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Search results 301 to 400 out of 423 for Ulk1

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Type Details Score
Publication
21460634 | -
First Author: Löffler AS
Year: 2011
Journal: Autophagy
Title: Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.
Volume: 7
Issue: 7
Pages: 696-706
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Protein Domain
IPR018731 | Atg13_N
Type: Domain
Description: This entry represents the N-terminal domain of autophagy-related protein 13 (Atg13) from yeasts, animals and plants. They function in autophagy.Fission yeast autophagy initiation is controlled by the Atg1 kinase complex, which is composed of the Ser/Thr kinase Atg1, the adaptor protein Atg13, and the ternary complex of Atg17-Atg31-Atg29. Atg13 recruits Atg1 to the site of autophagosome formation and enhancing Atg1 kinase activity. Atg13 may have additional functions that are independent of a direct interaction or permanent colocalization with Atg1 []. In vertebrates, the orthologous ULK1 kinase complex contains the Ser/Thr kinase ULK1 and the accessory proteins ATG13, RB1CC1, and ATG101 []. Through its regulation of ULK1 activity, Atg13 plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation [].
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Protein Domain
IPR040182 | ATG13
Type: Family
Description: This entry represents autophagy-related protein 13 (Atg13) from yeasts, animals and plants, which functions in autophagy.Fission yeast autophagy initiation is controlled by the Atg1 kinase complex, which is composed of the Ser/Thr kinase Atg1, the adaptor protein Atg13, and the ternary complex of Atg17-Atg31-Atg29. Atg13 recruits Atg1 to the site of autophagosome formation and enhancing Atg1 kinase activity. Atg13 may have additional functions that are independent of a direct interaction or permanent colocalization with Atg1 []. In vertebrates, the orthologous ULK1 kinase complex contains the Ser/Thr kinase ULK1 and the accessory proteins ATG13, RB1CC1, and ATG101 []. Through its regulation of ULK1 activity, Atg13 plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation [].
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GO Term
GO:1905864 | regulation of Atg1/ULK1 kinase complex assembly
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Protein
Q78YZ6
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: false
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Protein
A0A1D5RML7
Organism: Mus musculus/domesticus
Length: 47  
Fragment?: false
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Protein
A0A1D5RMF2
Organism: Mus musculus/domesticus
Length: 35  
Fragment?: true
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Publication
22354037 | -
First Author: McKnight NC
Year: 2012
Journal: EMBO J
Title: Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.
Volume: 31
Issue: 8
Pages: 1931-46
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Protein Domain
IPR019357 | SCOC
Type: Family
Description: This entry represents short coiled-coil protein (SCOC). In human, SCOC is required for autophagosome formation during amino acid starvation. It forms a starvation-sensitive trimeric complex with UVRAG (UV radiation resistance associated gene) and FEZ1 and may regulate ULK1 and Beclin 1 complex activities [].
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HT Experiment
GSE79508 | Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection
Series Id: E-GEOD-79508
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Protein
Q91YI1
Organism: Mus musculus/domesticus
Length: 516  
Fragment?: false
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Protein Domain
IPR016237 | Ser/Thr_kin_STPK_Ulk-1/2
Type: Family
Description: Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].This represents serine/threonine-protein kinases (), such as Ulk1 and Ulk2 (Unc-51-Like Kinase). Ulk1 and Ulk2 regulate filopodia extension and branching of sensory axons. They are important for axon growth, playing an essential role in neurite extension of cerebellar granule cells [, ].
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Publication
7389358 | -
   
Year: 1980
Journal: Contrib Nephrol
Title: Disturbances of water and electrolyte metabolism.
Volume: 21
Pages: 1-152
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Publication
28561066 | J:281251
 
First Author: Bakula D
Year: 2017
Journal: Nat Commun
Title: WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.
Volume: 8
Pages: 15637
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Publication
38026185 | J:355287
First Author: Day EA
Year: 2023
Journal: iScience
Title: Macrophage AMPK β1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice.
Volume: 26
Issue: 11
Pages: 108269
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Publication
30022064 | J:265033
First Author: Zhu L
Year: 2018
Journal: Nat Commun
Title: TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival.
Volume: 9
Issue: 1
Pages: 2812
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Publication
32042044 | J:287352
First Author: Byun S
Year: 2020
Journal: Nat Commun
Title: Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase.
Volume: 11
Issue: 1
Pages: 807
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Publication
32203415 | J:291404
First Author: Tsang T
Year: 2020
Journal: Nat Cell Biol
Title: Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma.
Volume: 22
Issue: 4
Pages: 412-424
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Publication
33718841 | J:314713
First Author: Ding S
Year: 2021
Journal: iScience
Title: Interactions between fungal hyaluronic acid and host CD44 promote internalization by recruiting host autophagy proteins to forming phagosomes.
Volume: 24
Issue: 3
Pages: 102192
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Publication
27551156 | J:237236
First Author: Qi X
Year: 2016
Journal: J Exp Med
Title: Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection.
Volume: 213
Issue: 10
Pages: 2081-97
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Publication
26039451 | J:226124
First Author: Bujak AL
Year: 2015
Journal: Cell Metab
Title: AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging.
Volume: 21
Issue: 6
Pages: 883-90
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Publication
32850000 | J:313544
 
First Author: Yu H
Year: 2020
Journal: Oxid Med Cell Longev
Title: O-GlcNAcylation Is Essential for Autophagy in Cardiomyocytes.
Volume: 2020
Pages: 5602396
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Publication
23109424 | J:192845
First Author: Fetalvero KM
Year: 2013
Journal: Mol Cell Biol
Title: Defective autophagy and mTORC1 signaling in myotubularin null mice.
Volume: 33
Issue: 1
Pages: 98-110
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Publication
34862201 | J:330507
First Author: Israeli T
Year: 2022
Journal: Diabetes
Title: Nutrient Sensor mTORC1 Regulates Insulin Secretion by Modulating β-Cell Autophagy.
Volume: 71
Issue: 3
Pages: 453-469
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Publication
39532100 | J:359566
First Author: Longo M
Year: 2024
Journal: Mol Cell
Title: Opposing roles for AMPK in regulating distinct mitophagy pathways.
Volume: 84
Issue: 22
Pages: 4350-4367.e9
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Publication
25891078 | J:347306
First Author: Chauhan S
Year: 2015
Journal: Mol Cell
Title: IRGM governs the core autophagy machinery to conduct antimicrobial defense.
Volume: 58
Issue: 3
Pages: 507-21
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Publication
21241894 | J:173134
First Author: Bodemann BO
Year: 2011
Journal: Cell
Title: RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly.
Volume: 144
Issue: 2
Pages: 253-67
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Publication
26344566 | J:227511
First Author: Zhang J
Year: 2015
Journal: Nat Cell Biol
Title: ATM functions at the peroxisome to induce pexophagy in response to ROS.
Volume: 17
Issue: 10
Pages: 1259-1269
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Publication
38195627 | J:344380
First Author: Berglund R
Year: 2024
Journal: Nat Commun
Title: The aging mouse CNS is protected by an autophagy-dependent microglia population promoted by IL-34.
Volume: 15
Issue: 1
Pages: 383
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Protein
Q8K0Q7
Organism: Mus musculus/domesticus
Length: 327  
Fragment?: true
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Publication
16887826 | -
First Author: Ogura K
Year: 2006
Journal: Development
Title: The autophagy-related kinase UNC-51 and its binding partner UNC-14 regulate the subcellular localization of the Netrin receptor UNC-5 in Caenorhabditis elegans.
Volume: 133
Issue: 17
Pages: 3441-50
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Publication
17890369 | -
First Author: Aladzsity I
Year: 2007
Journal: Genetics
Title: Autophagy genes unc-51 and bec-1 are required for normal cell size in Caenorhabditis elegans.
Volume: 177
Issue: 1
Pages: 655-60
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Publication
19377305 | -
First Author: Tian E
Year: 2009
Journal: Autophagy
Title: epg-1 functions in autophagy-regulated processes and may encode a highly divergent Atg13 homolog in C. elegans.
Volume: 5
Issue: 5
Pages: 608-15
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Publication
24793651 | -
First Author: Fujioka Y
Year: 2014
Journal: Nat Struct Mol Biol
Title: Structural basis of starvation-induced assembly of the autophagy initiation complex.
Volume: 21
Issue: 6
Pages: 513-21
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Publication
15367757 | -
First Author: Colicelli J
Year: 2004
Journal: Sci STKE
Title: Human RAS superfamily proteins and related GTPases.
Volume: 2004
Issue: 250
Pages: RE13
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Publication
15950903 | -
First Author: Lim KH
Year: 2005
Journal: Cancer Cell
Title: Activation of RalA is critical for Ras-induced tumorigenesis of human cells.
Volume: 7
Issue: 6
Pages: 533-45
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Publication
17018283 | -
First Author: Chien Y
Year: 2006
Journal: Cell
Title: RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival.
Volume: 127
Issue: 1
Pages: 157-70
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Publication
24056301 | -
First Author: Simicek M
Year: 2013
Journal: Nat Cell Biol
Title: The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.
Volume: 15
Issue: 10
Pages: 1220-30
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Publication
15511640 | -
First Author: Lebreton S
Year: 2004
Journal: Mech Dev
Title: RLIP mediates downstream signalling from RalB to the actin cytoskeleton during Xenopus early development.
Volume: 121
Issue: 12
Pages: 1481-94
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Publication
21984698 | -
First Author: Suttangkakul A
Year: 2011
Journal: Plant Cell
Title: The ATG1/ATG13 protein kinase complex is both a regulator and a target of autophagic recycling in Arabidopsis.
Volume: 23
Issue: 10
Pages: 3761-79
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Protein Domain
IPR045269 | Atg1-like
Type: Family
Description: This entry represents a group of Serine/threonine-protein kinases, including Atg1 from yeasts, Unc-51 from C. elegans, Ulk1-3 from humans and ATG1a/b/c/t from Arabidopsis.Atg1 is required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway [].Ulk1-3 are involved in autophagy in response to starvation [, ]. Ulk1 and Ulk2 regulate filopodia extension and branching of sensory axons. They are important for axon growth, playing an essential role in neurite extension of cerebellar granule cells [, ]. Unc-51 is important for axonal elongation and axonal guidance []. It is required for either the maintenance of axons (membrane turnover) or for an unknown neuronal function. C elegans worms lacking Unc-51 exhibit various abnormalities in axonal elongation and axonal structures. Unc-51 could also help control cell size along with Bec-1, as mutations in their corresponding genes results in a reduction in small body size without affecting cell number []. Unc-51 is also a component of the Unc-51/Atg-13 complex that is probably recruited by lgg-1 to preautophagosomes and is required for autophagosome formation [].In plants, the ATG1/13 complex is both a regulator and a target of autophagy [].
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Protein Domain
IPR028412 | Ral
Type: Family
Description: Ral protein family, including RALA and RALB, belongs to the RAS family of small GTPases. Like other RAS GTPases, Ral proteins function as molecular switches alternating between inactive GDP-bound and active GT-bound states [].In humans, RALA and RALB are activated in tumour-derived cell lines. RALA severely impairs the anchorage-independent proliferation of cancer cell lines [], while RALB is required to suppress apoptotic checkpoint activation and is essential for the survival of a variety of tumour-derived cell lines []. RALA and RALB share the same effector molecules, such as SEC5 and EXO84. However, they seem to function in distinct but inter-related biological processes. RALA regulates the assembly interface of a full octameric exocyst complex through interaction with Sec5 and Exo84 []. The RALB/Sec5 effector complex is involved in the TBK1-dependent innate immune signaling [], while the interaction between PALB and EXO84 promotes the assembly of catalytically active ULK1 and the beclin-1-VPS34 autophagy initiation complex []. This entry also includes Xenopus RalA and RalB. RalB regulates the actin cytoskeleton during the early development and affects gastrulation [].
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Protein Domain
IPR022708 | Atg1-like_tMIT
Type: Domain
Description: This the Atg13-binding region of Atg1 which comprises two tandem MIT (microtubule interacting and transport) domains, named tMIT [].Members of this entry are Serine/threonine-protein kinases, including Atg1 from yeasts, Unc-51 from C. elegans and Ulk1-2 from humans.Atg1 is required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway [, ].Ulk1-2 are involved in autophagy in response to starvation [, ]. Ulk1 and Ulk2 regulate filopodia extension and branching of sensory axons. They are important for axon growth, playing an essential role in neurite extension of cerebellar granule cells [, ]. Unc-51 is important for axonal elongation and axonal guidance []. It is required for either the maintenance of axons (membrane turnover) or for an unknown neuronal function. C elegans worms lacking Unc-51 exhibit various abnormalities in axonal elongation and axonal structures. Unc-51 could also help control cell size along with Bec-1, as mutations in their corresponding genes results in a reduction in small body size without affecting cell number []. Unc-51 is also a component of the Unc-51/Atg-13 complex that is probably recruited by lgg-1 to preautophagosomes and is required for autophagosome formation [].
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Publication
17204848 | -
First Author: Meijer WH
Year: 2007
Journal: Autophagy
Title: ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes.
Volume: 3
Issue: 2
Pages: 106-16
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Publication
21068542 | J:220511
First Author: Takahashi Y
Year: 2011
Journal: Autophagy
Title: Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy.
Volume: 7
Issue: 1
Pages: 61-73
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Publication
24901456 | J:246920
First Author: Owen KA
Year: 2014
Journal: PLoS Pathog
Title: Activation of focal adhesion kinase by Salmonella suppresses autophagy via an Akt/mTOR signaling pathway and promotes bacterial survival in macrophages.
Volume: 10
Issue: 6
Pages: e1004159
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Publication
29686674 | J:337031
 
First Author: Jati S
Year: 2018
Journal: Front Immunol
Title: Wnt5A Signaling Promotes Defense Against Bacterial Pathogens by Activating a Host Autophagy Circuit.
Volume: 9
Pages: 679
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Publication
29945885 | J:284426
 
First Author: Singh BK
Year: 2018
Journal: Sci Signal
Title: Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function.
Volume: 11
Issue: 536
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Publication
28317932 | J:323759
 
First Author: Hubber A
Year: 2017
Journal: Sci Rep
Title: Bacterial secretion system skews the fate of Legionella-containing vacuoles towards LC3-associated phagocytosis.
Volume: 7
Pages: 44795
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Publication
35320362 | J:332343
First Author: Tsang T
Year: 2022
Journal: Mol Cancer Res
Title: BRAFV600E-Driven Lung Adenocarcinoma Requires Copper to Sustain Autophagic Signaling and Processing.
Volume: 20
Issue: 7
Pages: 1096-1107
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Publication
35805144 | J:327555
 
First Author: Luis LB
Year: 2022
Journal: Cells
Title: Salmonella Promotes Its Own Survival in B Cells by Inhibiting Autophagy.
Volume: 11
Issue: 13
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Publication
32865519 | J:297440
First Author: Zhu M
Year: 2020
Journal: J Clin Invest
Title: Beclin 2 negatively regulates innate immune signaling and tumor development.
Volume: 130
Issue: 10
Pages: 5349-5369
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Publication
25383523 | J:217540
First Author: Seok S
Year: 2014
Journal: Nature
Title: Transcriptional regulation of autophagy by an FXR-CREB axis.
Volume: 516
Issue: 7529
Pages: 108-11
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Publication
32512189 | J:299849
First Author: Gong Y
Year: 2020
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Double knockout of Akt2 and AMPK accentuates high fat diet-induced cardiac anomalies through a cGAS-STING-mediated mechanism.
Volume: 1866
Issue: 10
Pages: 165855
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Publication
36061025 | J:352103
First Author: Tong WH
Year: 2022
Journal: Heliyon
Title: Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia.
Volume: 8
Issue: 8
Pages: e10371
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Publication
25024188 | J:212250
First Author: Bandyopadhyay U
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Absence of lipofuscin in motor neurons of SOD1-linked ALS mice.
Volume: 111
Issue: 30
Pages: 11055-60
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Publication
35365653 | J:323886
First Author: Saleiro D
Year: 2022
Journal: Nat Commun
Title: Discovery of a signaling feedback circuit that defines interferon responses in myeloproliferative neoplasms.
Volume: 13
Issue: 1
Pages: 1750
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Publication
30961637 | J:290312
First Author: Abd-Elrahman KS
Year: 2019
Journal: Mol Brain
Title: Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington's pathology in zQ175 mice.
Volume: 12
Issue: 1
Pages: 35
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Publication
32891637 | J:298086
 
First Author: Liu F
Year: 2020
Journal: J Mol Cell Cardiol
Title: Beclin1 Haploinsufficiency accentuates second-hand smoke exposure -induced myocardial Remodeling and contractile dysfunction through a STING-mediated mechanism.
Volume: 148
Pages: 78-88
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Publication
28674405 | J:252774
First Author: Liu C
Year: 2017
Journal: Sci Rep
Title: Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus.
Volume: 7
Issue: 1
Pages: 4543
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Publication
25411424 | J:220772
First Author: Li-Harms X
Year: 2015
Journal: Blood
Title: Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice.
Volume: 125
Issue: 1
Pages: 162-74
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Publication
28821398 | J:261227
 
First Author: Sheng YL
Year: 2017
Journal: Exp Neurol
Title: Urate promotes SNCA/α-synuclein clearance via regulating mTOR-dependent macroautophagy.
Volume: 297
Pages: 138-147
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Publication
25315696 | J:218407
First Author: Britto FA
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: REDD1 deletion prevents dexamethasone-induced skeletal muscle atrophy.
Volume: 307
Issue: 11
Pages: E983-93
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Publication
26487002 | J:229689
First Author: Steiner JL
Year: 2015
Journal: Am J Physiol Endocrinol Metab
Title: Disruption of REDD1 gene ameliorates sepsis-induced decrease in mTORC1 signaling but has divergent effects on proteolytic signaling in skeletal muscle.
Volume: 309
Issue: 12
Pages: E981-94
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Publication
28011637 | J:240888
First Author: Saleem S
Year: 2017
Journal: J Biol Chem
Title: Tribbles Pseudokinase 3 Induces Both Apoptosis and Autophagy in Amyloid-β-induced Neuronal Death.
Volume: 292
Issue: 7
Pages: 2571-2585
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Publication
27800610 | J:308966
First Author: Sung HK
Year: 2017
Journal: J Cell Physiol
Title: Lipocalin-2 (NGAL) Attenuates Autophagy to Exacerbate Cardiac Apoptosis Induced by Myocardial Ischemia.
Volume: 232
Issue: 8
Pages: 2125-2134
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Publication
22451512 | J:200810
First Author: Guo R
Year: 2012
Journal: Cardiovasc Res
Title: Deficiency in AMPK attenuates ethanol-induced cardiac contractile dysfunction through inhibition of autophagosome formation.
Volume: 94
Issue: 3
Pages: 480-91
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Publication
30679495 | J:275526
First Author: Corcino YL
Year: 2019
Journal: Sci Rep
Title: Epidermal growth factor receptor promotes cerebral and retinal invasion by Toxoplasma gondii.
Volume: 9
Issue: 1
Pages: 669
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Publication
26644405 | J:236139
First Author: Kaizuka T
Year: 2015
Journal: Mol Cell Biol
Title: Atg13 Is Essential for Autophagy and Cardiac Development in Mice.
Volume: 36
Issue: 4
Pages: 585-95
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Publication
22456507 | J:197801
First Author: Orsi A
Year: 2012
Journal: Mol Biol Cell
Title: Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy.
Volume: 23
Issue: 10
Pages: 1860-73
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Publication
30669939 | J:302617
First Author: Ho WY
Year: 2019
Journal: Autophagy
Title: The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy.
Volume: 15
Issue: 5
Pages: 827-842
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Publication
11146101 | J:67006
First Author: Okazaki N
Year: 2000
Journal: Brain Res Mol Brain Res
Title: Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation.
Volume: 85
Issue: 1-2
Pages: 1-12
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Publication
23878245 | J:200700
First Author: Tripathi DN
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1.
Volume: 110
Issue: 32
Pages: E2950-7
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Publication
9693035 | J:49113
First Author: Kuroyanagi H
Year: 1998
Journal: Genomics
Title: Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment.
Volume: 51
Issue: 1
Pages: 76-85
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Publication
25695398 | J:224566
First Author: Jensen TE
Year: 2015
Journal: Biochem J
Title: PT-1 selectively activates AMPK-Îł1 complexes in mouse skeletal muscle, but activates all three Îł subunit complexes in cultured human cells by inhibiting the respiratory chain.
Volume: 467
Issue: 3
Pages: 461-72
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Publication
27689873 | J:259874
First Author: RodrĂ­guez-Vargas JM
Year: 2016
Journal: Cell Death Differ
Title: Autophagy requires poly(adp-ribosyl)ation-dependent AMPK nuclear export.
Volume: 23
Issue: 12
Pages: 2007-2018
•
•
•
•
•
Publication
31290228 | J:295425
First Author: Lopez Corcino Y
Year: 2019
Journal: Cell Microbiol
Title: Toxoplasma gondii induces prolonged host epidermal growth factor receptor signalling to prevent parasite elimination by autophagy: Perspectives for in vivo control of the parasite.
Volume: 21
Issue: 10
Pages: e13084
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•
•
•
•
Publication
30511961 | J:329650
First Author: Saito T
Year: 2019
Journal: J Clin Invest
Title: An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia.
Volume: 129
Issue: 2
Pages: 802-819
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•
•
•
•
Publication
32340512 | J:319332
First Author: Liu G
Year: 2020
Journal: Ren Fail
Title: miR-25-3p promotes proliferation and inhibits autophagy of renal cells in polycystic kidney mice by regulating ATG14-Beclin 1.
Volume: 42
Issue: 1
Pages: 333-342
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•
•
•
•
Publication
27459239 | J:318383
First Author: Wang J
Year: 2016
Journal: Autophagy
Title: Role for DUSP1 (dual-specificity protein phosphatase 1) in the regulation of autophagy.
Volume: 12
Issue: 10
Pages: 1791-1803
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•
•
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•
Publication
31109947 | J:320003
 
First Author: Portillo JC
Year: 2019
Journal: Infect Immun
Title: CD40 in Endothelial Cells Restricts Neural Tissue Invasion by Toxoplasma gondii.
Volume: 87
Issue: 8
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•
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GO Term
GO:1905865 | negative regulation of Atg1/ULK1 kinase complex assembly
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•
•
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GO Term
GO:1905866 | positive regulation of Atg1/ULK1 kinase complex assembly
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•
Publication
28330873 | J:242770
First Author: Zhang M
Year: 2017
Journal: J Biol Chem
Title: AMP-activated protein kinase α1 promotes atherogenesis by increasing monocyte-to-macrophage differentiation.
Volume: 292
Issue: 19
Pages: 7888-7903
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•
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•
Publication
31538542 | J:306961
First Author: Barroso-Chinea P
Year: 2020
Journal: Autophagy
Title: DRD3 (dopamine receptor D3) but not DRD2 activates autophagy through MTORC1 inhibition preserving protein synthesis.
Volume: 16
Issue: 7
Pages: 1279-1295
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•
Publication
34345207 | J:336894
First Author: Jia Y
Year: 2021
Journal: Int J Biol Sci
Title: Crosstalk between hypoxia-sensing ULK1/2 and YAP-driven glycolysis fuels pancreatic ductal adenocarcinoma development.
Volume: 17
Issue: 11
Pages: 2772-2794
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Publication
31913745 | J:337050
First Author: Lee DH
Year: 2020
Journal: Autophagy
Title: SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
Volume: 16
Issue: 11
Pages: 1949-1973
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•
•
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Publication
34964695 | J:339463
First Author: Cho CS
Year: 2022
Journal: Autophagy
Title: Simultaneous loss of TSC1 and DEPDC5 in skeletal and cardiac muscles produces early-onset myopathy and cardiac dysfunction associated with oxidative damage and SQSTM1/p62 accumulation.
Volume: 18
Issue: 10
Pages: 2303-2322
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•
•
•
•
Publication
39596118 | J:361432
 
First Author: Armeli F
Year: 2024
Journal: Int J Mol Sci
Title: FAAH Inhibition Counteracts Neuroinflammation via Autophagy Recovery in AD Models.
Volume: 25
Issue: 22
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•
•
•
•
Publication
25071026 | J:230250
First Author: Liu Y
Year: 2015
Journal: Diabetes
Title: Adiponectin stimulates autophagy and reduces oxidative stress to enhance insulin sensitivity during high-fat diet feeding in mice.
Volume: 64
Issue: 1
Pages: 36-48
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•
Publication
31865844 | J:313587
First Author: Bork T
Year: 2020
Journal: Autophagy
Title: Podocytes maintain high basal levels of autophagy independent of mtor signaling.
Volume: 16
Issue: 11
Pages: 1932-1948
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Publication
36409897 | J:342744
First Author: Desjardins EM
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids.
Volume: 119
Issue: 48
Pages: e2119824119
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•
Publication
24732703 | J:215220
First Author: Ost M
Year: 2014
Journal: PLoS One
Title: Activation of AMPKα2 is not crucial for mitochondrial uncoupling-induced metabolic effects but required to maintain skeletal muscle integrity.
Volume: 9
Issue: 4
Pages: e94689
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•
•
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•
Publication
24368095 | J:224960
 
First Author: Zhang Y
Year: 2014
Journal: J Mol Cell Cardiol
Title: Akt2 knockout alleviates prolonged caloric restriction-induced change in cardiac contractile function through regulation of autophagy.
Volume: 71
Pages: 81-91
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•
•
•
•
Publication
29898994 | J:265551
First Author: He JP
Year: 2018
Journal: Cancer Res
Title: Flightless-I Blocks p62-Mediated Recognition of LC3 to Impede Selective Autophagy and Promote Breast Cancer Progression.
Volume: 78
Issue: 17
Pages: 4853-4864
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Protein
Q9QY01
Organism: Mus musculus/domesticus
Length: 1037  
Fragment?: false
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•
•
•
Protein
Q3UFT4
Organism: Mus musculus/domesticus
Length: 1057  
Fragment?: false
•
•
•
•
•
Protein
Q6PB82
Organism: Mus musculus/domesticus
Length: 1057  
Fragment?: false
•
•
•
•
•
Protein
A0A0R4J0B3
Organism: Mus musculus/domesticus
Length: 1051  
Fragment?: false
•
•
•
•
•
Protein
Q3UG39
Organism: Mus musculus/domesticus
Length: 1037  
Fragment?: false
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•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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