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Search results 301 to 400 out of 766 for Vav1

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Type Details Score
Publication
8661125 | J:33929
First Author: Doyle J
Year: 1996
Journal: Genomics
Title: Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins.
Volume: 35
Issue: 1
Pages: 227-30
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Publication
7558021 | J:27402
First Author: Bozza M
Year: 1995
Journal: Genomics
Title: Structural characterization and chromosomal location of the mouse macrophage migration inhibitory factor gene and pseudogenes.
Volume: 27
Issue: 3
Pages: 412-9
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Publication
22732588 | J:189787
First Author: Lesourne R
Year: 2012
Journal: J Immunol
Title: Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.
Volume: 189
Issue: 3
Pages: 1154-61
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Publication
22683124 | J:187430
First Author: Dong Z
Year: 2012
Journal: Immunity
Title: The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.
Volume: 36
Issue: 6
Pages: 974-85
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Publication
8164679 | J:17787
First Author: Bae SC
Year: 1994
Journal: Mol Cell Biol
Title: PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials.
Volume: 14
Issue: 5
Pages: 3242-52
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Publication
8288240 | J:15564
First Author: Okazaki T
Year: 1993
Journal: Genomics
Title: Molecular diversity of the SCG10/stathmin gene family in the mouse.
Volume: 18
Issue: 2
Pages: 360-73
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Publication
19141316 | J:148967
First Author: Glassmann A
Year: 2009
Journal: Neuroscience
Title: Basic molecular fingerprinting of immature cerebellar cortical inhibitory interneurons and their precursors.
Volume: 159
Issue: 1
Pages: 69-82
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Publication
15728722 | J:100216
First Author: Aoki K
Year: 2005
Journal: Mol Biol Cell
Title: Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells.
Volume: 16
Issue: 5
Pages: 2207-17
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Publication
10679268 | J:64951
First Author: Masuhara M
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains.
Volume: 268
Issue: 3
Pages: 697-703
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Publication
21257963 | J:169412
First Author: Boyle KB
Year: 2011
Journal: J Immunol
Title: Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae.
Volume: 186
Issue: 5
Pages: 2978-89
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Publication
31591574 | J:282407
First Author: Voisinne G
Year: 2019
Journal: Nat Immunol
Title: Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics.
Volume: 20
Issue: 11
Pages: 1530-1541
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Publication
18606643 | J:137420
First Author: Hara H
Year: 2008
Journal: J Immunol
Title: Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9.
Volume: 181
Issue: 2
Pages: 918-30
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Publication
9811459 | J:50937
First Author: Okada H
Year: 1998
Journal: Oncogene
Title: AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene.
Volume: 17
Issue: 18
Pages: 2287-93
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Publication
8211130 | J:14384
First Author: Copeland NG
Year: 1993
Journal: Science
Title: A genetic linkage map of the mouse: current applications and future prospects.
Volume: 262
Issue: 5130
Pages: 57-66
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Publication
8530024 | J:25776
First Author: Steingrímsson E
Year: 1995
Journal: Genomics
Title: Murine chromosomal location of five bHLH-Zip transcription factor genes.
Volume: 28
Issue: 2
Pages: 179-83
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Publication
23793062 | J:205441
First Author: Liang Y
Year: 2013
Journal: Nat Immunol
Title: The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Volume: 14
Issue: 8
Pages: 858-66
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Publication
35326399 | J:322608
 
First Author: Shalom B
Year: 2022
Journal: Cells
Title: Vav1 Promotes B-Cell Lymphoma Development.
Volume: 11
Issue: 6
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Publication
- | J:104190
     
First Author: The Australian Phenomics Facility at The Australian National University
Year: 2006
Journal: MGI Direct Data Submission
Title: Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein Domain
IPR035729 | VAV1_SH3_2
Type: Domain
Description: VAV1 (also known as proto-oncogene vav) is expressed predominantly in the hematopoietic system and it plays an important role in the development and activation of B and T cells [, , ]. It is activated by tyrosine phosphorylation to function as a guanine nucleotide exchange factor (GEF) for Rho GTPases following cell surface receptor activation, triggering various effects such as cytoskeletal reorganization, transcription regulation, cell cycle progression, and calcium mobilization [, ]. It also serves as a scaffold protein and has been shown to interact with Ku70, Socs1, Janus kinase 2, SIAH2, S100B, Abl gene, ZAP-70, SLP76, and Syk, among others []. The VAV protein family members are multiple domain proteins, including Vav from flies and VAV1/2/3 from mammals. VAV1 predominates in hematopoietic cells, whereas VAV2 and VAV3 are more broadly expressed. They have a calponin homology (CH) domain, an acidic domain (AC), a Dbl homology (DH) domain, a pleckstrin homology (PH) domain, a cysteine-rich (CR) domain containing a zinc finger, and a complex region with SH2 and SH3 domains. Therefore they may participate in the activity of several pathways [, ]. They are signal transducer proteins that couple tyrosine kinase signals with the activation of the Rho/Rac GTPases, [, , ]. This entry represents the second SH3 domain of VAV1. This domain interacts with a wide variety of proteins including cytoskeletal regulators (zyxin), RNA-binding proteins (Sam68), transcriptional regulators, viral proteins, and dynamin 2 [].
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Protein Domain
IPR035730 | VAV1_SH3_1
Type: Domain
Description: VAV1 (also known as proto-oncogene vav) is expressed predominantly in the hematopoietic system and it plays an important role in the development and activation of B and T cells [, , ]. It is activated by tyrosine phosphorylation to function as a guanine nucleotide exchange factor (GEF) for Rho GTPases following cell surface receptor activation, triggering various effects such as cytoskeletal reorganization, transcription regulation, cell cycle progression, and calcium mobilization [, ]. It also serves as a scaffold protein and has been shown to interact with Ku70, Socs1, Janus kinase 2, SIAH2, S100B, Abl gene, ZAP-70, SLP76, and Syk, among others []. The VAV protein family members are multiple domain proteins, including Vav from flies and VAV1/2/3 from mammals. VAV1 predominates in hematopoietic cells, whereas VAV2 and VAV3 are more broadly expressed. They have a calponin homology (CH) domain, an acidic domain (AC), a Dbl homology (DH) domain, a pleckstrin homology (PH) domain, a cysteine-rich (CR) domain containing a zinc finger, and a complex region with SH2 and SH3 domains. Therefore they may participate in the activity of several pathways [, ]. They are signal transducer proteins that couple tyrosine kinase signals with the activation of the Rho/Rac GTPases, [, , ]. This entry represents the first SH3 domain of VAV1.
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Pathway
R-MMU-389359 | CD28 dependent Vav1 pathway
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Publication
25531316 | J:224247
First Author: Lindsey JC
Year: 2015
Journal: Oncogene
Title: Cross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenance.
Volume: 34
Issue: 36
Pages: 4746-57
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Publication
17237383 | J:143660
First Author: Dennehy KM
Year: 2007
Journal: J Immunol
Title: Mitogenic CD28 signals require the exchange factor Vav1 to enhance TCR signaling at the SLP-76-Vav-Itk signalosome.
Volume: 178
Issue: 3
Pages: 1363-71
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Interaction Experiment
Raberger J (2008)
Description: Impaired T-cell development in the absence of Vav1 and Itk.
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Publication
30410484 | J:302816
 
First Author: Bernard I
Year: 2018
Journal: Front Immunol
Title: A Natural Variant of the Signaling Molecule Vav1 Enhances Susceptibility to Myasthenia Gravis and Influences the T Cell Receptor Repertoire.
Volume: 9
Pages: 2399
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Publication
32079227 | J:304892
 
First Author: Hong J
Year: 2020
Journal: Int J Mol Sci
Title: The Rho/Rac Guanine Nucleotide Exchange Factor Vav1 Regulates Hif-1α and Glut-1 Expression and Glucose Uptake in the Brain.
Volume: 21
Issue: 4
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Publication
32317318 | J:292169
 
First Author: Teymournejad O
Year: 2020
Journal: mBio
Title: Ehrlichia chaffeensis Uses an Invasin To Suppress Reactive Oxygen Species Generation by Macrophages via CD147-Dependent Inhibition of Vav1 To Block Rac1 Activation.
Volume: 11
Issue: 2
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Allele
Commd10<Tg(Vav1-icre)A2Kio> | MGI:2449949
Name: COMM domain containing 10; transgene insertion A2, Dimitris Kioussis
Allele Type: Transgenic
Attribute String: Null/knockout, Recombinase
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Publication
12405184 | -
 
First Author: Turner M
Year: 2002
Journal: Adv Exp Med Biol
Title: The role of Vav proteins in B cell responses.
Volume: 512
Pages: 29-34
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Publication
14592821 | -
First Author: Katzav S
Year: 2004
Journal: Blood
Title: Vav1: an oncogene that regulates specific transcriptional activation of T cells.
Volume: 103
Issue: 7
Pages: 2443-51
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Publication
17590270 | -
First Author: Katzav S
Year: 2007
Journal: Cancer Lett
Title: Flesh and blood: the story of Vav1, a gene that signals in hematopoietic cells but can be transforming in human malignancies.
Volume: 255
Issue: 2
Pages: 241-54
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Publication
12670394 | -
 
First Author: Tybulewicz VL
Year: 2003
Journal: Immunol Rev
Title: Vav1: a key signal transducer downstream of the TCR.
Volume: 192
Pages: 42-52
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Publication
12165654 | -
First Author: Michel F
Year: 2002
Journal: Sci STKE
Title: CD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76?
Volume: 2002
Issue: 144
Pages: pe35
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Publication
18511940 | -
First Author: Rapley J
Year: 2008
Journal: EMBO Rep
Title: Crucial structural role for the PH and C1 domains of the Vav1 exchange factor.
Volume: 9
Issue: 7
Pages: 655-61
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Publication
15850391 | -
First Author: Heo J
Year: 2005
Journal: Biochemistry
Title: Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factors.
Volume: 44
Issue: 17
Pages: 6573-85
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Publication
15886116 | -
First Author: Tybulewicz VL
Year: 2005
Journal: Curr Opin Immunol
Title: Vav-family proteins in T-cell signalling.
Volume: 17
Issue: 3
Pages: 267-74
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Allele
Tg(Vav1-STAT5B)731Biat | MGI:6164041
Name: transgene insertion 731, Biomodels Austria
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Vav1<em1Smoc> | MGI:7293112
Name: vav 1 oncogene; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Igs2<em9(Vav1-icre)Cya> | MGI:7657274
Name: intergenic site 2; endonuclease-mediated mutation 9, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Recombinase
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Publication
17050525 | -
First Author: Miletic AV
Year: 2006
Journal: J Biol Chem
Title: Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation.
Volume: 281
Issue: 50
Pages: 38257-65
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Strain
MGI:6164044 | C57BL/6NCrl-Tg(Vav1-STAT5B)731Biat/Biat
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:6429773 | C57BL/6JSmoc-Vav1<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7657584 | C57BL/6J-Igs2<em9(Vav1-icre)Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Tg(Vav1-STAT5B)731Biat/?
Background: C57BL/6NCrl-Tg(Vav1-STAT5B)731Biat/Biat
Zygosity: ot
Has Mutant Allele: true
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Publication
29200404 | J:257519
First Author: Pham HTT
Year: 2018
Journal: J Clin Invest
Title: STAT5BN642H is a driver mutation for T cell neoplasia.
Volume: 128
Issue: 1
Pages: 387-401
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Allele
Tg(Vav1-cre)1Cgp | MGI:2450339
Name: transgene insertion 1, Cristin G Print
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Vav1-cre/ERT2)#Boui | MGI:6113431
Name: transgene insertion, Philippe Bouillet
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Allele
Tg(Vav1-BCL2L1)670Biat | MGI:7857132
Name: transgene insertion 670, Biomodels Austria
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Vav1-BCL2A1)686Biat | MGI:7857135
Name: transgene insertion 686, Biomodels Austria
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Vav1-ERG)#Jpim | MGI:5141633
Name: transgene insertion, John E Pimanda
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Vav1-STAT5B*N642H)726Biat | MGI:6164037
Name: transgene insertion 726, Biomodels Austria
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
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Allele
Tg(Vav1-HBEGF,-GFP)1Cfors | MGI:7464989
Name: transgene insertion 1, Camilla Forsberg
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Protein Coding Gene
MGI:88327 | Cd28
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:101773 | Cd86
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:101775 | Cd80
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P42082
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
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Protein
P31041
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Protein
Q00609
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: false
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Publication
29113963 | J:257690
First Author: Yang H
Year: 2018
Journal: Blood
Title: Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies.
Volume: 131
Issue: 3
Pages: 328-341
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Allele
Tg(Vav1-cre)1Awr | MGI:3043860
Name: transgene insertion 1, Andrew W Roberts
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Vav1-cre)8Cgp | MGI:4888391
Name: transgene insertion 8, Cristin G Print
Allele Type: Transgenic
Attribute String: Recombinase
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Publication
23974202 | J:203438
First Author: Goldberg L
Year: 2013
Journal: Blood
Title: Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia.
Volume: 122
Issue: 15
Pages: 2694-703
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Allele
Tg(Vav1-cre)#Cgp | MGI:5527187
Name: transgene insertion, Cristin G Print
Allele Type: Transgenic
Attribute String: Recombinase
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Strain
MGI:6164042 | C57BL/6NCrl-Tg(Vav1-STAT5B*N642H)726Biat
Attribute String: mutant strain, transgenic, coisogenic
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Strain
MGI:6335544 | C57BL/6N-Tg(STAT5BN/H)726Biat
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:7607342 | C57BL/6J-Tg(Vav1-HBEGF,-GFP)1Cfors/Mmucd
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:6335844 | C57BL/6N-Tg(Vav1-BCL2L1)670Biat/Biat
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:6335843 | C57BL/6N-Tg(Vav1-BCL2A1)686Biat/Biat
Attribute String: coisogenic, mutant strain, transgenic
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Genotype
Genotype
Symbol: Tg(Vav1-ERG)#Jpim/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Vav1-STAT5B*N642H)726Biat/?
Background: C57BL/6NCrl-Tg(Vav1-STAT5B*N642H)726Biat
Zygosity: ot
Has Mutant Allele: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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