe: MGI:2178610
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:7580875
Age: embryonic day 9.5
Image: 6 E9.5
Note: Immunopositive striations alternated with Tmod1 striations.
Specimen Label: 6 E9.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:2178610
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:7580875
Age: embryonic day 9.5
Image: 6 E9.5
Note: Immunopositive striations alternated with Tmod1 striations.
Specimen Label: 6 E9.5
Detected: true
Specimen Num: 2
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Allele
Tmod4<tm1(KOMP)Wtsi> | MGI:4419118
Name: tropomodulin 4; targeted mutation 1, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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GXD Expression
GXD Expression
Probe: MGI:2178610
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268812
Pattern: Not Specified
Stage: TS12
Assay Id: MGI:7580875
Age: embryonic day 8.0-8.5
Image: 6 E8-8.5
Note: Sarcomeric alpha-actinin (Actn2) is a marker for myofibril assembly. In cardiac myocytes staining was detected as periodic dots. Tmod1 immunostaining was observed between the dots.
Specimen Label: 6 E8-8.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:2178610
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268812
Pattern: Not Specified
Stage: TS12
Assay Id: MGI:7580875
Age: embryonic day 8.0-8.5
Image: 6 E8-8.5
Note: Sarcomeric alpha-actinin (Actn2) is a marker for myofibril assembly. In cardiac myocytes staining was detected as periodic dots. Tmod1 immunostaining was observed between the dots.
Specimen Label: 6 E8-8.5
Detected: true
Specimen Num: 1
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Genotype
Genotype
Symbol: Tmod4/Tmod4
Background: involves: C57BL/6J * C57BL/6N
Zygosity: hm
Has Mutant Allele: true
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GXD Expression
GXD Expression
Probe: MGI:2178610
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:7580875
Age: embryonic day 9.5
Image: 8 E9.5 -/-
Note: In the Tmod1 null E9.5 embryos, no striated myofibrils could be found, and nascent myofibril-like structures with dots of Actn2 staining were rarely observed. Instead, most Actn2 and F-actin appeared to be disorganized and to have accumulated into large aggregates.
Specimen Label: 8 E9.5 -/-
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
Probe: MGI:2178610
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:7580875
Age: embryonic day 9.5
Image: 8 E9.5 -/-
Note: In the Tmod1 null E9.5 embryos, no striated myofibrils could be found, and nascent myofibril-like structures with dots of Actn2 staining were rarely observed. Instead, most Actn2 and F-actin appeared to be disorganized and to have accumulated into large aggregates.
Specimen Label: 8 E9.5 -/-
Detected: true
Specimen Num: 7
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Allele
Tg(Myh6-Tmod1)65Msus | MGI:3622294
Name: transgene insertion 65, Mark A Sussman
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:3622338 | FVB/N-Tg(Myh6-Tmod1)65Msus
Attribute String: coisogenic, mutant strain, transgenic
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Publication
9421465 | J:107823
First Author: Sussman MA
Year: 1998
Journal: J Clin Invest
Title: Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice.
Volume: 101
Issue: 1
Pages: 51-61
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Genotype
Genotype
Symbol: Tg(Myh6-Tmod1)65Msus/Tg(Myh6-Tmod1)65Msus
Background: involves: FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-Tmod1)65Msus/Tg(Myh6-Tmod1)65Msus
Background: FVB/N-Tg(Myh6-Tmod1)65Msus
Zygosity: hm
Has Mutant Allele: true
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Protein Domain
IPR030129 | TMOD4
Type: Family
Description: The Tropomodulin (Tmod) family consist of four Tmods (Tmods 1-4) and three larger variants termed leiomodins (Lmods 1-3), which are expressed in a tissue-specific and developmentally regulated fashion []. Members of the Tmod family are actin filament pointed-end-capping proteins that regulate actin subunit association and dissociation from pointed ends in a tropomyosin-dependent manner [].Tropomodulin-4 (Tmod4) binds with F-actin []. Tmod1 and Tmod4 are sarcomeric Tmods that maintain thin filament stability and correctly specified thin filament lengths in cardiac muscles via their interactions with terminal tropomyosins and their ability to regulate actin subunit exchange at pointed ends [].
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Publication
9733519 | J:49872
First Author: Sussman MA
Year: 1998
Journal: Science
Title: Prevention of cardiac hypertrophy in mice by calcineurin inhibition.
Volume: 281
Issue: 5383
Pages: 1690-3
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Publication
12397029 | J:130997
First Author: Sayen MR
Year: 2003
Journal: Am J Physiol Cell Physiol
Title: Calcineurin transgenic mice have mitochondrial dysfunction and elevated superoxide production.
Volume: 284
Issue: 2
Pages: C562-70
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Publication
10727657 | J:61245
First Author: Sussman MA
Year: 2000
Journal: Cardiovasc Res
Title: Hypertrophic defect unmasked by calcineurin expression in asymptomatic tropomodulin overexpressing transgenic mice.
Volume: 46
Issue: 1
Pages: 90-101
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Genotype
Genotype
Symbol: Hspb7/Hspb7 Tg(Myh6-Tmod1)65Msus/Tg(Myh6-Tmod1)65Msus
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Publication
33742108 | J:314467
First Author: Colpan M
Year: 2021
Journal: Commun Biol
Title: CAP2 is a regulator of actin pointed end dynamics and myofibrillogenesis in cardiac muscle.
Volume: 4
Issue: 1
Pages: 365
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Publication
10756124 | J:307966
First Author: Lim HW
Year: 2000
Journal: J Mol Cell Cardiol
Title: Reversal of cardiac hypertrophy in transgenic disease models by calcineurin inhibition.
Volume: 32
Issue: 4
Pages: 697-709
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Publication
11934830 | J:128671
First Author: Welch S
Year: 2002
Journal: Circ Res
Title: Cardiac-specific IGF-1 expression attenuates dilated cardiomyopathy in tropomodulin-overexpressing transgenic mice.
Volume: 90
Issue: 6
Pages: 641-8
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Protein
D3Z5Q9
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: true
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Publication
20736303 | J:164228
First Author: Tsukada T
Year: 2010
Journal: J Cell Sci
Title: Leiomodin-2 is an antagonist of tropomodulin-1 at the pointed end of the thin filaments in cardiac muscle.
Volume: 123
Issue: Pt 18
Pages: 3136-45
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Publication
29223925 | J:257799
 
First Author: Arslan B
Year: 2018
Journal: Arch Biochem Biophys
Title: Characterizing interaction forces between actin and proteins of the tropomodulin family reveals the presence of the N-terminal actin-binding site in leiomodin.
Volume: 638
Pages: 18-26
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Publication
30333143 | J:267371
 
First Author: Cheng C
Year: 2018
Journal: J Cell Sci
Title: Tropomyosin 3.5 protects the F-actin networks required for tissue biomechanical properties.
Volume: 131
Issue: 23
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Publication
31339916 | J:277979
First Author: Wang W
Year: 2019
Journal: PLoS One
Title: Quantitative proteomics reveals TMOD1-related proteins associated with water balance regulation.
Volume: 14
Issue: 7
Pages: e0219932
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Protein
Q9JLH8
Organism: Mus musculus/domesticus
Length: 345  
Fragment?: false
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Protein
Q3UN19
Organism: Mus musculus/domesticus
Length: 345  
Fragment?: false
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Publication
27139341 | J:237825
 
First Author: Kolb J
Year: 2016
Journal: J Mol Cell Cardiol
Title: Thin filament length in the cardiac sarcomere varies with sarcomere length but is independent of titin and nebulin.
Volume: 97
Pages: 286-94
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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