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Search results 301 to 373 out of 373 for Xpa

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Type Details Score
Protein Domain
IPR009061 | DNA-bd_dom_put_sf
Type: Homologous_superfamily
Description: A putative DNA-binding domain with a conserved structure is found in several different protein families. The core structure of the domain consists of a three-helical fold that is architecturally similar to that of the "winged-helix"fold, but is topologically distinct. Representatives of this domain can be found in domains B1 and B5 from the beta subunit of phenylalanine-tRNA synthetases [], the C-terminal region of the DNA/RPA-binding domain of the DNA excision repair factor XPA [], the N-terminal domain of the transcriptional activators BmrR and MtaN [], the most conserved domain of the retinal development protein Dachshund [], and the DNA-binding domain of the gpNU1 subunit from the bacteriophage lambda viral packing protein terminase [].
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Publication
39738787 | J:360526
First Author: Shen CL
Year: 2024
Journal: Commun Biol
Title: RBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar foliation.
Volume: 7
Issue: 1
Pages: 1712
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Genotype
Genotype
Symbol: Ercc3/Ercc3 Xpa/Xpa
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Xpa/Xpa Tg(CAG-cre)13Miya/?
Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Publication
15598745 | J:95281
First Author: Marchetto MC
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Gene transduction in skin cells: preventing cancer in xeroderma pigmentosum mice.
Volume: 101
Issue: 51
Pages: 17759-64
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Protein
E0CYV9
Organism: Mus musculus/domesticus
Length: 1786  
Fragment?: false
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Protein
D3Z1D3
Organism: Mus musculus/domesticus
Length: 1412  
Fragment?: false
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Protein
A0A087WR45
Organism: Mus musculus/domesticus
Length: 1010  
Fragment?: false
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Protein
Q3UKG2
Organism: Mus musculus/domesticus
Length: 1006  
Fragment?: true
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Publication
19240791 | -
First Author: Graubert TA
Year: 2009
Journal: PLoS One
Title: Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis.
Volume: 4
Issue: 2
Pages: e4583
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Protein Domain
IPR027838 | DUF4585
Type: Domain
Description: The function of this domain is yet to be characterised. It is often found in eukaryotes, and is approximately 70 amino acids in length. It has a conserved DPE sequence motif. This domain is putatively thought to lie in the C terminus of the DNA nucleotide repair protein, Xeroderma pigmentosa complementation group A (XPA). The function of XPA is to bind to DNA and repair any mismatched base pairs. In humans, this protein is encoded for in chromosome 5 open reading frame 65. Mutations in the gene lead to myelodysplastic syndromes, where there is inefficient stem cell production in the bone marrow. This suggests that the protein may have a role in forming blood cells [].
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Publication
19026994 | J:147809
 
First Author: Masuda T
Year: 2009
Journal: Brain Res
Title: Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.
Volume: 1249
Pages: 61-7
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Strain
MGI:6199704 | B6;129-Xpa<tm1Hvs> Trp53<tm1Holl> Tg(pUR288)1Vij/H
Attribute String: targeted mutation, transgenic, mutant stock
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Genotype
Genotype
Symbol: Ercc6/Ercc6 Xpa/Xpa Tg(CAG-cre)13Miya/?
Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ercc6/Ercc6 Xpa/Xpa Tg(Camk2a-cre)1Szi/?
Background: involves: 129P2/OlaHsd * C57BL/6J * CBA
Zygosity: cn
Has Mutant Allele: true
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Publication
15654980 | J:96282
First Author: van Schanke A
Year: 2005
Journal: J Invest Dermatol
Title: Single UVB overexposure stimulates melanocyte proliferation in murine skin, in contrast to fractionated or UVA-1 exposure.
Volume: 124
Issue: 1
Pages: 241-7
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Publication
24380836 | J:211958
First Author: Mulder JE
Year: 2014
Journal: Toxicol Appl Pharmacol
Title: Up-regulation of nucleotide excision repair in mouse lung and liver following chronic exposure to aflatoxin B₁ and its dependence on p53 genotype.
Volume: 275
Issue: 2
Pages: 96-103
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Publication
10602497 | J:59014
First Author: Ananthaswamy HN
Year: 1999
Journal: Oncogene
Title: Persistence of p53 mutations and resistance of keratinocytes to apoptosis are associated with the increased susceptibility of mice lacking the XPC gene to UV carcinogenesis.
Volume: 18
Issue: 51
Pages: 7395-8
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Publication
9540983 | J:120557
First Author: Berg RJ
Year: 1998
Journal: J Invest Dermatol
Title: Defective global genome repair in XPC mice is associated with skin cancer susceptibility but not with sensitivity to UVB induced erythema and edema.
Volume: 110
Issue: 4
Pages: 405-9
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Publication
12466203 | J:80586
First Author: Hsia KT
Year: 2003
Journal: Development
Title: DNA repair gene Ercc1 is essential for normal spermatogenesis and oogenesis and for functional integrity of germ cell DNA in the mouse.
Volume: 130
Issue: 2
Pages: 369-78
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Publication
14729965 | J:87684
First Author: Tian M
Year: 2004
Journal: Mol Cell Biol
Title: Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF.
Volume: 24
Issue: 3
Pages: 1200-5
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Publication
12505318 | J:81073
 
First Author: Mitsumori K
Year: 2002
Journal: Toxicology
Title: Evaluation on carcinogenicity of chemicals using transgenic mice.
Volume: 181-182
Pages: 241-4
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Publication
21765012 | J:179158
First Author: Fishelevich R
Year: 2011
Journal: J Immunol
Title: Imiquimod-induced TLR7 signaling enhances repair of DNA damage induced by ultraviolet light in bone marrow-derived cells.
Volume: 187
Issue: 4
Pages: 1664-73
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Publication
24326454 | J:210555
First Author: Ahmad I
Year: 2014
Journal: J Invest Dermatol
Title: Toll-like receptor-4 deficiency enhances repair of UVR-induced cutaneous DNA damage by nucleotide excision repair mechanism.
Volume: 134
Issue: 6
Pages: 1710-1717
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Publication
27298253 | J:250280
First Author: Kaushik Tiwari M
Year: 2016
Journal: Nucleic Acids Res
Title: Triplex structures induce DNA double strand breaks via replication fork collapse in NER deficient cells.
Volume: 44
Issue: 16
Pages: 7742-54
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Publication
21844196 | -
First Author: Staresincic L
Year: 2011
Journal: J Biol Chem
Title: GTP-dependent binding and nuclear transport of RNA polymerase II by Npa3 protein.
Volume: 286
Issue: 41
Pages: 35553-61
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Publication
12057194 | -
First Author: Kim SS
Year: 2002
Journal: Structure
Title: Structure of the retinal determination protein Dachshund reveals a DNA binding motif.
Volume: 10
Issue: 6
Pages: 787-95
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Genotype
Genotype
Symbol: Ercc6/Ercc6 Xpa/Xpa Tg(Pcp2-cre)2Mpin/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Publication
14965359 | J:88757
First Author: Ishikawa T
Year: 2004
Journal: Cancer Sci
Title: DNA repair and cancer: lessons from mutant mouse models.
Volume: 95
Issue: 2
Pages: 112-7
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Publication
- | J:85678
First Author: van Schanke A
Year: 2003
Journal: Pigment Cell Res
Title: IL-18 UV-induced melanocyte proliferation and nevi in mice.
Volume: 16
Issue: 5
Pages: 579-80 (Abstr.)
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Protein
Q9QYB2
Organism: Mus musculus/domesticus
Length: 751  
Fragment?: false
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Protein
Q925Q8
Organism: Mus musculus/domesticus
Length: 634  
Fragment?: false
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Protein
Q68G54
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: true
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Protein
Z4YN47
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: true
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Protein
Z4YLL5
Organism: Mus musculus/domesticus
Length: 65  
Fragment?: true
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Protein
Q3UTV2
Organism: Mus musculus/domesticus
Length: 673  
Fragment?: false
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Publication
17468740 | -
First Author: Gras S
Year: 2007
Journal: EMBO Rep
Title: Structural insights into a new homodimeric self-activated GTPase family.
Volume: 8
Issue: 6
Pages: 569-75
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Protein
Q80YR3
Organism: Mus musculus/domesticus
Length: 822  
Fragment?: false
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Protein
A0A087WS80
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: true
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Protein
D3Z3X7
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: false
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Protein
G3X9M2
Organism: Mus musculus/domesticus
Length: 909  
Fragment?: false
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Protein
D6RCY0
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: false
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Protein
Q8VCE2
Organism: Mus musculus/domesticus
Length: 372  
Fragment?: false
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Protein
Q4VAB2
Organism: Mus musculus/domesticus
Length: 372  
Fragment?: false
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Protein
D3YYG2
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: true
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Protein
Q8BX46
Organism: Mus musculus/domesticus
Length: 964  
Fragment?: false
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Protein
Q60665
Organism: Mus musculus/domesticus
Length: 675  
Fragment?: false
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Protein
Q60698
Organism: Mus musculus/domesticus
Length: 725  
Fragment?: false
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Protein
A7M7C7
Organism: Mus musculus/domesticus
Length: 1008  
Fragment?: false
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Protein
Q60979
Organism: Mus musculus/domesticus
Length: 674  
Fragment?: false
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Protein
Q6NV61
Organism: Mus musculus/domesticus
Length: 675  
Fragment?: false
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Protein
B1AUF2
Organism: Mus musculus/domesticus
Length: 675  
Fragment?: false
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Protein
Q3TRA0
Organism: Mus musculus/domesticus
Length: 369  
Fragment?: false
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Protein
D3YX64
Organism: Mus musculus/domesticus
Length: 925  
Fragment?: false
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Protein
Q3TQJ9
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: true
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Protein
D3Z7C5
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: false
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Protein
B1AUF1
Organism: Mus musculus/domesticus
Length: 727  
Fragment?: false
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Protein
Q3TB81
Organism: Mus musculus/domesticus
Length: 629  
Fragment?: false
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Protein
Q9WUA2
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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Protein
Q8C644
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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Protein
Q3TG12
Organism: Mus musculus/domesticus
Length: 588  
Fragment?: true
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Protein
Q3TI98
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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Protein
Q3UYC2
Organism: Mus musculus/domesticus
Length: 490  
Fragment?: false
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Protein
Q9CZU5
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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Protein
Q3TMX6
Organism: Mus musculus/domesticus
Length: 536  
Fragment?: false
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Publication
15345747 | -
First Author: Ballif BA
Year: 2004
Journal: Mol Cell Proteomics
Title: Phosphoproteomic analysis of the developing mouse brain.
Volume: 3
Issue: 11
Pages: 1093-101
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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