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Type Details Score
Publication
22870887 | J:191444
First Author: Wieschhaus A
Year: 2012
Journal: Biochem J
Title: Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology.
Volume: 448
Issue: 1
Pages: 141-52
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Publication
27060346 | J:246253
First Author: Rodríguez-Rodríguez N
Year: 2016
Journal: Eur J Immunol
Title: Pro-inflammatory self-reactive T cells are found within murine TCR-αβ(+) CD4(-) CD8(-) PD-1(+) cells.
Volume: 46
Issue: 6
Pages: 1383-91
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Publication
21139565 | J:169256
First Author: Mishra SK
Year: 2011
Journal: EMBO J
Title: TRPV1-lineage neurons are required for thermal sensation.
Volume: 30
Issue: 3
Pages: 582-93
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Publication
14983025 | J:88643
First Author: Rosenberger CM
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Interplay between antibacterial effectors: a macrophage antimicrobial peptide impairs intracellular Salmonella replication.
Volume: 101
Issue: 8
Pages: 2422-7
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Publication
26929330 | J:230995
First Author: Woo JS
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells.
Volume: 113
Issue: 10
Pages: 2762-7
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Publication
19004801 | J:142512
First Author: Ferdinandusse S
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Ataxia with loss of Purkinje cells in a mouse model for Refsum disease.
Volume: 105
Issue: 46
Pages: 17712-7
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Publication
37956287 | J:348405
First Author: Schultz LE
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: A nemaline myopathy-linked mutation inhibits the actin-regulatory functions of tropomodulin and leiomodin.
Volume: 120
Issue: 47
Pages: e2315820120
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Publication
31522122 | J:342866
 
First Author: Ahad A
Year: 2019
Journal: iScience
Title: NCoR1: Putting the Brakes on the Dendritic Cell Immune Tolerance.
Volume: 19
Pages: 996-1011
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Publication
21254335 | J:167974
First Author: Diéguez-Hurtado R
Year: 2011
Journal: Genesis
Title: A Cre-reporter transgenic mouse expressing the far-red fluorescent protein Katushka.
Volume: 49
Issue: 1
Pages: 36-45
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Publication
7972060 | J:21726
First Author: Champion KM
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Identification of a heritable deficiency of the folate-dependent enzyme 10-formyltetrahydrofolate dehydrogenase in mice.
Volume: 91
Issue: 24
Pages: 11338-42
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Publication
15684072 | J:96471
First Author: Li W
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations.
Volume: 102
Issue: 6
Pages: 2162-7
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Publication
33293360 | J:302570
First Author: Lesnikova A
Year: 2021
Journal: J Neurosci
Title: Chondroitinase and Antidepressants Promote Plasticity by Releasing TRKB from Dephosphorylating Control of PTPσ in Parvalbumin Neurons.
Volume: 41
Issue: 5
Pages: 972-980
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Publication
25557080 | J:219289
First Author: Boj SF
Year: 2015
Journal: Cell
Title: Organoid models of human and mouse ductal pancreatic cancer.
Volume: 160
Issue: 1-2
Pages: 324-38
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Publication
24223903 | J:209322
First Author: Lidster K
Year: 2013
Journal: PLoS One
Title: Neuroprotection in a novel mouse model of multiple sclerosis.
Volume: 8
Issue: 11
Pages: e79188
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Publication
17204561 | -
First Author: Longstaff DG
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: A natural genetic code expansion cassette enables transmissible biosynthesis and genetic encoding of pyrrolysine.
Volume: 104
Issue: 3
Pages: 1021-6
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Publication
15642952 | J:96497
First Author: Ehrenreich H
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain.
Volume: 102
Issue: 3
Pages: 862-7
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Publication
17698153 | J:124366
First Author: Sood A
Year: 2007
Journal: Neuropharmacology
Title: The effects of JWB1-84-1 on memory-related task performance by amyloid Abeta transgenic mice and by young and aged monkeys.
Volume: 53
Issue: 5
Pages: 588-600
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Publication
33893149 | J:309415
First Author: Papachristodoulou A
Year: 2021
Journal: Cancer Discov
Title: NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation.
Volume: 11
Issue: 9
Pages: 2316-2333
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Publication
34533565 | J:324225
 
First Author: Hermann CD
Year: 2021
Journal: J Exp Med
Title: TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer.
Volume: 218
Issue: 11
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Publication
20308565 | J:159316
First Author: Jacques-Silva MC
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic beta cell.
Volume: 107
Issue: 14
Pages: 6465-70
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Publication
25675519 | J:220170
First Author: Wang MY
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway.
Volume: 112
Issue: 8
Pages: 2503-8
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Publication
32636268 | J:292243
First Author: Tummala H
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: A frameshift variant in specificity protein 1 triggers superactivation of Sp1-mediated transcription in familial bone marrow failure.
Volume: 117
Issue: 29
Pages: 17151-17155
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Publication
23953115 | J:199355
First Author: Schraml BU
Year: 2013
Journal: Cell
Title: Genetic tracing via DNGR-1 expression history defines dendritic cells as a hematopoietic lineage.
Volume: 154
Issue: 4
Pages: 843-58
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Publication
25316086 | J:244967
 
First Author: Maraschi A
Year: 2014
Journal: Nat Commun
Title: Parkin regulates kainate receptors by interacting with the GluK2 subunit.
Volume: 5
Pages: 5182
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Publication
32382029 | J:288979
First Author: Gaub A
Year: 2020
Journal: Nat Commun
Title: Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation.
Volume: 11
Issue: 1
Pages: 2243
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Publication
15797382 | -
First Author: Chacinska A
Year: 2005
Journal: Cell
Title: Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17.
Volume: 120
Issue: 6
Pages: 817-29
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Publication
12514741 | -
First Author: Nikulin A
Year: 2003
Journal: Nat Struct Biol
Title: Structure of the L1 protuberance in the ribosome.
Volume: 10
Issue: 2
Pages: 104-8
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Publication
15753982 | -
First Author: Hamamoto A
Year: 2005
Journal: Int J Oncol
Title: Aberrant expression of the gastric mucin MUC6 in human pulmonary adenocarcinoma xenografts.
Volume: 26
Issue: 4
Pages: 891-6
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Publication
28105518 | J:240958
First Author: Blasco-Baque V
Year: 2017
Journal: Diabetologia
Title: Associations between hepatic miRNA expression, liver triacylglycerols and gut microbiota during metabolic adaptation to high-fat diet in mice.
Volume: 60
Issue: 4
Pages: 690-700
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Publication
20616083 | -
First Author: Gu Y
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Identification of a cellulose synthase-associated protein required for cellulose biosynthesis.
Volume: 107
Issue: 29
Pages: 12866-71
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Publication
35243212 | J:327760
First Author: Uematsu S
Year: 2022
Journal: iScience
Title: Multi-omics-based label-free metabolic flux inference reveals obesity-associated dysregulatory mechanisms in liver glucose metabolism.
Volume: 25
Issue: 2
Pages: 103787
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Publication
31980596 | J:301140
First Author: Plana-Bonamaisó A
Year: 2020
Journal: Cell Death Dis
Title: GCAP neuronal calcium sensor proteins mediate photoreceptor cell death in the rd3 mouse model of LCA12 congenital blindness by involving endoplasmic reticulum stress.
Volume: 11
Issue: 1
Pages: 62
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Publication
19050295 | J:142047
First Author: Giorgini A
Year: 2008
Journal: J Immunol
Title: Fc gamma RIII and Fc gamma RIV are indispensable for acute glomerular inflammation induced by switch variant monoclonal antibodies.
Volume: 181
Issue: 12
Pages: 8745-52
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Publication
11069886 | J:65766
First Author: Fleischmann A
Year: 2000
Journal: Genes Dev
Title: Fra-1 replaces c-Fos-dependent functions in mice.
Volume: 14
Issue: 21
Pages: 2695-700
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Publication
35129434 | J:322946
   
First Author: Maul A
Year: 2022
Journal: Elife
Title: The Cl--channel TMEM16A is involved in the generation of cochlear Ca2+ waves and promotes the refinement of auditory brainstem networks in mice.
Volume: 11
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Protein Coding Gene
MGI:1923990 | Efr3a
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
9861029 | J:51663
First Author: Krege JH
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Generation and reproductive phenotypes of mice lacking estrogen receptor beta.
Volume: 95
Issue: 26
Pages: 15677-82
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Publication
19629168 | J:151781
First Author: Vincent DF
Year: 2009
Journal: PLoS Genet
Title: Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas.
Volume: 5
Issue: 7
Pages: e1000575
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Publication
17309606 | J:121914
First Author: Montelius A
Year: 2007
Journal: Differentiation
Title: Emergence of the sensory nervous system as defined by Foxs1 expression.
Volume: 75
Issue: 5
Pages: 404-17
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Publication
14761651 | J:88053
First Author: Perea-Gomez A
Year: 2004
Journal: Curr Biol
Title: Initiation of gastrulation in the mouse embryo is preceded by an apparent shift in the orientation of the anterior-posterior axis.
Volume: 14
Issue: 3
Pages: 197-207
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Protein Coding Gene
MGI:1918351 | Uvssa
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
3496540 | J:8775
First Author: Brunet JF
Year: 1987
Journal: Nature
Title: A new member of the immunoglobulin superfamily--CTLA-4.
Volume: 328
Issue: 6127
Pages: 267-70
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Publication
30054204 | J:278002
First Author: Lim HY
Year: 2018
Journal: Immunity
Title: Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.
Volume: 49
Issue: 2
Pages: 326-341.e7
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Protein Domain
IPR008133 | 5HT3_rcpt_A
Type: Family
Description: Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [, ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily:Nicotinic acetylcholine receptor (AchR), an excitatory cation channel in vertebrates and invertebrates; in vertebrate motor endplates it is composed of alpha, beta, gamma and delta/epsilon subunits; in neurons it is composed of alpha and non-alpha (or beta) subunits [].Glycine receptor, an inhibitory chloride ion channel composed of alpha and beta subunits [].Gamma-aminobutyric acid (GABA) receptor, an inhibitory chloride ion channel; at least four types of subunits (alpha, beta, gamma and delta) are known [].Serotonin 5HT3 receptor, of which there are seven major types (5HT3-5HT7) [].Glutamate receptor, an excitatory cation channel of which at least three types have been described (kainate, N-methyl-D-aspartate (NMDA) and quisqualate) [].These receptors possess a pentameric structure (made up of varying subunits), surrounding a central pore. All known sequences of subunits from neurotransmitter-gated ion-channels are structurally related. They are composed of a large extracellular glycosylated N-terminal ligand-binding domain, followed by three hydrophobic transmembrane regions which form the ionic channel, followed by an intracellular region of variable length. A fourth hydrophobic region is found at the C-terminal of the sequence [, ].Serotonin (5-hydroxytryptamine, 5-HT) is widely distributed in both the central and peripheral nervous system, where it acts as a neurotransmitterand neuromodulator []. It has been implicated in several aspects of brain function, including regulation of affective states, ingestive behavior and addiction. 5-HT can activate a number of different receptor subtypes that produce diverse neuronal responses, principally through activation of G-protein-mediated signalling pathways. Signalling through the 5-HT3 receptor (5-HT3R) differs, since this subtype belongs to the ligand-gated ion channel (LGIC) superfamily, which also includes the inhibitory gamma-aminobutyric acid type A and glycine receptors, and excitatory nicotinic acetylcholine receptors (nAChR) []. 5-HT3 receptor function has been implicated in a variety of neural processes, including pain perception, emesis, anxiety and drug abuse.Like the other members of the LGIC superfamily, the 5HT3R exhibits a high degree of sequence similarity, and therefore putative structural similarity, with nAChRs []. Thus, functional 5HT3Rs comprise a pentamer: the ion channel is formed at the centre of a rosette formed between five homologous subunits. Two classes of 5-HT3R subunit are currently known, termed 5-HT3A and 5-HT3B. Whilst homomeric pentamers of 5-HT3A form functional receptors, heteromeric assemblies display channel conductances, cation permeabilities and current-voltage relationships typical of characterised neuronal 5-HT3 channels [].The proposed topology of 5-HT3R subunits comprises four putative transmembrane (TM) domains (designated M1-4); a large extracellular N-terminal region (~200 amino acids); and a variable cytoplasmic loop between M3 and M4. The M2 domains from each subunit are thought to form the channel pore. The agonist binding site is formed by the N terminus, which, on binding, induces a conformational change in the channel pore, a process often referred to as "gating"[]. Opening of the pore allows cation flux through the neuronal membrane and depolarises the membrane potential. Thus, 5-HT3Rs may be thought of as excitatory receptors [].Cloning of the 5-HT3A subunit from a neuroblastoma expression library wasreported in 1991 []. Whilst recombinant expression of 5-HT3A yieldsfunctional receptors, the channel conductance and permeability to cationsare different from that observed for native receptors []. Alternative exonsplicing gives rise to two isoforms of 5-HT3A, termed 5-HT3AS and 5-HT3ALfor short and long variants, respectively. The 5-HT3RA subunit is widelyexpressed throughout the peripheral and central nervous systems, includingseveral regions of the brain.
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Protein Domain
IPR008100 | GABAAp_rcpt
Type: Family
Description: Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [, ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily:Nicotinic acetylcholine receptor (AchR), an excitatory cation channel in vertebrates and invertebrates; in vertebrate motor endplates it is composed of alpha, beta, gamma and delta/epsilon subunits; in neurons it is composed of alpha and non-alpha (or beta) subunits [].Glycine receptor, an inhibitory chloride ion channel composed of alpha and beta subunits [].Gamma-aminobutyric acid (GABA) receptor, an inhibitory chloride ion channel; at least four types of subunits (alpha, beta, gamma and delta) are known [].Serotonin 5HT3 receptor, of which there are seven major types (5HT3-5HT7) [].Glutamate receptor, an excitatory cation channel of which at least three types have been described (kainate, N-methyl-D-aspartate (NMDA) and quisqualate) [].These receptors possess a pentameric structure (made up of varying subunits), surrounding a central pore. All known sequences of subunits from neurotransmitter-gated ion-channels are structurally related. They are composed of a large extracellular glycosylated N-terminal ligand-binding domain, followed by three hydrophobic transmembrane regions which form the ionic channel, followed by an intracellular region of variable length. A fourth hydrophobic region is found at the C-terminal of the sequence [, ].Gamma-aminobutyric acid type A (GABAA) receptors are members of the neurotransmitter ligand-gated ion channels: they mediate neuronal inhibition on binding GABA. The effects of GABA on GABAA receptors are modulated by a range of therapeutically important drugs, including barbiturates, anaesthetics and benzodiazepines (BZs) []. The BZs are a diverse range of compounds, including widely prescribed drugs, such as librium and valium, and their interaction with GABAA receptors provides the most potent pharmacological means of distinguishing different GABAA receptor subtypes.GABAA receptors are pentameric membrane proteins that operate GABA-gated chloride channels []. Eight types of receptor subunit have been cloned, with multiple subtypes withinsome classes: alpha 1-6, beta 1-4, gamma 1-4, delta, epsilon, pi, rho 1-3 and theta [, ]. Subunits are typically 50-60kDa in size and comprise a long N-terminal extracellular domain, containing a putative signal peptide and a disulphide-bonded beta structural loop; 4 putative transmembrane (TM) domains; and a large cytoplasmic loop connecting the third and fourth TM domains. Amongst family members, the large cytoplasmic loop displays the most divergence in terms of primary structure, the TM domains showing the highest level of sequence conservation [].Most GABAA receptors contain one type of alpha and beta subunit, and a single gamma polypeptide in a ratio of 2:2:1 [], though in some cases other subunits such as epsilon or delta may replace gamma. The BZ binding site is located at the interface of adjacent alpha and gamma subunits; therefore, the type of alpha and gamma subunits present is instrumental in determining BZ selectivity and sensitivity. Receptors can be categorised into 3 groups based on their alpha subunit content and, hence, sensitivity to BZs: alpha 1-containing receptors have greatest sensitivity towards BZs (type I); alpha 2, 3 and 5-containing receptors have similar but distinguishable properties (type II); and alpha 4- and 6-containing assemblies have very low BZ affinity []. A conserved histidine residue in the alpha subunit of type I and II receptors is believed to be responsible for BZ affinity []. The existence of a pi subunit was first reported in 1997, where it wasdetected in a number of human and rat tissues. The subunit shares 30-40%amino acid identity with other members of the GABAA receptor subunit family.The polypeptide is found in several peripheral tissues, including theuterus, where its function appears to be related to tissue contractility: pisubunits can co-assemble with other GABAA receptor subunits to formrecombinant receptors with altered sensitivity to pregnenalone [].
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Publication
25853564 | J:233521
First Author: Rivera-Barahona A
Year: 2015
Journal: PLoS One
Title: Functional characterization of the spf/ash splicing variation in OTC deficiency of mice and man.
Volume: 10
Issue: 4
Pages: e0122966
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Publication
22081301 | J:183318
First Author: Amin A
Year: 2012
Journal: J Pathol
Title: Chronic inhibition of endoplasmic reticulum stress and inflammation prevents ischaemia-induced vascular pathology in type II diabetic mice.
Volume: 227
Issue: 2
Pages: 165-74
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Publication
32747017 | J:303590
First Author: Zahoor A
Year: 2020
Journal: Immunobiology
Title: MerTK negatively regulates Staphylococcus aureus induced inflammatory response via SOCS1/SOCS3 and Mal.
Volume: 225
Issue: 4
Pages: 151960
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Publication
23843215 | J:202505
First Author: Solini A
Year: 2013
Journal: J Pathol
Title: The purinergic 2X7 receptor participates in renal inflammation and injury induced by high-fat diet: possible role of NLRP3 inflammasome activation.
Volume: 231
Issue: 3
Pages: 342-53
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Publication
37279604 | J:337246
 
First Author: Czyżowska A
Year: 2023
Journal: Redox Biol
Title: Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness.
Volume: 64
Pages: 102761
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Publication
12403809 | J:79972
First Author: Jaeschke A
Year: 2002
Journal: J Cell Biol
Title: Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent.
Volume: 159
Issue: 2
Pages: 217-24
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Publication
18378896 | J:133771
First Author: Yoshimura FK
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Up-regulation of a cellular protein at the translational level by a retrovirus.
Volume: 105
Issue: 14
Pages: 5543-8
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Publication
28544355 | J:294692
First Author: Svensson K
Year: 2017
Journal: Acta Physiol (Oxf)
Title: Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis.
Volume: 221
Issue: 3
Pages: 193-203
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Publication
8618846 | J:67674
First Author: Hennet T
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination.
Volume: 92
Issue: 26
Pages: 12070-4
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Publication
21518865 | J:172196
First Author: Talbot JJ
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Polycystin-1 regulates STAT activity by a dual mechanism.
Volume: 108
Issue: 19
Pages: 7985-90
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Publication
21472842 | J:215150
First Author: Jung S
Year: 2011
Journal: Birth Defects Res A Clin Mol Teratol
Title: Developmental cardiac hypertrophy in a mouse model of prolidase deficiency.
Volume: 91
Issue: 4
Pages: 204-17
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Publication
24441829 | J:206863
First Author: Khalifeh-Soltani A
Year: 2014
Journal: Nat Med
Title: Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids.
Volume: 20
Issue: 2
Pages: 175-83
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Publication
22632729 | J:188361
First Author: Giménez-Cassina A
Year: 2012
Journal: Neuron
Title: BAD-dependent regulation of fuel metabolism and K(ATP) channel activity confers resistance to epileptic seizures.
Volume: 74
Issue: 4
Pages: 719-30
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Publication
36407762 | J:331470
 
First Author: Sirp A
Year: 2022
Journal: Front Mol Neurosci
Title: Expression of alternative transcription factor 4 mRNAs and protein isoforms in the developing and adult rodent and human tissues.
Volume: 15
Pages: 1033224
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Publication
23954789 | J:202763
First Author: Avila A
Year: 2013
Journal: Cell Rep
Title: Glycine receptor α2 subunit activation promotes cortical interneuron migration.
Volume: 4
Issue: 4
Pages: 738-50
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Publication
12566313 | J:81529
First Author: Suzuki A
Year: 2003
Journal: Cancer Res
Title: Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation.
Volume: 63
Issue: 3
Pages: 674-81
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Publication
31761670 | J:284187
First Author: Klingseisen A
Year: 2019
Journal: Dev Cell
Title: Oligodendrocyte Neurofascin Independently Regulates Both Myelin Targeting and Sheath Growth in the CNS.
Volume: 51
Issue: 6
Pages: 730-744.e6
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Publication
19062086 | J:147599
First Author: Wilson A
Year: 2008
Journal: Cell
Title: Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair.
Volume: 135
Issue: 6
Pages: 1118-29
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Publication
12642593 | J:83579
First Author: Hiol A
Year: 2003
Journal: J Biol Chem
Title: Palmitoylation regulates regulators of G-protein signaling (RGS) 16 function. I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residue.
Volume: 278
Issue: 21
Pages: 19301-8
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Publication
3901003 | J:34984
First Author: Cook KS
Year: 1985
Journal: Proc Natl Acad Sci U S A
Title: A developmentally regulated mRNA from 3T3 adipocytes encodes a novel serine protease homologue.
Volume: 82
Issue: 19
Pages: 6480-4
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Publication
27133129 | J:235379
First Author: Yavari A
Year: 2016
Journal: Cell Metab
Title: Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.
Volume: 23
Issue: 5
Pages: 821-36
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Publication
36882066 | J:339184
First Author: Smirnov A
Year: 2023
Journal: J Leukoc Biol
Title: Phagocytosis via complement receptor 3 enables microbes to evade killing by neutrophils.
Volume: 114
Issue: 1
Pages: 1-20
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Publication
18689792 | J:161886
First Author: El-Armouche A
Year: 2008
Journal: Cardiovasc Res
Title: Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy.
Volume: 80
Issue: 3
Pages: 396-406
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Publication
9278480 | -
First Author: Esposito D
Year: 1997
Journal: Nucleic Acids Res
Title: The integrase family of tyrosine recombinases: evolution of a conserved active site domain.
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Publication
9858508 | J:51675
First Author: Dinkel A
Year: 1998
Journal: J Exp Med
Title: The transcription factor early growth response 1 (Egr-1) advances differentiation of pre-B and immature B cells.
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Pages: 2215-24
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Publication
15057752 | J:92091
First Author: Micsenyi A
Year: 2004
Journal: Gastroenterology
Title: Beta-catenin is temporally regulated during normal liver development.
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Pages: 1134-46
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Publication
8530040 | J:28022
First Author: Walter L
Year: 1995
Journal: Genomics
Title: Identification of a novel conserved human gene, TEGT.
Volume: 28
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Pages: 301-4
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Publication
31390572 | J:288448
First Author: Uzquiano A
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Journal: Cell Rep
Title: Mutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary Cilia.
Volume: 28
Issue: 6
Pages: 1596-1611.e10
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Publication
15366020 | J:93085
First Author: Hashizume A
Year: 2004
Journal: Dev Dyn
Title: Expression patterns of claudin family of tight junction membrane proteins in developing mouse submandibular gland.
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Pages: 425-31
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Publication
10541808 | J:58323
First Author: Tsuiji M
Year: 1999
Journal: Immunogenetics
Title: Genomic structure and chromosomal location of the mouse macrophage C-type lectin gene.
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Publication
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Journal: J Cell Mol Med
Title: Deletion of pancreatic β-cell adenosine kinase improves glucose homeostasis in young mice and ameliorates streptozotocin-induced hyperglycaemia.
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Journal: PLoS One
Title: Impaired Ca(2+) signaling in β-cells lacking leptin receptors by Cre-loxP recombination.
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Journal: PLoS One
Title: Survivin is required for beta-cell mass expansion in the pancreatic duct-ligated mouse model.
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31580427 | J:281725
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Journal: Endocrinology
Title: The Loss of ARNT/HIF1β in Male Pancreatic β-Cells Is Protective Against High-Fat Diet-Induced Diabetes.
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Pages: 2825-2836
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Journal: Am J Physiol Endocrinol Metab
Title: Critical roles for the TSC-mTOR pathway in β-cell function.
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Journal: Am J Physiol Gastrointest Liver Physiol
Title: Acinar cell-specific knockout of the PTHrP gene decreases the proinflammatory and profibrotic responses in pancreatitis.
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Pages: G533-49
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First Author: Liu C
Year: 2018
Journal: J Leukoc Biol
Title: ITGB4 is essential for containing HDM-induced airway inflammation and airway hyperresponsiveness.
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Journal: Am J Physiol Lung Cell Mol Physiol
Title: Surface tension influences cell shape and phagocytosis in alveolar macrophages.
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Journal: J Cell Mol Med
Title: Airway epithelial ITGB4 deficiency in early life mediates pulmonary spontaneous inflammation and enhanced allergic immune response.
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First Author: Gokhin DS
Year: 2012
Journal: PLoS One
Title: Tmod1 and CP49 synergize to control the fiber cell geometry, transparency, and mechanical stiffness of the mouse lens.
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33039594 | J:304600
First Author: Yuan J
Year: 2021
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Pancreas-specific deletion of protein kinase D attenuates inflammation, necrosis, and severity of acute pancreatitis.
Volume: 1867
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Publication
28751580 | J:265106
First Author: Xu Y
Year: 2017
Journal: EMBO Mol Med
Title: Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis.
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31189131 | J:316211
First Author: Xu J
Year: 2019
Journal: J Endocrinol
Title: Endothelial adenosine kinase deficiency ameliorates diet-induced insulin resistance.
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21236676 | J:171832
First Author: Manor U
Year: 2011
Journal: Curr Biol
Title: Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8.
Volume: 21
Issue: 2
Pages: 167-72
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HT Experiment
E-GEOD-38573 | Expression data from cerebrum in a spontaneous mutant mouse, laggard
Series Id: GSE38573
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE132034 | A Time-resolved Multi-omic Atlas of the Developing Mouse Liver
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE137721 | RNA-seq analyses of cochleae from a mouse model of DFNB39
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE113073 | Transcription Factor SOX30 Is a Key Regulator of Mouse Spermiogenesis
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE239863 | The Rogdi Knockout Mouse is a Model for Kohlschutter-Tonz Syndrome
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
G3UYU0
Organism: Mus musculus/domesticus
Length: 520  
Fragment?: false
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Publication
32875720 | J:317139
First Author: Villa-Bellosta R
Year: 2020
Journal: EMBO Mol Med
Title: Dietary magnesium supplementation improves lifespan in a mouse model of progeria.
Volume: 12
Issue: 10
Pages: e12423
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Publication
23152144 | J:197885
First Author: Nagalski A
Year: 2013
Journal: Brain Struct Funct
Title: Postnatal isoform switch and protein localization of LEF1 and TCF7L2 transcription factors in cortical, thalamic, and mesencephalic regions of the adult mouse brain.
Volume: 218
Issue: 6
Pages: 1531-49
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Publication
27123980 | J:283196
First Author: Hirano A
Year: 2016
Journal: PLoS One
Title: USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock.
Volume: 11
Issue: 4
Pages: e0154263
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Publication
16816390 | J:172990
First Author: Albor A
Year: 2006
Journal: J Biol Chem
Title: The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB.
Volume: 281
Issue: 35
Pages: 25850-66
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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