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Search results 301 to 400 out of 639 for Xrcc1

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Type Details Score
Publication
15501676 | -
First Author: Glover JN
Year: 2004
Journal: Trends Biochem Sci
Title: Interactions between BRCT repeats and phosphoproteins: tangled up in two.
Volume: 29
Issue: 11
Pages: 579-85
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Publication
15044383 | -
First Author: Gueven N
Year: 2004
Journal: Hum Mol Genet
Title: Aprataxin, a novel protein that protects against genotoxic stress.
Volume: 13
Issue: 10
Pages: 1081-93
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Publication
16547001 | -
First Author: Kijas AW
Year: 2006
Journal: J Biol Chem
Title: Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities.
Volume: 281
Issue: 20
Pages: 13939-48
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Publication
17276982 | -
First Author: Rass U
Year: 2007
Journal: J Biol Chem
Title: Actions of aprataxin in multiple DNA repair pathways.
Volume: 282
Issue: 13
Pages: 9469-74
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Publication
24362567 | -
First Author: Tumbale P
Year: 2014
Journal: Nature
Title: Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.
Volume: 506
Issue: 7486
Pages: 111-5
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Publication
11586299 | J:71921
First Author: Date H
Year: 2001
Journal: Nat Genet
Title: Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene.
Volume: 29
Issue: 2
Pages: 184-8
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Publication
15555565 | -
First Author: Date H
Year: 2004
Journal: Biochem Biophys Res Commun
Title: The FHA domain of aprataxin interacts with the C-terminal region of XRCC1.
Volume: 325
Issue: 4
Pages: 1279-85
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Publication
21984208 | -
First Author: Gong Y
Year: 2011
Journal: Nat Struct Mol Biol
Title: Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA.
Volume: 18
Issue: 11
Pages: 1297-9
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Protein Domain
IPR001357 | BRCT_dom
Type: Domain
Description: The breast cancer susceptibility gene contains at its C terminus two copies of a conserved domain that was named BRCT for BRCA1 C terminus. This domain of about 95 amino acids is found in a large variety of proteins involved in DNA repair, recombination and cell cycle control [, , ]. The BRCT domain is not limited to the C-terminal of protein sequences and can be found in multiple copies or in a single copy as in RAP1 and TdT. BRCT domains are often found as tandem-repeat pairs []. Some data []indicate that the BRCT domain functions as a protein-protein interaction module.The structure of the first of the two C-terminal BRCT domains of the human DNA repair protein XRCC1 has been determined by X-ray crystallography [].Structures of the BRCA1 BRCT domains revealed a basis for a widely utilised head-to-tail BRCT-BRCT oligomerization mode []. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants [].
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Protein Domain
IPR026963 | Aprataxin-like
Type: Family
Description: Aprataxin is a DNA-binding protein involved in single-strand and double-strand DNA break repair, and base excision repair [, , ]. In yeast the aprataxin orthologue is known as Hnt3 (Hit family protein 3) []. Aprataxin is a member of the histidine triad (HIT) superfamily of nucleotide hydrolases and transferases, named for their characteristic HxHxHxx catalytic motif, where x is a hydrophobic amino acid []. It also contains an N-terminal forkhead associated (FHA) domain, which is thought to mediate interactions with the ligase cofactors XRCC1 and XRCC4, and a C-terminal zinc finger domain implicated in DNA binding [, ].Aprataxin repairs adenylated RNA-DNA junctions []. It resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. It catalyses the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined []. Mutations in the aprataxin gene cause the neurological disorder ataxia oculomotor apraxia-1 (AOA1).This entry also includes the Aprataxin-like protein BHLH140.
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Protein
Q9D842
Organism: Mus musculus/domesticus
Length: 499  
Fragment?: false
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Protein
Q6NZQ4
Organism: Mus musculus/domesticus
Length: 1056  
Fragment?: false
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Protein
Q7TT79
Organism: Mus musculus/domesticus
Length: 822  
Fragment?: false
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Publication
11780069 | J:73356
First Author: Himanen JP
Year: 2001
Journal: Nature
Title: Crystal structure of an Eph receptor-ephrin complex.
Volume: 414
Issue: 6866
Pages: 933-8
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Protein
Q8BPK1
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
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Protein
Q3UGB7
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
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Protein
Q3UGD2
Organism: Mus musculus/domesticus
Length: 600  
Fragment?: false
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Protein
E9PX19
Organism: Mus musculus/domesticus
Length: 600  
Fragment?: false
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Protein
Q8BVD9
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: false
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Protein
Q99LI1
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: true
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Protein
Q9CWX2
Organism: Mus musculus/domesticus
Length: 328  
Fragment?: false
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Protein
Q8BX80
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
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Protein
Q8BWR2
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: false
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Protein
Q9R244
Organism: Mus musculus/domesticus
Length: 1172  
Fragment?: false
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Protein
B1AV57
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
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Protein
Q3TNJ2
Organism: Mus musculus/domesticus
Length: 242  
Fragment?: false
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Protein
A0A0J9YUT2
Organism: Mus musculus/domesticus
Length: 53  
Fragment?: false
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Protein
A2AQ17
Organism: Mus musculus/domesticus
Length: 328  
Fragment?: false
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Protein
H3BK10
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: true
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Protein
H3BIZ5
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: true
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Protein
A0A0G2JE02
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: false
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Protein
A0A0J9YVH5
Organism: Mus musculus/domesticus
Length: 59  
Fragment?: false
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Protein
F8VQM8
Organism: Mus musculus/domesticus
Length: 1264  
Fragment?: false
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Protein
A0A0R4J081
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Protein
H3BIW1
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: true
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Protein
H3BL29
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: true
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Protein
A0A494BB31
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: true
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Protein
Q5F0M4
Organism: Mus musculus/domesticus
Length: 1119  
Fragment?: false
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Protein
A0A0J9YTV1
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: false
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Protein
Q3TAJ0
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: true
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Protein
B1AV58
Organism: Mus musculus/domesticus
Length: 65  
Fragment?: true
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Protein
E0CXB7
Organism: Mus musculus/domesticus
Length: 48  
Fragment?: false
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Publication
18784084 | -
First Author: Caines ME
Year: 2008
Journal: J Biol Chem
Title: The structural basis for T-antigen hydrolysis by Streptococcus pneumoniae: a target for structure-based vaccine design.
Volume: 283
Issue: 46
Pages: 31279-83
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Protein
Q8K2H6
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: false
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Protein
G3X9C2
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
Q8C341
Organism: Mus musculus/domesticus
Length: 1250  
Fragment?: false
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Protein
Q9Z1L4
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: false
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Protein
A0A0A6YXY2
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: true
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Protein
A0A0A6YX94
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: true
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Protein
Q2PAY0
Organism: Mus musculus/domesticus
Length: 65  
Fragment?: true
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Protein
E9PW79
Organism: Mus musculus/domesticus
Length: 244  
Fragment?: false
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Protein
A0A338P6F1
Organism: Mus musculus/domesticus
Length: 79  
Fragment?: true
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Protein
F7BZR8
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: true
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Protein
B2RRF3
Organism: Mus musculus/domesticus
Length: 1254  
Fragment?: false
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Protein
B0V2H9
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: true
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Protein
A0A0A0MQ97
Organism: Mus musculus/domesticus
Length: 291  
Fragment?: false
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Protein
Q9R1M6
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: false
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Protein
Q9CYI2
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: false
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Protein
Q2PAX8
Organism: Mus musculus/domesticus
Length: 65  
Fragment?: true
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Protein
A0A494B9R7
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: false
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Protein
Q9DA12
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
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Protein
C6EQJ2
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: false
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Protein
B1AU64
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: false
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Protein
Q8C7H9
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: true
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Protein
F6Q1R4
Organism: Mus musculus/domesticus
Length: 577  
Fragment?: true
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Protein
B0V2I0
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: true
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Protein
F6UI76
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
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Protein
Q3TZ77
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: false
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Protein
Q3TEI7
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
Q5PSV9
Organism: Mus musculus/domesticus
Length: 1707  
Fragment?: false
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Protein
Q91VL8
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: false
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Protein
P70399
Organism: Mus musculus/domesticus
Length: 1969  
Fragment?: false
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Protein
Q8R3P9
Organism: Mus musculus/domesticus
Length: 1054  
Fragment?: false
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Protein
Q8C0U1
Organism: Mus musculus/domesticus
Length: 714  
Fragment?: false
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Protein
E9QK89
Organism: Mus musculus/domesticus
Length: 1708  
Fragment?: false
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Protein
Q3V1P7
Organism: Mus musculus/domesticus
Length: 689  
Fragment?: true
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Protein
A0A5H1ZRL7
Organism: Mus musculus/domesticus
Length: 1919  
Fragment?: false
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Protein
Q8BZ87
Organism: Mus musculus/domesticus
Length: 613  
Fragment?: true
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Protein
Q8C9Y7
Organism: Mus musculus/domesticus
Length: 692  
Fragment?: false
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Publication
2002850 | -
First Author: Ito N
Year: 1991
Journal: Nature
Title: Novel thioether bond revealed by a 1.7 A crystal structure of galactose oxidase.
Volume: 350
Issue: 6313
Pages: 87-90
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Protein
Q9JHX6
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
Q9QZN4
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Protein
Q3U487
Organism: Mus musculus/domesticus
Length: 861  
Fragment?: false
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Protein
P21956
Organism: Mus musculus/domesticus
Length: 463  
Fragment?: false
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Protein
Q8VC60
Organism: Mus musculus/domesticus
Length: 646  
Fragment?: false
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Protein
Q6DIA9
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
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Protein
Q8BK26
Organism: Mus musculus/domesticus
Length: 255  
Fragment?: false
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Protein
Q80UW2
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: false
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Protein
Q9QZM8
Organism: Mus musculus/domesticus
Length: 286  
Fragment?: false
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Protein
G3UYF5
Organism: Mus musculus/domesticus
Length: 276  
Fragment?: false
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Protein
A2A7H5
Organism: Mus musculus/domesticus
Length: 255  
Fragment?: false
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Protein
A0A494B9Q1
Organism: Mus musculus/domesticus
Length: 435  
Fragment?: false
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Protein
Q9QWQ1
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: true
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Protein
A2A7H1
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: true
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Protein
Q3V064
Organism: Mus musculus/domesticus
Length: 286  
Fragment?: false
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Protein
A0A494B989
Organism: Mus musculus/domesticus
Length: 385  
Fragment?: false
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Protein
E9PUJ0
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Protein
G3UXE5
Organism: Mus musculus/domesticus
Length: 584  
Fragment?: true
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Protein
A2A7H6
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: false
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Protein
A2A7H4
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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Cambridge CB2 3EH, United Kingdom