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Search results 3001 to 3100 out of 3238 for Psen1

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Type Details Score
Publication
35687689 | J:326121
First Author: Thomas J
Year: 2022
Journal: Sci Adv
Title: Excessive local host-graft connectivity in aging and amyloid-loaded brain.
Volume: 8
Issue: 23
Pages: eabg9287
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Publication
21946562 | J:177339
First Author: Zovoilis A
Year: 2011
Journal: EMBO J
Title: microRNA-34c is a novel target to treat dementias.
Volume: 30
Issue: 20
Pages: 4299-308
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Publication
34216585 | J:317307
 
First Author: Alzghool OM
Year: 2021
Journal: Neuropharmacology
Title: (S)-[18F]THK5117 brain uptake is associated with Aβ plaques and MAO-B enzyme in a mouse model of Alzheimer's disease.
Volume: 196
Pages: 108676
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Publication
30013047 | J:267923
First Author: Mlodzianoski MJ
Year: 2018
Journal: Nat Methods
Title: Active PSF shaping and adaptive optics enable volumetric localization microscopy through brain sections.
Volume: 15
Issue: 8
Pages: 583-586
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Publication
32757390 | J:307504
First Author: Mosser S
Year: 2021
Journal: J Neurochem
Title: Identification of truncated C-terminal fragments of the Alzheimer's disease amyloid protein precursor derived from sequential proteolytic pathways.
Volume: 156
Issue: 6
Pages: 943-956
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Publication
21873424 | J:177577
First Author: Kilger E
Year: 2011
Journal: J Biol Chem
Title: BRI2 protein regulates β-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE).
Volume: 286
Issue: 43
Pages: 37446-57
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Publication
22277262 | J:191174
First Author: Poisnel G
Year: 2012
Journal: Neurobiol Aging
Title: PET imaging with [18F]AV-45 in an APP/PS1-21 murine model of amyloid plaque deposition.
Volume: 33
Issue: 11
Pages: 2561-71
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Publication
31143103 | J:281788
 
First Author: Van den Broeck L
Year: 2019
Journal: Front Behav Neurosci
Title: Impaired Reversal Learning in APPPS1-21 Mice in the Touchscreen Visual Discrimination Task.
Volume: 13
Pages: 92
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Publication
22511962 | J:187087
First Author: Hoxha E
Year: 2012
Journal: PLoS One
Title: Excitability and synaptic alterations in the cerebellum of APP/PS1 mice.
Volume: 7
Issue: 4
Pages: e34726
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Publication
21949026 | J:179436
First Author: Toly-Ndour C
Year: 2011
Journal: J Immunol
Title: MHC-independent genetic factors control the magnitude of CD4+ T cell responses to amyloid-β peptide in mice through regulatory T cell-mediated inhibition.
Volume: 187
Issue: 9
Pages: 4492-500
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Publication
26017149 | J:237739
First Author: Jährling N
Year: 2015
Journal: PLoS One
Title: Cerebral β-Amyloidosis in Mice Investigated by Ultramicroscopy.
Volume: 10
Issue: 5
Pages: e0125418
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Publication
24358348 | J:211135
First Author: Shah D
Year: 2013
Journal: PLoS One
Title: Resting state FMRI reveals diminished functional connectivity in a mouse model of amyloidosis.
Volume: 8
Issue: 12
Pages: e84241
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Publication
22431726 | J:193008
First Author: Lutz D
Year: 2012
Journal: J Biol Chem
Title: Generation and nuclear translocation of sumoylated transmembrane fragment of cell adhesion molecule L1.
Volume: 287
Issue: 21
Pages: 17161-75
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Publication
30645585 | J:273284
First Author: Hollnagel JO
Year: 2019
Journal: PLoS One
Title: Early alterations in hippocampal perisomatic GABAergic synapses and network oscillations in a mouse model of Alzheimer's disease amyloidosis.
Volume: 14
Issue: 1
Pages: e0209228
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Publication
22621777 | J:194437
First Author: Ramalho RM
Year: 2013
Journal: Neurobiol Aging
Title: Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice.
Volume: 34
Issue: 2
Pages: 551-61
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Publication
33556539 | J:307704
 
First Author: Basak JM
Year: 2021
Journal: Neurobiol Dis
Title: Bacterial sepsis increases hippocampal fibrillar amyloid plaque load and neuroinflammation in a mouse model of Alzheimer's disease.
Volume: 152
Pages: 105292
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Publication
29909177 | J:267041
 
First Author: Takkinen JS
Year: 2018
Journal: Neurobiol Aging
Title: [18F]FMPEP-d2 PET imaging shows age- and genotype-dependent impairments in the availability of cannabinoid receptor 1 in a mouse model of Alzheimer's disease.
Volume: 69
Pages: 199-208
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Publication
37018887 | J:335276
 
First Author: Jia YL
Year: 2023
Journal: Biochem Biophys Res Commun
Title: The mitochondria-targeted small molecule SS31 delays progression of behavioral deficits by attenuating β-amyloid plaque formation and mitochondrial/synaptic deterioration in APP/PS1 mice.
Volume: 658
Pages: 36-43
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Publication
24863668 | J:218079
First Author: Becerril-Ortega J
Year: 2014
Journal: Neurobiol Aging
Title: Iron overload accelerates neuronal amyloid-β production and cognitive impairment in transgenic mice model of Alzheimer's disease.
Volume: 35
Issue: 10
Pages: 2288-301
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Publication
27600841 | J:266169
First Author: Ovsepian SV
Year: 2017
Journal: Cereb Cortex
Title: Ambient Glutamate Promotes Paroxysmal Hyperactivity in Cortical Pyramidal Neurons at Amyloid Plaques via Presynaptic mGluR1 Receptors.
Volume: 27
Issue: 10
Pages: 4733-4749
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Publication
32424118 | J:292239
First Author: Dodiya HB
Year: 2020
Journal: Sci Rep
Title: Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer's transgenic mice.
Volume: 10
Issue: 1
Pages: 8183
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Publication
23184605 | J:234763
First Author: Govindarajan N
Year: 2013
Journal: EMBO Mol Med
Title: Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease.
Volume: 5
Issue: 1
Pages: 52-63
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Publication
22863679 | J:192494
 
First Author: Hafez DM
Year: 2012
Journal: Neuroscience
Title: F-spondin gene transfer improves memory performance and reduces amyloid-β levels in mice.
Volume: 223
Pages: 465-72
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Genotype
Genotype
Symbol: Psen1/Psen1
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: App/App Tg(PDGFB-PSEN1M146L)2Jhd/?
Background: involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSWE)2576Kha/? Tg(PDGFB-PSEN1M146L)2Jhd/?
Background: involves: C57BL/6 * DBA/2 * SJL * SW
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSWE)2576Kha/? Tg(PDGFB-PSEN1M146L)2Jhd/?
Background: involves: C57BL/6 * DBA/2 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(PRNP-APPSweInd)8Dwst/? Tg(PSEN1*L286V)1274Citr/?
Background: involves: C3H/HeJ * C57BL/6J * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPDutch)#Jckr/? Tg(Thy1-PSEN1*G384A)45Jckr/?
Background: involves: C57BL/6 * C57BL/6J * DBA/2
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPDutch)#Jckr/? Tg(Thy1-PSEN1*G384A)45Jckr/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Hmgcr-PSEN1*M146L)#Lpr/? Tg(Thy1-APPLon)2Vln/?
Background: involves: C57BL/6 * CBA * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSWE)2576Kha/? Tg(PDGFB-PSEN1M146L)2Jhd/?
Background: involves: C57BL/6 * DBA/2 * SJL * SW
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Background: C57BL/6-Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/?
Background: involves: C57BL/6 * C57BL/6N * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: App/App Tg(PDGFB-PSEN1)1Jhd/?
Background: involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hdac6/Hdac6 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/? Trem2/Trem2<+>
Background: involves: C57BL/6J * C57BL/6NTac
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Psen1/Psen1 Psen2/Psen2
Background: involves: 129S7/SvEvBrd
Zygosity: cx
Has Mutant Allele: true
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Publication
26566997 | J:340366
 
First Author: Xu G
Year: 2015
Journal: Acta Neuropathol Commun
Title: Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits.
Volume: 3
Pages: 72
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Protein Coding Gene
MGI:1913590 | Psenen
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
33076948 | J:303244
First Author: Serneels L
Year: 2020
Journal: Mol Neurodegener
Title: Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer's disease.
Volume: 15
Issue: 1
Pages: 60
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Publication
32595447 | J:311244
 
First Author: Loeffler T
Year: 2020
Journal: Front Neurosci
Title: Neurofilament-Light Chain as Biomarker of Neurodegenerative and Rare Diseases With High Translational Value.
Volume: 14
Pages: 579
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Publication
35394029 | J:324255
 
First Author: Koller EJ
Year: 2022
Journal: Dis Model Mech
Title: Temporal and spatially controlled APP transgene expression using Cre-dependent alleles.
Volume: 15
Issue: 5
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Publication
35573205 | J:328754
First Author: Takahashi F
Year: 2022
Journal: iScience
Title: Immune-mediated neurodegenerative trait provoked by multimodal derepression of long-interspersed nuclear element-1.
Volume: 25
Issue: 5
Pages: 104278
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Publication
28602351 | J:324482
First Author: Keren-Shaul H
Year: 2017
Journal: Cell
Title: A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease.
Volume: 169
Issue: 7
Pages: 1276-1290.e17
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Publication
37328454 | J:355740
First Author: Cho E
Year: 2023
Journal: Nat Commun
Title: Ratiometric measurement of MAM Ca(2+) dynamics using a modified CalfluxVTN.
Volume: 14
Issue: 1
Pages: 3586
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Publication
30046111 | J:265289
First Author: Da Mesquita S
Year: 2018
Journal: Nature
Title: Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease.
Volume: 560
Issue: 7717
Pages: 185-191
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Publication
34262178 | J:335093
First Author: McAlpine CS
Year: 2021
Journal: Nature
Title: Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease.
Volume: 595
Issue: 7869
Pages: 701-706
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Publication
30373880 | J:269026
First Author: Wang ZH
Year: 2018
Journal: J Exp Med
Title: Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies.
Volume: 215
Issue: 12
Pages: 3038-3056
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Publication
36352225 | J:339995
First Author: Drieu A
Year: 2022
Journal: Nature
Title: Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid.
Volume: 611
Issue: 7936
Pages: 585-593
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Publication
37541210 | J:339355
First Author: Yoo Y
Year: 2023
Journal: Cell Stem Cell
Title: A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease.
Volume: 30
Issue: 8
Pages: 1043-1053.e6
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Publication
29859094 | J:264653
First Author: Cheng-Hathaway PJ
Year: 2018
Journal: Mol Neurodegener
Title: The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.
Volume: 13
Issue: 1
Pages: 29
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Publication
11744223 | J:108752
First Author: Wirths O
Year: 2001
Journal: Neurosci Lett
Title: Reelin in plaques of beta-amyloid precursor protein and presenilin-1 double-transgenic mice.
Volume: 316
Issue: 3
Pages: 145-8
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Publication
36611872 | J:332599
 
First Author: Rudan Njavro J
Year: 2022
Journal: Cells
Title: Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model.
Volume: 12
Issue: 1
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Publication
23178247 | J:194214
First Author: Vom Berg J
Year: 2012
Journal: Nat Med
Title: Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline.
Volume: 18
Issue: 12
Pages: 1812-9
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Publication
10613521 | J:59778
First Author: Umans L
Year: 1999
Journal: Neuroscience
Title: Lipoprotein receptor-related protein in brain and in cultured neurons of mice deficient in receptor-associated protein and transgenic for apolipoprotein E4 or amyloid precursor protein.
Volume: 94
Issue: 1
Pages: 315-21
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Publication
29472246 | J:262255
 
First Author: Steeland S
Year: 2018
Journal: EMBO Mol Med
Title: Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease.
Volume: 10
Issue: 4
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Publication
23202730 | J:194181
First Author: Ly PT
Year: 2013
Journal: J Clin Invest
Title: Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes.
Volume: 123
Issue: 1
Pages: 224-35
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Publication
17065436 | J:114690
First Author: Yin KJ
Year: 2006
Journal: J Neurosci
Title: Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism.
Volume: 26
Issue: 43
Pages: 10939-48
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Publication
28637503 | J:312842
First Author: Steffen J
Year: 2017
Journal: Acta Neuropathol Commun
Title: Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice.
Volume: 5
Issue: 1
Pages: 49
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Publication
26885753 | J:255079
First Author: Chaput D
Year: 2016
Journal: Oncotarget
Title: Potential role of PCTAIRE-2, PCTAIRE-3 and P-Histone H4 in amyloid precursor protein-dependent Alzheimer pathology.
Volume: 7
Issue: 8
Pages: 8481-97
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Publication
16730391 | J:121975
First Author: Costa DA
Year: 2007
Journal: Neurobiol Aging
Title: Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms.
Volume: 28
Issue: 6
Pages: 831-44
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Strain
MGI:5301810 | FVB.Cg-Abcc1<tm1Bor> Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Publication
18624920 | J:138852
First Author: Zhou J
Year: 2008
Journal: J Neurochem
Title: Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer's disease.
Volume: 106
Issue: 5
Pages: 2080-92
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Publication
23040664 | J:203385
First Author: Kiyota T
Year: 2013
Journal: Neurobiol Aging
Title: CCL2 affects β-amyloidosis and progressive neurocognitive dysfunction in a mouse model of Alzheimer's disease.
Volume: 34
Issue: 4
Pages: 1060-8
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Publication
16774924 | J:116517
First Author: Culbert AA
Year: 2006
Journal: J Biol Chem
Title: MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease.
Volume: 281
Issue: 33
Pages: 23658-67
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Publication
12402041 | J:80429
First Author: Tan J
Year: 2002
Journal: Nat Neurosci
Title: Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice.
Volume: 5
Issue: 12
Pages: 1288-93
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Publication
28877763 | J:338512
First Author: Schweig JE
Year: 2017
Journal: Acta Neuropathol Commun
Title: Alzheimer's disease pathological lesions activate the spleen tyrosine kinase.
Volume: 5
Issue: 1
Pages: 69
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Publication
25675483 | J:220176
First Author: Han BH
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice.
Volume: 112
Issue: 8
Pages: E881-90
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Publication
31473905 | J:344796
First Author: Gil-Iturbe E
Year: 2020
Journal: Mol Neurobiol
Title: GLUT12 Expression in Brain of Mouse Models of Alzheimer's Disease.
Volume: 57
Issue: 2
Pages: 798-805
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Publication
26099047 | J:224864
First Author: Bachhuber T
Year: 2015
Journal: Nat Med
Title: Inhibition of amyloid-β plaque formation by α-synuclein.
Volume: 21
Issue: 7
Pages: 802-7
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Publication
21248127 | J:168561
First Author: Beckmann N
Year: 2011
Journal: J Neurosci
Title: Noninvasive magnetic resonance imaging detection of cerebral amyloid angiopathy-related microvascular alterations using superparamagnetic iron oxide particles in APP transgenic mouse models of Alzheimer's disease: application to passive Abeta immunotherapy.
Volume: 31
Issue: 3
Pages: 1023-31
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Publication
25911278 | J:224496
First Author: Mahler J
Year: 2015
Journal: Neurobiol Aging
Title: Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice.
Volume: 36
Issue: 7
Pages: 2241-2247
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Publication
28701326 | J:249736
First Author: Ye L
Year: 2017
Journal: EMBO Rep
Title: Aβ seeding potency peaks in the early stages of cerebral β-amyloidosis.
Volume: 18
Issue: 9
Pages: 1536-1544
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Publication
36443293 | J:331959
First Author: Rother C
Year: 2022
Journal: Nat Commun
Title: Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae.
Volume: 13
Issue: 1
Pages: 7333
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Publication
18077058 | J:152963
First Author: Priller C
Year: 2009
Journal: Neurobiol Aging
Title: Excitatory synaptic transmission is depressed in cultured hippocampal neurons of APP/PS1 mice.
Volume: 30
Issue: 8
Pages: 1227-37
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Publication
23863834 | J:213474
First Author: Maia LF
Year: 2013
Journal: Sci Transl Med
Title: Changes in amyloid-β and Tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor protein.
Volume: 5
Issue: 194
Pages: 194re2
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Publication
18467698 | J:136190
First Author: Ermini FV
Year: 2008
Journal: Am J Pathol
Title: Neurogenesis and alterations of neural stem cells in mouse models of cerebral amyloidosis.
Volume: 172
Issue: 6
Pages: 1520-8
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Publication
25315299 | J:230461
First Author: Barone E
Year: 2014
Journal: Biochim Biophys Acta
Title: Inactivation of brain Cofilin-1 by age, Alzheimer's disease and γ-secretase.
Volume: 1842
Issue: 12 Pt A
Pages: 2500-9
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Publication
23999102 | J:204530
First Author: Heilbronner G
Year: 2013
Journal: EMBO Rep
Title: Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice.
Volume: 14
Issue: 11
Pages: 1017-22
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Strain
MGI:5301852 | FVB.Cg-Abcg2<tm1Ahs> Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Attribute String: congenic, targeted mutation, transgenic
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Publication
15921918 | J:102542
First Author: Köhler C
Year: 2005
Journal: Neurobiol Dis
Title: Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels.
Volume: 20
Issue: 2
Pages: 528-40
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Publication
28768717 | J:248773
First Author: Agís-Balboa RC
Year: 2017
Journal: EMBO J
Title: Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia.
Volume: 36
Issue: 19
Pages: 2815-2828
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Publication
26663083 | J:259402
First Author: Schnöder L
Year: 2016
Journal: J Biol Chem
Title: Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.
Volume: 291
Issue: 5
Pages: 2067-79
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Publication
30341179 | J:269291
First Author: Rush T
Year: 2018
Journal: J Neurosci
Title: Synaptotoxicity in Alzheimer's Disease Involved a Dysregulation of Actin Cytoskeleton Dynamics through Cofilin 1 Phosphorylation.
Volume: 38
Issue: 48
Pages: 10349-10361
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Publication
20970889 | J:188225
First Author: Rupp NJ
Year: 2011
Journal: Neurobiol Aging
Title: Early onset amyloid lesions lead to severe neuritic abnormalities and local, but not global neuron loss in APPPS1 transgenic mice.
Volume: 32
Issue: 12
Pages: 2324.e1-6
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Publication
14751770 | J:128645
First Author: Boutajangout A
Year: 2004
Journal: Neurobiol Dis
Title: Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1.
Volume: 15
Issue: 1
Pages: 47-60
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Publication
30911686 | J:278879
 
First Author: Woo JA
Year: 2019
Journal: Commun Biol
Title: Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics.
Volume: 2
Pages: 112
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Publication
19213921 | J:144934
First Author: Thathiah A
Year: 2009
Journal: Science
Title: The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons.
Volume: 323
Issue: 5916
Pages: 946-51
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Publication
29724785 | J:265685
First Author: Reichenbach N
Year: 2018
Journal: J Exp Med
Title: P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer's disease model.
Volume: 215
Issue: 6
Pages: 1649-1663
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Publication
11021833 | J:129692
First Author: Van Dorpe J
Year: 2000
Journal: Am J Pathol
Title: Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons.
Volume: 157
Issue: 4
Pages: 1283-98
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Publication
17673336 | J:145815
First Author: Dewachter I
Year: 2009
Journal: Neurobiol Aging
Title: Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice.
Volume: 30
Issue: 2
Pages: 241-56
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Publication
31122931 | J:284721
 
First Author: Götzl JK
Year: 2019
Journal: EMBO Mol Med
Title: Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.
Volume: 11
Issue: 6
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Publication
23100432 | J:192173
First Author: Cameron B
Year: 2012
Journal: J Neurosci
Title: Loss of interleukin receptor-associated kinase 4 signaling suppresses amyloid pathology and alters microglial phenotype in a mouse model of Alzheimer's disease.
Volume: 32
Issue: 43
Pages: 15112-23
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Strain
MGI:4452508 | C57BL/6-Tg(Prnp-ITM2B*)7Jckr Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Attribute String: transgenic, mutant strain, coisogenic
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Publication
30617257 | J:277170
First Author: Parhizkar S
Year: 2019
Journal: Nat Neurosci
Title: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.
Volume: 22
Issue: 2
Pages: 191-204
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Publication
24893973 | J:241976
 
First Author: Ulrich JD
Year: 2014
Journal: Mol Neurodegener
Title: Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2.
Volume: 9
Pages: 20
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Publication
21228171 | J:180835
First Author: Hefendehl JK
Year: 2011
Journal: J Neurosci
Title: Long-term in vivo imaging of β-amyloid plaque appearance and growth in a mouse model of cerebral β-amyloidosis.
Volume: 31
Issue: 2
Pages: 624-9
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Publication
26458768 | J:229027
First Author: Prokop S
Year: 2015
Journal: J Exp Med
Title: Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer's disease-like mice.
Volume: 212
Issue: 11
Pages: 1811-8
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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