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Search results 301 to 352 out of 352 for Vdac1

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0.023s

Type

Details

Score

Publication

26801612 | J:231222

First Author:	Chaudhuri AD
Year:	2016
Journal:	J Biol Chem
Title:	MicroRNA-7 Regulates the Function of Mitochondrial Permeability Transition Pore by Targeting VDAC1 Expression.
Volume:	291
Issue:	12
Pages:	6483-93

•

Publication

39272828 | J:354203

First Author:	Melnikov N
Year:	2024
Journal:	Cancers (Basel)
Title:	Mitochondrial VDAC1 Silencing in Urethane-Induced Lung Cancer Inhibits Tumor Growth and Alters Cancer Oncogenic Properties.
Volume:	16
Issue:	17

•

Publication

27483469 | J:252551

First Author:	Yan C
Year:	2016
Journal:	PLoS One
Title:	CFTR Deletion in Mouse Testis Induces VDAC1 Mediated Inflammatory Pathway Critical for Spermatogenesis.
Volume:	11
Issue:	8
Pages:	e0158994

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GXD Expression

Probe:	MGI:7662287
Assay Type:	Immunohistochemistry
Annotation Date:	2024-07-02
Strength:	Present
Sex:	Not Specified
Emaps:	EMAPS:3276828
Pattern:	Not Specified
Stage:	TS28
Assay Id:	MGI:7662352
Age:	postnatal adult

Note:	Expression co-localized with Vdac1 in the hippocampus neuronal mitochondria.
Specimen Label:	5B Hippocampus top
Detected:	true
Specimen Num:	4

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Interaction Experiment

Gatliff J (2014)

Description:

TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control.

•

Interaction Experiment

Zhu Y (2023)

Description:

The E3 ubiquitin ligase NEDD4-1 protects against acetaminophen-induced liver injury by targeting VDAC1 for degradation.

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GXD Expression

Probe:	MGI:6507611
Assay Type:	Immunohistochemistry
Annotation Date:	2022-01-07
Strength:	Present
Sex:	Male
Emaps:	EMAPS:2910628
Pattern:	Not Specified
Stage:	TS28
Assay Id:	MGI:6850045
Age:	postnatal adult
Image:	4C
Note:	Colocalization of Tspo and Vdac1 expression was noted in Leydig cells and Sertoli cells.
Specimen Label:	4C
Detected:	true
Specimen Num:	2

•

GXD Expression

Probe:	MGI:6507611
Assay Type:	Immunohistochemistry
Annotation Date:	2022-01-07
Strength:	Present
Sex:	Male
Emaps:	EMAPS:2965528
Pattern:	Not Specified
Stage:	TS28
Assay Id:	MGI:6850045
Age:	postnatal adult
Image:	4C
Note:	Colocalization of Tspo and Vdac1 expression was noted in Leydig cells and Sertoli cells.
Specimen Label:	4C
Detected:	true
Specimen Num:	2

•

Publication

37139424 | -

First Author:	Zhu Y
Year:	2023
Journal:	Acta Pharm Sin B
Title:	The E3 ubiquitin ligase NEDD4-1 protects against acetaminophen-induced liver injury by targeting VDAC1 for degradation.
Volume:	13
Issue:	4
Pages:	1616-1630

•

Allele

Tg(Vdac1-EGFP)JF127Gsat | MGI:4847528

Name:	transgene insertion JF127, GENSAT Project at Rockefeller University
Allele Type:	Transgenic
Attribute String:	Reporter

•

Strain

MGI:5003964 | STOCK Tg(Vdac1-EGFP)JF127Gsat/Mmucd

Attribute String:

mutant stock, transgenic

•

Publication

20875390 | J:170197

First Author:	Anflous-Pharayra K
Year:	2011
Journal:	Biochim Biophys Acta
Title:	VDAC3 has differing mitochondrial functions in two types of striated muscles.
Volume:	1807
Issue:	1
Pages:	150-6

•

Publication

11311949 | J:69151

First Author:	Hinsch KD
Year:	2001
Journal:	Biochim Biophys Acta
Title:	VDAC2 (porin-2) expression pattern and localization in the bovine testis.
Volume:	1518
Issue:	3
Pages:	329-33

•

Publication

34610308 | J:326966

First Author:	Angelini A
Year:	2021
Journal:	Cell Rep
Title:	PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes.
Volume:	37
Issue:	1
Pages:	109767

•

Publication

38753484 | J:350653

First Author:	Tang Y
Year:	2024
Journal:	Cell Rep
Title:	Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia.
Volume:	43
Issue:	5
Pages:	114237

•

Publication

33602982 | J:303741

First Author:	Lee J
Year:	2021
Journal:	Sci Rep
Title:	Loss of primary cilia promotes mitochondria-dependent apoptosis in thyroid cancer.
Volume:	11
Issue:	1
Pages:	4181

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Publication

22935710 | -

First Author:	Majumder S
Year:	2012
Journal:	Cell Cycle
Title:	VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes.
Volume:	11
Issue:	19
Pages:	3666-78

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Publication

23388454 | -

First Author:	Majumder S
Year:	2013
Journal:	Cell Cycle
Title:	VDAC3 and Mps1 negatively regulate ciliogenesis.
Volume:	12
Issue:	5
Pages:	849-58

•

Publication

11507092 | J:72188

First Author:	Sampson MJ
Year:	2001
Journal:	J Biol Chem
Title:	Immotile sperm and infertility in mice lacking mitochondrial voltage-dependent anion channel type 3.
Volume:	276
Issue:	42
Pages:	39206-12

•

Publication

25171321 | -

First Author:	Checchetto V
Year:	2014
Journal:	Cell Physiol Biochem
Title:	Recombinant human voltage dependent anion selective channel isoform 3 (hVDAC3) forms pores with a very small conductance.
Volume:	34
Issue:	3
Pages:	842-53

•

Publication

12881569 | J:182407

First Author:	Cheng EH
Year:	2003
Journal:	Science
Title:	VDAC2 inhibits BAK activation and mitochondrial apoptosis.
Volume:	301
Issue:	5632
Pages:	513-7

•

Publication

19820692 | -

First Author:	Roy SS
Year:	2009
Journal:	EMBO Rep
Title:	VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria.
Volume:	10
Issue:	12
Pages:	1341-7

•

Publication

24269536 | -

First Author:	Veresov VG
Year:	2014
Journal:	Cell Signal
Title:	Structural insights into proapoptotic signaling mediated by MTCH2, VDAC2, TOM40 and TOM22.
Volume:	26
Issue:	2
Pages:	370-82

•

Protein Domain

IPR030271 | VDAC3

Type:

Family

Description:

This entry includes VDAC3 from animals. Recombinant VDAC3 shows a channel activity with a very small conductance []. VDAC3 is involved in the transport of ADP across the mitochondrial outer membrane in the cardiac muscle (oxidative muscle) but not in the gastrocnemius muscle (mixed muscle) []. VDAC3 is also a centrosomal protein that interacts with the centrosomal protein kinase Mps1 []. VDAC3 and Mps1 negatively regulate ciliogenesis; they promote ciliary disassembly during cell cycle entry and suppress cilia assembly in proliferating cells []. Mice lacking VDAC3 suffered from immotile sperm and infertility [].Voltage dependent anion channels (VDACs) or porins by analogy with bacterial porins, are pore-forming proteins associated with mitochondria, although they are also present in the endoplasmic reticulum (ER) []and plasma membrane []. In mammals, three VDAC isoforms have been identified: VDAC1 to 3. They have a very similar predicted structure, consisting of a 19 amphipathic β-strands barrel with an N-terminal α-helix in the central pore [, ]. The channel opening faces both the cytosol and mitochondrial intermembrane space [, ]. They play a major role in cellular energetic metabolism due to its ability to allow the exchange of molecules between the cytosol and the mitochondrial intermembrane space. They may also play a role in cell death. However, several mouse gene knock out studies show that VDACs are dispensable for both MPT (mitochondrial permeability transition) and Bcl-2 family member-driven cell death [, ].

•

Protein Domain

IPR030277 | VDAC2

Type:

Family

Description:

VDAC2 is a voltage dependent anion channel that mediates the flow of metabolites and ions across the outer mitochondrial membrane. It may play a role in mitochondrial apoptosis through its involvement in the mitochondrial recruitment of BAK, a protein belonging to the BCL-2 protein family [, , ].Voltage dependent anion channels (VDACs) or porins by analogy with bacterial porins, are pore-forming proteins associated with mitochondria, although they are also present in the endoplasmic reticulum (ER) []and plasma membrane []. In mammals, three VDAC isoforms have been identified: VDAC1 to 3. They have a very similar predicted structure, consisting of a 19 amphipathic β-strands barrel with an N-terminal α-helix in the central pore [, ]. The channel opening faces both the cytosol and mitochondrial intermembrane space [, ]. They play a major role in cellular energetic metabolism due to its ability to allow the exchange of molecules between the cytosol and the mitochondrial intermembrane space. They may also play a role in cell death. However, several mouse gene knock out studies show that VDACs are dispensable for both MPT (mitochondrial permeability transition) and Bcl-2 family member-driven cell death [, ].

•

Publication

29908149 | J:270528

First Author:	Behar V
Year:	2018
Journal:	J Invest Dermatol
Title:	A Hexokinase 2 Modulator for Field-Directed Treatment of Experimental Actinic Keratoses.
Volume:	138
Issue:	12
Pages:	2635-2643

•

Publication

33401721 | J:305964

First Author:	Ha BG
Year:	2021
Journal:	Int J Mol Sci
Title:	Depletion of Mitochondrial Components from Extracellular Vesicles Secreted from Astrocytes in a Mouse Model of Fragile X Syndrome.
Volume:	22
Issue:	1

•

Publication

25695797 | J:226204

First Author:	Yang X
Year:	2015
Journal:	PLoS One
Title:	Gene co-expression network analysis provides novel insights into myostatin regulation at three different mouse developmental timepoints.
Volume:	10
Issue:	2
Pages:	e0117607

•

Publication

23720737 | J:199650

First Author:	Huang H
Year:	2013
Journal:	J Biol Chem
Title:	An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake.
Volume:	288
Issue:	27
Pages:	19870-81

•

Publication

39039044 | J:352129

First Author:	Li Y
Year:	2024
Journal:	Cell Death Dis
Title:	mtDNA release promotes cGAS-STING activation and accelerated aging of postmitotic muscle cells.
Volume:	15
Issue:	7
Pages:	523

•

Publication

19640925 | J:153101

First Author:	Kielar C
Year:	2009
Journal:	Hum Mol Genet
Title:	Molecular correlates of axonal and synaptic pathology in mouse models of Batten disease.
Volume:	18
Issue:	21
Pages:	4066-80

•

Publication

38890305 | J:360340

First Author:	Zhang JR
Year:	2024
Journal:	Nat Commun
Title:	Augmented microglial endoplasmic reticulum-mitochondria contacts mediate depression-like behavior in mice induced by chronic social defeat stress.
Volume:	15
Issue:	1
Pages:	5199

•

Publication

26616244 | J:231343

First Author:	Liu C
Year:	2016
Journal:	Aging Cell
Title:	The Immp2l mutation causes age-dependent degeneration of cerebellar granule neurons prevented by antioxidant treatment.
Volume:	15
Issue:	1
Pages:	167-76

•

Publication

28096195 | J:262014

First Author:	Fazal L
Year:	2017
Journal:	Circ Res
Title:	Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death.
Volume:	120
Issue:	4
Pages:	645-657

•

Publication

10430654 | J:359364

First Author:	Xu X
Year:	1999
Journal:	J Membr Biol
Title:	Mouse VDAC isoforms expressed in yeast: channel properties and their roles in mitochondrial outer membrane permeability.
Volume:	170
Issue:	2
Pages:	89-102

•

Publication

7517385 | J:17232

First Author:	Blachly-Dyson E
Year:	1994
Journal:	Genomics
Title:	Human genes encoding the voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane: mapping and identification of two new isoforms.
Volume:	20
Issue:	1
Pages:	62-7

•

Publication

26878172 | J:232421

First Author:	Gonzalez S
Year:	2016
Journal:	J Clin Invest
Title:	Blocking mitochondrial calcium release in Schwann cells prevents demyelinating neuropathies.
Volume:	126
Issue:	3
Pages:	1023-38

•

Publication

28396346 | J:243669

First Author:	Budelier MM
Year:	2017
Journal:	J Biol Chem
Title:	Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1.
Volume:	292
Issue:	22
Pages:	9294-9304

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Publication

27116927 | J:255627

First Author:	Naghdi S
Year:	2016
Journal:	Biochim Biophys Acta
Title:	VDAC2-specific cellular functions and the underlying structure.
Volume:	1863
Issue:	10
Pages:	2503-14

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Publication

31377553 | J:326309

First Author:	Niemann J
Year:	2019
Journal:	Cell Calcium
Title:	Cytosolic and mitochondrial Ca²⁺ concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation.
Volume:	82

Pages:	102055

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Protein

Q60931

Organism:	Mus musculus/domesticus
Length:	283
Fragment?:	false

•

Protein

Q60930

Organism:	Mus musculus/domesticus
Length:	295
Fragment?:	false

•

Protein

Q5EBQ0

Organism:	Mus musculus/domesticus
Length:	284
Fragment?:	false

•

Protein

Q3TTN3

Organism:	Mus musculus/domesticus
Length:	283
Fragment?:	false

•

Protein

D3YZT5

Organism:	Mus musculus/domesticus
Length:	201
Fragment?:	true

•

Protein

Q3UFA8

Organism:	Mus musculus/domesticus
Length:	75
Fragment?:	true

•

Protein

J3QMG3

Organism:	Mus musculus/domesticus
Length:	284
Fragment?:	false

•

Protein

D3YUN8

Organism:	Mus musculus/domesticus
Length:	75
Fragment?:	true

•

Protein

A0A286YCR8

Organism:	Mus musculus/domesticus
Length:	246
Fragment?:	true

•

Protein

G3UX26

Organism:	Mus musculus/domesticus
Length:	283
Fragment?:	false

•

Protein

Q3TX38

Organism:	Mus musculus/domesticus
Length:	283
Fragment?:	false

•

Publication

- | J:100256

First Author:	The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year:	2005
Journal:	Database Download
Title:	MGI download of GENSAT transgene data

•

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