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Search results 301 to 400 out of 419 for Tpo

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Type Details Score
Publication
24184684 | J:207699
First Author: de Laval B
Year: 2014
Journal: Blood
Title: Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1.
Volume: 123
Issue: 4
Pages: 509-19
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Publication
15337790 | J:93918
First Author: Tong W
Year: 2004
Journal: J Exp Med
Title: Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis.
Volume: 200
Issue: 5
Pages: 569-80
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Publication
18618018 | J:140879
First Author: Bersenev A
Year: 2008
Journal: J Clin Invest
Title: Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2.
Volume: 118
Issue: 8
Pages: 2832-44
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Publication
19059699 | J:146577
First Author: Chan ER
Year: 2009
Journal: Exp Hematol
Title: An ENU-induced recessive mutation in Mpl leads to thrombocytopenia with overdominance.
Volume: 37
Issue: 2
Pages: 276-84
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Publication
22242190 | J:184146
First Author: Rodriguez W
Year: 2012
Journal: PLoS One
Title: Deletion of the RNaseIII enzyme dicer in thyroid follicular cells causes hypothyroidism with signs of neoplastic alterations.
Volume: 7
Issue: 1
Pages: e29929
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Publication
29097774 | J:256934
First Author: Au AE
Year: 2017
Journal: Sci Rep
Title: Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling.
Volume: 7
Issue: 1
Pages: 14953
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Publication
25339357 | J:220785
First Author: Sangkhae V
Year: 2014
Journal: Blood
Title: The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm.
Volume: 124
Issue: 26
Pages: 3956-63
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Publication
32721504 | J:299431
 
First Author: Hacein-Bey-Abina S
Year: 2020
Journal: Exp Hematol
Title: Erythropoietin is a major regulator of thrombopoiesis in thrombopoietin-dependent and -independent contexts.
Volume: 88
Pages: 15-27
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Publication
25636339 | J:223526
First Author: Rozenova K
Year: 2015
Journal: Blood
Title: MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling.
Volume: 125
Issue: 11
Pages: 1730-8
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Publication
9345025 | J:43759
First Author: Bunting S
Year: 1997
Journal: Blood
Title: Normal platelets and megakaryocytes are produced in vivo in the absence of thrombopoietin.
Volume: 90
Issue: 9
Pages: 3423-9
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Publication
8704234 | J:34532
First Author: Carver-Moore K
Year: 1996
Journal: Blood
Title: Low levels of erythroid and myeloid progenitors in thrombopoietin-and c-mpl-deficient mice.
Volume: 88
Issue: 3
Pages: 803-8
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Publication
8630374 | J:110858
First Author: Fielder PJ
Year: 1996
Journal: Blood
Title: Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets.
Volume: 87
Issue: 6
Pages: 2154-61
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Publication
23990627 | J:209544
First Author: Tan W
Year: 2013
Journal: J Leukoc Biol
Title: Requirement of TPO/c-mpl for IL-17A-induced granulopoiesis and megakaryopoiesis.
Volume: 94
Issue: 6
Pages: 1303-8
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Publication
16051888 | J:111935
First Author: Amano H
Year: 2005
Journal: Circ Res
Title: Thrombopoietin gene transfer-mediated enhancement of angiogenic responses to acute ischemia.
Volume: 97
Issue: 4
Pages: 337-45
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Publication
10611229 | J:87416
First Author: Luoh SM
Year: 2000
Journal: Mol Cell Biol
Title: Role of the distal half of the c-Mpl intracellular domain in control of platelet production by thrombopoietin in vivo.
Volume: 20
Issue: 2
Pages: 507-15
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Publication
8630375 | J:32131
First Author: Alexander WS
Year: 1996
Journal: Blood
Title: Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl.
Volume: 87
Issue: 6
Pages: 2162-70
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Publication
18796624 | J:145455
First Author: Lannutti BJ
Year: 2009
Journal: Blood
Title: Incomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis.
Volume: 113
Issue: 8
Pages: 1778-85
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Publication
9448308 | J:45659
First Author: Kimura S
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin.
Volume: 95
Issue: 3
Pages: 1195-200
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Publication
19264867 | J:158187
First Author: Misharin AV
Year: 2009
Journal: Endocrinology
Title: Studies in mice deficient for the autoimmune regulator (Aire) and transgenic for the thyrotropin receptor reveal a role for Aire in tolerance for thyroid autoantigens.
Volume: 150
Issue: 6
Pages: 2948-56
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Publication
15705785 | J:124818
First Author: Kirito K
Year: 2005
Journal: Blood
Title: Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-1alpha.
Volume: 105
Issue: 11
Pages: 4258-63
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Publication
27152938 | J:252428
First Author: Meinders M
Year: 2016
Journal: PLoS One
Title: Repercussion of Megakaryocyte-Specific Gata1 Loss on Megakaryopoiesis and the Hematopoietic Precursor Compartment.
Volume: 11
Issue: 5
Pages: e0154342
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Publication
17925492 | J:130102
First Author: Hitchcock IS
Year: 2008
Journal: Blood
Title: Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout.
Volume: 111
Issue: 2
Pages: 596-604
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Publication
22628264 | J:194567
First Author: Du J
Year: 2012
Journal: Stem Cells
Title: Signaling profiling at the single-cell level identifies a distinct signaling signature in murine hematopoietic stem cells.
Volume: 30
Issue: 7
Pages: 1447-54
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Publication
17260004 | J:119498
First Author: Kosone T
Year: 2007
Journal: Lab Invest
Title: Hepatocyte growth factor accelerates thrombopoiesis in transgenic mice.
Volume: 87
Issue: 3
Pages: 284-91
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Publication
30728366 | J:307441
First Author: Moore SF
Year: 2019
Journal: Sci Rep
Title: Critical roles for the phosphatidylinositide 3-kinase isoforms p110β and p110γ in thrombopoietin-mediated priming of platelet function.
Volume: 9
Issue: 1
Pages: 1468
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Publication
35358295 | J:326879
First Author: Gostynska S
Year: 2022
Journal: Blood Adv
Title: Megakaryocyte/platelet-derived TGF-β1 inhibits megakaryopoiesis in bone marrow by regulating thrombopoietin production in liver.
Volume: 6
Issue: 11
Pages: 3321-3328
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Publication
24191050 | J:202976
First Author: Hong SH
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Rescue of a primary myelofibrosis model by retinoid-antagonist therapy.
Volume: 110
Issue: 47
Pages: 18820-5
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Publication
22378845 | J:184997
First Author: Pecquet C
Year: 2012
Journal: Blood
Title: Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes.
Volume: 119
Issue: 20
Pages: 4625-35
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Publication
12393382 | J:82323
First Author: Xie X
Year: 2003
Journal: Blood
Title: Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs.
Volume: 101
Issue: 4
Pages: 1329-35
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Publication
11071383 | J:65793
First Author: Tonelli R
Year: 2000
Journal: Hum Genet
Title: Compound heterozygosity for two different amino-acid substitution mutations in the thrombopoietin receptor (c-mpl gene) in congenital amegakaryocytic thrombocytopenia (CAMT).
Volume: 107
Issue: 3
Pages: 225-33
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Publication
7809166 | J:22080
First Author: Foster DC
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization.
Volume: 91
Issue: 26
Pages: 13023-7
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Publication
7536928 | J:24396
First Author: Kaushansky K
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development.
Volume: 92
Issue: 8
Pages: 3234-8
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Publication
7796811 | J:26539
First Author: Pallard C
Year: 1995
Journal: EMBO J
Title: Thrombopoietin activates a STAT5-like factor in hematopoietic cells.
Volume: 14
Issue: 12
Pages: 2847-56
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Publication
8537317 | J:31664
First Author: Kato T
Year: 1995
Journal: J Biochem
Title: Purification and characterization of thrombopoietin.
Volume: 118
Issue: 1
Pages: 229-36
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Publication
8555478 | J:30622
First Author: Stoffel R
Year: 1996
Journal: Blood
Title: Thrombopoietin in thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets.
Volume: 87
Issue: 2
Pages: 567-73
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Publication
8628315 | J:32526
First Author: Porteu F
Year: 1996
Journal: Mol Cell Biol
Title: Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin.
Volume: 16
Issue: 5
Pages: 2473-82
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Publication
8652674 | J:33422
First Author: Van Renterghem P
Year: 1996
Journal: Biochim Biophys Acta
Title: Pax 8 expression in primary cultured dog thyrocyte is increased by cyclic AMP.
Volume: 1307
Issue: 1
Pages: 97-103
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Publication
8695786 | J:34102
First Author: Yan XQ
Year: 1996
Journal: Blood
Title: A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation.
Volume: 88
Issue: 2
Pages: 402-9
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Publication
8943846 | J:37479
First Author: Ku H
Year: 1996
Journal: Blood
Title: Soluble thrombopoietin receptor (Mpl) and granulocyte colony-stimulating factor receptor directly stimulate proliferation of primitive hematopoietic progenitors of mice in synergy with steel factor or the ligand for Flt3/Flk2.
Volume: 88
Issue: 11
Pages: 4124-31
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Publication
9070902 | J:38624
First Author: Hoshi S
Year: 1997
Journal: Biochem Biophys Res Commun
Title: Megakaryocytopoietic activity of a truncated variant of mouse thrombopoietin.
Volume: 231
Issue: 3
Pages: 823-6
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Publication
9108383 | J:39828
First Author: Nagata Y
Year: 1997
Journal: Blood
Title: Activation of JNK signaling pathway by erythropoietin, thrombopoietin, and interleukin-3.
Volume: 89
Issue: 8
Pages: 2664-9
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Publication
9216731 | J:41395
First Author: Nomura S
Year: 1997
Journal: Exp Hematol
Title: Cellular localization of thrombopoietin mRNA in the liver by in situ hybridization.
Volume: 25
Issue: 7
Pages: 565-72
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Publication
9322925 | J:43696
First Author: Wakikawa T
Year: 1997
Journal: Endocrinology
Title: Thrombopoietin inhibits in vitro osteoclastogenesis from murine bone marrow cells.
Volume: 138
Issue: 10
Pages: 4160-6
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Publication
9446653 | J:45712
First Author: Cardier JE
Year: 1998
Journal: Blood
Title: Thrombopoietin and its receptor, c-mpl, are constitutively expressed by mouse liver endothelial cells: evidence of thrombopoietin as a growth factor for liver endothelial cells.
Volume: 91
Issue: 3
Pages: 923-9
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Publication
9551904 | J:45173
First Author: Frey BM
Year: 1998
Journal: J Immunol
Title: Adenovector-mediated expression of human thrombopoietin cDNA in immune-compromised mice: insights into the pathophysiology of osteomyelofibrosis.
Volume: 160
Issue: 2
Pages: 691-9
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Publication
9924196 | J:52824
First Author: Kotani T
Year: 1999
Journal: J Endocrinol
Title: A novel mutation in the human thyroid peroxidase gene resulting in a total iodide organification defect.
Volume: 160
Issue: 2
Pages: 267-73
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Publication
17482640 | J:124227
First Author: Hayward SL
Year: 2007
Journal: J Immunol Methods
Title: A radioligand binding assay to measure anti-thyroperoxidase autoantibodies in mice.
Volume: 323
Issue: 2
Pages: 114-22
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Publication
10595398 | J:128412
First Author: Sohn BH
Year: 1999
Journal: DNA Cell Biol
Title: Expression and characterization of bioactive human thrombopoietin in the milk of transgenic mice.
Volume: 18
Issue: 11
Pages: 845-52
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Publication
11964286 | J:132050
First Author: Kirito K
Year: 2002
Journal: Blood
Title: A functional role of Stat3 in in vivo megakaryopoiesis.
Volume: 99
Issue: 9
Pages: 3220-7
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Publication
18487512 | J:138743
First Author: Hitchcock IS
Year: 2008
Journal: Blood
Title: YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation.
Volume: 112
Issue: 6
Pages: 2222-31
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Publication
18773906 | J:142764
First Author: Eguchi M
Year: 2008
Journal: J Mol Cell Cardiol
Title: Lesion-targeted thrombopoietin potentiates vasculogenesis by enhancing motility and enlivenment of transplanted endothelial progenitor cells via activation of Akt/mTOR/p70S6kinase signaling pathway.
Volume: 45
Issue: 5
Pages: 661-9
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Publication
18845793 | J:145447
First Author: Tiedt R
Year: 2009
Journal: Blood
Title: Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes.
Volume: 113
Issue: 8
Pages: 1768-77
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Publication
19880496 | J:157793
First Author: Saur SJ
Year: 2010
Journal: Blood
Title: Ubiquitination and degradation of the thrombopoietin receptor c-Mpl.
Volume: 115
Issue: 6
Pages: 1254-63
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Publication
19500160 | J:158263
First Author: Huang X
Year: 2009
Journal: Genes Cells
Title: Thrombopoietin controls proliferation of embryonic multipotent hematopoietic progenitors.
Volume: 14
Issue: 7
Pages: 851-60
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Publication
21292776 | J:170499
First Author: Bishton MJ
Year: 2011
Journal: Blood
Title: Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor-induced thrombocytopenia.
Volume: 117
Issue: 13
Pages: 3658-68
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Publication
23341970 | J:195857
First Author: Schaap-Oziemlak AM
Year: 2013
Journal: PLoS One
Title: Wnt5a does not support hematopoiesis in stroma-free, serum-free cultures.
Volume: 8
Issue: 1
Pages: e53669
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Publication
28630120 | J:243850
First Author: Machlus KR
Year: 2017
Journal: Blood
Title: Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis.
Volume: 130
Issue: 9
Pages: 1132-1143
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Publication
30755420 | J:275430
First Author: Donaghy R
Year: 2019
Journal: Blood
Title: The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination.
Volume: 133
Issue: 14
Pages: 1560-1571
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Publication
32157300 | J:301274
First Author: Morodomi Y
Year: 2020
Journal: Blood
Title: Mechanisms of anti-GPIbα antibody-induced thrombocytopenia in mice.
Volume: 135
Issue: 25
Pages: 2292-2301
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Publication
33754019 | J:336034
First Author: Chen X
Year: 2021
Journal: Theranostics
Title: Aurka loss in CD19(+) B cells promotes megakaryocytopoiesis via IL-6/STAT3 signaling-mediated thrombopoietin production.
Volume: 11
Issue: 10
Pages: 4655-4671
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Publication
39042698 | J:361500
First Author: Morino-Koga S
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: Transition of signal requirement in hematopoietic stem cell development from hemogenic endothelial cells.
Volume: 121
Issue: 31
Pages: e2404193121
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Publication
17637498 | J:126562
First Author: Tong W
Year: 2007
Journal: Exp Hematol
Title: Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal.
Volume: 35
Issue: 9
Pages: 1447-55
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Publication
20711984 | J:199353
First Author: Fleury M
Year: 2010
Journal: Int J Dev Biol
Title: Mpl receptor defect leads to earlier appearance of hematopoietic cells/hematopoietic stem cells in the Aorta-Gonad-Mesonephros region, with increased apoptosis.
Volume: 54
Issue: 6-7
Pages: 1067-74
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Publication
11493447 | J:115603
First Author: Levin J
Year: 2001
Journal: Blood
Title: Thrombocytopenic c-mpl(-/-) mice can produce a normal level of platelets after administration of 5-fluorouracil: the effect of age on the response.
Volume: 98
Issue: 4
Pages: 1019-27
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Publication
31184281 | J:296992
First Author: McLachlan SM
Year: 2019
Journal: Thyroid
Title: A Mouse Thyrotropin Receptor A-Subunit Transgene Expressed in Thyroiditis-Prone Mice May Provide Insight into Why Graves' Disease Only Occurs in Humans.
Volume: 29
Issue: 8
Pages: 1138-1146
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Publication
28938453 | J:247628
First Author: McLachlan SM
Year: 2017
Journal: Endocrinology
Title: Variable Effects of Dietary Selenium in Mice That Spontaneously Develop a Spectrum of Thyroid Autoantibodies.
Volume: 158
Issue: 11
Pages: 3754-3764
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Publication
11180827 | J:62213
First Author: Ogasawara M
Year: 2000
Journal: Dev Genes Evol
Title: Overlapping expression of amphioxus homologs of the thyroid transcription factor-1 gene and thyroid peroxidase gene in the endostyle: insight into evolution of the thyroid gland.
Volume: 210
Issue: 5
Pages: 231-42
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Publication
9373248 | J:44316
First Author: Villeval JL
Year: 1997
Journal: Blood
Title: High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice.
Volume: 90
Issue: 11
Pages: 4369-83
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Publication
10419886 | J:56628
First Author: Yang FC
Year: 1999
Journal: Blood
Title: Differential effects of human granulocyte colony-stimulating factor (hG-CSF) and thrombopoietin on megakaryopoiesis and platelet function in hG-CSF receptor-transgenic mice.
Volume: 94
Issue: 3
Pages: 950-8
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Publication
18814950 | J:143378
First Author: Barroga CF
Year: 2008
Journal: Exp Hematol
Title: Thrombopoietin regulates c-Myb expression by modulating micro RNA 150 expression.
Volume: 36
Issue: 12
Pages: 1585-92
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Publication
28207794 | J:248510
First Author: Castillo GM
Year: 2017
Journal: PLoS One
Title: Protected graft copolymer-formulated fibroblast growth factors mitigate the lethality of partial body irradiation injury.
Volume: 12
Issue: 2
Pages: e0171703
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Publication
32867390 | J:304338
 
First Author: Josa V
Year: 2020
Journal: Int J Mol Sci
Title: Thrombocytosis and Effects of IL-6 Knock-Out in a Colitis-Associated Cancer Model.
Volume: 21
Issue: 17
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Protein
A7M7R7
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: true
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Protein
F8WGZ9
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: true
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Protein Domain
IPR019791 | Haem_peroxidase_animal
Type: Family
Description: Peroxidases are haem-containing enzymes that use hydrogen peroxide as the electron acceptor to catalyse a number of oxidative reactions.Peroxidases are found in bacteria, fungi, plants and animals. On the basis of sequence similarity, a number of animal haem peroxidases can be categorised as members of a superfamily: myeloperoxidase (MPO); eosinophil peroxidase (EPO); lactoperoxidase (LPO); thyroid peroxidase (TPO); prostaglandin H synthase (PGHS); and peroxidasin [, , ]. MPO plays a major role in the oxygen-dependent microbicidal system of neutrophils. EPO from eosinophilic granulocytes participates in immunological reactions, and potentiates tumor necrosis factor (TNF) production and hydrogen peroxide release by human monocyte-derived macrophages [, ]. In the main, MPO (and possibly EPO) utilises Cl-ions and H2O2to form hypochlorous acid (HOCl), which can effectively kill bacteria or parasites. In secreted fluids, LPO catalyses the oxidation of thiocyanate ions (SCN-) by H2O2, producing the weak oxidising agent hypothiocyanite (OSCN-), which has bacteriostatic activity []. TPO uses I-ions and H2O2to generate iodine, and plays a central role in the biosynthesis of thyroid hormones T(3) and T(4). To date, the 3D structures of MPO and PGHS have been reported. MPO is a homodimer: each monomer consists of a light (A or B) and a heavy (C or D) chain resulting from post-translational excision of 6 residues from the common precursor. Monomers are linked by a single inter-chain disulphide. Each monomer includes a bound calcium ion []. PGHS exists as a symmetric dimer, each monomer of which consists of 3 domains: an N-terminal epidermal growth factor (EGF) like module; a membrane-binding domain; and a large C-terminal catalytic domain containing the cyclooxygenase and the peroxidase active sites. The catalytic domain shows striking structural similarity to MPO. The cyclooxygenase active site, which catalyses the formation of prostaglandin G2 (PGG2) from arachidonic acid, resides at the apex of a long hydrophobic channel, extending from the membrane-binding domain to the centre of the molecule. The peroxidase active site, which catalyses the reduction of PGG2 to PGH2, is located on the other side of the molecule, at the haem binding site []. Both MPO and the catalytic domain of PGHS are mainly α-helical, 19 helices being identified as topologically and spatially equivalent; PGHS contains 5 additional N-terminal helices that have no equivalent in MPO. In both proteins, three Asn residues in each monomer are glycosylated.
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Protein Domain
IPR037120 | Haem_peroxidase_sf_animal
Type: Homologous_superfamily
Description: Peroxidases are haem-containing enzymes that use hydrogen peroxide as the electron acceptor to catalyse a number of oxidative reactions.Peroxidases are found in bacteria, fungi, plants and animals. On the basis of sequence similarity, a number of animal haem peroxidases can be categorised as members of a superfamily: myeloperoxidase (MPO); eosinophil peroxidase (EPO); lactoperoxidase (LPO); thyroid peroxidase (TPO); prostaglandin H synthase (PGHS); and peroxidasin [, , ]. MPO plays a major role in the oxygen-dependent microbicidal system of neutrophils. EPO from eosinophilic granulocytes participates in immunological reactions, and potentiates tumor necrosis factor (TNF) production and hydrogen peroxide release by human monocyte-derived macrophages [, ]. In the main, MPO (and possibly EPO) utilises Cl-ions and H2O2to form hypochlorous acid (HOCl), which can effectively kill bacteria or parasites. In secreted fluids, LPO catalyses the oxidation of thiocyanate ions (SCN-) by H2O2, producing the weak oxidising agent hypothiocyanite (OSCN-), which has bacteriostatic activity []. TPO uses I-ions and H2O2to generate iodine, and plays a central role in the biosynthesis of thyroid hormones T(3) and T(4). To date, the 3D structures of MPO and PGHS have been reported. MPO is a homodimer: each monomer consists of a light (A or B) and a heavy (C or D) chain resulting from post-translational excision of 6 residues from the common precursor. Monomers are linked by a single inter-chain disulphide. Each monomer includes a bound calcium ion []. PGHS exists as a symmetric dimer, each monomer of which consists of 3 domains: an N-terminal epidermal growth factor (EGF) like module; a membrane-binding domain; and a large C-terminal catalytic domain containing the cyclooxygenase and the peroxidase active sites. The catalytic domain shows striking structural similarity to MPO. The cyclooxygenase active site, which catalyses the formation of prostaglandin G2 (PGG2) from arachidonic acid, resides at the apex of a long hydrophobic channel, extending from the membrane-binding domain to the centre of the molecule. The peroxidase active site, which catalyses the reduction of PGG2 to PGH2, is located on the other side of the molecule, at the haem binding site []. Both MPO and the catalytic domain of PGHS are mainly α-helical, 19 helices being identified as topologically and spatially equivalent; PGHS contains 5 additional N-terminal helices that have no equivalent in MPO. In both proteins, three Asn residues in each monomer are glycosylated.
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Protein
P11247
Organism: Mus musculus/domesticus
Length: 718  
Fragment?: false
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Publication
3773894 | J:8455
First Author: Shoemaker CB
Year: 1986
Journal: Mol Cell Biol
Title: Murine erythropoietin gene: cloning, expression, and human gene homology.
Volume: 6
Issue: 3
Pages: 849-58
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Protein
P07321
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
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Protein
Q0VED9
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
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Protein
Q6RFG4
Organism: Mus musculus/domesticus
Length: 718  
Fragment?: false
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Protein
A0A0A0MQL9
Organism: Mus musculus/domesticus
Length: 166  
Fragment?: true
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Protein
Q91WA0
Organism: Mus musculus/domesticus
Length: 710  
Fragment?: false
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Protein
Q7TMS4
Organism: Mus musculus/domesticus
Length: 718  
Fragment?: false
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Protein
Q3TR82
Organism: Mus musculus/domesticus
Length: 183  
Fragment?: true
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Protein
Q5SW46
Organism: Mus musculus/domesticus
Length: 710  
Fragment?: false
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Protein
Q571G0
Organism: Mus musculus/domesticus
Length: 718  
Fragment?: true
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Protein
F7DC05
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
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Protein
B7ZMY9
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: false
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Publication
2548579 | -
First Author: Kimura S
Year: 1989
Journal: Biochemistry
Title: Structure of the human thyroid peroxidase gene: comparison and relationship to the human myeloperoxidase gene.
Volume: 28
Issue: 10
Pages: 4481-9
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Publication
6295491 | -
First Author: Wever R
Year: 1982
Journal: Biochim Biophys Acta
Title: The peroxidation of thiocyanate catalysed by myeloperoxidase and lactoperoxidase.
Volume: 709
Issue: 2
Pages: 212-9
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Publication
7774640 | -
First Author: Spessotto P
Year: 1995
Journal: Eur J Immunol
Title: Human eosinophil peroxidase enhances tumor necrosis factor and hydrogen peroxide release by human monocyte-derived macrophages.
Volume: 25
Issue: 5
Pages: 1366-73
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Publication
1320128 | -
First Author: Zeng J
Year: 1992
Journal: J Mol Biol
Title: X-ray crystal structure of canine myeloperoxidase at 3 A resolution.
Volume: 226
Issue: 1
Pages: 185-207
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Publication
8121489 | -
First Author: Picot D
Year: 1994
Journal: Nature
Title: The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1.
Volume: 367
Issue: 6460
Pages: 243-9
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Publication
2840655 | -
First Author: Kimura S
Year: 1988
Journal: Proteins
Title: Human myeloperoxidase and thyroid peroxidase, two enzymes with separate and distinct physiological functions, are evolutionarily related members of the same gene family.
Volume: 3
Issue: 2
Pages: 113-20
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Publication
37560296 | J:347818
 
First Author: Martinez ME
Year: 2023
Journal: Front Endocrinol (Lausanne)
Title: Paternal developmental thyrotoxicosis disrupts neonatal leptin leading to increased adiposity and altered physiology of the melanocortin system.
Volume: 14
Pages: 1210414
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Protein
A0A087WPT2
Organism: Mus musculus/domesticus
Length: 62  
Fragment?: true
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Protein
P49290
Organism: Mus musculus/domesticus
Length: 716  
Fragment?: false
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Protein
P22437
Organism: Mus musculus/domesticus
Length: 602  
Fragment?: false
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Protein
Q05769
Organism: Mus musculus/domesticus
Length: 604  
Fragment?: false
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