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Search results 301 to 400 out of 462 for Xiap

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Type Details Score
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication
First Author: Hu J
Year: 2010
Journal: J Am Soc Nephrol
Title: XIAP reduces muscle proteolysis induced by CKD.
Volume: 21
Issue: 7
Pages: 1174-83
Protein
Organism: Mus musculus/domesticus
Length: 106  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 52  
Fragment?: true
Publication
First Author: Edison N
Year: 2017
Journal: Cell Rep
Title: Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis.
Volume: 21
Issue: 2
Pages: 442-454
Publication
First Author: Chen M
Year: 2023
Journal: Cell Rep
Title: Identification of XAF1 as an endogenous AKT inhibitor.
Volume: 42
Issue: 7
Pages: 112690
Allele
Name: X-linked inhibitor of apoptosis; targeted mutation 1, Craig B Thompson
Allele Type: Targeted
Attribute String: Null/knockout
Publication
First Author: Krieg A
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: XIAP mediates NOD signaling via interaction with RIP2.
Volume: 106
Issue: 34
Pages: 14524-9
Publication
First Author: Damgaard RB
Year: 2013
Journal: EMBO Mol Med
Title: Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling.
Volume: 5
Issue: 8
Pages: 1278-95
Publication
First Author: Heim VJ
Year: 2020
Journal: EMBO Rep
Title: A regulatory region on RIPK2 is required for XIAP binding and NOD signaling activity.
Volume: 21
Issue: 11
Pages: e50400
Interaction Experiment
Description: Regulation of apoptosis by XIAP ubiquitin-ligase activity.
Publication
First Author: Wong WW
Year: 2014
Journal: Blood
Title: cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner.
Volume: 123
Issue: 16
Pages: 2562-72
Publication
First Author: Yao J
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: XIAP therapy increases survival of transplanted rod precursors in a degenerating host retina.
Volume: 52
Issue: 3
Pages: 1567-72
Publication
First Author: Conte D
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Thymocyte-targeted overexpression of xiap transgene disrupts T lymphoid apoptosis and maturation.
Volume: 98
Issue: 9
Pages: 5049-54
Publication
First Author: Baek HS
Year: 2019
Journal: Biochim Biophys Acta Mol Cell Res
Title: CYP1B1 prevents proteasome-mediated XIAP degradation by inducing PKCε activation and phosphorylation of XIAP.
Volume: 1866
Issue: 12
Pages: 118553
Allele  
Name: XIAP associated factor 1; wild type
Allele Type: Not Specified
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Nishimura Y
Year: 2022
Journal: Acta Diabetol
Title: XAF1 overexpression exacerbates diabetes by promoting pancreatic β-cell apoptosis.
Volume: 59
Issue: 10
Pages: 1275-1286
Publication
First Author: Kuang M
Year: 2023
Journal: Sci Adv
Title: XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility.
Volume: 9
Issue: 33
Pages: eadg5211
GXD Expression    
Probe: MGI:6385896
Assay Type: RT-PCR
Annotation Date: 2020-01-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:6386181
Age: embryonic day 11.5
Image: 3
Specimen Label: wild type
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6385896
Assay Type: RT-PCR
Annotation Date: 2020-01-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:6386181
Age: embryonic day 11.5
Image: 3
Specimen Label: Adar1-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6385896
Assay Type: RT-PCR
Annotation Date: 2020-01-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:6386181
Age: embryonic day 11.5
Image: 3
Specimen Label: Adar1-/-;Ifnar1-/-
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6385896
Assay Type: RT-PCR
Annotation Date: 2020-01-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:6386181
Age: embryonic day 11.5
Image: 3
Specimen Label: Adar1-/-;Mavs-/-
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6385896
Assay Type: RT-PCR
Annotation Date: 2020-01-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:6386223
Age: embryonic day 11.5
Image: S2
Specimen Label: wild type
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6385896
Assay Type: RT-PCR
Annotation Date: 2020-01-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:6386223
Age: embryonic day 11.5
Image: S2
Specimen Label: Ifnar1-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6385896
Assay Type: RT-PCR
Annotation Date: 2020-01-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:6386223
Age: embryonic day 11.5
Image: S2
Specimen Label: Mavs-/-
Detected: true
Specimen Num: 3
Publication
First Author: Liston P
Year: 2001
Journal: Nat Cell Biol
Title: Identification of XAF1 as an antagonist of XIAP anti-Caspase activity.
Volume: 3
Issue: 2
Pages: 128-33
Allele  
Name: XIAP associated factor 1; gene trap OST467639, Lexicon Genetics
Allele Type: Gene trapped
Allele
Name: XIAP associated factor 1; endonuclease-mediated mutation 40, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: XIAP associated factor 1; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele
Name: XIAP associated factor 1; endonuclease-mediated mutation 1, Daming Gao
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: XIAP associated factor 1; endonuclease-mediated mutation 1, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Publication
First Author: Burstein E
Year: 2004
Journal: EMBO J
Title: A novel role for XIAP in copper homeostasis through regulation of MURR1.
Volume: 23
Issue: 1
Pages: 244-54
Publication
First Author: MacFarlane M
Year: 2002
Journal: J Biol Chem
Title: Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro.
Volume: 277
Issue: 39
Pages: 36611-6
Publication  
First Author: Van Themsche C
Year: 2010
Journal: Mol Cancer
Title: XIAP gene expression and function is regulated by autocrine and paracrine TGF-beta signaling.
Volume: 9
Pages: 216
Allele
Name: X-linked inhibitor of apoptosis; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: XIAP associated factor 1; endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: XIAP associated factor 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Genotype
Symbol: Xaf1/Xaf1
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
Interaction Experiment
Description: XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2.
Interaction Experiment
Description: Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation.
Interaction Experiment
Description: SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L.
Publication
First Author: Gu L
Year: 2009
Journal: Cancer Cell
Title: Regulation of XIAP translation and induction by MDM2 following irradiation.
Volume: 15
Issue: 5
Pages: 363-75
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Publication
First Author: Choo Z
Year: 2016
Journal: Oncotarget
Title: XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis.
Volume: 7
Issue: 23
Pages: 34229-39
Publication
First Author: Liu BQ
Year: 2023
Journal: EMBO Rep
Title: XAF1 prevents hyperproduction of type I interferon upon viral infection by targeting IRF7.
Volume: 24
Issue: 1
Pages: e55387
Strain
Attribute String: coisogenic, targeted mutation
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Genotype
Symbol: Xaf1/Xaf1
Background: C57BL/6N-Xaf1/MbpMmucd
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Liu WH
Year: 2007
Journal: EMBO J
Title: Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation.
Volume: 26
Issue: 6
Pages: 1660-9
Publication
First Author: Zhu C
Year: 2019
Journal: J Exp Med
Title: SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease.
Volume: 216
Issue: 4
Pages: 743-756
Publication
First Author: Shin H
Year: 2005
Journal: Biochem J
Title: The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition.
Volume: 385
Issue: Pt 1
Pages: 1-10
Publication
First Author: Suzuki Y
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death.
Volume: 98
Issue: 15
Pages: 8662-7
Publication
First Author: Sanna MG
Year: 2002
Journal: J Biol Chem
Title: ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis.
Volume: 277
Issue: 34
Pages: 30454-62
Publication
First Author: Duckett CS
Year: 1996
Journal: EMBO J
Title: A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.
Volume: 15
Issue: 11
Pages: 2685-94
Publication
First Author: Vaux DL
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Mammalian mitochondrial IAP binding proteins.
Volume: 304
Issue: 3
Pages: 499-504
Protein Domain
Type: Domain
Description: XIAP, also called baculoviral IAP repeat-containing protein 4 (BIRC4), is a potent suppressor of apoptosis that directly inhibits specific members of the caspase family of cysteine proteases, including caspase-3, -7, and -9 [, ]. It promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death []. The ubiquitin-protein ligase (E3) activity of XIAP also exhibits in the ubiquitination of second mitochondria-derived activator of caspases (Smac) []. The mitochondrial proteins, Smac/DIABLO and Omi/HtrA2, can inhibit the antiapoptotic activity of XIAP []. XIAP has also been implicated in several intracellular signaling cascades involved in the cellular response to stress, such as the c-Jun N-terminal kinase (JNK) pathway, the nuclear factor-kappaB (NF-kappaB) pathway, and the transforming growth factor-beta (TGF-beta) pathway [, , ]. Moreover, XIAP can regulate copper homeostasis through interacting with MURR1 []. BIRC8, also called inhibitor of apoptosis-like protein 2 (IAP-like protein 2 or ILP-2), or testis-specific inhibitor of apoptosis, is a tissue-specific homologue of E3 ubiquitin-protein ligase XIAP. It has been implicated in the control of apoptosis in the testis by direct inhibition of caspase 9 []. Both XIAP and BIRC8 contain three N-terminal baculoviral IAP repeat (BIR) domains, a ubiquitin-association (UBA) domain and a RING domain at the carboxyl terminus.This entry represents the UBA domain found in XIAP and BIRC8.
Publication
First Author: Straszewski-Chavez SL
Year: 2007
Journal: J Biol Chem
Title: XAF1 mediates tumor necrosis factor-alpha-induced apoptosis and X-linked inhibitor of apoptosis cleavage by acting through the mitochondrial pathway.
Volume: 282
Issue: 17
Pages: 13059-72
Protein Domain
Type: Family
Description: XAF1 (X-linked inhibitor of apoptosis (XIAP)-associated factor 1) is a proapoptotic protein that antagonises the caspase-inhibitory activity of XIAP [, ]. It is a tumor suppressor that is frequently inactivated in many human cancers. It forms a positive feedback loop with p53 and acts as a molecular switch in p53-mediated cell-fate decisions favoring apoptosis over cell-cycle arrest [].
Publication
First Author: Deveraux QL
Year: 1997
Journal: Nature
Title: X-linked IAP is a direct inhibitor of cell-death proteases.
Volume: 388
Issue: 6639
Pages: 300-4
Publication
First Author: Gyrd-Hansen M
Year: 2010
Journal: Nat Rev Cancer
Title: IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.
Volume: 10
Issue: 8
Pages: 561-74
Publication
First Author: Mannion NM
Year: 2014
Journal: Cell Rep
Title: The RNA-editing enzyme ADAR1 controls innate immune responses to RNA.
Volume: 9
Issue: 4
Pages: 1482-94
Publication
First Author: Galande S
Year: 2001
Journal: Mol Cell Biol
Title: SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis.
Volume: 21
Issue: 16
Pages: 5591-604
Publication
First Author: Slee EA
Year: 1999
Journal: J Cell Biol
Title: Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner.
Volume: 144
Issue: 2
Pages: 281-92
Publication
First Author: Baumgartner R
Year: 2009
Journal: Biochem J
Title: The crystal structure of caspase-6, a selective effector of axonal degeneration.
Volume: 423
Issue: 3
Pages: 429-39
Publication
First Author: Talanian RV
Year: 1997
Journal: J Biol Chem
Title: Substrate specificities of caspase family proteases.
Volume: 272
Issue: 15
Pages: 9677-82
Publication
First Author: Wang XJ
Year: 2010
Journal: EMBO Rep
Title: Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation.
Volume: 11
Issue: 11
Pages: 841-7
Publication
First Author: Orth K
Year: 1996
Journal: J Biol Chem
Title: The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A.
Volume: 271
Issue: 28
Pages: 16443-6
Publication
First Author: Cowling V
Year: 2002
Journal: Cell Death Differ
Title: Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain.
Volume: 9
Issue: 10
Pages: 1046-56
Publication
First Author: Inoue S
Year: 2009
Journal: Cell Death Differ
Title: Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway.
Volume: 16
Issue: 7
Pages: 1053-61
Publication
First Author: Bideshi DK
Year: 2005
Journal: Genes Dev
Title: A viral caspase contributes to modified apoptosis for virus transmission.
Volume: 19
Issue: 12
Pages: 1416-21
Protein Domain
Type: Family
Description: Caspase-6 (EC 3.4.22.59; MEROPS identifier C14.005) is a cysteine endopeptidase from family C14. It cleaves aspartyl bonds, and has a preference for Val in P4, Glu or Gln in P3, His or Val in P2 and Gly in P1' [, ]similar to the initiator caspases 8 and 9 []. Caspase-6 processes its own precursor to generate a two-chain form [, ]and lamin A []and STAB1 [], which are not cleaved by caspases 3 or 7. Unusually, caspase-6 activity is unaffected by XIAP []. Caspase-6 is an initiator caspase activated by caspases 3 and 7 []and activating caspase-8 [, ]. It also translocates to the nucleus where processing of lamin A occurs.This entry also includes SfAV caspase from Spodoptera frugiperda ascovirus (MEROPS identifier C14.037), which is an executioner caspase that can induce apoptosis in host insect cells [].
Publication
First Author: Roberts EA
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Developmental expression of Commd1 in the liver of the Jackson toxic milk mouse.
Volume: 363
Issue: 4
Pages: 921-5
Publication
First Author: Li Z
Year: 2010
Journal: Cell
Title: Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization.
Volume: 141
Issue: 5
Pages: 859-71
Publication
First Author: Inoue H
Year: 2003
Journal: EMBO J
Title: The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model.
Volume: 22
Issue: 24
Pages: 6665-74
Publication
First Author: Lunardi A
Year: 2013
Journal: Nat Genet
Title: A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer.
Volume: 45
Issue: 7
Pages: 747-55