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Search results 3001 to 3100 out of 4514 for Cdc42

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Type Details Score
Protein Domain
Type: Domain
Description: Ephexin-1 is a RhoGEF (Rho-type guanine nucleotide exchange factor) that activates RhoA, Tac1, and Cdc42 by exchanging bound GDP for free GTP []. It is expressed mainly in the brain in a region associated with movement control. It regulates the stability of postsynaptic acetylcholine receptor (AChR) clusters and thus plays a critical role in the maturation and neurotransmission of neuromuscular junctions []. Ephexin-1 directly interacts with the ephrin receptor EphA4 and their coexpression enhances the ability of ephexin-1 to activate RhoA []. It is required for normal axon growth and EphA-induced growth cone collapse []. Ephexin-1 contains RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH) and SH3 domains. This entry represents the SH3 domain.
Protein Domain
Type: Domain
Description: This entry represents the SH3 domain found in srGAP proteins 1, 2 and 3. srGAP1 (also called ARHGAP13) is a key GTPase activating protein (GAP) downstream of Slit-Robo pathway, and has been shown to inhibit neuronal migration and glioma cell invasion by reducing the activation of Cdc42 []. srGAP2 (ARHGAP34) regulates neuronal morphogenesis through the ability of its F-BAR domain to regulate membrane deformation and induce filopodia formation []. srGAP3 (ARHGAP14) interacts with lamellipodin at the cell membrane and regulates Rac-dependent cellular protrusions []. The SLIT-ROBO Rho GTPase-activating protein (srGAP) family consists of four members: srGAP1, -2, -3 and -4. They contain F-BAR, RhoGAP and SH3 domains. Their RhoGAP domain is involved in negative regulation of Rho GTPase activities important for cytoskeleton rearrangement []. The srGAP family members have an "inverse F-BAR"or IF-BAR domain that is distinct from other F-BAR domains such as FBP17. They are multifunctional adaptor proteins involved in various aspects of neuronal development [].
Protein Domain
Type: Domain
Description: This entry represents the SH3 domain of srGAP4. srGAP4 is highly expressed in hematopoietic cells and may play a role in lymphocyte differentiation []. It is able to stimulate the GTPase activity of three members of Rho GTPases, Rac1, Cdc42 and RhoA. In the nervous system, srGAP4 has been detected in differentiating neurites and may be involved in axon and dendritic growth [].The SLIT-ROBO Rho GTPase-activating protein (srGAP) family consists of four members: srGAP1, -2, -3 and -4. They contain F-BAR, RhoGAP and SH3 domains. Their RhoGAP domain is involved in negative regulation of Rho GTPase activities important for cytoskeleton rearrangement []. The srGAP family members have an "inverse F-BAR"or IF-BAR domain that is distinct from other F-BAR domains such as FBP17. They are multifunctional adaptor proteins involved in various aspects of neuronal development [].
Protein Domain
Type: Domain
Description: VAV2 is widely expressed and functions as a guanine nucleotide exchange factor (GEF) for RhoA, RhoB and RhoG and also activates Rac1 and Cdc42 []. It is implicated in many cellular and physiological functions including blood pressure control, eye development, neurite outgrowth and branching, EGFR endocytosis and degradation, and cell cluster morphology, among others [, , , , ]. It has been reported to associate with Nek3. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The SH3 domain of VAV is involved in the localization of proteins to specific sites within the cell, by interacting with proline-rich sequences within target proteins [, , ].This entry represents the second SH3 domain of VAV2.
Protein Domain
Type: Domain
Description: VAV2 is widely expressed and functions as a guanine nucleotide exchange factor (GEF) for RhoA, RhoB and RhoG and also activates Rac1 and Cdc42 []. It is implicated in many cellular and physiological functions including blood pressure control, eye development, neurite outgrowth and branching, EGFR endocytosis and degradation, and cell cluster morphology, among others [, , , , ]. It has been reported to associate with Nek3. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The SH3 domain of VAV is involved in the localization of proteins to specific sites within the cell, by interacting with proline-rich sequences within target proteins [, , ].This entry represents the first SH3 domain of VAV2.
Protein Domain
Type: Domain
Description: Intersectin-2 (ITSN2) is an adaptor protein that functions in exo- and endocytosis, actin cytoskeletal reorganization, and signal transduction []. It plays a role in clathrin-coated pit (CCP) formation []. It binds to many proteins through its multidomain structure and facilitates the assembly of multimeric complexes. ITSN2 also functions as a specific GEF for Cdc42 activation in epithelial morphogenesis, and is required in mitotic spindle orientation []. It exists in alternatively spliced short and long isoforms. The short isoform contains two Eps15 homology domains (EH1 and EH2), a coiled-coil region and five SH3 domains (SH3A-E), while the long isoform, in addition, contains RhoGEF (also called Dbl-homologous or DH), Pleckstrin homology (PH) and C2 domains. This entry represents the first SH3 domain of ITSN2.
Protein Domain
Type: Domain
Description: Intersectin-2 (ITSN2) is an adaptor protein that functions in exo- and endocytosis, actin cytoskeletal reorganization, and signal transduction []. It plays a role in clathrin-coated pit(CCP) formation []. It binds to many proteins through its multidomain structure and facilitates the assembly of multimeric complexes. ITSN2 also functions as a specific GEF for Cdc42 activation in epithelial morphogenesis, and is required in mitotic spindle orientation []. It exists in alternatively spliced short and long isoforms. The short isoform contains two Eps15 homology domains (EH1 and EH2), a coiled-coil region and five SH3 domains (SH3A-E), while the long isoform, in addition, contains RhoGEF (also called Dbl-homologous or DH), Pleckstrin homology (PH) and C2 domains. This entry represents the second SH3 domain of ITSN2.
Protein Domain
Type: Domain
Description: Intersectin-2 (ITSN2) is an adaptor protein that functions in exo- and endocytosis, actin cytoskeletal reorganization, and signal transduction []. It plays a role in clathrin-coated pit (CCP) formation []. It binds to many proteins through its multidomain structure and facilitates the assembly of multimeric complexes. ITSN2 also functions as a specific GEF for Cdc42 activation in epithelial morphogenesis, and is required in mitotic spindle orientation []. It exists in alternatively spliced short and long isoforms. The short isoform contains two Eps15 homology domains (EH1 and EH2), a coiled-coil region and five SH3 domains (SH3A-E), while the long isoform, in addition, contains RhoGEF (also called Dbl-homologous or DH), Pleckstrin homology (PH) and C2 domains. This entry represents the third SH3 domain of ITSN2.
Protein Domain
Type: Domain
Description: Intersectin-2 (ITSN2) is an adaptor protein that functions in exo- and endocytosis, actin cytoskeletal reorganization, and signal transduction []. It plays a role in clathrin-coated pit (CCP) formation []. It binds to many proteins through its multidomain structure and facilitates the assembly of multimeric complexes. ITSN2 also functions as a specific GEF for Cdc42 activation in epithelial morphogenesis, and is required in mitotic spindle orientation []. It exists in alternatively spliced short and long isoforms. The short isoform contains two Eps15 homology domains (EH1 and EH2), a coiled-coil region and five SH3 domains (SH3A-E), while the long isoform, in addition, contains RhoGEF (also called Dbl-homologous or DH), Pleckstrin homology (PH) and C2 domains. This entry represents the fourth SH3 domain of ITSN2.
Protein Domain
Type: Domain
Description: Intersectin-2 (ITSN2) is an adaptor protein that functions in exo- and endocytosis, actin cytoskeletal reorganization, and signal transduction []. It plays a role in clathrin-coated pit (CCP) formation []. It binds to many proteins through its multidomain structure and facilitates the assembly of multimeric complexes. ITSN2 also functions as a specific GEF for Cdc42 activation in epithelial morphogenesis, and is required in mitotic spindle orientation []. It exists in alternatively spliced short and long isoforms. The short isoform contains two Eps15 homology domains (EH1 and EH2), a coiled-coil region and five SH3 domains (SH3A-E), while the long isoform, in addition, contains RhoGEF (also called Dbl-homologous or DH), Pleckstrin homology (PH) and C2 domains. This entry represents the fifth SH3 domain of ITSN2.
Protein Domain
Type: Domain
Description: Beta-PIX, also called Rho guanine nucleotide exchange factor 7 (ARHGEF7) or Cool (Cloned out of Library)-1, activates small GTPases by exchanging bound GDP for free GTP. It acts as a GEF for both Cdc42 and Rac1 [], and plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion [, , , ].PIX proteins contain an N-terminal SH3 domain followed by RhoGEF (also called Dbl-homologous or DH) and Pleckstrin Homology (PH) domains, and a C-terminal leucine-zipper domain for dimerization. The SH3 domain of PIX binds to an atypical PxxxPR motif in p21-activated kinases (PAKs) with high affinity. The binding of PAKs to PIX facilitate the localization of PAKs to focal complexes and also localizes PAKs to PIX targets Cdc43 and Rac, leading to the activation of PAKs [, ].This entry represents the SH3 domain of beta-PIX.
Protein Domain
Type: Family
Description: PAK2 plays a role in pro-apoptotic signaling. It is cleaved and activated by caspases leading to morphological changes during apoptosis []. PAK2 is also activated in response to a variety of stresses including DNA damage, hyperosmolarity, serum starvation, and contact inhibition, and may play a role in coordinating the stress response []. PAK2 also contributes to cancer cell invasion through a mechanism distinct from that of PAK1 []. PAK2 belongs to the group I PAKs.Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac [].
Protein Domain
Type: Family
Description: PAK6 may play a role in stress responses through its activation by the mitogen-activated protein kinase (MAPK) p38 and MAPK kinase 6 (MKK6) pathway []. PAK6 is highly expressed in the brain. It is not required for viability, but together with PAK5, it is required for normal levels of locomotion and activity, and for learning and memory []. Increased expression of PAK6 is found in primary and metastatic prostate cancer [].PAK6 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites []. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac [].
Protein Domain
Type: Family
Description: Abr (active breakpoint cluster region-related protein) and Bcr (breakpoint cluster region protein) are homologous proteins containing a C-terminal domain with GTPase-activating protein (GAP) activity specific for Rac. They control multiple cellular functions of murine macrophages []. They contain several domains, including tandem DH-PH, C2 and GAP domains. Bcr has an extra N-terminal oligomerization domain []. Bcr has been shown to fused to Abl tyrosine kinase in leukemia. The fusion of Bcr to Abl deregulates the tyrosine kinase activity of Abl []. The N-terminal oligomerization domain is thought to be the most critical component that allows the formation of homo-tetramer Bcr/Abl complexes and deregulates the Abl tyrosine kinase [, ]. The GTPase-activating activity of Bcr has been shown to be regulated by transglutaminase 2 (TG2), a multifunctional protein that has been implicated in numerous pathologies including that of neurodegeneration and celiac disease [, ].Abr is a critical regulator of Rho and Cdc42 during the single cell wound healing [].
Protein Domain
Type: Domain
Description: Rho GTPase-activating protein 26 (ARHGAP26), also known as GTPase regulator associated with focal adhesion kinase (GRAF), is a GTPase-activating protein for the small GTPases of the Rho family RhoA and CDC42 [, ]. GRAF influences cytoskeletal changes mediated by Rho proteins []. It is recognised as a tumor suppressor []. GRAF contains an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, a Rho GAP domain, and a C-terminal SH3 domain. The SH3 domain of GRAF binds PKNbeta, a target of the small GTPase Rho [].This entry represents the BAR domain of GRAF. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions. The BAR domain of GRAF directly interacts with its Rho GAP domain and inhibits its activity. Autoinhibited GRAF is capable of binding membranes and tubulating liposomes, showing that the membrane-tubulation and GAP-inhibitory functions of the BAR domain can occur simultaneously [].
Protein Domain
Type: Family
Description: NDE-like 1 (NDEL1/NUDEL) and its paralogue, NDE, are involved in mitosis and neurodevelopment that have been implicated in psychiatric and neurodevelopmental disorders. NDEL1 contains the N-terminal LIS1-binding domain that stimulates the movement of dynein and the C-terminal domain that causes dynein-microtubule dissociation [, , ]. It can also bind the motor domain of dynein in its heavy-chain []. It has been shown to affect many aspects of dynein function, such as transport along the microtubule network of vesicles and lysosomes, with effects on the correct structure of the Golgi apparatus, as well as on the transport of intermediate filament proteins, short microtubules and viral glycoproteins. Its phosphorilation by Aurora-A kinase is essential for centrosomal separation and mitotic entry []. It also facilitates neurofilament polymerization, promotes axonal regeneration, regulates Cdc42 at the leading edge of migrating neurons and the GTPase activity of the microtubule remodeling protein Dynamin 2, etc [, ].
Protein
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: true
Publication
First Author: Bokoch GM
Year: 1998
Journal: Cell Death Differ
Title: Caspase-mediated activation of PAK2 during apoptosis: proteolytic kinase activation as a general mechanism of apoptotic signal transduction?
Volume: 5
Issue: 8
Pages: 637-45
Publication  
First Author: Roig J
Year: 2001
Journal: Vitam Horm
Title: Cytostatic p21 G protein-activated protein kinase gamma-PAK.
Volume: 62
Pages: 167-98
Publication
First Author: Coniglio SJ
Year: 2008
Journal: Mol Cell Biol
Title: Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms.
Volume: 28
Issue: 12
Pages: 4162-72
Publication
First Author: Moon MS
Year: 2010
Journal: Mol Cell Neurosci
Title: Balanced Vav2 GEF activity regulates neurite outgrowth and branching in vitro and in vivo.
Volume: 44
Issue: 2
Pages: 118-28
Publication
First Author: Thalappilly S
Year: 2010
Journal: Oncogene
Title: VAV2 regulates epidermal growth factor receptor endocytosis and degradation.
Volume: 29
Issue: 17
Pages: 2528-39
Publication
First Author: Sauzeau V
Year: 2010
Journal: J Clin Invest
Title: The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells.
Volume: 120
Issue: 1
Pages: 315-30
Publication
First Author: Holthusen K
Year: 2009
Journal: Am J Ther
Title: Guanine exchange factor Vav2: a novel potential target for the development of drugs effective in the prevention of papillomavirus infection and disease.
Volume: 16
Issue: 6
Pages: 496-507
Publication
First Author: Arora PD
Year: 2008
Journal: Am J Physiol Cell Physiol
Title: Collagen phagocytosis is regulated by the guanine nucleotide exchange factor Vav2.
Volume: 295
Issue: 1
Pages: C130-7
Publication
First Author: Nie J
Year: 2012
Journal: J Biol Chem
Title: Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells.
Volume: 287
Issue: 31
Pages: 26435-44
Publication
First Author: Bagrodia S
Year: 1999
Journal: J Biol Chem
Title: A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins.
Volume: 274
Issue: 32
Pages: 22393-400
Publication
First Author: Kuroiwa M
Year: 2011
Journal: J Cell Sci
Title: The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation.
Volume: 124
Issue: Pt 10
Pages: 1726-38
Publication
First Author: Sakai H
Year: 2006
Journal: Bone
Title: Activated c-Fms recruits Vav and Rac during CSF-1-induced cytoskeletal remodeling and spreading in osteoclasts.
Volume: 39
Issue: 6
Pages: 1290-301
Publication
First Author: Sampaio NG
Year: 2011
Journal: J Cell Sci
Title: Phosphorylation of CSF-1R Y721 mediates its association with PI3K to regulate macrophage motility and enhancement of tumor cell invasion.
Volume: 124
Issue: Pt 12
Pages: 2021-31
Publication
First Author: Neudauer CL
Year: 2001
Journal: Biochem Biophys Res Commun
Title: PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10.
Volume: 280
Issue: 2
Pages: 541-7
Publication
First Author: Yamaguchi A
Year: 1997
Journal: J Biol Chem
Title: An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1.
Volume: 272
Issue: 50
Pages: 31230-4
Publication
First Author: Jenna S
Year: 2002
Journal: J Biol Chem
Title: The activity of the GTPase-activating protein CdGAP is regulated by the endocytic protein intersectin.
Volume: 277
Issue: 8
Pages: 6366-73
Publication
First Author: Kurogane Y
Year: 2012
Journal: Arterioscler Thromb Vasc Biol
Title: FGD5 mediates proangiogenic action of vascular endothelial growth factor in human vascular endothelial cells.
Volume: 32
Issue: 4
Pages: 988-96
Publication
First Author: Holland PM
Year: 1997
Journal: J Biol Chem
Title: MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous.
Volume: 272
Issue: 40
Pages: 24994-8
Publication
First Author: Foltz IN
Year: 1998
Journal: J Biol Chem
Title: Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli.
Volume: 273
Issue: 15
Pages: 9344-51
Publication  
First Author: Yuan Z
Year: 2019
Journal: Cells
Title: Agenesis and Hypomyelination of Corpus Callosum in Mice Lacking Nsun5, an RNA Methyltransferase.
Volume: 8
Issue: 6
Publication
First Author: Kreis P
Year: 2007
Journal: J Biol Chem
Title: The p21-activated kinase 3 implicated in mental retardation regulates spine morphogenesis through a Cdc42-dependent pathway.
Volume: 282
Issue: 29
Pages: 21497-506
Publication
First Author: Shaheen R
Year: 2011
Journal: Am J Hum Genet
Title: Recessive mutations in DOCK6, encoding the guanidine nucleotide exchange factor DOCK6, lead to abnormal actin cytoskeleton organization and Adams-Oliver syndrome.
Volume: 89
Issue: 2
Pages: 328-33
Publication
First Author: Ikeda W
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Identification of splicing variants of Frabin with partly different functions and tissue distribution.
Volume: 286
Issue: 5
Pages: 1066-72
Publication
First Author: Bryan BA
Year: 2005
Journal: Mol Cell Biol
Title: Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT.
Volume: 25
Issue: 24
Pages: 11089-101
Publication
First Author: Gerwins P
Year: 1997
Journal: J Biol Chem
Title: Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway.
Volume: 272
Issue: 13
Pages: 8288-95
Publication
First Author: Himmel KL
Year: 2002
Journal: J Biol Chem
Title: Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias.
Volume: 277
Issue: 16
Pages: 13463-72
Publication
First Author: Quilliam LA
Year: 1996
Journal: J Biol Chem
Title: Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling.
Volume: 271
Issue: 46
Pages: 28772-6
Publication
First Author: Benesch S
Year: 2002
Journal: J Biol Chem
Title: Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2.
Volume: 277
Issue: 40
Pages: 37771-6
Publication
First Author: Zhao C
Year: 2003
Journal: J Biol Chem
Title: GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2.
Volume: 278
Issue: 36
Pages: 34641-53
Publication
First Author: Vignal E
Year: 2000
Journal: J Biol Chem
Title: Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42.
Volume: 275
Issue: 46
Pages: 36457-64
Publication
First Author: Dong X
Year: 2005
Journal: Curr Biol
Title: P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils.
Volume: 15
Issue: 20
Pages: 1874-9
Publication
First Author: Vartiainen M
Year: 2000
Journal: Mol Cell Biol
Title: Mouse A6/twinfilin is an actin monomer-binding protein that localizes to the regions of rapid actin dynamics.
Volume: 20
Issue: 5
Pages: 1772-83
Publication
First Author: Harada A
Year: 2000
Journal: J Biol Chem
Title: Nadrin, a novel neuron-specific GTPase-activating protein involved in regulated exocytosis.
Volume: 275
Issue: 47
Pages: 36885-91
Publication
First Author: Fukuoka M
Year: 2001
Journal: J Cell Biol
Title: A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42.
Volume: 152
Issue: 3
Pages: 471-82
Publication
First Author: Komai K
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Characterization of novel splicing variants of the mouse MCF-2 (DBL) proto-oncogene.
Volume: 309
Issue: 4
Pages: 906-9
Publication
First Author: Chen Y
Year: 2013
Journal: Blood
Title: Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling.
Volume: 122
Issue: 10
Pages: 1695-706
Publication
First Author: Cotteret S
Year: 2003
Journal: Mol Cell Biol
Title: p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD.
Volume: 23
Issue: 16
Pages: 5526-39
Publication
First Author: Miyashita M
Year: 2004
Journal: Mol Biol Cell
Title: Promotion of neurite and filopodium formation by CD47: roles of integrins, Rac, and Cdc42.
Volume: 15
Issue: 8
Pages: 3950-63
Publication
First Author: Liu Y
Year: 2017
Journal: J Am Soc Nephrol
Title: Variations in MicroRNA-25 Expression Influence the Severity of Diabetic Kidney Disease.
Volume: 28
Issue: 12
Pages: 3627-3638
Publication
First Author: Meseke M
Year: 2013
Journal: Eur J Neurosci
Title: Reelin and the Cdc42/Rac1 guanine nucleotide exchange factor αPIX/Arhgef6 promote dendritic Golgi translocation in hippocampal neurons.
Volume: 37
Issue: 9
Pages: 1404-12
Publication    
First Author: Burbage M
Year: 2018
Journal: Elife
Title: Tuning of in vivo cognate B-T cell interactions by Intersectin 2 is required for effective anti-viral B cell immunity.
Volume: 7
Publication
First Author: Gur-Cohen S
Year: 2015
Journal: Nat Med
Title: PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.
Volume: 21
Issue: 11
Pages: 1307-17
Publication
First Author: Palmer E
Year: 2016
Journal: Eur J Immunol
Title: Opposing effects of actin signaling and LFA-1 on establishing the affinity threshold for inducing effector T-cell responses in mice.
Volume: 46
Issue: 8
Pages: 1887-901
Publication
First Author: Díaz-Muñoz MD
Year: 2013
Journal: J Immunol
Title: Cyclooxygenase-2 deficiency in macrophages leads to defective p110γ PI3K signaling and impairs cell adhesion and migration.
Volume: 191
Issue: 1
Pages: 395-406
Publication
First Author: Wang QQ
Year: 2008
Journal: J Immunol
Title: Integrin beta 1 regulates phagosome maturation in macrophages through Rac expression.
Volume: 180
Issue: 4
Pages: 2419-28
Publication
First Author: Azim AC
Year: 2007
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Regulation of cyclooxygenase-2 expression by small GTPase Rac2 in bone marrow macrophages.
Volume: 293
Issue: 3
Pages: L668-73
Publication
First Author: Long T
Year: 2022
Journal: Gut
Title: RNA binding protein DDX5 directs tuft cell specification and function to regulate microbial repertoire and disease susceptibility in the intestine.
Volume: 71
Issue: 9
Pages: 1790-1802
Publication
First Author: Drabek K
Year: 2006
Journal: Curr Biol
Title: Role of CLASP2 in microtubule stabilization and the regulation of persistent motility.
Volume: 16
Issue: 22
Pages: 2259-64
Publication
First Author: Lee JJ
Year: 2013
Journal: Infect Immun
Title: Toll-like receptor 4-linked Janus kinase 2 signaling contributes to internalization of Brucella abortus by macrophages.
Volume: 81
Issue: 7
Pages: 2448-58
Publication
First Author: Kempf T
Year: 2011
Journal: Nat Med
Title: GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice.
Volume: 17
Issue: 5
Pages: 581-8
Publication
First Author: Ishihara D
Year: 2012
Journal: PLoS One
Title: The chemotactic defect in wiskott-Aldrich syndrome macrophages is due to the reduced persistence of directional protrusions.
Volume: 7
Issue: 1
Pages: e30033
Publication
First Author: Westerberg L
Year: 2001
Journal: Blood
Title: Cdc42, Rac1, and the Wiskott-Aldrich syndrome protein are involved in the cytoskeletal regulation of B lymphocytes.
Volume: 98
Issue: 4
Pages: 1086-94
Publication
First Author: Murata T
Year: 2006
Journal: J Neurosci
Title: CD47 promotes neuronal development through Src- and FRG/Vav2-mediated activation of Rac and Cdc42.
Volume: 26
Issue: 48
Pages: 12397-407
Publication
First Author: Takatsuka A
Year: 2008
Journal: Dev Biol
Title: Ablation of Csk in neural crest lineages causes corneal anomaly by deregulating collagen fibril organization and cell motility.
Volume: 315
Issue: 2
Pages: 474-88
Publication
First Author: Miyamoto Y
Year: 2013
Journal: Sci Signal
Title: Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons.
Volume: 6
Issue: 265
Pages: ra15
Publication
First Author: Chen Y
Year: 2018
Journal: PLoS One
Title: Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice.
Volume: 13
Issue: 10
Pages: e0199341
Publication
First Author: Tsuda Y
Year: 2017
Journal: Sci Rep
Title: Identification of a p53 target, CD137L, that mediates growth suppression and immune response of osteosarcoma cells.
Volume: 7
Issue: 1
Pages: 10739
Publication
First Author: Razidlo GL
Year: 2015
Journal: Cancer Res
Title: Targeting Pancreatic Cancer Metastasis by Inhibition of Vav1, a Driver of Tumor Cell Invasion.
Volume: 75
Issue: 14
Pages: 2907-15
Publication
First Author: Zahra FT
Year: 2019
Journal: Sci Rep
Title: Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis.
Volume: 9
Issue: 1
Pages: 11666
Publication
First Author: Villarroel-Campos D
Year: 2016
Journal: J Neurosci
Title: Rab35 Functions in Axon Elongation Are Regulated by P53-Related Protein Kinase in a Mechanism That Involves Rab35 Protein Degradation and the Microtubule-Associated Protein 1B.
Volume: 36
Issue: 27
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Journal: Mol Cell Neurosci
Title: Integrin-linked kinase regulates Bergmann glial differentiation during cerebellar development.
Volume: 33
Issue: 2
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Year: 2010
Journal: J Am Soc Nephrol
Title: Aberrant regulation of planar cell polarity in polycystic kidney disease.
Volume: 21
Issue: 9
Pages: 1521-32
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Journal: Stem Cells
Title: Vascular Stem/Progenitor Cell Migration Induced by Smooth Muscle Cell-Derived Chemokine (C-C Motif) Ligand 2 and Chemokine (C-X-C motif) Ligand 1 Contributes to Neointima Formation.
Volume: 34
Issue: 9
Pages: 2368-80
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First Author: Wells CM
Year: 2004
Journal: J Cell Sci
Title: Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration.
Volume: 117
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Year: 2019
Journal: J Genet Genomics
Title: Distinct functions of Trio GEF domains in axon outgrowth of cerebellar granule neurons.
Volume: 46
Issue: 2
Pages: 87-96
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First Author: López Tobón A
Year: 2018
Journal: Sci Rep
Title: The guanine nucleotide exchange factor Arhgef7/βPix promotes axon formation upstream of TC10.
Volume: 8
Issue: 1
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Year: 2007
Journal: Mol Cell Biol
Title: The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.
Volume: 27
Issue: 8
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Year: 2020
Journal: JCI Insight
Title: Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation.
Volume: 5
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Year: 2022
Journal: Cereb Cortex
Title: Disrupted Timing of MET Signaling Derails the Developmental Maturation of Cortical Circuits and Leads to Altered Behavior in Mice.
Volume: 32
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Journal: Sci Signal
Title: Itk controls the spatiotemporal organization of T cell activation.
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Journal: Dev Biol
Title: Impaired spermatogenic ability of testicular germ cells in mice deficient in the LIM-kinase 2 gene.
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Journal: J Cell Biol
Title: The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex.
Volume: 170
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Journal: Mol Cancer Ther
Title: ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade Gliomas.
Volume: 15
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Year: 2022
Journal: Int J Mol Sci
Title: Dock10 Regulates Cardiac Function under Neurohormonal Stress.
Volume: 23
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Year: 2020
Journal: Mol Biol Cell
Title: Flightless anchors IQGAP1 and R-ras to mediate cell extension formation and matrix remodeling.
Volume: 31
Issue: 15
Pages: 1595-1610
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Year: 2008
Journal: Mol Biol Cell
Title: Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation of integrin-linked kinase in the epidermis.
Volume: 19
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Year: 2018
Journal: Development
Title: Connexin 30 controls astroglial polarization during postnatal brain development.
Volume: 145
Issue: 4