|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 301 to 384 out of 384 for Vps35

<< First    < Previous  |  Next >    Last >>
0.039s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Allele
Vps35l<Gt(OST42427)Lex> | MGI:4157966
 
Name: VPS35 endosomal protein sorting factor like; gene trap OST42427, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Vps35l<Gt(OST137942)Lex> | MGI:4200737
 
Name: VPS35 endosomal protein sorting factor like; gene trap OST137942, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Vps35l<Gt(OST196390)Lex> | MGI:4226707
 
Name: VPS35 endosomal protein sorting factor like; gene trap OST196390, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Vps35l<Gt(OST200368)Lex> | MGI:4228816
 
Name: VPS35 endosomal protein sorting factor like; gene trap OST200368, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Vps35l<Gt(OST202300)Lex> | MGI:4229892
 
Name: VPS35 endosomal protein sorting factor like; gene trap OST202300, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Vps35l<Gt(OST346344)Lex> | MGI:4288370
 
Name: VPS35 endosomal protein sorting factor like; gene trap OST346344, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Vps35l<Gt(OST382951)Lex> | MGI:4301205
 
Name: VPS35 endosomal protein sorting factor like; gene trap OST382951, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Vps35l<Gt(OST432522)Lex> | MGI:4315220
 
Name: VPS35 endosomal protein sorting factor like; gene trap OST432522, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Vps35l<Gt(OST450009)Lex> | MGI:4321402
 
Name: VPS35 endosomal protein sorting factor like; gene trap OST450009, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Vps35<Gt(AL0099)Wtsi> | MGI:4345471
 
Name: VPS35 retromer complex component; gene trap AL0099, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
•
•
•
•
•
Allele
Vps35<Gt(AQ0265)Wtsi> | MGI:4345645
 
Name: VPS35 retromer complex component; gene trap AQ0265, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
•
•
•
•
•
Allele
Vps35l<Gt(AM0256)Wtsi> | MGI:4346317
 
Name: VPS35 endosomal protein sorting factor like; gene trap AM0256, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
•
•
•
•
•
Allele
Vps35l<Gt(EUCE00107e02)Hmgu> | MGI:4369830
 
Name: VPS35 endosomal protein sorting factor like; gene trap EUCE00107e02, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
•
•
•
•
•
Allele
Vps35l<Gt(EUCE00107c02)Hmgu> | MGI:4376313
 
Name: VPS35 endosomal protein sorting factor like; gene trap EUCE00107c02, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
•
•
•
•
•
Allele
Vps35<tm1a(EUCOMM)Hmgu> | MGI:5296180
Name: VPS35 retromer complex component; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
•
•
•
•
•
Allele
Vps35<tm1e(EUCOMM)Hmgu> | MGI:5296150
Name: VPS35 retromer complex component; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
•
•
•
•
•
Allele
Vps35<tm1.2Mjff> | MGI:5466855
Name: VPS35 retromer complex component; targeted mutation 1.2,The Michael J Fox Foundation
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
•
•
•
•
•
Strain
MGI:6408081 | C57BL/6N-Vps35<em1(IMPC)H>/H
Attribute String: coisogenic, targeted mutation
•
•
•
•
•
Strain
MGI:6335777 | C57BL/6NTac-Vps35<em1(IMPC)H>/H
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
•
•
•
•
•
Strain
MGI:6866844 | C57BL/6NTac-Vps35<em1(IMPC)H>/Mmucd
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Allele
Vps35<tm1c(EUCOMM)Hmgu> | MGI:6197919
Name: VPS35 retromer complex component; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
•
•
•
•
•
Allele
Vps35l<em2Shis> | MGI:6507963
Name: VPS35 endosomal protein sorting factor like; endonuclease-mediated mutation 2, Shinji Saitoh
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Allele
Vps35l<em1Shis> | MGI:6507962
Name: VPS35 endosomal protein sorting factor like; endonuclease-mediated mutation 1, Shinji Saitoh
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Strain
MGI:7836951 | C57BL/6N-Vps35<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Strain
MGI:7839695 | C57BL/6N-Vps35<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Genotype
Genotype
Symbol: Vps35/Vps35
Background: B6.129P2-Vps35
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Vps35/Vps35
Background: C57BL/6N-Vps35/H
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Publication
24819384 | -
 
First Author: Zavodszky E
Year: 2014
Journal: Nat Commun
Title: Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy.
Volume: 5
Pages: 3828
•
•
•
•
•
Allele
Gt(ROSA)26Sor<tm1(CAG-VPS35*D620N)Lze> | MGI:6718577
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Li Zeng
Allele Type: Targeted
Attribute String: Conditional ready, Epitope tag, Humanized sequence, Inserted expressed sequence
•
•
•
•
•
Allele
Vps35l<Gt(IST14224C10)Tigm> | MGI:5211097
 
Name: VPS35 endosomal protein sorting factor like; gene trap IST14224C10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
•
•
•
•
•
Strain
MGI:5526108 | B6.Cg-Vps35<tm1.2Mjff>/J
Attribute String: congenic, targeted mutation, mutant strain
•
•
•
•
•
Strain
MGI:7378803 | B6.Cg-Vps35<tm1.1Mjff>
Attribute String: congenic, mutant strain, targeted mutation
•
•
•
•
•
Strain
MGI:5607778 | B6.Cg-Vps35<tm1.1Mjff>/J
Attribute String: congenic, mutant strain, targeted mutation
•
•
•
•
•
Strain
MGI:7666440 | C57BL/6N-Vps35<tm1c(EUCOMM)Hmgu>/Cmsu
Attribute String: coisogenic, targeted mutation, mutant strain
•
•
•
•
•
Genotype
Genotype
Symbol: Vps35/Vps35 Tg(Vil1-cre/ERT2)23Syr/?
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Vps35l/Vps35l
Background: involves: C57BL/6N
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Vps35l/Vps35l
Background: involves: C57BL/6N
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Vps35/Vps35
Background: B6.Cg-Vps35
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Vps35/Vps35<+>
Background: C57BL/6N-Vps35/H
Zygosity: ht
Has Mutant Allele: true
•
•
•
•
•
Protein Domain
IPR042491 | Vps35_C
Type: Homologous_superfamily
Description: This superfamily represents the α-helical C-terminal domain found in vacuolar protein sorting-associated protein 35 (Vps35) from eukaryotes.Vps35 is a core component of the retromer complex which functions in the endosome-to-Golgi retrieval cargo transport pathway [, ]. Vps35 is part of the a cargo-selective complex trimer (CSC) of the retromer, which is composed of Vps26, Vps29 and Vps35 and is responsible for binding to and sorting protein cargo []. Mutations in the Vps35 gene have been linked to Parkinson's disease []. Structurally, VPS35 forms a horseshoe-shaped, right-handed, α-helical solenoid [].
•
•
•
•
•
Publication
9105038 | -
First Author: Seaman MN
Year: 1997
Journal: J Cell Biol
Title: Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products.
Volume: 137
Issue: 1
Pages: 79-92
•
•
•
•
•
Publication
36353989 | J:342813
First Author: Vos DY
Year: 2023
Journal: Arterioscler Thromb Vasc Biol
Title: Cargo-Specific Role for Retriever Subunit VPS26C in Hepatocyte Lipoprotein Receptor Recycling to Control Postprandial Triglyceride-Rich Lipoproteins.
Volume: 43
Issue: 1
Pages: e29-e45
•
•
•
•
•
Genotype
Genotype
Symbol: Vps35/Vps35<+> Tg(APPSWE)2576Kha/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Vps35/Vps35<+>
Background: involves: C57BL/6
Zygosity: ht
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Vps35/Vps35<+>
Background: B6.Cg-Vps35
Zygosity: ht
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Cx3cr1/Cx3cr1<+> Vps35/Vps35
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
•
•
•
•
•
Publication
24440570 | J:259423
 
First Author: Morabito MV
Year: 2014
Journal: Neurobiol Dis
Title: Hyperleucinemia causes hippocampal retromer deficiency linking diabetes to Alzheimer's disease.
Volume: 65
Pages: 188-92
•
•
•
•
•
Publication
35749364 | J:357610
First Author: Pérez-Torres EJ
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Retromer dysfunction in amyotrophic lateral sclerosis.
Volume: 119
Issue: 26
Pages: e2118755119
•
•
•
•
•
Publication
32737286 | J:303339
First Author: Muzio L
Year: 2020
Journal: Nat Commun
Title: Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis.
Volume: 11
Issue: 1
Pages: 3848
•
•
•
•
•
Publication
11062004 | J:65471
First Author: Edgar AJ
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Human homologues of yeast vacuolar protein sorting 29 and 35.
Volume: 277
Issue: 3
Pages: 622-30
•
•
•
•
•
Publication
31694921 | J:282176
First Author: Curnock R
Year: 2019
Journal: J Cell Biol
Title: TFEB controls retromer expression in response to nutrient availability.
Volume: 218
Issue: 12
Pages: 3954-3966
•
•
•
•
•
Publication
37541258 | J:356212
     
First Author: Buck TM
Year: 2023
Journal: Stem Cell Reports
Title: CRB1 is required for recycling by RAB11A+ vesicles in human retinal organoids.
•
•
•
•
•
Protein
E9PXS9
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: false
•
•
•
•
•
Publication
12194858 | -
First Author: Babst M
Year: 2002
Journal: Dev Cell
Title: Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body.
Volume: 3
Issue: 2
Pages: 283-9
•
•
•
•
•
Publication
15469844 | -
First Author: Teo H
Year: 2004
Journal: Dev Cell
Title: ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes.
Volume: 7
Issue: 4
Pages: 559-69
•
•
•
•
•
Publication
15579210 | -
First Author: Wernimont AK
Year: 2004
Journal: BMC Struct Biol
Title: Crystal structure of subunit VPS25 of the endosomal trafficking complex ESCRT-II.
Volume: 4
Issue: 1
Pages: 10
•
•
•
•
•
Protein Domain
IPR014041 | ESCRT-II_cplx_Vps25-sub_N
Type: Homologous_superfamily
Description: This superfamily represents the N-terminal winged helix domain of the vps25 subunit (vacuolar protein sorting-associated protein 25) of the endosome-associated complex ESCRT-II (Endosomal Sorting Complexes Required for Transport protein II). ESCRT (ESCRT-I, -II, -III) complexes orchestrate efficient sorting of ubiquitinated transmembrane receptors to lysosomes via multivesicular bodies (MVBs) []. ESCRT-II recruits the transport machinery for protein sorting at MVB []. In addition, the human ESCRT-II has been shown to form a complex with RNA polymerase II elongation factor ELL in order to exert transcriptional control activity. ESCRT-II transiently associates with the endosomal membrane and thereby initiates the formation of ESCRT-III, a membrane-associated protein complex that functions immediately downstream of ESCRT-II during sorting of MVB cargo. ESCRT-II in turn functions downstream of ESCRT-I, a protein complex that binds to ubiquitinated endosomal cargo [].ESCRT-II is a trilobal complex composed of two copies of vps25, one copy of vps22 and the C-terminal region of vps36. The crystal structure of vps25 revealed two winged-helix domains, the N-terminal domain of vps25 interacting with vps22 and vps35 [].
•
•
•
•
•
Protein Domain
IPR008570 | ESCRT-II_cplx_Vps25-sub
Type: Family
Description: This entry represents the Vps25 subunit (vacuolar protein sorting-associated protein 25) of the endosome-associated complex ESCRT-II (Endosomal Sorting Complexes Required for Transport protein II). ESCRT (ESCRT-I, -II, -III) complexes orchestrate efficient sorting of ubiquitinated transmembrane receptors to lysosomes via multivesicular bodies (MVBs) []. ESCRT-II recruits the transport machinery for protein sorting at MVB []. In addition, the human ESCRT-II has been shown to form a complex with RNA polymerase II elongation factor ELL in order to exert transcriptional control activity. ESCRT-II transiently associates with the endosomal membrane and thereby initiates the formation of ESCRT-III, a membrane-associated protein complex that functions immediately downstream of ESCRT-II during sorting of MVB cargo. ESCRT-II in turn functions downstream of ESCRT-I, a protein complex that binds to ubiquitinated endosomal cargo [].ESCRT-II is a trilobal complex composed of two copies of vps25, one copy of vps22 and the C-terminal region of vps36. The crystal structure of vps25 revealed two winged-helix domains, the N-terminal domain of vps25 interacting with vps22 and vps35 [].
•
•
•
•
•
Protein
Q9CQ80
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: false
•
•
•
•
•
Protein
A2A4K0
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
•
•
•
•
•
Protein
A2A4J8
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
•
•
•
•
•
Protein
A8XY17
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
•
•
•
•
•
Publication
20881129 | J:164876
First Author: Lane RF
Year: 2010
Journal: J Neurosci
Title: Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.
Volume: 30
Issue: 39
Pages: 13110-5
•
•
•
•
•
Publication
30733594 | J:311353
First Author: Li JG
Year: 2020
Journal: Mol Psychiatry
Title: Full recovery of the Alzheimer's disease phenotype by gain of function of vacuolar protein sorting 35.
Volume: 25
Issue: 10
Pages: 2630-2640
•
•
•
•
•
Publication
25190809 | J:311816
First Author: Kang Y
Year: 2014
Journal: J Biol Chem
Title: A combined transgenic proteomic analysis and regulated trafficking of neuroligin-2.
Volume: 289
Issue: 42
Pages: 29350-64
•
•
•
•
•
Publication
35776681 | J:327105
 
First Author: Lara Ordóñez AJ
Year: 2022
Journal: Biol Open
Title: The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization.
Volume: 11
Issue: 8
•
•
•
•
•
Publication
37900275 | J:342260
 
First Author: Meindl K
Year: 2023
Journal: Front Cell Dev Biol
Title: A missense mutation in Ehd1 associated with defective spermatogenesis and male infertility.
Volume: 11
Pages: 1240558
•
•
•
•
•
Publication
23331060 | J:219175
First Author: Helfer E
Year: 2013
Journal: Biol Cell
Title: Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer.
Volume: 105
Issue: 5
Pages: 191-207
•
•
•
•
•
Publication
17215868 | -
First Author: Gill DJ
Year: 2007
Journal: EMBO J
Title: Structural insight into the ESCRT-I/-II link and its role in MVB trafficking.
Volume: 26
Issue: 2
Pages: 600-12
•
•
•
•
•
Publication
28847807 | J:252862
First Author: Wu S
Year: 2017
Journal: J Neurosci
Title: The Dopamine Transporter Recycles via a Retromer-Dependent Postendocytic Mechanism: Tracking Studies Using a Novel Fluorophore-Coupling Approach.
Volume: 37
Issue: 39
Pages: 9438-9452
•
•
•
•
•
Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
•
•
•
•
•
Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
•
•
•
•
•
Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
•
•
•
•
•
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
•
•
•
•
•
Publication
11042159 | J:68323
First Author: Carninci P
Year: 2000
Journal: Genome Res
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume: 10
Issue: 10
Pages: 1617-30
•
•
•
•
•
Publication
10349636 | J:80645
 
First Author: Carninci P
Year: 1999
Journal: Methods Enzymol
Title: High-efficiency full-length cDNA cloning.
Volume: 303
Pages: 19-44
•
•
•
•
•
Publication
11076861 | J:68324
First Author: Shibata K
Year: 2000
Journal: Genome Res
Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Volume: 10
Issue: 11
Pages: 1757-71
•
•
•
•
•
Publication
16141073 | -
First Author: Katayama S
Year: 2005
Journal: Science
Title: Antisense transcription in the mammalian transcriptome.
Volume: 309
Issue: 5740
Pages: 1564-6
•
•
•
•
•
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
•
•
•
•
•
Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
•
•
•
•
•
Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
•
•
•
•
•
Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom