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5 |
| Issue: |
8 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zaloszyc A |
| Year: |
2022 |
| Journal: |
Int J Mol Sci |
| Title: |
Inactivation of Osteoblast PKC Signaling Reduces Cortical Bone Mass and Density and Aggravates Renal Osteodystrophy in Mice with Chronic Kidney Disease on High Phosphate Diet. |
| Volume: |
23 |
| Issue: |
12 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yun J |
| Year: |
2023 |
| Journal: |
Nat Commun |
| Title: |
Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling. |
| Volume: |
14 |
| Issue: |
1 |
| Pages: |
156 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
D'Rozario J |
| Year: |
2023 |
| Journal: |
Eur J Immunol |
| Title: |
Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages. |
| Volume: |
53 |
| Issue: |
9 |
| Pages: |
e2250355 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhu Q |
| Year: |
2023 |
| Journal: |
Signal Transduct Target Ther |
| Title: |
OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
142 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang Q |
| Year: |
2017 |
| Journal: |
Sci Immunol |
| Title: |
LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes. |
| Volume: |
2 |
| Issue: |
9 |
|
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, targeted mutation, transgenic, congenic |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Lag3/Lag3 Tg(Foxp3-EGFP/cre)1cJbs/? |
| Background: |
NOD.Cg-Lag3 Tg(Foxp3-EGFP/cre)1cJbs |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Lag3/Lag3<+> Tg(Foxp3-EGFP/cre)1cJbs/? |
| Background: |
NOD.Cg-Lag3 Tg(Foxp3-EGFP/cre)1cJbs |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Garey CE |
| Year: |
1994 |
| Journal: |
Nat Genet |
| Title: |
Ceruloplasmin gene defect associated with epilepsy in EL mice. |
| Volume: |
6 |
| Issue: |
4 |
| Pages: |
426-31 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shishodia S |
| Year: |
1998 |
| Journal: |
Immunol Lett |
| Title: |
Protein kinase C: a potential pathway of macrophage activation with cisplatin. |
| Volume: |
61 |
| Issue: |
2-3 |
| Pages: |
179-86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hart MC |
| Year: |
2000 |
| Journal: |
BMC Genomics |
| Title: |
Mapping of the mouse actin capping protein beta subunit gene. |
| Volume: |
1 |
|
| Pages: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Billet O |
| Year: |
1995 |
| Journal: |
J Virol |
| Title: |
In vivo activity of the hepatitis B virus core promoter: tissue specificity and temporal regulation. |
| Volume: |
69 |
| Issue: |
9 |
| Pages: |
5912-6 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
289
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
123
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
82
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
64
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
268
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pazzagli L |
| Year: |
1999 |
| Journal: |
J Biol Chem |
| Title: |
Purification, characterization, and amino acid sequence of cerato-platanin, a new phytotoxic protein from Ceratocystis fimbriata f. sp. platani. |
| Volume: |
274 |
| Issue: |
35 |
| Pages: |
24959-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sbrana F |
| Year: |
2007 |
| Journal: |
Eur Biophys J |
| Title: |
Atomic force microscopy images suggest aggregation mechanism in cerato-platanin. |
| Volume: |
36 |
| Issue: |
7 |
| Pages: |
727-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carresi L |
| Year: |
2006 |
| Journal: |
Protein Expr Purif |
| Title: |
Cerato-platanin, a phytotoxic protein from Ceratocystis fimbriata: expression in Pichia pastoris, purification and characterization. |
| Volume: |
49 |
| Issue: |
2 |
| Pages: |
159-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kusmierczyk AR |
| Year: |
2011 |
| Journal: |
Nat Struct Mol Biol |
| Title: |
A conserved 20S proteasome assembly factor requires a C-terminal HbYX motif for proteasomal precursor binding. |
| Volume: |
18 |
| Issue: |
5 |
| Pages: |
622-9 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
The 26S proteasome plays a critical role in a number of cellular processes including cell-cycle control, transcription, signal transduction and DNA repair []. This complex is composed of a catalytic 20S proteasome and two axially positioned 19S regulatory complexes. The overall structure is highly conserved among eukaryotes and is essential for cell viability. Assembly of the catalytic 20S proteasome CP (core particle) initiates with the formation of rings composed of seven alpha subunits and involves proteasome-assembly chaperones PAC1-PAC2, PAC3-PAC4 and UMP1 []. Two heterodimeric proteasome-assembly chaperones, PAC1-PAC2 and PAC3-PAC4, interact with alpha subunits and promote the correct assembly of alpha rings. PAC3-PAC4 leaves the complex during subsequent assembly of beta subunits, while PAC1-PAC2 remains bound until the assembly of the CP is completed [].This entry represents proteasome assembly chaperone 1 (PAC1). |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
The 26S proteasome plays a critical role in a number of cellular processes including cell-cycle control, transcription, signal transduction and DNA repair []. This complex is composed of a catalytic 20S proteasome and two axially positioned 19S regulatory complexes. The overall structure is highly conserved among eukaryotes and is essential for cell viability. Assembly of the catalytic 20S proteasome CP (core particle) initiates with the formation of rings composed of seven alpha subunits and involves proteasome-assembly chaperones PAC1-PAC2, PAC3-PAC4 and UMP1 []. Two heterodimeric proteasome-assembly chaperones, PAC1-PAC2 and PAC3-PAC4, interact with alpha subunits and promote the correct assembly of alpha rings. PAC3-PAC4 leaves the complex during subsequent assembly of beta subunits, while PAC1-PAC2 remains bound until the assembly of the CP is completed [].This family consists of proteasome assembly chaperone 4 (PAC4, PSMG4). At the very C terminus there is a crucial HbYX or hydrophobic-tyrosine-X sequence motif that, in proteasome activators, opens the 20S proteasome entry pore []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Cerato-platanin (CP) is the first member of the cerato-platanin family. It is produced by the Ascomycete Ceratocystis fimbriata f. sp. platani and causes the severe plant disease: canker stain. This protein occurs in the cell wall of the fungus and is involved in the host-plane interaction and induces both cell necrosis and phytoalexin synthesis which is one of the first plant defense-related events. CP, like other fungal surface proteins, is able to self assemble in vitro []. CP is a 120 amino acid protein, containing 40% hydrophobic residues and two S-S bridges. It contains four cysteine residues that form two disulphide bonds []. The N-terminal region of CP is very similar to cerato-ulmin, a phytotoxic protein produced by the Ophiostoma species belonging to the hydrophobin family, which also self-assembles []. This entry also includes other precursor proteins. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Matias AC |
| Year: |
2010 |
| Journal: |
Biochem Soc Trans |
| Title: |
Chaperone-assisted assembly of the proteasome core particle. |
| Volume: |
38 |
| Issue: |
Pt 1 |
| Pages: |
29-33 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Murata S |
| Year: |
2009 |
| Journal: |
Nat Rev Mol Cell Biol |
| Title: |
Molecular mechanisms of proteasome assembly. |
| Volume: |
10 |
| Issue: |
2 |
| Pages: |
104-15 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ksander BR |
| Year: |
2014 |
| Journal: |
Nature |
| Title: |
ABCB5 is a limbal stem cell gene required for corneal development and repair. |
| Volume: |
511 |
| Issue: |
7509 |
| Pages: |
353-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Parry DA |
| Year: |
2009 |
| Journal: |
Am J Hum Genet |
| Title: |
Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice. |
| Volume: |
84 |
| Issue: |
5 |
| Pages: |
683-91 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gulbins E |
| Year: |
2013 |
| Journal: |
Nat Med |
| Title: |
Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs. |
| Volume: |
19 |
| Issue: |
7 |
| Pages: |
934-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Coppieters F |
| Year: |
2016 |
| Journal: |
Am J Hum Genet |
| Title: |
Isolated and Syndromic Retinal Dystrophy Caused by Biallelic Mutations in RCBTB1, a Gene Implicated in Ubiquitination. |
| Volume: |
99 |
| Issue: |
2 |
| Pages: |
470-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meunier I |
| Year: |
2016 |
| Journal: |
Hum Mol Genet |
| Title: |
A dominant mutation in MAPKAPK3, an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium. |
| Volume: |
25 |
| Issue: |
5 |
| Pages: |
916-26 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nogusa S |
| Year: |
2016 |
| Journal: |
Cell Host Microbe |
| Title: |
RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus. |
| Volume: |
20 |
| Issue: |
1 |
| Pages: |
13-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kolakowski LF Jr |
| Year: |
1998 |
| Journal: |
J Neurochem |
| Title: |
Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3. |
| Volume: |
71 |
| Issue: |
6 |
| Pages: |
2239-51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Howard SR |
| Year: |
2016 |
| Journal: |
EMBO Mol Med |
| Title: |
IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal migration resulting in delayed puberty. |
| Volume: |
8 |
| Issue: |
6 |
| Pages: |
626-42 |
|
•
•
•
•
•
|