Type |
Details |
Score |
Genotype |
Symbol: |
Isl1/Isl1 Tg(Pax2-cre)1Akg/? |
Background: |
involves: 129S6/SvEvTac |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Meis2/Meis2 Tg(Pax2-cre)1Akg/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Dude CM |
Year: |
2009 |
Journal: |
Dev Biol |
Title: |
Activation of Pax3 target genes is necessary but not sufficient for neurogenesis in the ophthalmic trigeminal placode. |
Volume: |
326 |
Issue: |
2 |
Pages: |
314-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Waters AM |
Year: |
2008 |
Journal: |
J Am Soc Nephrol |
Title: |
Ectopic notch activation in developing podocytes causes glomerulosclerosis. |
Volume: |
19 |
Issue: |
6 |
Pages: |
1139-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pippin JW |
Year: |
2013 |
Journal: |
Am J Pathol |
Title: |
Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease. |
Volume: |
183 |
Issue: |
2 |
Pages: |
542-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ye H |
Year: |
2017 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
The regulatory 1α subunit of protein kinase A modulates renal cystogenesis. |
Volume: |
313 |
Issue: |
3 |
Pages: |
F677-F686 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao XP |
Year: |
2014 |
Journal: |
Diabetologia |
Title: |
Maternal diabetes modulates kidney formation in murine progeny: the role of hedgehog interacting protein (HHIP). |
Volume: |
57 |
Issue: |
9 |
Pages: |
1986-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singh S |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Molecular characterization of Wdr13 knockout female mice uteri: a model for human endometrial hyperplasia. |
Volume: |
10 |
Issue: |
1 |
Pages: |
14621 |
|
•
•
•
•
•
|
Publication |
First Author: |
Represa J |
Year: |
2000 |
Journal: |
Acta Otolaryngol |
Title: |
Genetic patterning of embryonic inner ear development. |
Volume: |
120 |
Issue: |
1 |
Pages: |
5-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wagner N |
Year: |
2006 |
Journal: |
Am J Physiol Regul Integr Comp Physiol |
Title: |
Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1. |
Volume: |
291 |
Issue: |
3 |
Pages: |
R779-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dziarmaga A |
Year: |
2003 |
Journal: |
J Am Soc Nephrol |
Title: |
Ureteric bud apoptosis and renal hypoplasia in transgenic PAX2-Bax fetal mice mimics the renal-coloboma syndrome. |
Volume: |
14 |
Issue: |
11 |
Pages: |
2767-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hueber PA |
Year: |
2009 |
Journal: |
Pediatr Dev Pathol |
Title: |
PAX3 is expressed in the stromal compartment of the developing kidney and in Wilms tumors with myogenic phenotype. |
Volume: |
12 |
Issue: |
5 |
Pages: |
347-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burger A |
Year: |
2011 |
Journal: |
Genesis |
Title: |
Generation of a novel rtTA transgenic mouse to induce time-controlled, tissue-specific alterations in Pax2-expressing cells. |
Volume: |
49 |
Issue: |
10 |
Pages: |
797-802 |
|
•
•
•
•
•
|
Publication |
First Author: |
Riedhammer KM |
Year: |
2024 |
Journal: |
Kidney Int |
Title: |
Implication of transcription factor FOXD2 dysfunction in syndromic congenital anomalies of the kidney and urinary tract (CAKUT). |
Volume: |
105 |
Issue: |
4 |
Pages: |
844-864 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bohuslavova R |
Year: |
2017 |
Journal: |
Mol Neurobiol |
Title: |
Pax2-Islet1 Transgenic Mice Are Hyperactive and Have Altered Cerebellar Foliation. |
Volume: |
54 |
Issue: |
2 |
Pages: |
1352-1368 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suzuki A |
Year: |
2012 |
Journal: |
Dev Growth Differ |
Title: |
Nuclear translocation of FGF8 and its implication to induce Sprouty2. |
Volume: |
54 |
Issue: |
4 |
Pages: |
463-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Russo A |
Year: |
2021 |
Journal: |
Cell Death Dis |
Title: |
Silencing PTEN in the fallopian tube promotes enrichment of cancer stem cell-like function through loss of PAX2. |
Volume: |
12 |
Issue: |
4 |
Pages: |
375 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1056
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Chang W |
Year: |
2008 |
Journal: |
PLoS Genet |
Title: |
Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e1000050 |
|
•
•
•
•
•
|
Publication |
First Author: |
Knapp L |
Year: |
2023 |
Journal: |
eNeuro |
Title: |
Rab11a Is Essential for the Development and Integrity of the Stereocilia and Kinocilia in the Mammalian Organ of Corti. |
Volume: |
10 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kersigo J |
Year: |
2015 |
Journal: |
Front Aging Neurosci |
Title: |
Inner ear hair cells deteriorate in mice engineered to have no or diminished innervation. |
Volume: |
7 |
|
Pages: |
33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kopecky B |
Year: |
2011 |
Journal: |
Dev Dyn |
Title: |
Conditional deletion of N-Myc disrupts neurosensory and non-sensory development of the ear. |
Volume: |
240 |
Issue: |
6 |
Pages: |
1373-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu LM |
Year: |
2023 |
Journal: |
Sci Adv |
Title: |
Cx26 heterozygous mutations cause hyperacusis-like hearing oversensitivity and increase susceptibility to noise. |
Volume: |
9 |
Issue: |
6 |
Pages: |
eadf4144 |
|
•
•
•
•
•
|
Publication |
First Author: |
Son EJ |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea. |
Volume: |
112 |
Issue: |
12 |
Pages: |
3746-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arnold JS |
Year: |
2006 |
Journal: |
Hum Mol Genet |
Title: |
Tissue-specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patients. |
Volume: |
15 |
Issue: |
10 |
Pages: |
1629-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Y |
Year: |
2009 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Targeted connexin26 ablation arrests postnatal development of the organ of Corti. |
Volume: |
385 |
Issue: |
1 |
Pages: |
33-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Elliott KL |
Year: |
2017 |
Journal: |
Front Neural Circuits |
Title: |
Spiral Ganglion Neuron Projection Development to the Hindbrain in Mice Lacking Peripheral and/or Central Target Differentiation. |
Volume: |
11 |
|
Pages: |
25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fritzsch B |
Year: |
2010 |
Journal: |
PLoS One |
Title: |
Canal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activity. |
Volume: |
5 |
Issue: |
2 |
Pages: |
e9377 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim HJ |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Patterns of gene expression associated with Pten deficiency in the developing inner ear. |
Volume: |
9 |
Issue: |
6 |
Pages: |
e97544 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun C |
Year: |
2014 |
Journal: |
Neuroreport |
Title: |
PTEN regulation of the proliferation and differentiation of auditory progenitors through the PTEN/PI3K/Akt-signaling pathway in mice. |
Volume: |
25 |
Issue: |
3 |
Pages: |
177-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohyama T |
Year: |
2010 |
Journal: |
J Neurosci |
Title: |
BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea. |
Volume: |
30 |
Issue: |
45 |
Pages: |
15044-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gilbert BL |
Year: |
2021 |
Journal: |
Front Cell Dev Biol |
Title: |
Actin Crosslinking Family Protein 7 Deficiency Does Not Impair Hearing in Young Mice. |
Volume: |
9 |
|
Pages: |
709442 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luo XJ |
Year: |
2013 |
Journal: |
Hum Mol Genet |
Title: |
GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea. |
Volume: |
22 |
Issue: |
18 |
Pages: |
3609-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eckrich S |
Year: |
2019 |
Journal: |
Front Cell Neurosci |
Title: |
Cochlea-Specific Deletion of Cav1.3 Calcium Channels Arrests Inner Hair Cell Differentiation and Unravels Pitfalls of Conditional Mouse Models. |
Volume: |
13 |
|
Pages: |
225 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu Y |
Year: |
2015 |
Journal: |
Sci Rep |
Title: |
Connexin26 gap junction mediates miRNA intercellular genetic communication in the cochlea and is required for inner ear development. |
Volume: |
5 |
|
Pages: |
15647 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jahan I |
Year: |
2010 |
Journal: |
PLoS One |
Title: |
Neurod1 suppresses hair cell differentiation in ear ganglia and regulates hair cell subtype development in the cochlea. |
Volume: |
5 |
Issue: |
7 |
Pages: |
e11661 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jahan I |
Year: |
2010 |
Journal: |
Cell Tissue Res |
Title: |
Neurod1 regulates survival and formation of connections in mouse ear and brain. |
Volume: |
341 |
Issue: |
1 |
Pages: |
95-110 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deuper L |
Year: |
2022 |
Journal: |
Development |
Title: |
Mesenchymal FGFR1 and FGFR2 control patterning of the ureteric mesenchyme by balancing SHH and BMP4 signaling. |
Volume: |
149 |
Issue: |
17 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Z |
Year: |
2013 |
Journal: |
Development |
Title: |
Kif5b controls the localization of myofibril components for their assembly and linkage to the myotendinous junctions. |
Volume: |
140 |
Issue: |
3 |
Pages: |
617-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma JH |
Year: |
2019 |
Journal: |
Biochem Biophys Res Commun |
Title: |
CTCF deficiency causes expansion of the sensory domain in the mouse cochlea. |
Volume: |
512 |
Issue: |
4 |
Pages: |
896-901 |
|
•
•
•
•
•
|
Publication |
First Author: |
Soukup GA |
Year: |
2009 |
Journal: |
Dev Biol |
Title: |
Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice. |
Volume: |
328 |
Issue: |
2 |
Pages: |
328-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gnedeva K |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
SoxC transcription factors are essential for the development of the inner ear. |
Volume: |
112 |
Issue: |
45 |
Pages: |
14066-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song H |
Year: |
2022 |
Journal: |
Dev Biol |
Title: |
Tbx2 and Tbx3 regulate cell fate progression of the otic vesicle for inner ear development. |
Volume: |
494 |
|
Pages: |
71-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Duncan JS |
Year: |
2017 |
Journal: |
Dev Biol |
Title: |
Celsr1 coordinates the planar polarity of vestibular hair cells during inner ear development. |
Volume: |
423 |
Issue: |
2 |
Pages: |
126-137 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao HB |
Year: |
2015 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Pannexin 1 deficiency can induce hearing loss. |
Volume: |
463 |
Issue: |
1-2 |
Pages: |
143-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Salehi P |
Year: |
2017 |
Journal: |
PLoS Genet |
Title: |
Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea. |
Volume: |
13 |
Issue: |
10 |
Pages: |
e1007048 |
|
•
•
•
•
•
|
Publication |
First Author: |
Durruthy-Durruthy R |
Year: |
2018 |
Journal: |
Front Genet |
Title: |
Single Cell Transcriptomics Reveal Abnormalities in Neurosensory Patterning of the Chd7 Mutant Mouse Ear. |
Volume: |
9 |
|
Pages: |
473 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang T |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Prickle1 regulates neurite outgrowth of apical spiral ganglion neurons but not hair cell polarity in the murine cochlea. |
Volume: |
12 |
Issue: |
8 |
Pages: |
e0183773 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matern MS |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
Transcriptional dynamics of delaminating neuroblasts in the mouse otic vesicle. |
Volume: |
42 |
Issue: |
6 |
Pages: |
112545 |
|
•
•
•
•
•
|
Publication |
First Author: |
Durruthy-Durruthy R |
Year: |
2014 |
Journal: |
Cell |
Title: |
Reconstruction of the mouse otocyst and early neuroblast lineage at single-cell resolution. |
Volume: |
157 |
Issue: |
4 |
Pages: |
964-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gnedeva K |
Year: |
2020 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Organ of Corti size is governed by Yap/Tead-mediated progenitor self-renewal. |
Volume: |
117 |
Issue: |
24 |
Pages: |
13552-13561 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cederroth CR |
Year: |
2019 |
Journal: |
Curr Biol |
Title: |
Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids. |
Volume: |
29 |
Issue: |
15 |
Pages: |
2477-2487.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miranda CO |
Year: |
2023 |
Journal: |
Int J Mol Sci |
Title: |
Synaptic Targets of Glycinergic Neurons in Laminae I-III of the Spinal Dorsal Horn. |
Volume: |
24 |
Issue: |
8 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Nie X |
Year: |
2014 |
Journal: |
Differentiation |
Title: |
Novel roles of Pkd2 in male reproductive system development. |
Volume: |
87 |
Issue: |
3-4 |
Pages: |
161-71 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Slc12a2/Slc12a2 Tbx1/Tbx1<+> Tg(Pax2-cre)1Akg/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Pax2-cre)1Akg/? Vangl2/Vangl2 |
Background: |
involves: 129S6/SvEvTac * C57BL/6 * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Chd7/Chd7 Tg(Pax2-cre)1Akg/? |
Background: |
involves: 129S * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ctnnb1/Ctnnb1 Tg(Pax2-cre)1Akg/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rbpj/Rbpj Tg(Pax2-cre)1Akg/? |
Background: |
involves: 129P2/OlaHsd * ICR |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tbx2/Tbx2 Tbx3/Tbx3 Tg(Pax2-cre)10Shwl/? Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * NMRI * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Pkd1/Pkd1 Tg(Pax2-cre)1Akg/? |
Background: |
involves: 129S4/SvJae |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Pax2-cre)1Akg/? |
Background: |
involves: 129S4/SvJaeSor * C57BL/6 * CD-1 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(CAG-Bgeo/GFP)21Lbe/? Tg(Pax2-cre)1Akg/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Pten/Pten Tg(Pax2-cre)1Akg/? |
Background: |
involves: 129S4/SvJae |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Pax2-cre)1Akg/? |
Background: |
involves: C57BL/6J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Isl1/Isl1 Pou4f1/Pou4f1 Tg(Pax2-cre)1Akg/? |
Background: |
involves: 129S7/SvEvBrd |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Cunanan J |
Year: |
2020 |
Journal: |
PLoS One |
Title: |
Quercetin treatment reduces the severity of renal dysplasia in a beta-catenin dependent manner. |
Volume: |
15 |
Issue: |
6 |
Pages: |
e0234375 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim D |
Year: |
2007 |
Journal: |
J Am Soc Nephrol |
Title: |
Pax transactivation-domain interacting protein is required for urine concentration and osmotolerance in collecting duct epithelia. |
Volume: |
18 |
Issue: |
5 |
Pages: |
1458-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Poleev A |
Year: |
1992 |
Journal: |
Development |
Title: |
PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors. |
Volume: |
116 |
Issue: |
3 |
Pages: |
611-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pfeffer PL |
Year: |
1998 |
Journal: |
Development |
Title: |
Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function. |
Volume: |
125 |
Issue: |
16 |
Pages: |
3063-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abraira VE |
Year: |
2010 |
Journal: |
PLoS One |
Title: |
Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis. |
Volume: |
5 |
Issue: |
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