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Search results 301 to 378 out of 378 for Tpp1

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Type Details Score
Publication
25917818 | J:222308
First Author: Fairfield H
Year: 2015
Journal: Genome Res
Title: Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.
Volume: 25
Issue: 7
Pages: 948-57
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Publication
- | J:101679
     
First Author: Deltagen Inc
Year: 2005
Journal: MGI Direct Data Submission
Title: NIH initiative supporting placement of Deltagen, Inc. mice into public repositories
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Publication
14651853 | J:86816
First Author: Mootha VK
Year: 2003
Journal: Cell
Title: Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Volume: 115
Issue: 5
Pages: 629-40
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Acd<em1Cek> | MGI:6864320
Name: adrenocortical dysplasia; endonuclease-mediated mutation 1, Catherine Keegan
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Publication
19648609 | J:159057
First Author: Wan M
Year: 2009
Journal: J Biol Chem
Title: OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation.
Volume: 284
Issue: 39
Pages: 26725-31
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Interaction Experiment
Rai R (2011)
Description: The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.
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Publication
16880378 | -
First Author: O'Connor MS
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly.
Volume: 103
Issue: 32
Pages: 11874-9
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Allele
Tpp1<tm1Plob> | MGI:3521972
Name: tripeptidyl peptidase I; targeted mutation 1, Peter Lobel and David Sleat
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout
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Allele
Tpp1<m1J> | MGI:5512906
 
Name: tripeptidyl peptidase I; mutation 1, Jackson
Allele Type: Chemically induced (ENU)
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Genotype
Genotype
Symbol: Tpp1/Tpp1
Background: involves: 129S1/Sv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tpp1/Tpp1
Background: B6.129S1-Tpp1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tpp1/Tpp1
Background: B6.129S1-Tpp1/Tpp1
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tpp1/Tpp1
Background: STOCK Tpp1/GrsrJ
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0110726 | neuronal ceroid lipofuscinosis 2
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Allele
Gt(ROSA)26Sor<tm1(CAG-Tpp1)Plob> | MGI:6259153
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Peter Lobel and David Sleat
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
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DO Term
DOID:0080059 | autosomal recessive spinocerebellar ataxia 7
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Strain
MGI:7594099 | B6.Cg-Gt(ROSA)26Sor<tm1(CAG-Tpp1)Plob>/J
Attribute String: congenic, targeted mutation, mutant strain
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Publication
16418502 | -
First Author: Yang CP
Year: 2006
Journal: Nucleic Acids Res
Title: Saccharomyces cerevisiae Est3p dimerizes in vitro and dimerization contributes to efficient telomere replication in vivo.
Volume: 34
Issue: 2
Pages: 407-16
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Publication
16884717 | -
First Author: Sharanov YS
Year: 2006
Journal: FEBS Lett
Title: Saccharomyces cerevisiae telomerase subunit Est3p binds DNA and RNA and stimulates unwinding of RNA/DNA heteroduplexes.
Volume: 580
Issue: 19
Pages: 4683-90
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Publication
20884318 | -
First Author: Shubernetskaya O
Year: 2011
Journal: Biochimie
Title: Yeast telomerase protein Est3 is a novel type of GTPase.
Volume: 93
Issue: 2
Pages: 202-6
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Publication
15231715 | -
First Author: Ye JZ
Year: 2004
Journal: Genes Dev
Title: POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.
Volume: 18
Issue: 14
Pages: 1649-54
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Publication
22965356 | -
First Author: Armanios M
Year: 2012
Journal: Nat Rev Genet
Title: The telomere syndromes.
Volume: 13
Issue: 10
Pages: 693-704
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Protein Domain
IPR019437 | TPP1/Est3
Type: Domain
Description: TPP1 (Est3 in yeast) is a component of the telomerase holoenzyme (shelterin complex), involved in telomere replication. It has been demonstrated that TPP1 dimerises and binds to DNA and RNA. Furthermore, TPP1 stimulates the dissociation of RNA/DNA hetero-duplexes [, ]. Yeast telomerase protein TPP1 (Est3) is a novel type of GTPase []. The key residues in Saccharomyces cerevisiae are an Asp at residue 86 and the Arg at residue 110. The Asp is totally conserved in the family, whereas the Arg is not so well conserved. The N-terminal of TPP1 is likely to be the binding surface for TIN2, whereas the C terminus probably binds to POT1, thereby tethering POT1 to the shelterin complex []. The complex bound to telomeric DNA increases the activity and processivity of the human telomerase core enzyme, thus helping to maintain the length of the telomeres [, , ].The human shelterin complex includes six proteins: telomere repeat binding factor 1 (TRF1); TRF2, repressor/activator protein 1 (RAP1); TRF1-interacting nuclear protein 2 (TIN2); TIN2-interacting protein 1 (TPP1), also known as ACD from adrenocortical dysplasia protein; and protection of telomeres 1 (POT1) [].
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Protein
Q5EE38
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
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Protein
A0A1D5RM77
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: false
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Protein
A0A1D5RLA2
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: false
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Protein
B2RS36
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
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Publication
17237768 | -
First Author: Wang F
Year: 2007
Journal: Nature
Title: The POT1-TPP1 telomere complex is a telomerase processivity factor.
Volume: 445
Issue: 7127
Pages: 506-10
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Publication
18535244 | -
First Author: Miyoshi T
Year: 2008
Journal: Science
Title: Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.
Volume: 320
Issue: 5881
Pages: 1341-4
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Publication
15537664 | J:95686
First Author: Keegan CE
Year: 2005
Journal: Hum Mol Genet
Title: Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator.
Volume: 14
Issue: 1
Pages: 113-23
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Protein Domain
IPR028631 | ACD
Type: Family
Description: Adrenocortical dysplasia protein (acd, also known as TPP1) is a component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways []. It also forms a heterodimer with POT1 that increases the activity and processivity of the telomerase core enzyme [].This entry also includes fission yeast TPP1 homologue, Tpz1. Together with Pot1 it forms a complex that protects telomeres and regulates telomere length [].
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Protein Domain
IPR038240 | Stn1_C_sf
Type: Homologous_superfamily
Description: Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex []. These three interacting proteins associate with the telomeric overhang in budding yeast, whereas a single protein known as Pot1 (protection of telomeres-1) performs this function in fission yeast. Two separate protein complexes are required for chromosome end protection in fission yeast while a two-subunit complex consisting of POT1 and TPP1 associates with telomeric ssDNA in humans. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution [].This entry represents the C-terminal domain of Stn1 and consists of tandem winged helix-turn-helix motifs [, ].
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Protein Domain
IPR024263 | Stn1_C_fungi
Type: Domain
Description: Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex []. These three interacting proteins associate with the telomeric overhang in budding yeast, whereas a single protein known as Pot1 (protection of telomeres-1) performs this function in fission yeast. Two separate protein complexes are required for chromosome end protection in fission yeast while a two-subunit complex consisting of POT1 and TPP1 associates with telomeric ssDNA in humans. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution [].This entry represents the C-terminal domain of Stn1 and consists of tandem winged helix-turn-helix motifs [, ].
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Publication
33086033 | J:300232
First Author: Wang L
Year: 2020
Journal: Cell Metab
Title: FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping.
Volume: 32
Issue: 5
Pages: 860-877.e9
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Publication
17632522 | J:159142
First Author: Hockemeyer D
Year: 2007
Journal: Nat Struct Mol Biol
Title: Telomere protection by mammalian Pot1 requires interaction with Tpp1.
Volume: 14
Issue: 8
Pages: 754-61
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Publication
17293872 | -
First Author: Gao H
Year: 2007
Journal: Nat Struct Mol Biol
Title: RPA-like proteins mediate yeast telomere function.
Volume: 14
Issue: 3
Pages: 208-14
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Publication
17715303 | -
First Author: Martín V
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Protection of telomeres by a conserved Stn1-Ten1 complex.
Volume: 104
Issue: 35
Pages: 14038-43
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Publication
19884503 | -
First Author: Gelinas AD
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain.
Volume: 106
Issue: 46
Pages: 19298-303
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Publication
19854124 | -
First Author: Wellinger RJ
Year: 2009
Journal: Mol Cell
Title: The CST complex and telomere maintenance: the exception becomes the rule.
Volume: 36
Issue: 2
Pages: 168-9
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Protein Domain
IPR024222 | Ten1_fungal
Type: Family
Description: Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length []. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex []. These three interacting proteins associate with the telomeric overhang in budding yeast, whereas a single protein known as Pot1 (protection of telomeres-1) performs this function in fission yeast, and a two-subunit complex consisting of POT1 and TPP1 associates with telomeric ssDNA in humans. S.pombe has Stn1- and Ten1-like proteins that are essential for chromosome end protection. Stn1 orthologues exist in all species that have Pot1, whereas Ten1-like proteins can be found in all fungi. Fission yeast Stn1 and Ten1 localise at telomeres in a manner that correlates with the length of the ssDNA overhang, suggesting that they specifically associate with the telomeric ssDNA. Two separate protein complexes are required for chromosome end protection in fission yeast. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution []. Ten1 is one of the three components of the CST complex, which, in conjunction with the Shelterin complex helps protect telomeres from attack by DNA-repair mechanisms [].This entry represent Ten1 from fungi.
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Publication
18185984 | J:143815
First Author: Else T
Year: 2007
Journal: Chromosome Res
Title: Tpp1/Acd maintains genomic stability through a complex role in telomere protection.
Volume: 15
Issue: 8
Pages: 1001-13
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Publication
24725274 | J:210514
First Author: Martínez P
Year: 2014
Journal: Aging Cell
Title: Essential role for the TRF2 telomere protein in adult skin homeostasis.
Volume: 13
Issue: 4
Pages: 656-68
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Publication
18955498 | J:145042
First Author: Palm W
Year: 2009
Journal: Mol Cell Biol
Title: Functional dissection of human and mouse POT1 proteins.
Volume: 29
Issue: 2
Pages: 471-82
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Publication
27559927 | J:254623
First Author: Ahmad T
Year: 2017
Journal: Am J Respir Cell Mol Biol
Title: Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease.
Volume: 56
Issue: 1
Pages: 38-49
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Publication
20008938 | -
First Author: Sun J
Year: 2009
Journal: Genes Dev
Title: Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.
Volume: 23
Issue: 24
Pages: 2900-14
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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