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Search results 3001 to 3100 out of 4701 for Bcl2

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Type Details Score
Allele
Name: G protein-coupled receptor 68; targeted mutation 1.1, Akihiro Harada
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: transgene insertion 535, Ruslan Medzhitov
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: beclin 1, autophagy related; targeted mutation 2.1, Beth Levine
Allele Type: Targeted
Attribute String: Constitutively active
Allele
Name: alcohol dehydrogenase, iron containing, 1; transposon insertion IR3.PV404, Junji Takeda
Allele Type: Transposon induced
Attribute String: Null/knockout
Allele
Name: AF4/FMR2 family, member 3; transposon insertion IR3.PV516, Junji Takeda
Allele Type: Transposon induced
Attribute String: Not Specified
Allele
Name: adhesion G protein-coupled receptor B3; transposon insertion PV449, Junji Takeda
Allele Type: Transposon induced
Attribute String: Reporter
Allele
Name: coiled-coil domain containing 3; transposon insertion PV449, Junji Takeda
Allele Type: Transposon induced
Attribute String: Reporter
Allele
Name: myeloid-associated differentiation marker; transposon insertion PV324, Junji Takeda
Allele Type: Transposon induced
Attribute String: Reporter
Allele
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4; transposon insertion PV630, Junji Takeda
Allele Type: Transposon induced
Attribute String: Reporter
Allele
Name: RAD54 like 2 (S. cerevisiae); transposon insertion PV405, Junji Takeda
Allele Type: Transposon induced
Attribute String: Reporter
Allele
Name: single-stranded DNA binding protein 2; transposon insertion PV486, Junji Takeda
Allele Type: Transposon induced
Attribute String: Reporter
Allele
Name: syntaxin 3; transposon insertion PV579, Junji Takeda
Allele Type: Transposon induced
Attribute String: Reporter
Allele
Name: transmembrane protein 117; transposon insertion PV416, Junji Takeda
Allele Type: Transposon induced
Attribute String: Reporter
Allele
Name: zinc finger protein 326; transposon insertion PV484, Junji Takeda
Allele Type: Transposon induced
Attribute String: Reporter
Allele
Name: transposon insertion PV250, Junji Takeda
Allele Type: Transposon induced
Attribute String: Reporter
Allele
Name: transposon insertion PV372, Junji Takeda
Allele Type: Transposon induced
Attribute String: Reporter
Genotype
Symbol: Fnip1/Fnip1 Tg(BCL2)22Wehi/?
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Caucheteux SM
Year: 2005
Journal: Int Immunol
Title: Pregnancy-induced alterations of B cell maturation and survival are differentially affected by Fas and Bcl-2, independently of BcR expression.
Volume: 17
Issue: 1
Pages: 55-63
Publication
First Author: Ota T
Year: 2008
Journal: Int Immunol
Title: Autoreactive B-cell elimination by pathogenic IgG specific for the same antigen: implications for peripheral tolerance.
Volume: 20
Issue: 10
Pages: 1351-60
Publication
First Author: Stohl W
Year: 2020
Journal: J Immunol
Title: Promotion of T Regulatory Cells in Mice by B Cells and BAFF.
Volume: 204
Issue: 9
Pages: 2416-2428
Publication
First Author: Iglesias M
Year: 2016
Journal: PLoS One
Title: Selective Impairment of TH17-Differentiation and Protection against Autoimmune Arthritis after Overexpression of BCL2A1 in T Lymphocytes.
Volume: 11
Issue: 7
Pages: e0159714
Publication
First Author: Sun B
Year: 2013
Journal: J Immunol
Title: Sox4 is required for the survival of pro-B cells.
Volume: 190
Issue: 5
Pages: 2080-9
Publication
First Author: Sitte S
Year: 2012
Journal: J Immunol
Title: JAB1 is essential for B cell development and germinal center formation and inversely regulates Fas ligand and Bcl6 expression.
Volume: 188
Issue: 6
Pages: 2677-86
Publication
First Author: Daffis S
Year: 2010
Journal: Nature
Title: 2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members.
Volume: 468
Issue: 7322
Pages: 452-6
Publication
First Author: Saitoh T
Year: 2011
Journal: Immunity
Title: Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.
Volume: 34
Issue: 3
Pages: 352-63
Publication
First Author: Gong W
Year: 2015
Journal: J Biol Chem
Title: Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex.
Volume: 290
Issue: 24
Pages: 15350-61
Publication
First Author: Dolfi DV
Year: 2011
Journal: J Immunol
Title: Dendritic cells and CD28 costimulation are required to sustain virus-specific CD8+ T cell responses during the effector phase in vivo.
Volume: 186
Issue: 8
Pages: 4599-608
Publication
First Author: Unterholzner L
Year: 2010
Journal: Nat Immunol
Title: IFI16 is an innate immune sensor for intracellular DNA.
Volume: 11
Issue: 11
Pages: 997-1004
Publication  
First Author: Xiong X
Year: 2014
Journal: Elife
Title: Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis.
Volume: 3
Pages: e02236
Publication
First Author: Kon N
Year: 2011
Journal: Cell Death Differ
Title: Roles of HAUSP-mediated p53 regulation in central nervous system development.
Volume: 18
Issue: 8
Pages: 1366-75
Publication
First Author: Wang J
Year: 2010
Journal: J Immunol
Title: NF-kappa B RelA subunit is crucial for early IFN-beta expression and resistance to RNA virus replication.
Volume: 185
Issue: 3
Pages: 1720-9
Publication
First Author: Xing Y
Year: 2016
Journal: Nat Immunol
Title: Late stages of T cell maturation in the thymus involve NF-κB and tonic type I interferon signaling.
Volume: 17
Issue: 5
Pages: 565-73
Publication
First Author: Velázquez P
Year: 2008
Journal: J Immunol
Title: Villous B cells of the small intestine are specialized for invariant NK T cell dependence.
Volume: 180
Issue: 7
Pages: 4629-38
Publication
First Author: Chang EY
Year: 2007
Journal: J Immunol
Title: Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production.
Volume: 178
Issue: 11
Pages: 6705-9
Publication
First Author: Imai Y
Year: 2008
Journal: Cell
Title: Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.
Volume: 133
Issue: 2
Pages: 235-49
Publication
First Author: Temizoz B
Year: 2015
Journal: Eur J Immunol
Title: TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN.
Volume: 45
Issue: 4
Pages: 1159-69
Publication
First Author: Dietrich N
Year: 2010
Journal: PLoS One
Title: Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartments.
Volume: 5
Issue: 4
Pages: e10250
Publication
First Author: Humpton TJ
Year: 2021
Journal: Genes Dev
Title: Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice.
Volume: 35
Issue: 1-2
Pages: 117-132
Publication  
First Author: Lu Z
Year: 2014
Journal: Nat Commun
Title: Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.
Volume: 5
Pages: 3463
Publication
First Author: Chen S
Year: 2008
Journal: J Immunol
Title: Chlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activation.
Volume: 181
Issue: 10
Pages: 7186-93
Publication
First Author: Chessler AD
Year: 2008
Journal: J Immunol
Title: A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts.
Volume: 181
Issue: 11
Pages: 7917-24
Publication
First Author: Yount JS
Year: 2008
Journal: J Immunol
Title: MDA5 participates in the detection of paramyxovirus infection and is essential for the early activation of dendritic cells in response to Sendai Virus defective interfering particles.
Volume: 180
Issue: 7
Pages: 4910-8
Publication
First Author: Rongvaux A
Year: 2014
Journal: Cell
Title: Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.
Volume: 159
Issue: 7
Pages: 1563-77
Publication
First Author: Van den Ackerveken P
Year: 2017
Journal: Cell Death Differ
Title: The miR-183/ItgA3 axis is a key regulator of prosensory area during early inner ear development.
Volume: 24
Issue: 12
Pages: 2054-2065
Publication
First Author: Ma F
Year: 2015
Journal: EMBO Rep
Title: Positive feedback regulation of type I interferon by the interferon-stimulated gene STING.
Volume: 16
Issue: 2
Pages: 202-12
Publication
First Author: Kobayashi H
Year: 2015
Journal: Cell Rep
Title: Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING.
Volume: 11
Issue: 1
Pages: 71-84
Publication
First Author: Lazear HM
Year: 2013
Journal: PLoS Pathog
Title: IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling.
Volume: 9
Issue: 1
Pages: e1003118
Publication
First Author: Mukherjee P
Year: 2013
Journal: Immunity
Title: Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death.
Volume: 38
Issue: 4
Pages: 705-16
Publication
First Author: del Fresno C
Year: 2013
Journal: Immunity
Title: Interferon-β production via Dectin-1-Syk-IRF5 signaling in dendritic cells is crucial for immunity to C. albicans.
Volume: 38
Issue: 6
Pages: 1176-86
Publication
First Author: Wang J
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Effective and lesion-free cutaneous influenza vaccination.
Volume: 112
Issue: 16
Pages: 5005-10
Publication
First Author: Kamran N
Year: 2013
Journal: PLoS One
Title: Toll-like receptor ligands induce expression of the costimulatory molecule CD155 on antigen-presenting cells.
Volume: 8
Issue: 1
Pages: e54406
Publication
First Author: Taylor KG
Year: 2014
Journal: J Virol
Title: Age-dependent myeloid dendritic cell responses mediate resistance to la crosse virus-induced neurological disease.
Volume: 88
Issue: 19
Pages: 11070-9
Publication
First Author: You F
Year: 2013
Journal: Nat Immunol
Title: ELF4 is critical for induction of type I interferon and the host antiviral response.
Volume: 14
Issue: 12
Pages: 1237-46
Publication
First Author: Negishi H
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Beneficial innate signaling interference for antibacterial responses by a Toll-like receptor-mediated enhancement of the MKP-IRF3 axis.
Volume: 110
Issue: 49
Pages: 19884-9
Publication
First Author: Sander LE
Year: 2011
Journal: Nature
Title: Detection of prokaryotic mRNA signifies microbial viability and promotes immunity.
Volume: 474
Issue: 7351
Pages: 385-9
Publication
First Author: Ono C
Year: 2014
Journal: J Virol
Title: Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells.
Volume: 88
Issue: 4
Pages: 2157-67
Publication
First Author: Okabe Y
Year: 2008
Journal: Eur J Immunol
Title: IFN regulatory factor (IRF) 3/7-dependent and -independent gene induction by mammalian DNA that escapes degradation.
Volume: 38
Issue: 11
Pages: 3150-8
Publication
First Author: Migliorini D
Year: 2011
Journal: J Clin Invest
Title: Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice.
Volume: 121
Issue: 4
Pages: 1329-43
Publication
First Author: Taniguchi Y
Year: 2017
Journal: Arthritis Rheumatol
Title: Regulation of Chondrocyte Survival in Mouse Articular Cartilage by p63.
Volume: 69
Issue: 3
Pages: 598-609
Publication
First Author: Lin X
Year: 2024
Journal: Mol Cell
Title: Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts.
Volume: 84
Issue: 20
Pages: 3916-3931.e7
HT Experiment
Series Id: GSE7020
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: E-GEOD-38741
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment
Series Id: E-GEOD-79035
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Xiang Z
Year: 2010
Journal: J Clin Invest
Title: Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.
Volume: 120
Issue: 6
Pages: 2109-18
Publication
First Author: Djajawi TM
Year: 2020
Journal: Cell Death Differ
Title: MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex.
Volume: 27
Issue: 8
Pages: 2484-2499
Publication
First Author: Fernandes R
Year: 2012
Journal: Biol Reprod
Title: NLRP5 mediates mitochondrial function in mouse oocytes and embryos.
Volume: 86
Issue: 5
Pages: 138, 1-10
Publication
First Author: Hanson CH
Year: 2023
Journal: Cell Rep
Title: CD62L expression marks a functionally distinct subset of memory B cells.
Volume: 42
Issue: 12
Pages: 113542
Publication
First Author: Brescia P
Year: 2018
Journal: Cancer Cell
Title: MEF2B Instructs Germinal Center Development and Acts as an Oncogene in B Cell Lymphomagenesis.
Volume: 34
Issue: 3
Pages: 453-465.e9
Protein
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 51  
Fragment?: true
Publication
First Author: Chakraborty M
Year: 2001
Journal: Cancer Res
Title: Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression.
Volume: 61
Issue: 19
Pages: 7255-63
Publication
First Author: Johnstone RW
Year: 1996
Journal: Mol Cell Biol
Title: A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1.
Volume: 16
Issue: 12
Pages: 6945-56
Publication
First Author: Xie J
Year: 2005
Journal: J Biol Chem
Title: PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein.
Volume: 280
Issue: 14
Pages: 13824-32
Protein Domain
Type: Family
Description: Prostate apoptosis response 4 (Par-4) induced apoptosis of selective prostate cancer cells PC-3, DU-145, and TSU-Pr and caused tumor regression by inhibition of NF-kappaB activity and cell membrane trafficking of Fas and FasL that leads to the activation of the Fas-Fas-associated death domain-caspase-8 pro-death pathway []. It modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1. It down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1 []. Par-4 also regulates the amyloid precursor protein (APP) cleavage activity of BACE1 [].
Publication
First Author: Healy ME
Year: 2020
Journal: Gastroenterology
Title: MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice.
Volume: 159
Issue: 1
Pages: 183-199
Publication
First Author: Wakatsuki S
Year: 2017
Journal: J Cell Biol
Title: GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration.
Volume: 216
Issue: 2
Pages: 477-493
Publication
First Author: Weng SY
Year: 2011
Journal: J Hepatol
Title: Synergism between p53 and Mcl-1 in protecting from hepatic injury, fibrosis and cancer.
Volume: 54
Issue: 4
Pages: 685-94
Publication
First Author: Landsman L
Year: 2009
Journal: Blood
Title: CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival.
Volume: 113
Issue: 4
Pages: 963-72
Publication
First Author: Jensen CT
Year: 2008
Journal: Blood
Title: Permissive roles of hematopoietin and cytokine tyrosine kinase receptors in early T-cell development.
Volume: 111
Issue: 4
Pages: 2083-90
Publication
First Author: Simon DJ
Year: 2012
Journal: J Neurosci
Title: A caspase cascade regulating developmental axon degeneration.
Volume: 32
Issue: 49
Pages: 17540-53
Publication
First Author: Jackson JT
Year: 2020
Journal: Eur J Immunol
Title: Hhex regulates murine lymphoid progenitor survival independently of Stat5 and Cdkn2a.
Volume: 50
Issue: 7
Pages: 959-971
Publication
First Author: Knittel G
Year: 2016
Journal: Blood
Title: B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice.
Volume: 127
Issue: 22
Pages: 2732-41
Publication
First Author: Müller L
Year: 2017
Journal: Sci Rep
Title: The corepressor NCOR1 regulates the survival of single-positive thymocytes.
Volume: 7
Issue: 1
Pages: 15928
Publication
First Author: Niebuhr B
Year: 2013
Journal: Blood
Title: Runx1 is essential at two stages of early murine B-cell development.
Volume: 122
Issue: 3
Pages: 413-23
Publication
First Author: Palmer VL
Year: 2015
Journal: J Immunol
Title: VprBP Is Required for Efficient Editing and Selection of Igκ+ B Cells, but Is Dispensable for Igλ+ and Marginal Zone B Cell Maturation and Selection.
Volume: 195
Issue: 4
Pages: 1524-37
Publication
First Author: Coffre M
Year: 2016
Journal: Cell Rep
Title: miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation.
Volume: 17
Issue: 9
Pages: 2271-2285
Publication    
First Author: Burger ML
Year: 2014
Journal: Elife
Title: T cell-specific inhibition of multiple apoptotic pathways blocks negative selection and causes autoimmunity.
Volume: 3
Protein
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: true
Publication
First Author: Walter L
Year: 1995
Journal: Genomics
Title: Identification of a novel conserved human gene, TEGT.
Volume: 28
Issue: 2
Pages: 301-4
Publication
First Author: Albu DI
Year: 2007
Journal: J Exp Med
Title: BCL11B is required for positive selection and survival of double-positive thymocytes.
Volume: 204
Issue: 12
Pages: 3003-15
Publication
First Author: Brady BL
Year: 2013
Journal: J Immunol
Title: Requirement for dicer in survival of proliferating thymocytes experiencing DNA double-strand breaks.
Volume: 190
Issue: 7
Pages: 3256-66
Publication  
First Author: Tam H
Year: 2024
Journal: J Exp Med
Title: Phosphatidylserine phospholipase A1 enables GPR34-dependent immune cell accumulation in the peritoneal cavity.
Volume: 221
Issue: 11
Publication
First Author: Campbell KJ
Year: 2012
Journal: Cell Death Differ
Title: Elevated Mcl-1 inhibits thymocyte apoptosis and alters thymic selection.
Volume: 19
Issue: 12
Pages: 1962-71
Publication
First Author: Turnis ME
Year: 2021
Journal: Blood
Title: Requirement for antiapoptotic MCL-1 during early erythropoiesis.
Volume: 137
Issue: 14
Pages: 1945-1958
Publication
First Author: Lassot I
Year: 2010
Journal: Cell Death Differ
Title: Trim17, a novel E3 ubiquitin-ligase, initiates neuronal apoptosis.
Volume: 17
Issue: 12
Pages: 1928-41
Publication
First Author: Wilkinson B
Year: 2001
Journal: Cell Immunol
Title: Requirement for sustained MAPK signaling in both CD4 and CD8 lineage commitment: a threshold model.
Volume: 211
Issue: 2
Pages: 86-95
Publication
First Author: Selimi F
Year: 2000
Journal: J Neurosci
Title: Bax inactivation in lurcher mutants rescues cerebellar granule cells but not purkinje cells or inferior olivary neurons.
Volume: 20
Issue: 14
Pages: 5339-45