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Search results 301 to 400 out of 426 for Zp3

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Type Details Score
Publication
10963869 | J:83251
First Author: Rankin T
Year: 2000
Journal: Mol Cell Endocrinol
Title: The mouse zona pellucida: folliculogenesis, fertility and pre-implantation development.
Volume: 163
Issue: 1-2
Pages: 21-5
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Protein
Q8VH71
Organism: Mus musculus/domesticus
Length: 60  
Fragment?: true
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Protein
Q8VH73
Organism: Mus musculus/domesticus
Length: 60  
Fragment?: true
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Protein
Q8VH72
Organism: Mus musculus/domesticus
Length: 60  
Fragment?: true
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Protein
Q8VH74
Organism: Mus musculus/domesticus
Length: 60  
Fragment?: true
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Protein Domain
IPR042235 | ZP-C
Type: Homologous_superfamily
Description: The zona pellucida (ZP) domain is a protein polymerisation module of ~260 amino acid module, which is found at the C terminus of many secreted eukaryotic glycoproteins that play fundamental roles in development, hearing, immunity, and cancer [, , , ].The ZP module is not only conserved in egg coat components but is also found in many other secreted eukaryotic proteins with variable architecture and biological function. It is responsible for the incorporation of ZP3 and other subunits into the ZP and consists of two domains, ZP-N and ZP-C, that are separated by a protease-sensitive linker. Whereas ZP-N is thought to constitute a basic building block of ZP filaments, ZP-C may mediate the specificity of interaction between subunits. These processes are controlled by an external hydrophobic patch (EHP) contained within the C-terminal propeptide of ZP component precursors and an internal hydrophobic patch (IHP) inside the ZP module.This superfamily represents the ZP-C domain.
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Protein Domain
IPR017977 | ZP_dom_CS
Type: Conserved_site
Description: The zona pellucida (ZP) domain is a protein polymerisation module of ~260amino acid module, which is found at the C terminus of many secretedeukaryotic glycoproteins that play fundamental roles in development, hearing,immunity, and cancer [, , , ].Proteins containing a ZP domain include:Sperm receptor proteins ZP2 and ZP3. Along with protein ZP1, proteins ZP2and ZP3 are responsible for sperm-adhesion to the zona pellucida. ZP3 firstbinds to specific sperm proteins, thus mediating sperm contacts with theoocyte. ZP2 acts as a second sperm receptor reinforcing the interactions.ZP1 cross-links the polymers formed by ZP2 and ZP3.Zona pellucida sperm-binding protein B (ZP-B) (also known as ZP-X in rabbitand ZP-3 alpha in pig).Glycoprotein GP2, the major component of pancreatic secretory granulemembranes.TGF-beta receptor type III (also known as betaglycan). This protein is aproteoglycan that binds to TGF-beta and could be involved in capturing andretaining TGF-beta for presentation to the signalling receptors.Uromodulin (also known as Tamm-Horsfall urinary glycoprotein). The functionof this protein, which is the most abundant in human urine, is not yetclear.Chicken beta-tectorin, a major glycoprotein of avian tectorial membrane.Most ZP domain proteins are synthesized as precursors with carboxy-terminaltransmembrane domains or glycosyl phosphatidylinositol (GPI) anchors [].The ZP domain contains eight strictly conserved cysteines, which formdisulphide bridges. The disulphide bonds within the ZP domainsare divided intotwo groups, suggesting that the ZP domain consists of two subdomains. Inaddition to the conserved cysteines, only a few aromatic or hydrophobic aminoacids are absolutely invariant, probably as a result of structural rather thanfunctional constraints [, , ].This entry represents a conserved site found within the zona pellucida domain, and includes 2 conserved Cys residues.
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Publication
12799077 | J:84239
First Author: Waters ST
Year: 2003
Journal: Gene Expr Patterns
Title: Cloning and embryonic expression analysis of the mouse Gbx1 gene.
Volume: 3
Issue: 3
Pages: 313-7
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Publication
11124114 | J:66592
First Author: Liu A
Year: 2001
Journal: Development
Title: EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region.
Volume: 128
Issue: 2
Pages: 181-91
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Publication
11748135 | J:73067
First Author: Li JY
Year: 2001
Journal: Development
Title: Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression.
Volume: 128
Issue: 24
Pages: 4979-91
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Publication
11704761 | J:72984
First Author: Ye W
Year: 2001
Journal: Nat Neurosci
Title: Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8.
Volume: 4
Issue: 12
Pages: 1175-81
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Strain
MGI:3664258 | B6.129-Gbx2<tm1.1Mrt> Fgf8<tm1.4Mrt>
Attribute String: congenic, mutant strain, targeted mutation
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Publication
15483110 | J:132550
First Author: Huffman KJ
Year: 2004
Journal: J Neurosci
Title: Fgf8 regulates the development of intra-neocortical projections.
Volume: 24
Issue: 41
Pages: 8917-23
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Publication
32244588 | J:286303
 
First Author: Buckley DM
Year: 2020
Journal: J Dev Biol
Title: Gbx1 and Gbx2 Are Essential for Normal Patterning and Development of Interneurons and Motor Neurons in the Embryonic Spinal Cord.
Volume: 8
Issue: 2
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Publication
15996652 | J:100584
First Author: Byrd NA
Year: 2005
Journal: Dev Biol
Title: Loss of Gbx2 results in neural crest cell patterning and pharyngeal arch artery defects in the mouse embryo.
Volume: 284
Issue: 1
Pages: 233-45
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Publication
17923703 | J:128982
First Author: Tenno M
Year: 2007
Journal: Mol Cell Biol
Title: Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity.
Volume: 27
Issue: 24
Pages: 8783-96
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Publication
18773292 | J:146690
First Author: Williams SA
Year: 2009
Journal: Glycoconj J
Title: Complex N-glycans or core 1-derived O-glycans are not required for the expression of stage-specific antigens SSEA-1, SSEA-3, SSEA-4, or Le(Y) in the preimplantation mouse embryo.
Volume: 26
Issue: 3
Pages: 335-47
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Publication
18445292 | J:136658
 
First Author: Ge C
Year: 2008
Journal: BMC Dev Biol
Title: In vivo consequences of deleting EGF repeats 8-12 including the ligand binding domain of mouse Notch1.
Volume: 8
Pages: 48
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Publication
38270391 | J:354047
First Author: Lu L
Year: 2023
Journal: J Biol Chem
Title: In vivo evidence for GDP-fucose transport in the absence of transporter SLC35C1 and putative transporter SLC35C2.
Volume: 299
Issue: 12
Pages: 105406
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Publication
31217192 | J:282560
First Author: Sin JH
Year: 2019
Journal: J Exp Med
Title: The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses.
Volume: 216
Issue: 9
Pages: 2024-2037
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Publication
16227600 | J:102175
First Author: Shi S
Year: 2005
Journal: Mol Cell Biol
Title: Canonical Notch signaling is dispensable for early cell fate specifications in mammals.
Volume: 25
Issue: 21
Pages: 9503-8
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Publication
12198163 | J:78939
First Author: Ghazvini M
Year: 2002
Journal: EMBO J
Title: A cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regeneration.
Volume: 21
Issue: 17
Pages: 4612-20
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Publication
24753105 | J:213602
First Author: Arora R
Year: 2014
Journal: Dev Dyn
Title: Novel domains of expression for orphan receptor tyrosine kinase Ror2 in the human and mouse reproductive system.
Volume: 243
Issue: 8
Pages: 1037-45
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Strain
MGI:2164622 | FVB/N-Tg(ZP3)7812Dean/J
Attribute String: mutant strain, transgenic
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Genotype
Genotype
Symbol: Tg(ZP3)7812Dean/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gbx2/Gbx2 Fgf8/Fgf8<+>
Background: B6.129-Gbx2 Fgf8
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gbx2/Gbx2<+> Fgf8/Fgf8<+>
Background: B6.129-Gbx2 Fgf8
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: En1/En1<+> Gbx2/Gbx2
Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gbx2/Gbx2
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gbx2/Gbx2 Otx2/Otx2
Background: involves: 129 * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gbx2/Gbx2 Otx2/Otx2
Background: involves: 129 * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gbx1/Gbx1 Gbx2/Gbx2
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Figla-EGFP,-icre)ZP3Dean/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gbx2/Gbx2
Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Zygosity: ht
Has Mutant Allele: true
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Publication
12021773 | -
First Author: Jovine L
Year: 2002
Journal: Nat Cell Biol
Title: The ZP domain is a conserved module for polymerization of extracellular proteins.
Volume: 4
Issue: 6
Pages: 457-61
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Protein
O08524
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: false
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Protein
O88393
Organism: Mus musculus/domesticus
Length: 850  
Fragment?: false
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Protein
P20239
Organism: Mus musculus/domesticus
Length: 713  
Fragment?: false
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Protein
Q3UX44
Organism: Mus musculus/domesticus
Length: 676  
Fragment?: false
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Protein
D3Z3Y6
Organism: Mus musculus/domesticus
Length: 339  
Fragment?: false
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Protein
F6Z818
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: true
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Protein
Q6IR45
Organism: Mus musculus/domesticus
Length: 713  
Fragment?: false
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Protein
Q1HL20
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: false
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Protein
A0A0R4J097
Organism: Mus musculus/domesticus
Length: 850  
Fragment?: false
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Publication
1313375 | -
First Author: Bork P
Year: 1992
Journal: FEBS Lett
Title: A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor.
Volume: 300
Issue: 3
Pages: 237-40
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Publication
12878193 | -
First Author: Yonezawa N
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Identification of the carboxyl termini of porcine zona pellucida glycoproteins ZPB and ZPC.
Volume: 307
Issue: 4
Pages: 877-82
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Publication
15079052 | -
First Author: Jovine L
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: A duplicated motif controls assembly of zona pellucida domain proteins.
Volume: 101
Issue: 16
Pages: 5922-7
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Protein
Q9D6X7
Organism: Mus musculus/domesticus
Length: 573  
Fragment?: false
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Protein
Q3U5T0
Organism: Mus musculus/domesticus
Length: 325  
Fragment?: true
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Protein
A0A140LHP0
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: false
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Publication
9362457 | J:51735
First Author: Liang L
Year: 1997
Journal: Development
Title: FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes.
Volume: 124
Issue: 24
Pages: 4939-47
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Publication
9114055 | J:40164
First Author: Zhu X
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Fertilization antigen-1: cDNA cloning, testis-specific expression, and immunocontraceptive effects.
Volume: 94
Issue: 9
Pages: 4704-9
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Publication
1690843 | J:10389
First Author: Liang LF
Year: 1990
Journal: Mol Cell Biol
Title: Oocyte-specific expression of mouse Zp-2: developmental regulation of the zona pellucida genes.
Volume: 10
Issue: 4
Pages: 1507-15
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Publication
15031116 | J:92197
First Author: Yu J
Year: 2004
Journal: Dev Biol
Title: Transgenic RNAi-mediated reduction of MSY2 in mouse oocytes results in reduced fertility.
Volume: 268
Issue: 1
Pages: 195-206
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Publication
10433913 | J:56560
First Author: Rankin T
Year: 1999
Journal: Development
Title: Abnormal zonae pellucidae in mice lacking ZP1 result in early embryonic loss.
Volume: 126
Issue: 17
Pages: 3847-55
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Publication
21690297 | J:175085
First Author: Le Masson F
Year: 2011
Journal: Mol Cell Biol
Title: Identification of heat shock factor 1 molecular and cellular targets during embryonic and adult female meiosis.
Volume: 31
Issue: 16
Pages: 3410-23
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Publication
12376108 | J:79546
First Author: Yamagata K
Year: 2002
Journal: Dev Biol
Title: Sperm from the calmegin-deficient mouse have normal abilities for binding and fusion to the egg plasma membrane.
Volume: 250
Issue: 2
Pages: 348-57
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Publication
34977916 | J:326522
First Author: Nguyen H
Year: 2022
Journal: Biol Reprod
Title: Deletion of Orc4 during oogenesis severely reduces polar body extrusion and blocks zygotic DNA replication†.
Volume: 106
Issue: 4
Pages: 730-740
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Publication
18005958 | J:130120
First Author: Gershon E
Year: 2008
Journal: Dev Biol
Title: Oocyte-directed depletion of connexin43 using the Cre-LoxP system leads to subfertility in female mice.
Volume: 313
Issue: 1
Pages: 1-12
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Publication
18032785 | J:128531
First Author: Li TY
Year: 2007
Journal: J Cell Sci
Title: Rescue of oogenesis in Cx37-null mutant mice by oocyte-specific replacement with Cx43.
Volume: 120
Issue: Pt 23
Pages: 4117-25
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Publication
11331878 | J:90939
First Author: Jungnickel MK
Year: 2001
Journal: Nat Cell Biol
Title: Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3.
Volume: 3
Issue: 5
Pages: 499-502
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Publication
2385582 | J:10676
First Author: Chamberlin ME
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: Human homolog of the mouse sperm receptor.
Volume: 87
Issue: 16
Pages: 6014-8
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Publication
7508920 | J:17087
First Author: Kalab P
Year: 1994
Journal: J Biol Chem
Title: p95, the major phosphotyrosine-containing protein in mouse spermatozoa, is a hexokinase with unique properties.
Volume: 269
Issue: 5
Pages: 3810-7
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Publication
10216911 | J:53921
First Author: McCartney CA
Year: 1999
Journal: Zygote
Title: Cloning and characterisation of a zona pellucida 3 cDNA from a marsupial, the brushtail possum Trichosurus vulpecula.
Volume: 7
Issue: 1
Pages: 1-9
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Publication
10216914 | J:53922
First Author: Scobie GA
Year: 1999
Journal: Zygote
Title: Cloning, sequencing and site of origin of the rat sperm receptor protein, ZP3.
Volume: 7
Issue: 1
Pages: 27-35
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Publication
10456839 | J:57056
First Author: Bagavant H
Year: 1999
Journal: Biol Reprod
Title: Autoimmune ovarian inflammation triggered by proinflammatory (Th1) T cells is compatible with normal ovarian function in mice.
Volume: 61
Issue: 3
Pages: 635-42
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Publication
12074561 | J:77827
First Author: Carmona E
Year: 2002
Journal: Dev Biol
Title: Arylsulfatase a is present on the pig sperm surface and is involved in sperm-zona pellucida binding.
Volume: 247
Issue: 1
Pages: 182-96
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Publication
12654301 | J:82704
First Author: Stein P
Year: 2003
Journal: Dev Biol
Title: Transgenic RNAi in mouse oocytes: a simple and fast approach to study gene function.
Volume: 256
Issue: 1
Pages: 187-93
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Protein
Q62005
Organism: Mus musculus/domesticus
Length: 623  
Fragment?: false
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Protein
A0A140LHB2
Organism: Mus musculus/domesticus
Length: 423  
Fragment?: true
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Protein
Q059L1
Organism: Mus musculus/domesticus
Length: 623  
Fragment?: false
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Publication
28663440 | J:244834
First Author: Ho L
Year: 2017
Journal: Science
Title: ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice.
Volume: 357
Issue: 6352
Pages: 707-713
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Publication
11967891 | J:76341
First Author: Hevner RF
Year: 2002
Journal: J Comp Neurol
Title: Cortical and thalamic axon pathfinding defects in Tbr1, Gbx2, and Pax6 mutant mice: evidence that cortical and thalamic axons interact and guide each other.
Volume: 447
Issue: 1
Pages: 8-17
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Publication
24400092 | J:209947
First Author: Lin RS
Year: 2014
Journal: PLoS One
Title: Figla-Cre transgenic mice expressing myristoylated EGFP in germ cells provide a model for investigating perinatal oocyte dynamics.
Volume: 9
Issue: 1
Pages: e84477
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Publication
11731459 | J:72725
First Author: Martinez-Barbera JP
Year: 2001
Journal: Development
Title: Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2.
Volume: 128
Issue: 23
Pages: 4789-800
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Publication
10686600 | J:67903
First Author: de Vries WN
Year: 2000
Journal: Genesis
Title: Expression of Cre recombinase in mouse oocytes: a means to study maternal effect genes.
Volume: 26
Issue: 2
Pages: 110-2
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Publication
14749383 | J:93112
First Author: O'Donnell N
Year: 2004
Journal: Mol Cell Biol
Title: Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability.
Volume: 24
Issue: 4
Pages: 1680-90
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Publication
27046834 | J:240228
First Author: Balasooriya GI
Year: 2016
Journal: Dev Cell
Title: An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium.
Volume: 37
Issue: 1
Pages: 85-97
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Publication
26826184 | J:246427
First Author: Sousa Martins JP
Year: 2016
Journal: J Cell Sci
Title: DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation.
Volume: 129
Issue: 6
Pages: 1271-82
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Publication
32170089 | J:286388
First Author: Yang CR
Year: 2020
Journal: Nat Commun
Title: The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation.
Volume: 11
Issue: 1
Pages: 1399
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Publication
37155904 | J:342347
First Author: Ikami K
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Branched germline cysts and female-specific cyst fragmentation facilitate oocyte determination in mice.
Volume: 120
Issue: 20
Pages: e2219683120
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Publication
21309068 | J:170337
First Author: Pospichalova V
Year: 2011
Journal: Genesis
Title: Generation of two modified mouse alleles of the Hic1 tumor suppressor gene.
Volume: 49
Issue: 3
Pages: 142-51
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Publication
20015870 | J:212313
First Author: Takamatsu S
Year: 2010
Journal: Glycobiology
Title: Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and -IVb double deficient mice.
Volume: 20
Issue: 4
Pages: 485-97
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Publication
30952665 | J:293659
 
First Author: Daldello EM
Year: 2019
Journal: Development
Title: Cyclin B2 is required for progression through meiosis in mouse oocytes.
Volume: 146
Issue: 8
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Publication
36697412 | J:332850
First Author: Takahashi N
Year: 2023
Journal: Nat Commun
Title: CPEB1-dependent disruption of the mRNA translation program in oocytes during maternal aging.
Volume: 14
Issue: 1
Pages: 416
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Genotype
Genotype
Symbol: Zp3/Zp3 Tg(ZP3)7812Dean/?
Background: involves: 129S4/SvJae * C57BL/6J * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gbx2/Gbx2 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Figla/Figla Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Figla-EGFP,-icre)ZP3Dean/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Publication
8253842 | J:302574
First Author: Miller DJ
Year: 1993
Journal: J Cell Biol
Title: Egg cortical granule N-acetylglucosaminidase is required for the mouse zona block to polyspermy.
Volume: 123
Issue: 6 Pt 1
Pages: 1431-40
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Publication
11245577 | J:67817
First Author: Rankin TL
Year: 2001
Journal: Development
Title: Defective zonae pellucidae in Zp2-null mice disrupt folliculogenesis, fertility and development.
Volume: 128
Issue: 7
Pages: 1119-26
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Publication
8269854 | J:99375
First Author: Miller DJ
Year: 1993
Journal: Development
Title: Sperm require beta-N-acetylglucosaminidase to penetrate through the egg zona pellucida.
Volume: 118
Issue: 4
Pages: 1279-89
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•
Publication
8385033 | J:4310
First Author: Liang LF
Year: 1993
Journal: Dev Biol
Title: Conservation of mammalian secondary sperm receptor genes enables the promoter of the human gene to function in mouse oocytes.
Volume: 156
Issue: 2
Pages: 399-408
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•
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•
•
Publication
7556898 | J:28800
First Author: Johnston DS
Year: 1995
Journal: Dev Biol
Title: The gene encoding murine alpha 1,3-galactosyltransferase is expressed in female germ cells but not in male germ cells.
Volume: 171
Issue: 1
Pages: 224-32
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•
Publication
9266007 | J:42401
First Author: Afzalpurkar A
Year: 1997
Journal: Am J Reprod Immunol
Title: Identification of epitopes of monoclonal antibodies to porcine zona pellucida 3 beta glycoprotein, a homologue of the mouse/human sperm receptor.
Volume: 38
Issue: 1
Pages: 26-32
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Protein
Q8R4V5
Organism: Mus musculus/domesticus
Length: 546  
Fragment?: false
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•
•
•
•
Protein
A3KMM6
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: true
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•
•
•
Protein
Q91X17
Organism: Mus musculus/domesticus
Length: 642  
Fragment?: false
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•
•
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•
Protein
Q60997
Organism: Mus musculus/domesticus
Length: 2085  
Fragment?: false
•
•
•
•
•
Protein
O08523
Organism: Mus musculus/domesticus
Length: 2155  
Fragment?: false
•
•
•
•
•
Protein
B7ZWA6
Organism: Mus musculus/domesticus
Length: 2150  
Fragment?: false
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•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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