| Type |
Details |
Score |
| Publication |
| First Author: |
Li T |
| Year: |
2008 |
| Journal: |
J Clin Invest |
| Title: |
Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. |
| Volume: |
118 |
| Issue: |
2 |
| Pages: |
571-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mentink A |
| Year: |
2013 |
| Journal: |
Biomaterials |
| Title: |
Predicting the therapeutic efficacy of MSC in bone tissue engineering using the molecular marker CADM1. |
| Volume: |
34 |
| Issue: |
19 |
| Pages: |
4592-601 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Martin A |
| Year: |
2015 |
| Journal: |
Bone |
| Title: |
Estrogens antagonize RUNX2-mediated osteoblast-driven osteoclastogenesis through regulating RANKL membrane association. |
| Volume: |
75 |
|
| Pages: |
96-104 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Taoudi S |
| Year: |
2007 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Functional identification of the hematopoietic stem cell niche in the ventral domain of the embryonic dorsal aorta. |
| Volume: |
104 |
| Issue: |
22 |
| Pages: |
9399-403 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Priestley GV |
| Year: |
2007 |
| Journal: |
Blood |
| Title: |
Sustained alterations in biodistribution of stem/progenitor cells in Tie2Cre+ alpha4(f/f) mice are hematopoietic cell autonomous. |
| Volume: |
109 |
| Issue: |
1 |
| Pages: |
109-11 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schwermann N |
| Year: |
2023 |
| Journal: |
PLoS Pathog |
| Title: |
Pathogen-driven nucleotide overload triggers mitochondria-centered cell death in phagocytes. |
| Volume: |
19 |
| Issue: |
12 |
| Pages: |
e1011892 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Golson ML |
| Year: |
2009 |
| Journal: |
Gastroenterology |
| Title: |
Ductal malformation and pancreatitis in mice caused by conditional Jag1 deletion. |
| Volume: |
136 |
| Issue: |
5 |
| Pages: |
1761-71.e1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Finburgh EN |
| Year: |
2023 |
| Journal: |
Invest Ophthalmol Vis Sci |
| Title: |
Role of FGF10/FGFR2b Signaling in Homeostasis and Regeneration of Adult Lacrimal Gland and Corneal Epithelium Proliferation. |
| Volume: |
64 |
| Issue: |
1 |
| Pages: |
21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chabab S |
| Year: |
2016 |
| Journal: |
Cell Rep |
| Title: |
Uncovering the Number and Clonal Dynamics of Mesp1 Progenitors during Heart Morphogenesis. |
| Volume: |
14 |
| Issue: |
1 |
| Pages: |
1-10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Staeheli P |
| Year: |
1988 |
| Journal: |
Mol Cell Biol |
| Title: |
Identification of a second interferon-regulated murine Mx gene. |
| Volume: |
8 |
| Issue: |
10 |
| Pages: |
4524-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Swisa A |
| Year: |
2024 |
| Journal: |
Dev Cell |
| Title: |
The evolutionarily ancient FOXA transcription factors shape the murine gut microbiome via control of epithelial glycosylation. |
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•
•
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| Publication |
| First Author: |
Bushar ND |
| Year: |
2010 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Ablation of SLP-76 signaling after T cell priming generates memory CD4 T cells impaired in steady-state and cytokine-driven homeostasis. |
| Volume: |
107 |
| Issue: |
2 |
| Pages: |
827-31 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
951
 |
| Fragment?: |
true |
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•
•
•
•
|
| Publication |
| First Author: |
Sigel E |
| Year: |
1992 |
| Journal: |
EMBO J |
| Title: |
Point mutations affecting antagonist affinity and agonist dependent gating of GABAA receptor channels. |
| Volume: |
11 |
| Issue: |
6 |
| Pages: |
2017-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yadav S |
| Year: |
2012 |
| Journal: |
Dev Cell |
| Title: |
Golgin160 recruits the dynein motor to position the Golgi apparatus. |
| Volume: |
23 |
| Issue: |
1 |
| Pages: |
153-65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gilbert CE |
| Year: |
2014 |
| Journal: |
Int J Mol Sci |
| Title: |
Three basic residues of intracellular loop 3 of the beta-1 adrenergic receptor are required for golgin-160-dependent trafficking. |
| Volume: |
15 |
| Issue: |
2 |
| Pages: |
2929-45 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [, ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily:Nicotinic acetylcholine receptor (AchR), an excitatory cation channel in vertebrates and invertebrates; in vertebrate motor endplates it is composed of alpha, beta, gamma and delta/epsilon subunits; in neurons it is composed of alpha and non-alpha (or beta) subunits [].Glycine receptor, an inhibitory chloride ion channel composed of alpha and beta subunits [].Gamma-aminobutyric acid (GABA) receptor, an inhibitory chloride ion channel; at least four types of subunits (alpha, beta, gamma and delta) are known [].Serotonin 5HT3 receptor, of which there are seven major types (5HT3-5HT7) [].Glutamate receptor, an excitatory cation channel of which at least three types have been described (kainate, N-methyl-D-aspartate (NMDA) and quisqualate) [].These receptors possess a pentameric structure (made up of varying subunits), surrounding a central pore. All known sequences of subunits from neurotransmitter-gated ion-channels are structurally related. They are composed of a large extracellular glycosylated N-terminal ligand-binding domain, followed by three hydrophobic transmembrane regions which form the ionic channel, followed by an intracellular region of variable length. A fourth hydrophobic region is found at the C-terminal of the sequence [, ].Gamma-aminobutyric acid type A (GABAA) receptors are members of the neurotransmitter ligand-gated ion channels: they mediate neuronal inhibition on binding GABA. The effects of GABA on GABAA receptors are modulated by a range of therapeutically important drugs, including barbiturates, anaesthetics and benzodiazepines (BZs) []. The BZs are a diverse range of compounds, including widely prescribed drugs, such as librium and valium, and their interaction with GABAA receptors provides the most potent pharmacological means of distinguishing different GABAA receptor subtypes.GABAA receptors are pentameric membrane proteins that operate GABA-gated chloride channels []. Eight types of receptor subunit have been cloned, with multiple subtypes within some classes: alpha 1-6, beta 1-4, gamma 1-4, delta, epsilon, pi, rho 1-3 and theta [, ]. Subunits are typically 50-60kDa in size and comprise a long N-terminal extracellular domain, containing a putative signal peptide and a disulphide-bonded beta structural loop; 4 putative transmembrane (TM) domains; and a large cytoplasmic loop connecting the third and fourth TM domains. Amongst family members, the large cytoplasmic loop displays the most divergence in terms of primary structure, the TM domains showing the highest level of sequence conservation [].Most GABAA receptors contain one type of alpha and beta subunit, and a single gamma polypeptide in a ratio of 2:2:1 [], though in some cases other subunits such as epsilon or delta may replace gamma. The BZ binding site is located at the interface of adjacent alpha and gamma subunits; therefore, the type of alpha and gamma subunits present is instrumental in determining BZ selectivity and sensitivity. Receptors can be categorised into 3 groups based on their alpha subunit content and, hence, sensitivity to BZs: alpha 1-containing receptors have greatest sensitivity towards BZs (type I); alpha 2, 3 and 5-containing receptors have similar but distinguishable properties (type II); and alpha 4- and 6-containing assemblies have very low BZ affinity []. A conserved histidine residue in the alpha subunit of type I and II receptors is believed to be responsible for BZ affinity []. Alpha subunitslargely determine benzodiazepine binding properties []. Mutagenesis and agonist/antagonist binding studies have suggested a close functional and structural association of alpha-subunits with the agonist/antagonist binding site, and involvement of N-terminal portions of the extracellular domains of all subunits in the gating of the channel []. |
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•
•
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| Protein Domain |
| Type: |
Family |
| Description: |
GOLGA3 (Golgin160, Mea2) is a Golgi complex-associated protein that has been implicated in spermatogenesis [, ], as well as in apoptosis [, ], trafficking [], and positioning of the Golgi []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
Cucumoviruses are tripartite RNA plant viruses believed to share a closeevolutionary relationship with Brome mosaic virus (BMV). The cucumoviruses include: Cucumber mosaic virus [], Peanut stunt virus []and Tomato aspermy virus []. The viral coat proteins show a high degree of sequencesimilarity [].The core structure of cucumber mosaic virus (CMV) and chlorotic mottle virus (CCMV), both members of the Bromoviridae family, are highly homologous. In CCMV, the structures of the A, B, and C subunits are nearly identical except in their N termini. In contrast, the structures of two loops in subunit A of CMV differ from those in B and C []. This entry represents the structural domain of subunit A of the cucumber mosaic virus and other cucumovirusus []. |
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•
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| Publication |
| First Author: |
Duggan MC |
| Year: |
2017 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Identification of NRAS isoform 2 overexpression as a mechanism facilitating BRAF inhibitor resistance in malignant melanoma. |
| Volume: |
114 |
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36 |
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9629-9634 |
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| First Author: |
Guma M |
| Year: |
2009 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression. |
| Volume: |
106 |
| Issue: |
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•
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| First Author: |
Grati M |
| Year: |
2012 |
| Journal: |
J Neurosci |
| Title: |
Localization of PDZD7 to the stereocilia ankle-link associates this scaffolding protein with the Usher syndrome protein network. |
| Volume: |
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Ashkenazi A |
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2017 |
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Nature |
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Polyglutamine tracts regulate beclin 1-dependent autophagy. |
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545 |
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| First Author: |
Suzuki A |
| Year: |
1998 |
| Journal: |
Curr Biol |
| Title: |
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. |
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8 |
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21 |
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1169-78 |
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Bazzi H |
| Year: |
2017 |
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Proc Natl Acad Sci U S A |
| Title: |
STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo. |
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Nishio M |
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Proc Natl Acad Sci U S A |
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Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice. |
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Proc Natl Acad Sci U S A |
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ENPP1's regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling. |
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Yu Z |
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Proc Natl Acad Sci U S A |
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Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice. |
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Mironov A Jr |
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J Neurosci |
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Cytosolic prion protein in neurons. |
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Takayasu S |
| Year: |
2006 |
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Proc Natl Acad Sci U S A |
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A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice. |
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103 |
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Martello A |
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2020 |
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EMBO Rep |
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Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy. |
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Cariboni A |
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J Clin Invest |
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Dysfunctional SEMA3E signaling underlies gonadotropin-releasing hormone neuron deficiency in Kallmann syndrome. |
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Bulfone A |
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Mech Dev |
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Expression pattern of the Tbr2 (Eomesodermin) gene during mouse and chick brain development. |
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| Protein Coding Gene |
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protein_coding_gene |
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mouse, laboratory |
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Keightley PD |
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Mouse Genome |
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Long days enhance recognition memory and increase insulin-like growth factor 2 in the hippocampus. |
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Mitra R |
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The transcriptional coactivators, PGC-1α and β, cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistance. |
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| Allele |
| Name: |
transgene insertion 2, Leslie A Leinwand |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
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Foley K |
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Sci Signal |
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Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer. |
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