Type |
Details |
Score |
Allele |
Name: |
TRIO and F-actin binding protein; gene trap 363F1, Centre for Modeling Human Disease |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
TRIO and F-actin binding protein; gene trap IST13863H1, Texas A&M Institute for Genomic Medicine |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Allele |
Name: |
TRIO and F-actin binding protein; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
TRIO and F-actin binding protein; endonuclease-mediated mutation 2, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Triobp/Triobp |
Background: |
involves: 129P2/OlaHsd * C57BL/6J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Triobp/Triobp |
Background: |
involves: 129P2/OlaHsd * C57BL/6J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Triobp/Triobp |
Background: |
C57BL/6NJ-Triobp/Mmjax |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Debant A |
Year: |
1996 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains. |
Volume: |
93 |
Issue: |
11 |
Pages: |
5466-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zheng M |
Year: |
2004 |
Journal: |
Am J Pathol |
Title: |
TRIO amplification and abundant mRNA expression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer. |
Volume: |
165 |
Issue: |
1 |
Pages: |
63-9 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Triobp/Triobp |
Background: |
C57BL/6-Triobp |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Shahin H |
Year: |
2006 |
Journal: |
Am J Hum Genet |
Title: |
Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss. |
Volume: |
78 |
Issue: |
1 |
Pages: |
144-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Riazuddin S |
Year: |
2006 |
Journal: |
Am J Hum Genet |
Title: |
Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness. |
Volume: |
78 |
Issue: |
1 |
Pages: |
137-43 |
|
•
•
•
•
•
|
Allele |
Name: |
partner and localizer of BRCA2; targeted mutation 1.1, Bing Xia |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready |
|
•
•
•
•
•
|
Publication |
First Author: |
Du TT |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
LMO7 deficiency reveals the significance of the cuticular plate for hearing function. |
Volume: |
10 |
Issue: |
1 |
Pages: |
1117 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mahdi AH |
Year: |
2018 |
Journal: |
Cancer Res |
Title: |
Evidence of Intertissue Differences in the DNA Damage Response and the Pro-oncogenic Role of NF-κB in Mice with Disengaged BRCA1-PALB2 Interaction. |
Volume: |
78 |
Issue: |
14 |
Pages: |
3969-3981 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zechner R |
Year: |
2014 |
Journal: |
Cell Metab |
Title: |
Hormone-sensitive lipase deficiency in humans. |
Volume: |
20 |
Issue: |
2 |
Pages: |
199-201 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lelli A |
Year: |
2016 |
Journal: |
J Cell Biol |
Title: |
Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth. |
Volume: |
212 |
Issue: |
2 |
Pages: |
231-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Akturk A |
Year: |
2022 |
Journal: |
Sci Adv |
Title: |
RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells. |
Volume: |
8 |
Issue: |
42 |
Pages: |
eabq2826 |
|
•
•
•
•
•
|
Publication |
First Author: |
Simhadri S |
Year: |
2014 |
Journal: |
J Biol Chem |
Title: |
Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice. |
Volume: |
289 |
Issue: |
35 |
Pages: |
24617-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Su X |
Year: |
2018 |
Journal: |
Cell Death Dis |
Title: |
Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development. |
Volume: |
9 |
Issue: |
3 |
Pages: |
302 |
|
•
•
•
•
•
|
Publication |
First Author: |
Southard-Smith EM |
Year: |
1999 |
Journal: |
Mamm Genome |
Title: |
Comparative analyses of the Dominant megacolon-SOX10 genomic interval in mouse and human. |
Volume: |
10 |
Issue: |
7 |
Pages: |
744-9 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents a three-gene system broadly conserved among the Actinobacteria which includes MSMEG_4193 and homologues. Another member of the trio is a probable kinase, related to phosphatidylinositol kinases; that context supports the hypothesis that this protein acts as a phosphomutase. |
|
•
•
•
•
•
|
Publication |
First Author: |
Duncan JS |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Continued expression of GATA3 is necessary for cochlear neurosensory development. |
Volume: |
8 |
Issue: |
4 |
Pages: |
e62046 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
132
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
119
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Alam MR |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
Kalirin, a cytosolic protein with spectrin-like and GDP/GTP exchange factor-like domains that interacts with peptidylglycine alpha-amidating monooxygenase, an integral membrane peptide-processing enzyme. |
Volume: |
272 |
Issue: |
19 |
Pages: |
12667-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Penzes P |
Year: |
2001 |
Journal: |
J Neurosci |
Title: |
Distinct roles for the two Rho GDP/GTP exchange factor domains of kalirin in regulation of neurite growth and neuronal morphology. |
Volume: |
21 |
Issue: |
21 |
Pages: |
8426-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Youn H |
Year: |
2007 |
Journal: |
J Alzheimers Dis |
Title: |
Under-expression of Kalirin-7 Increases iNOS activity in cultured cells and correlates to elevated iNOS activity in Alzheimer's disease hippocampus. |
Volume: |
12 |
Issue: |
3 |
Pages: |
271-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mandela P |
Year: |
2012 |
Journal: |
Neural Plast |
Title: |
Kalirin, a key player in synapse formation, is implicated in human diseases. |
Volume: |
2012 |
|
Pages: |
728161 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dufurrena Q |
Year: |
2018 |
Journal: |
J Mol Endocrinol |
Title: |
Kalirin/Trio Rho GDP/GTP exchange factors regulate proinsulin and insulin secretion. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ferraro F |
Year: |
2007 |
Journal: |
Mol Biol Cell |
Title: |
Kalirin/Trio Rho guanine nucleotide exchange factors regulate a novel step in secretory granule maturation. |
Volume: |
18 |
Issue: |
12 |
Pages: |
4813-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Skowronek K |
Year: |
2003 |
Journal: |
Acta Crystallogr D Biol Crystallogr |
Title: |
Crystallization and initial crystal characterization of the N-terminal DH/PH domain of Trio. |
Volume: |
59 |
Issue: |
Pt 7 |
Pages: |
1273-5 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry includes a group of RhoGEFs, including Kalirin and TRIO from mammals. Kalirin and TRIO are encoded by separate genes in mammals and by a single one in invertebrates. Kalirin and TRIO share the same complex multidomain structure and display several splice variants. They are implicated in secretory granule (SG) maturation and exocytosis [, ]. The longest Kalirin and TRIO proteins have a Sec14 domain, a stretch of spectrin repeats, a RhoGEF(DH)/PH cassette (also called GEF1), an SH3 domain, a second RhoGEF(DH)/PH cassette (also called GEF2), a second SH3 domain, Ig/FNIII domains, and a kinase domain. The first RhoGEF(DH)/PH cassette catalyzes exchange on Rac1 and RhoG while the second RhoGEF(DH)/PH cassette is specific for RhoA. Kalirin and TRIO are closely related to p63RhoGEF and have PH domains of similar function. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner [, ].Triple functional domain protein (TRIO) contains a protein kinase domain and two guanine nucleotide exchange factor (GEF) domains []. These functional domains suggest that it may play a role in signalling pathways controlling cell proliferation []. TRIO may form a complex with LAR transmembrane protein tyrosine phosphatase (PT-Pase), which localises to the ends of focal adhesions and plays an important part in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration []. Its expression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer [].Kalirin () promotes the exchange of GDP by GTP and stimulates the activity of specific Rho GTPases []. There are several Kalirin isoforms in humans and mice. Each Kalirin isoform is composed of a unique collection of domains and may have different functions []. In rat, isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth, while isoform 6 is required for dendritic spine formation []. In humans, the major isoform of Kalirin in the adult brain is Kalirin-7, which plays a critical role in spine formation/synaptic plasticity. Kalirin-7 has been linked to neuropsychiatric and neurological diseases such as Alzheimer's, Huntingtin's, ischemic stroke, schizophrenia, depression, and cocaine addiction [, , ]. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
178
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Edwards M |
Year: |
2013 |
Journal: |
Mol Biol Cell |
Title: |
Physiological role of the interaction between CARMIL1 and capping protein. |
Volume: |
24 |
Issue: |
19 |
Pages: |
3047-55 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents leucine-rich repeat-containing protein 16A (LRRC16A). In humans it is also known as CARMIL1, which belongs to the CARMIL (capping protein, Arp2/3 and Myosin-I linker) family. CARMIL family members are potential regulators of actin capping proteins, which control the polymerisation of actin filaments by capping their barbed ends [, ]. CARMIL1 is essential for cell migration and may control lamellipodial actin assembly via effects on Trio and Rac1 [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Deinhardt K |
Year: |
2011 |
Journal: |
Sci Signal |
Title: |
Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. |
Volume: |
4 |
Issue: |
202 |
Pages: |
ra82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mori Y |
Year: |
2014 |
Journal: |
Biomed Res |
Title: |
S100A1 and S100B are dispensable for endochondral ossification during skeletal development. |
Volume: |
35 |
Issue: |
4 |
Pages: |
243-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Biben C |
Year: |
2023 |
Journal: |
Nat Commun |
Title: |
In vivo clonal tracking reveals evidence of haemangioblast and haematomesoblast contribution to yolk sac haematopoiesis. |
Volume: |
14 |
Issue: |
1 |
Pages: |
41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jeon Y |
Year: |
2011 |
Journal: |
Cell |
Title: |
YY1 tethers Xist RNA to the inactive X nucleation center. |
Volume: |
146 |
Issue: |
1 |
Pages: |
119-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Steven R |
Year: |
1998 |
Journal: |
Cell |
Title: |
UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans. |
Volume: |
92 |
Issue: |
6 |
Pages: |
785-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yap P |
Year: |
2023 |
Journal: |
Eur J Hum Genet |
Title: |
Biallelic ATP2B1 variants as a likely cause of a novel neurodevelopmental malformation syndrome with primary hypoparathyroidism. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lee HK |
Year: |
2020 |
Journal: |
Commun Biol |
Title: |
Cytosine base editor 4 but not adenine base editor generates off-target mutations in mouse embryos. |
Volume: |
3 |
Issue: |
1 |
Pages: |
19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Colomer V |
Year: |
1997 |
Journal: |
Hum Mol Genet |
Title: |
Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain. |
Volume: |
6 |
Issue: |
9 |
Pages: |
1519-25 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
823
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Hutchins AP |
Year: |
2013 |
Journal: |
Stem Cells |
Title: |
Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells. |
Volume: |
31 |
Issue: |
2 |
Pages: |
269-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ikeda T |
Year: |
2004 |
Journal: |
Arthritis Rheum |
Title: |
The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage. |
Volume: |
50 |
Issue: |
11 |
Pages: |
3561-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu CF |
Year: |
2015 |
Journal: |
Nucleic Acids Res |
Title: |
The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis. |
Volume: |
43 |
Issue: |
17 |
Pages: |
8183-203 |
|
•
•
•
•
•
|
Publication |
First Author: |
Smith JD |
Year: |
2014 |
Journal: |
Am J Hum Genet |
Title: |
Exome sequencing identifies a recurrent de novo ZSWIM6 mutation associated with acromelic frontonasal dysostosis. |
Volume: |
95 |
Issue: |
2 |
Pages: |
235-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kimple AJ |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2). |
Volume: |
284 |
Issue: |
29 |
Pages: |
19402-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rinchik EM |
Year: |
1995 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Pleiotropy in microdeletion syndromes: neurologic and spermatogenic abnormalities in mice homozygous for the p6H deletion are likely due to dysfunction of a single gene. |
Volume: |
92 |
Issue: |
14 |
Pages: |
6394-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang X |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
SEC14 and spectrin domains 1 (Sestd1) and Dapper antagonist of catenin 1 (Dact1) scaffold proteins cooperatively regulate the Van Gogh-like 2 (Vangl2) four-pass transmembrane protein and planar cell polarity (PCP) pathway during embryonic development in mice. |
Volume: |
288 |
Issue: |
28 |
Pages: |
20111-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sonoshita M |
Year: |
2015 |
Journal: |
Cancer Discov |
Title: |
Promotion of colorectal cancer invasion and metastasis through activation of NOTCH-DAB1-ABL-RHOGEF protein TRIO. |
Volume: |
5 |
Issue: |
2 |
Pages: |
198-211 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao L |
Year: |
2013 |
Journal: |
J Cell Sci |
Title: |
TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. |
Volume: |
126 |
Issue: |
Pt 24 |
Pages: |
5704-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Patel R |
Year: |
2013 |
Journal: |
J Clin Invest |
Title: |
Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression. |
Volume: |
123 |
Issue: |
3 |
Pages: |
1157-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Southgate RJ |
Year: |
2005 |
Journal: |
FASEB J |
Title: |
PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle. |
Volume: |
19 |
Issue: |
14 |
Pages: |
2072-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee WJ |
Year: |
2017 |
Journal: |
Biomed Res Int |
Title: |
An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos. |
Volume: |
2017 |
|
Pages: |
8932583 |
|
•
•
•
•
•
|
Publication |
First Author: |
Balaram P |
Year: |
2019 |
Journal: |
Neuroscience |
Title: |
Synergistic Transcriptional Changes in AMPA and GABAA Receptor Genes Support Compensatory Plasticity Following Unilateral Hearing Loss. |
Volume: |
407 |
|
Pages: |
108-119 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen CA |
Year: |
2020 |
Journal: |
Hum Mol Genet |
Title: |
Combination of whole exome sequencing and animal modeling identifies TMPRSS9 as a candidate gene for autism spectrum disorder. |
Volume: |
29 |
Issue: |
3 |
Pages: |
459-470 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song J |
Year: |
2012 |
Journal: |
Nature |
Title: |
Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision. |
Volume: |
489 |
Issue: |
7414 |
Pages: |
150-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han Y |
Year: |
2008 |
Journal: |
Mol Cell Biol |
Title: |
L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer. |
Volume: |
28 |
Issue: |
16 |
Pages: |
4999-5013 |
|
•
•
•
•
•
|
Publication |
First Author: |
Azzu V |
Year: |
2021 |
Journal: |
Mol Metab |
Title: |
Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. |
Volume: |
48 |
|
Pages: |
101210 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tobias ES |
Year: |
2024 |
Journal: |
Endocrine |
Title: |
SEC31A may be associated with pituitary hormone deficiency and gonadal dysgenesis. |
Volume: |
84 |
Issue: |
2 |
Pages: |
345-349 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bieker JJ |
Year: |
1996 |
Journal: |
DNA Cell Biol |
Title: |
Isolation, genomic structure, and expression of human erythroid Krüppel-like factor (EKLF). |
Volume: |
15 |
Issue: |
5 |
Pages: |
347-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sato T |
Year: |
2003 |
Journal: |
Genomics |
Title: |
Representational difference analysis, high-resolution physical mapping, and transcript identification of the zebrafish genomic region for a motor behavior. |
Volume: |
82 |
Issue: |
2 |
Pages: |
218-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Szénási T |
Year: |
2013 |
Journal: |
Biochim Biophys Acta |
Title: |
Hmgb1 can facilitate activation of the matrilin-1 gene promoter by Sox9 and L-Sox5/Sox6 in early steps of chondrogenesis. |
Volume: |
1829 |
Issue: |
10 |
Pages: |
1075-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang MJ |
Year: |
2024 |
Journal: |
Adv Sci (Weinh) |
Title: |
SEC16A Variants Predispose to Chronic Pancreatitis by Impairing ER-to-Golgi Transport and Inducing ER Stress. |
Volume: |
11 |
Issue: |
38 |
Pages: |
e2402550 |
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Publication |
First Author: |
Seachrist DD |
Year: |
2019 |
Journal: |
Endocrinology |
Title: |
The Activin Social Network: Activin, Inhibin, and Follistatin in Breast Development and Cancer. |
Volume: |
160 |
Issue: |
5 |
Pages: |
1097-1110 |
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Publication |
First Author: |
Bercier P |
Year: |
2023 |
Journal: |
Cancer Discov |
Title: |
Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function. |
Volume: |
13 |
Issue: |
12 |
Pages: |
2548-2565 |
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Publication |
First Author: |
Yang C |
Year: |
2005 |
Journal: |
Dev Cell |
Title: |
Mammalian CARMIL inhibits actin filament capping by capping protein. |
Volume: |
9 |
Issue: |
2 |
Pages: |
209-21 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
696
 |
Fragment?: |
false |
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Publication |
First Author: |
Liang Y |
Year: |
2009 |
Journal: |
Mol Biol Cell |
Title: |
Distinct roles for CARMIL isoforms in cell migration. |
Volume: |
20 |
Issue: |
24 |
Pages: |
5290-305 |
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Publication |
First Author: |
Kim T |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
Mechanism for CARMIL protein inhibition of heterodimeric actin-capping protein. |
Volume: |
287 |
Issue: |
19 |
Pages: |
15251-62 |
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Protein Domain |
Type: |
Homologous_superfamily |
Description: |
The CRAL-TRIO domain is a protein structural domain that binds small lipophilic molecules []. The domain is named after cellular retinaldehyde-binding protein (CRALBP) and TRIO guanine exchange factor.The CRAL-TRIO domain is found in GTPase-activating proteins (GAPs), guanine nucleotide exchange factors (GEFs) and a family of hydrophobic ligand binding proteins, including the yeast SEC14 protein and mammalian retinaldehyde- and alpha-tocopherol-binding proteins. The domain may either constitute all of the protein or only part of it [, , , ].The structure of the domain in SEC14 proteins has been determined []. The structure contains several alpha helices as well as a beta sheet composed of 6 strands. Strands 2,3,4 and 5 form a parallel beta sheet with strands 1 and 6 being anti-parallel. The structure also identified a hydrophobic binding pocket for lipid binding. |
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Protein Domain |
Type: |
Domain |
Description: |
The CRAL-TRIO domain is a protein structural domain that binds small lipophilic molecules []. The domain is named after cellular retinaldehyde-binding protein (CRALBP) and TRIO guanine exchange factor.The CRAL-TRIO domain is found in GTPase-activating proteins (GAPs), guanine nucleotide exchange factors (GEFs) and a family of hydrophobic ligand binding proteins, including the yeast SEC14 protein and mammalian retinaldehyde- and alpha-tocopherol-binding proteins. The domain may either constitute all of the protein or only part of it [, , , ].The structure of the domain in SEC14 proteins has been determined []. The structure contains several alpha helices as well as a beta sheet composed of 6 strands. Strands 2,3,4 and 5 form a parallel beta sheet with strands 1 and 6 being anti-parallel. The structure also identified a hydrophobic binding pocket for lipid binding. |
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Protein Domain |
Type: |
Family |
Description: |
This narrowly distributed protein family contains an N-terminal radical SAM domain. It occurs in Pseudomonas fluorescens Pf0-1, Ralstonia solanacearum, and numerous species and strains of Burkholderia. Members always occur next to a trio of three mutually homologous genes, all of which contain the domain as the whole of the protein (about 60 amino acids) or as the C-terminal domain. The function is unknown, but the fact that all phylogenetically correlated proteins are mutually homologous with prominent invariant motifs (an invariant tyrosine and a GDL motif) and as small as 60 amino acids suggests that post-translational modification of domain-containing proteins may be its function. This view is supported by closer homology to the PqqE radical SAM protein involved in PQQ biosynthesis from the PqqA precursor peptide than to other characterised radical SAM proteins. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
372
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
328
 |
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
326
 |
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
354
 |
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
327
 |
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
343
 |
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
278
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
278
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
314
 |
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
280
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
348
 |
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
395
 |
Fragment?: |
true |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
86
 |
Fragment?: |
true |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
245
 |
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
348
 |
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
195
 |
Fragment?: |
true |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
209
 |
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
259
 |
Fragment?: |
true |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
280
 |
Fragment?: |
false |
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