Type |
Details |
Score |
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hu J |
Year: |
2010 |
Journal: |
J Am Soc Nephrol |
Title: |
XIAP reduces muscle proteolysis induced by CKD. |
Volume: |
21 |
Issue: |
7 |
Pages: |
1174-83 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
106
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
52
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Edison N |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis. |
Volume: |
21 |
Issue: |
2 |
Pages: |
442-454 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen M |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
Identification of XAF1 as an endogenous AKT inhibitor. |
Volume: |
42 |
Issue: |
7 |
Pages: |
112690 |
|
•
•
•
•
•
|
Allele |
Name: |
X-linked inhibitor of apoptosis; targeted mutation 1, Craig B Thompson |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Krieg A |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
XIAP mediates NOD signaling via interaction with RIP2. |
Volume: |
106 |
Issue: |
34 |
Pages: |
14524-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Damgaard RB |
Year: |
2013 |
Journal: |
EMBO Mol Med |
Title: |
Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling. |
Volume: |
5 |
Issue: |
8 |
Pages: |
1278-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Heim VJ |
Year: |
2020 |
Journal: |
EMBO Rep |
Title: |
A regulatory region on RIPK2 is required for XIAP binding and NOD signaling activity. |
Volume: |
21 |
Issue: |
11 |
Pages: |
e50400 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Regulation of apoptosis by XIAP ubiquitin-ligase activity. |
|
•
•
•
•
•
|
Publication |
First Author: |
Wong WW |
Year: |
2014 |
Journal: |
Blood |
Title: |
cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. |
Volume: |
123 |
Issue: |
16 |
Pages: |
2562-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yao J |
Year: |
2011 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
XIAP therapy increases survival of transplanted rod precursors in a degenerating host retina. |
Volume: |
52 |
Issue: |
3 |
Pages: |
1567-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Conte D |
Year: |
2001 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Thymocyte-targeted overexpression of xiap transgene disrupts T lymphoid apoptosis and maturation. |
Volume: |
98 |
Issue: |
9 |
Pages: |
5049-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baek HS |
Year: |
2019 |
Journal: |
Biochim Biophys Acta Mol Cell Res |
Title: |
CYP1B1 prevents proteasome-mediated XIAP degradation by inducing PKCε activation and phosphorylation of XIAP. |
Volume: |
1866 |
Issue: |
12 |
Pages: |
118553 |
|
•
•
•
•
•
|
Allele |
Name: |
XIAP associated factor 1; wild type |
Allele Type: |
Not Specified |
|
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Nishimura Y |
Year: |
2022 |
Journal: |
Acta Diabetol |
Title: |
XAF1 overexpression exacerbates diabetes by promoting pancreatic β-cell apoptosis. |
Volume: |
59 |
Issue: |
10 |
Pages: |
1275-1286 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kuang M |
Year: |
2023 |
Journal: |
Sci Adv |
Title: |
XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility. |
Volume: |
9 |
Issue: |
33 |
Pages: |
eadg5211 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6385896 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-01-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603919 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6386181 |
Age: |
embryonic day 11.5 |
Image: |
3 |
|
Specimen Label: |
wild type |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6385896 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-01-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603919 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6386181 |
Age: |
embryonic day 11.5 |
Image: |
3 |
|
Specimen Label: |
Adar1-/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6385896 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-01-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603919 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6386181 |
Age: |
embryonic day 11.5 |
Image: |
3 |
|
Specimen Label: |
Adar1-/-;Ifnar1-/- |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6385896 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-01-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603919 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6386181 |
Age: |
embryonic day 11.5 |
Image: |
3 |
|
Specimen Label: |
Adar1-/-;Mavs-/- |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6385896 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-01-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603919 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6386223 |
Age: |
embryonic day 11.5 |
Image: |
S2 |
|
Specimen Label: |
wild type |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6385896 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-01-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603919 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6386223 |
Age: |
embryonic day 11.5 |
Image: |
S2 |
|
Specimen Label: |
Ifnar1-/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6385896 |
Assay Type: |
RT-PCR |
Annotation Date: |
2020-01-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603919 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6386223 |
Age: |
embryonic day 11.5 |
Image: |
S2 |
|
Specimen Label: |
Mavs-/- |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liston P |
Year: |
2001 |
Journal: |
Nat Cell Biol |
Title: |
Identification of XAF1 as an antagonist of XIAP anti-Caspase activity. |
Volume: |
3 |
Issue: |
2 |
Pages: |
128-33 |
|
•
•
•
•
•
|
Allele |
Name: |
XIAP associated factor 1; gene trap OST467639, Lexicon Genetics |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
XIAP associated factor 1; endonuclease-mediated mutation 40, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
XIAP associated factor 1; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
XIAP associated factor 1; endonuclease-mediated mutation 1, Daming Gao |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
XIAP associated factor 1; endonuclease-mediated mutation 1, Cyagen Biosciences |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Burstein E |
Year: |
2004 |
Journal: |
EMBO J |
Title: |
A novel role for XIAP in copper homeostasis through regulation of MURR1. |
Volume: |
23 |
Issue: |
1 |
Pages: |
244-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
MacFarlane M |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro. |
Volume: |
277 |
Issue: |
39 |
Pages: |
36611-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Van Themsche C |
Year: |
2010 |
Journal: |
Mol Cancer |
Title: |
XIAP gene expression and function is regulated by autocrine and paracrine TGF-beta signaling. |
Volume: |
9 |
|
Pages: |
216 |
|
•
•
•
•
•
|
Allele |
Name: |
X-linked inhibitor of apoptosis; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
XIAP associated factor 1; endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
XIAP associated factor 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Xaf1/Xaf1 |
Background: |
involves: C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L. |
|
•
•
•
•
•
|
Publication |
First Author: |
Gu L |
Year: |
2009 |
Journal: |
Cancer Cell |
Title: |
Regulation of XIAP translation and induction by MDM2 following irradiation. |
Volume: |
15 |
Issue: |
5 |
Pages: |
363-75 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Choo Z |
Year: |
2016 |
Journal: |
Oncotarget |
Title: |
XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis. |
Volume: |
7 |
Issue: |
23 |
Pages: |
34229-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu BQ |
Year: |
2023 |
Journal: |
EMBO Rep |
Title: |
XAF1 prevents hyperproduction of type I interferon upon viral infection by targeting IRF7. |
Volume: |
24 |
Issue: |
1 |
Pages: |
e55387 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Xaf1/Xaf1 |
Background: |
C57BL/6N-Xaf1/MbpMmucd |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu WH |
Year: |
2007 |
Journal: |
EMBO J |
Title: |
Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation. |
Volume: |
26 |
Issue: |
6 |
Pages: |
1660-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu C |
Year: |
2019 |
Journal: |
J Exp Med |
Title: |
SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease. |
Volume: |
216 |
Issue: |
4 |
Pages: |
743-756 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shin H |
Year: |
2005 |
Journal: |
Biochem J |
Title: |
The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition. |
Volume: |
385 |
Issue: |
Pt 1 |
Pages: |
1-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suzuki Y |
Year: |
2001 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. |
Volume: |
98 |
Issue: |
15 |
Pages: |
8662-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sanna MG |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis. |
Volume: |
277 |
Issue: |
34 |
Pages: |
30454-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Duckett CS |
Year: |
1996 |
Journal: |
EMBO J |
Title: |
A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. |
Volume: |
15 |
Issue: |
11 |
Pages: |
2685-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vaux DL |
Year: |
2003 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Mammalian mitochondrial IAP binding proteins. |
Volume: |
304 |
Issue: |
3 |
Pages: |
499-504 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
XIAP, also called baculoviral IAP repeat-containing protein 4 (BIRC4), is a potent suppressor of apoptosis that directly inhibits specific members of the caspase family of cysteine proteases, including caspase-3, -7, and -9 [, ]. It promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death []. The ubiquitin-protein ligase (E3) activity of XIAP also exhibits in the ubiquitination of second mitochondria-derived activator of caspases (Smac) []. The mitochondrial proteins, Smac/DIABLO and Omi/HtrA2, can inhibit the antiapoptotic activity of XIAP []. XIAP has also been implicated in several intracellular signaling cascades involved in the cellular response to stress, such as the c-Jun N-terminal kinase (JNK) pathway, the nuclear factor-kappaB (NF-kappaB) pathway, and the transforming growth factor-beta (TGF-beta) pathway [, , ]. Moreover, XIAP can regulate copper homeostasis through interacting with MURR1 []. BIRC8, also called inhibitor of apoptosis-like protein 2 (IAP-like protein 2 or ILP-2), or testis-specific inhibitor of apoptosis, is a tissue-specific homologue of E3 ubiquitin-protein ligase XIAP. It has been implicated in the control of apoptosis in the testis by direct inhibition of caspase 9 []. Both XIAP and BIRC8 contain three N-terminal baculoviral IAP repeat (BIR) domains, a ubiquitin-association (UBA) domain and a RING domain at the carboxyl terminus.This entry represents the UBA domain found in XIAP and BIRC8. |
|
•
•
•
•
•
|
Publication |
First Author: |
Straszewski-Chavez SL |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
XAF1 mediates tumor necrosis factor-alpha-induced apoptosis and X-linked inhibitor of apoptosis cleavage by acting through the mitochondrial pathway. |
Volume: |
282 |
Issue: |
17 |
Pages: |
13059-72 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
XAF1 (X-linked inhibitor of apoptosis (XIAP)-associated factor 1) is a proapoptotic protein that antagonises the caspase-inhibitory activity of XIAP [, ]. It is a tumor suppressor that is frequently inactivated in many human cancers. It forms a positive feedback loop with p53 and acts as a molecular switch in p53-mediated cell-fate decisions favoring apoptosis over cell-cycle arrest []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Deveraux QL |
Year: |
1997 |
Journal: |
Nature |
Title: |
X-linked IAP is a direct inhibitor of cell-death proteases. |
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Issue: |
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Pages: |
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Year: |
2010 |
Journal: |
Nat Rev Cancer |
Title: |
IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. |
Volume: |
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Pages: |
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Year: |
2014 |
Journal: |
Cell Rep |
Title: |
The RNA-editing enzyme ADAR1 controls innate immune responses to RNA. |
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First Author: |
Galande S |
Year: |
2001 |
Journal: |
Mol Cell Biol |
Title: |
SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis. |
Volume: |
21 |
Issue: |
16 |
Pages: |
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First Author: |
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Year: |
1999 |
Journal: |
J Cell Biol |
Title: |
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Volume: |
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Year: |
2009 |
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Biochem J |
Title: |
The crystal structure of caspase-6, a selective effector of axonal degeneration. |
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J Biol Chem |
Title: |
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Volume: |
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Year: |
2010 |
Journal: |
EMBO Rep |
Title: |
Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation. |
Volume: |
11 |
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11 |
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Year: |
1996 |
Journal: |
J Biol Chem |
Title: |
The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A. |
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First Author: |
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Year: |
2002 |
Journal: |
Cell Death Differ |
Title: |
Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain. |
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Journal: |
Cell Death Differ |
Title: |
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16 |
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Year: |
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Journal: |
Genes Dev |
Title: |
A viral caspase contributes to modified apoptosis for virus transmission. |
Volume: |
19 |
Issue: |
12 |
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Protein Domain |
Type: |
Family |
Description: |
Caspase-6 (EC 3.4.22.59; MEROPS identifier C14.005) is a cysteine endopeptidase from family C14. It cleaves aspartyl bonds, and has a preference for Val in P4, Glu or Gln in P3, His or Val in P2 and Gly in P1' [, ]similar to the initiator caspases 8 and 9 []. Caspase-6 processes its own precursor to generate a two-chain form [, ]and lamin A []and STAB1 [], which are not cleaved by caspases 3 or 7. Unusually, caspase-6 activity is unaffected by XIAP []. Caspase-6 is an initiator caspase activated by caspases 3 and 7 []and activating caspase-8 [, ]. It also translocates to the nucleus where processing of lamin A occurs.This entry also includes SfAV caspase from Spodoptera frugiperda ascovirus (MEROPS identifier C14.037), which is an executioner caspase that can induce apoptosis in host insect cells []. |
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First Author: |
Roberts EA |
Year: |
2007 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Developmental expression of Commd1 in the liver of the Jackson toxic milk mouse. |
Volume: |
363 |
Issue: |
4 |
Pages: |
921-5 |
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Publication |
First Author: |
Li Z |
Year: |
2010 |
Journal: |
Cell |
Title: |
Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization. |
Volume: |
141 |
Issue: |
5 |
Pages: |
859-71 |
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First Author: |
Inoue H |
Year: |
2003 |
Journal: |
EMBO J |
Title: |
The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model. |
Volume: |
22 |
Issue: |
24 |
Pages: |
6665-74 |
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Publication |
First Author: |
Lunardi A |
Year: |
2013 |
Journal: |
Nat Genet |
Title: |
A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer. |
Volume: |
45 |
Issue: |
7 |
Pages: |
747-55 |
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