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Search results 301 to 400 out of 476 for Ubp1

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Type Details Score
Protein
F6TH61
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: true
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Protein
F7ALR2
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: true
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Protein
G3X9U6
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
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Publication
23845989 | -
First Author: Eletr ZM
Year: 2014
Journal: Biochim Biophys Acta
Title: Regulation of proteolysis by human deubiquitinating enzymes.
Volume: 1843
Issue: 1
Pages: 114-28
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Protein Domain
IPR001394 | Peptidase_C19_UCH
Type: Domain
Description: Ubiquitin carboxyl-terminal hydrolases (UCH) () []are thiol proteases that recognise and hydrolyse the peptide bond at the C-terminal glycine of ubiquitin. These enzymes are involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins. The deubiquitinsing proteases can be split into 2 size ranges, 20-30kDa() and 100-200kDa []: the second class consist of large proteins (800 to 2000 residues) that belong to the peptidase family C19, and this group is currently represented by yeast UBP1 []. UCH thiol proteases contain an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions []. This entry represents the catalytic domain of UCH proteins of the UBP1 group.A cysteine peptidase is a proteolytic enzyme that hydrolyses a peptide bond using the thiol group of a cysteine residue as a nucleophile. Hydrolysis involves usually a catalytic triad consisting of the thiol group of the cysteine, the imidazolium ring of a histidine, and a third residue, usually asparagine or aspartic acid, to orientate and activate the imidazolium ring. In only one family of cysteine peptidases, is the role of the general base assigned to a residue other than a histidine: in peptidases from family C89 (acid ceramidase) an arginine is the general base. Cysteine peptidases can be grouped into fourteen different clans, with members of each clan possessing a tertiary fold unique to the clan. Four clans of cysteine peptidases share structural similarities with serine and threonine peptidases and asparagine lyases. From sequence similarities, cysteine peptidases can be clustered into over 80 different families []. Clans CF, CM, CN, CO, CP and PD contain only one family.Cysteine peptidases are often active at acidic pH and are therefore confined to acidic environments, such as the animal lysosome or plant vacuole. Cysteine peptidases can be endopeptidases, aminopeptidases, carboxypeptidases, dipeptidyl-peptidases or omega-peptidases. They are inhibited by thiol chelators such as iodoacetate, iodoacetic acid, N-ethylmaleimide or p-chloromercuribenzoate.Clan CA includes proteins with a papain-like fold. There is a catalytic triad which occurs in the order: Cys/His/Asn (or Asp). A fourth residue, usually Gln, is important for stabilising the acyl intermediate that forms during catalysis, and this precedes the active site Cys. The fold consists of two subdomains with the active site between them. One subdomain consists of a bundle of helices, with the catalytic Cys at the end of one of them, and the other subdomain is a β-barrel with the active site His and Asn (or Asp). There are over thirty families in the clan, and tertiary structures have been solved for members of most of these. Peptidases in clan CA are usually sensitive to the small molecule inhibitor E64, which is ineffective against peptidases from other clans of cysteine peptidases [].Clan CD includes proteins with a caspase-like fold. Proteins in the clan have an α/β/α sandwich structure. There is a catalytic dyad which occurs in the order His/Cys. The active site His occurs in a His-Gly motif and the active site Cys occurs in an Ala-Cys motif; both motifs are preceded by a block of hydrophobic residues []. Specificity is predominantly directed towards residues that occupy the S1 binding pocket, so that caspases cleave aspartyl bonds, legumains cleave asparaginyl bonds, and gingipains cleave lysyl or arginyl bonds.Clan CE includes proteins with an adenain-like fold. The fold consists of two subdomains with the active site between them. One domain is a bundle of helices, and the other a β-barrell. The subdomains are in the opposite order to those found in peptidases from clan CA, and this is reflected in the order of active site residues: His/Asn/Gln/Cys. This has prompted speculation that proteins in clans CA and CE are related, and that members of one clan are derived from a circular permutation of the structure of the other.Clan CL includes proteins with a sortase B-like fold. Peptidases in the clan hydrolyse and transfer bacterial cell wall peptides. The fold shows a closed β-barrel decorated with helices with the active site at one end of the barrel []. The active site consists of a His/Cys catalytic dyad.Cysteine peptidases with a chymotrypsin-like fold are included in clan PA, which also includes serine peptidases. Cysteine peptidases that are N-terminal nucleophile hydrolases are included in clan PB. Cysteine peptidases with a tertiary structure similar to that of the serine-type aspartyl dipeptidase are included in clan PC. Cysteine peptidases with an intein-like fold are included in clan PD, which also includes asparagine lyases.
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Protein
A2ALR8
Organism: Mus musculus/domesticus
Length: 631  
Fragment?: true
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Publication
1647207 | -
First Author: Jentsch S
Year: 1991
Journal: Biochim Biophys Acta
Title: Genetic analysis of the ubiquitin system.
Volume: 1089
Issue: 2
Pages: 127-39
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Protein
Q8BW70
Organism: Mus musculus/domesticus
Length: 1042  
Fragment?: false
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Protein
Q6ZPG3
Organism: Mus musculus/domesticus
Length: 1086  
Fragment?: true
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Protein
Q8R5K2
Organism: Mus musculus/domesticus
Length: 909  
Fragment?: false
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Protein
Q99K46
Organism: Mus musculus/domesticus
Length: 921  
Fragment?: false
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Protein
Q8R5H1
Organism: Mus musculus/domesticus
Length: 981  
Fragment?: false
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Protein
Q8C6M1
Organism: Mus musculus/domesticus
Length: 916  
Fragment?: false
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Protein
P35123
Organism: Mus musculus/domesticus
Length: 962  
Fragment?: false
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Protein
Q5DTK8
Organism: Mus musculus/domesticus
Length: 747  
Fragment?: true
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Protein
Q3TEX8
Organism: Mus musculus/domesticus
Length: 962  
Fragment?: false
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Protein
Q9CVR9
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: true
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Protein
G3UZF4
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: true
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Protein
A0A0H2UKB8
Organism: Mus musculus/domesticus
Length: 897  
Fragment?: false
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Protein
Q80TK2
Organism: Mus musculus/domesticus
Length: 837  
Fragment?: true
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Protein
Q921M8
Organism: Mus musculus/domesticus
Length: 915  
Fragment?: false
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Protein
A0A0A6YW28
Organism: Mus musculus/domesticus
Length: 915  
Fragment?: false
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Protein
Q80VA4
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: true
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Protein
Q5DTP2
Organism: Mus musculus/domesticus
Length: 512  
Fragment?: true
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Protein
A0A0A6YVY7
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
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Protein
F8VPZ3
Organism: Mus musculus/domesticus
Length: 1604  
Fragment?: false
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Protein
Q8VCJ2
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: false
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Protein
Q6NXV6
Organism: Mus musculus/domesticus
Length: 961  
Fragment?: true
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Protein
Q8BL06
Organism: Mus musculus/domesticus
Length: 1588  
Fragment?: false
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Protein
P15975
Organism: Mus musculus/domesticus
Length: 1069  
Fragment?: false
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Protein
Q3USD9
Organism: Mus musculus/domesticus
Length: 427  
Fragment?: true
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Protein
F7BAC1
Organism: Mus musculus/domesticus
Length: 153  
Fragment?: true
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Protein
D6RCG3
Organism: Mus musculus/domesticus
Length: 271  
Fragment?: false
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Protein
A0A0A6YW63
Organism: Mus musculus/domesticus
Length: 190  
Fragment?: true
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Protein
Q3TJI3
Organism: Mus musculus/domesticus
Length: 770  
Fragment?: false
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Protein
O88348
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: true
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Protein
Q8BSX5
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
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Protein
A0A0A6YWM7
Organism: Mus musculus/domesticus
Length: 394  
Fragment?: true
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Protein
A0A0G2JFC5
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
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Protein
A0A0J9YUP8
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: true
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Protein
Q9D9M2
Organism: Mus musculus/domesticus
Length: 370  
Fragment?: false
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Protein
E9Q9U0
Organism: Mus musculus/domesticus
Length: 468  
Fragment?: false
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Protein
Q80TQ2
Organism: Mus musculus/domesticus
Length: 952  
Fragment?: false
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Protein
P70398
Organism: Mus musculus/domesticus
Length: 2559  
Fragment?: false
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Protein
Q3TIX9
Organism: Mus musculus/domesticus
Length: 564  
Fragment?: false
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Protein
Q8BUM9
Organism: Mus musculus/domesticus
Length: 1132  
Fragment?: false
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Protein
Q3UN04
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: false
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Protein
Q6P8X6
Organism: Mus musculus/domesticus
Length: 390  
Fragment?: false
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Protein
Q8BWR4
Organism: Mus musculus/domesticus
Length: 1235  
Fragment?: false
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Protein
Q5I043
Organism: Mus musculus/domesticus
Length: 1051  
Fragment?: false
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Protein
Q8BY87
Organism: Mus musculus/domesticus
Length: 1376  
Fragment?: false
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Protein
Q7M764
Organism: Mus musculus/domesticus
Length: 540  
Fragment?: false
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Protein
Q9ES63
Organism: Mus musculus/domesticus
Length: 869  
Fragment?: false
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Protein
Q8BJQ2
Organism: Mus musculus/domesticus
Length: 784  
Fragment?: false
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Protein
Q61068
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
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Protein
B2RQC2
Organism: Mus musculus/domesticus
Length: 1324  
Fragment?: false
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Protein
O88623
Organism: Mus musculus/domesticus
Length: 613  
Fragment?: false
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Protein
Q9WTV6
Organism: Mus musculus/domesticus
Length: 368  
Fragment?: false
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Protein
Q6ZQ93
Organism: Mus musculus/domesticus
Length: 3582  
Fragment?: false
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Protein
P62069
Organism: Mus musculus/domesticus
Length: 366  
Fragment?: false
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Protein
G5E8G2
Organism: Mus musculus/domesticus
Length: 545  
Fragment?: false
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Protein
B1AQJ2
Organism: Mus musculus/domesticus
Length: 1098  
Fragment?: false
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Protein
Q80U87
Organism: Mus musculus/domesticus
Length: 1080  
Fragment?: false
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Protein
Q8CEG8
Organism: Mus musculus/domesticus
Length: 438  
Fragment?: false
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Protein
G5E8I7
Organism: Mus musculus/domesticus
Length: 545  
Fragment?: false
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Protein
P52479
Organism: Mus musculus/domesticus
Length: 792  
Fragment?: false
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Protein
Q99MX1
Organism: Mus musculus/domesticus
Length: 835  
Fragment?: false
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Protein
Q9QZL6
Organism: Mus musculus/domesticus
Length: 566  
Fragment?: false
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Protein
Q3TPN5
Organism: Mus musculus/domesticus
Length: 582  
Fragment?: true
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Protein
F6WJB7
Organism: Mus musculus/domesticus
Length: 3602  
Fragment?: true
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Protein
B2RRS6
Organism: Mus musculus/domesticus
Length: 368  
Fragment?: false
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Protein
M0QWN7
Organism: Mus musculus/domesticus
Length: 1009  
Fragment?: false
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Protein
Q4FE56
Organism: Mus musculus/domesticus
Length: 2554  
Fragment?: false
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Protein
Q3UAR6
Organism: Mus musculus/domesticus
Length: 368  
Fragment?: false
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Protein
Q3UQ26
Organism: Mus musculus/domesticus
Length: 988  
Fragment?: true
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Protein
Q7TT84
Organism: Mus musculus/domesticus
Length: 679  
Fragment?: true
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Protein
F6XDW8
Organism: Mus musculus/domesticus
Length: 287  
Fragment?: true
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Protein
Q8CCP4
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: true
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Protein
A0A0N4SVX5
Organism: Mus musculus/domesticus
Length: 60  
Fragment?: true
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Protein
Q3UZ62
Organism: Mus musculus/domesticus
Length: 1080  
Fragment?: false
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Protein
Q3V028
Organism: Mus musculus/domesticus
Length: 952  
Fragment?: false
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Protein
Q3TLH2
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: true
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Protein
F6ZE47
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: true
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Protein
D3YVJ5
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: true
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Protein
Q8BS89
Organism: Mus musculus/domesticus
Length: 705  
Fragment?: true
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Protein
A2AI52
Organism: Mus musculus/domesticus
Length: 1091  
Fragment?: false
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Protein
A0A087WRD2
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: false
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Protein
Q3TQZ9
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: false
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Protein
Z4YJJ5
Organism: Mus musculus/domesticus
Length: 955  
Fragment?: false
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Protein
Q8BZ53
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: true
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Protein
A0A0J9YV73
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
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Protein
Q3TMY1
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
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Protein
G3UWN7
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: true
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Protein
Q3T9X4
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
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Protein
V5SJE7
Organism: Mus musculus/domesticus
Length: 479  
Fragment?: false
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Protein
B0QZF8
Organism: Mus musculus/domesticus
Length: 890  
Fragment?: true
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Protein
H3BKR6
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: true
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Protein
F8VPU6
Organism: Mus musculus/domesticus
Length: 2556  
Fragment?: false
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Protein
Q8BMT7
Organism: Mus musculus/domesticus
Length: 474  
Fragment?: false
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Protein
A6PWR8
Organism: Mus musculus/domesticus
Length: 1127  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom