Type |
Details |
Score |
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
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Title: |
Cyagen Biosciences Website. |
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
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Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Zheng X |
Year: |
2014 |
Journal: |
Genes Dev |
Title: |
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. |
Volume: |
28 |
Issue: |
13 |
Pages: |
1429-44 |
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Interaction Experiment |
Description: |
Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics. |
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Publication |
First Author: |
Chen X |
Year: |
2019 |
Journal: |
J Proteome Res |
Title: |
Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics. |
Volume: |
18 |
Issue: |
6 |
Pages: |
2654-2665 |
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Interaction Experiment |
Description: |
USP9X counteracts differential ubiquitination of NPHP5 by MARCH7 and BBS11 to regulate ciliogenesis. |
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Interaction Experiment |
Description: |
USP9X deubiquitinates connexin43 to prevent high glucose-induced epithelial-to-mesenchymal transition in NRK-52E cells. |
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Interaction Experiment |
Description: |
Disruption of USP9X in macrophages promotes foam cell formation and atherosclerosis. |
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Allele |
Name: |
ubiquitin specific peptidase 9, X chromosome; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
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Interaction Experiment |
Description: |
Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKC Kinase Activity. |
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Publication |
First Author: |
Al-Hakim AK |
Year: |
2008 |
Journal: |
Biochem J |
Title: |
Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. |
Volume: |
411 |
Issue: |
2 |
Pages: |
249-60 |
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Publication |
First Author: |
Das A |
Year: |
2017 |
Journal: |
PLoS Genet |
Title: |
USP9X counteracts differential ubiquitination of NPHP5 by MARCH7 and BBS11 to regulate ciliogenesis. |
Volume: |
13 |
Issue: |
5 |
Pages: |
e1006791 |
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Publication |
First Author: |
Sun XH |
Year: |
2021 |
Journal: |
Biochem Pharmacol |
Title: |
USP9X deubiquitinates connexin43 to prevent high glucose-induced epithelial-to-mesenchymal transition in NRK-52E cells. |
Volume: |
188 |
|
Pages: |
114562 |
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HT Experiment |
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Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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DO Term |
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Publication |
First Author: |
Naik E |
Year: |
2016 |
Journal: |
J Immunol |
Title: |
Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCβ Kinase Activity. |
Volume: |
196 |
Issue: |
8 |
Pages: |
3438-51 |
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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DO Term |
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Publication |
First Author: |
Zhang L |
Year: |
2012 |
Journal: |
Cell Cycle |
Title: |
The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability. |
Volume: |
11 |
Issue: |
23 |
Pages: |
4378-84 |
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Publication |
First Author: |
Zhang L |
Year: |
2015 |
Journal: |
Cell Rep |
Title: |
The deubiquitinating enzyme USP24 is a regulator of the UV damage response. |
Volume: |
10 |
Issue: |
2 |
Pages: |
140-7 |
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•
•
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•
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Publication |
First Author: |
Wang YC |
Year: |
2016 |
Journal: |
Oncogene |
Title: |
Variants of ubiquitin-specific peptidase 24 play a crucial role in lung cancer malignancy. |
Volume: |
35 |
Issue: |
28 |
Pages: |
3669-80 |
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•
•
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Publication |
First Author: |
Peterson LF |
Year: |
2015 |
Journal: |
Blood |
Title: |
Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies. |
Volume: |
125 |
Issue: |
23 |
Pages: |
3588-97 |
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•
•
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Publication |
First Author: |
Sun Y |
Year: |
2018 |
Journal: |
J Virol |
Title: |
Human Cytomegalovirus Protein pUL38 Prevents Premature Cell Death by Binding to Ubiquitin-Specific Protease 24 and Regulating Iron Metabolism. |
Volume: |
92 |
Issue: |
13 |
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•
•
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Protein Domain |
Type: |
Family |
Description: |
Ubiquitin-specific peptidase 24 (USP24, MEROPS identifier C19.047) is a de-ubiquitinating enzyme that is associated with late-onset Parkinson's Disease []. The enzyme is known to remove ubiquitin from damage-specific DNA-binding protein 2 (DDB2), increasing its stability. DDB2 is involved in DNA damage recognition in the nucleotide excision repair pathway, and is a component of an E3 ligase that targets XPC, histones and DDB2 itself []. USP24 also de-ubiquitinates p53, and cells are resistant to apoptosis following UV irradiation if USP24 is depleted because p53 is stabilized []. Single-nucleotide polymorphisms of the USP24 gene have been identified in lung cancer malignancy and could be diagnostic markers for the disease []. The USP24 gene is up-regulated when the USP9X gene is down-regulated by shRNA, leading to increased survival of B-cell myeloma cells []. USP24 positively regulates ferritinophagy, a process in which ferritin is degraded in lysosomes and releases free iron []. |
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Publication |
First Author: |
Malenczyk K |
Year: |
2017 |
Journal: |
EMBO J |
Title: |
A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover. |
Volume: |
36 |
Issue: |
14 |
Pages: |
2107-2125 |
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•
•
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•
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Publication |
First Author: |
Wu YR |
Year: |
2010 |
Journal: |
Clin Chim Acta |
Title: |
Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's disease among Taiwanese. |
Volume: |
411 |
Issue: |
13-14 |
Pages: |
955-8 |
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•
•
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•
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Publication |
First Author: |
Taniguchi H |
Year: |
2017 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis by regulating the gene expression of deubiquitinating enzymes. |
Volume: |
484 |
Issue: |
1 |
Pages: |
176-183 |
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•
•
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•
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Publication |
First Author: |
Meyerovich K |
Year: |
2017 |
Journal: |
Diabetes |
Title: |
MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells. |
Volume: |
66 |
Issue: |
9 |
Pages: |
2446-2458 |
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•
•
•
•
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Publication |
First Author: |
La HM |
Year: |
2018 |
Journal: |
Development |
Title: |
GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenance. |
Volume: |
145 |
Issue: |
18 |
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•
•
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•
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Publication |
First Author: |
D'Amico G |
Year: |
2022 |
Journal: |
Development |
Title: |
ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning. |
Volume: |
149 |
Issue: |
13 |
|
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•
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•
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•
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Publication |
First Author: |
Koo H |
Year: |
2025 |
Journal: |
Nat Commun |
Title: |
Anti-proteolytic regulation of KRAS by USP9X/NDRG3 in KRAS-driven cancer development. |
Volume: |
16 |
Issue: |
1 |
Pages: |
628 |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2617
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2618
 |
Fragment?: |
false |
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•
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