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Type Details Score
Publication
18852460 | J:141100
First Author: Bobrovnikova-Marjon E
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation.
Volume: 105
Issue: 42
Pages: 16314-9
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Publication
16399505 | J:129665
First Author: Fujikura J
Year: 2006
Journal: Cell Metab
Title: Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas.
Volume: 3
Issue: 1
Pages: 59-65
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Publication
10224284 | J:110775
First Author: Cocea L
Year: 1999
Journal: J Exp Med
Title: A targeted deletion of a region upstream from the Jkappa cluster impairs kappa chain rearrangement in cis in mice and in the 103/bcl2 cell line.
Volume: 189
Issue: 9
Pages: 1443-50
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Publication
32041188 | J:297757
 
First Author: D'Angelo V
Year: 2020
Journal: Int J Mol Sci
Title: Dystonia: Sparse Synapses for D2 Receptors in Striatum of a DYT1 Knock-out Mouse Model.
Volume: 21
Issue: 3
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Publication
22949635 | J:190156
First Author: Miller MF
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Wnt ligands signal in a cooperative manner to promote foregut organogenesis.
Volume: 109
Issue: 38
Pages: 15348-53
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Publication
22265049 | J:179884
First Author: Takahashi A
Year: 2012
Journal: Am J Pathol
Title: Autophagy guards against cisplatin-induced acute kidney injury.
Volume: 180
Issue: 2
Pages: 517-25
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Publication
10781093 | J:61950
First Author: Menotti L
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: The murine homolog of human Nectin1delta serves as a species nonspecific mediator for entry of human and animal alpha herpesviruses in a pathway independent of a detectable binding to gD.
Volume: 97
Issue: 9
Pages: 4867-72
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Publication
23569259 | J:196151
First Author: Arvizo RR
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Inhibition of tumor growth and metastasis by a self-therapeutic nanoparticle.
Volume: 110
Issue: 17
Pages: 6700-5
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Publication
10954736 | J:64303
First Author: Collum RG
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: A Stat3-interacting protein (StIP1) regulates cytokine signal transduction.
Volume: 97
Issue: 18
Pages: 10120-5
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Publication
8134392 | J:17252
First Author: Nagasawa T
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Molecular cloning and structure of a pre-B-cell growth-stimulating factor.
Volume: 91
Issue: 6
Pages: 2305-9
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Publication
10688915 | J:60924
First Author: Hermeking H
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Identification of CDK4 as a target of c-MYC.
Volume: 97
Issue: 5
Pages: 2229-34
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Publication
6300842 | J:20096
First Author: Picard D
Year: 1983
Journal: Proc Natl Acad Sci U S A
Title: Correct transcription of a cloned mouse immunoglobulin gene in vivo.
Volume: 80
Issue: 2
Pages: 417-21
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Publication
1763047 | J:27575
First Author: Daley GQ
Year: 1991
Journal: Proc Natl Acad Sci U S A
Title: Blast crisis in a murine model of chronic myelogenous leukemia.
Volume: 88
Issue: 24
Pages: 11335-8
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Publication
1349171 | J:985
First Author: Violette SM
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Repression of the beta-amyloid gene in a Hox-3.1-producing cell line.
Volume: 89
Issue: 9
Pages: 3805-9
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Publication
7912438 | J:18995
First Author: Rosenberg M
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: "RFLP subtraction": a method for making libraries of polymorphic markers.
Volume: 91
Issue: 13
Pages: 6113-7
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Publication
7937743 | J:20517
First Author: Nystedt S
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Molecular cloning of a potential proteinase activated receptor.
Volume: 91
Issue: 20
Pages: 9208-12
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Publication
7831296 | J:23063
First Author: Ogura T
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: A retinoic acid-triggered cascade of HOXB1 gene activation.
Volume: 92
Issue: 2
Pages: 387-91
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Publication
9122206 | J:39330
First Author: Selig S
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Molecular characterization of Br-cadherin, a developmentally regulated, brain-specific cadherin.
Volume: 94
Issue: 6
Pages: 2398-403
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Publication
2217180 | J:81374
First Author: Skowronski J
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: Determinants of the B-cell response against a transgenic autoantigen.
Volume: 87
Issue: 19
Pages: 7487-91
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Publication
18645184 | J:138320
First Author: Gerashchenko D
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Identification of a population of sleep-active cerebral cortex neurons.
Volume: 105
Issue: 29
Pages: 10227-32
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Publication
21825155 | J:175985
First Author: Lee JS
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Hypoxia-induced methylation of a pontin chromatin remodeling factor.
Volume: 108
Issue: 33
Pages: 13510-5
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Publication
21997212 | J:177509
First Author: Yim HC
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: A role for c-Myc in regulating anti-mycobacterial responses.
Volume: 108
Issue: 43
Pages: 17749-54
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Publication
25201987 | J:216484
First Author: Liu K
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Neuronal necrosis is regulated by a conserved chromatin-modifying cascade.
Volume: 111
Issue: 38
Pages: 13960-5
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Publication
20371546 | J:290477
First Author: Kumar R
Year: 2010
Journal: J Gerontol A Biol Sci Med Sci
Title: A quantitative trait locus on chr.4 regulates thymic involution.
Volume: 65
Issue: 6
Pages: 620-5
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Publication
32546524 | J:297386
First Author: Sahara S
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: A common rule governing differentiation kinetics of mouse cortical progenitors.
Volume: 117
Issue: 26
Pages: 15221-15229
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Publication
33649239 | J:304795
 
First Author: Brosh R
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: A versatile platform for locus-scale genome rewriting and verification.
Volume: 118
Issue: 10
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Publication
33318181 | J:300391
First Author: Lohr KM
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model.
Volume: 117
Issue: 52
Pages: 33608-33618
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Publication
15075390 | J:356394
First Author: Su AI
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: A gene atlas of the mouse and human protein-encoding transcriptomes.
Volume: 101
Issue: 16
Pages: 6062-7
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Publication
20921395 | J:165539
First Author: Abdala AP
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Correction of respiratory disorders in a mouse model of Rett syndrome.
Volume: 107
Issue: 42
Pages: 18208-13
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Publication
36343238 | J:358741
First Author: Murphy KR
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: A tool for monitoring cell type-specific focused ultrasound neuromodulation and control of chronic epilepsy.
Volume: 119
Issue: 46
Pages: e2206828119
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Publication
34949717 | J:326316
 
First Author: Johnson MT
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: STIM1 is a core trigger of airway smooth muscle remodeling and hyperresponsiveness in asthma.
Volume: 119
Issue: 1
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Publication
19549859 | J:150823
First Author: Kamanaka M
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Amino acid polymorphisms altering the glycosylation of IL-2 do not protect from type 1 diabetes in the NOD mouse.
Volume: 106
Issue: 27
Pages: 11236-40
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Publication
23029473 | J:191963
First Author: Nalbandian A
Year: 2012
Journal: PLoS One
Title: The homozygote VCP(R¹⁵⁵H/R¹⁵⁵H) mouse model exhibits accelerated human VCP-associated disease pathology.
Volume: 7
Issue: 9
Pages: e46308
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Publication
39491648 | J:359500
First Author: Uota A
Year: 2024
Journal: J Biol Chem
Title: ARMC5 selectively degrades SCAP-free SREBF1 and is essential for fatty acid desaturation in adipocytes.
Volume: 300
Issue: 12
Pages: 107953
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Genotype
Genotype
Symbol: Gabbr1/Gabbr1 Hdc/Hdc<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Publication
26606997 | J:230569
First Author: Lin WC
Year: 2015
Journal: Neuron
Title: A Comprehensive Optogenetic Pharmacology Toolkit for In Vivo Control of GABA(A) Receptors and Synaptic Inhibition.
Volume: 88
Issue: 5
Pages: 879-891
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Publication
22009253 | J:180057
First Author: Lewis A
Year: 2012
Journal: J Pathol
Title: The C-terminus of Apc does not influence intestinal adenoma development or progression.
Volume: 226
Issue: 1
Pages: 73-83
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Publication
29186427 | J:255590
First Author: Aziz A
Year: 2018
Journal: Endocrinology
Title: Insulinlike Growth Factor-Binding Protein-1 Improves Vascular Endothelial Repair in Male Mice in the Setting of Insulin Resistance.
Volume: 159
Issue: 2
Pages: 696-709
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Publication
23785462 | J:203338
First Author: Bourgine A
Year: 2013
Journal: PLoS One
Title: Mice with hypomorphic expression of the sodium-phosphate cotransporter PiT1/Slc20a1 have an unexpected normal bone mineralization.
Volume: 8
Issue: 6
Pages: e65979
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Publication
23593003 | J:196654
First Author: Villegas-Mendez A
Year: 2013
Journal: PLoS Pathog
Title: IL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1 cells during malaria infection by repressing IL-12 dependent signals.
Volume: 9
Issue: 4
Pages: e1003293
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Publication
22740452 | J:189184
First Author: Elvers M
Year: 2012
Journal: Blood
Title: Intracellular cyclophilin A is an important Ca(2+) regulator in platelets and critically involved in arterial thrombus formation.
Volume: 120
Issue: 6
Pages: 1317-26
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Publication
- | J:125747
     
First Author: Hui D
Year: 2007
Journal: MGI Direct Data Submission
Title: Generation and description of gene trap mutation of Sorl1
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Publication
25175815 | J:232150
First Author: Liu J
Year: 2014
Journal: Int J Oncol
Title: Postnatal Notch1 activation induces T‑cell malignancy in conditional and inducible mouse models.
Volume: 45
Issue: 5
Pages: 1997-2004
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Publication
26123589 | J:236513
 
First Author: Kirschner LS
Year: 2016
Journal: Mol Cell Endocrinol
Title: Mouse models of thyroid cancer: A 2015 update.
Volume: 421
Pages: 18-27
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Publication
23019375 | J:190315
First Author: Rousseaux MW
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease.
Volume: 109
Issue: 39
Pages: 15918-23
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Publication
21795536 | J:174507
First Author: Ranganathan S
Year: 2011
Journal: J Neurosci
Title: LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking.
Volume: 31
Issue: 30
Pages: 10836-46
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Publication
23301081 | J:195817
First Author: Chevallier A
Year: 2013
Journal: PLoS One
Title: Oculomotor deficits in aryl hydrocarbon receptor null mouse.
Volume: 8
Issue: 1
Pages: e53520
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Publication
20937905 | J:165504
First Author: Ohno Y
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.
Volume: 107
Issue: 43
Pages: 18439-44
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Publication
26240359 | J:226563
First Author: Liang X
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock.
Volume: 112
Issue: 33
Pages: 10479-84
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Publication
26240314 | J:226569
First Author: Ohshima J
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.
Volume: 112
Issue: 33
Pages: E4581-90
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Protein Coding Gene
MGI:97305 | Neu1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
24548803 | J:211581
First Author: Kunne C
Year: 2014
Journal: Biochim Biophys Acta
Title: FXR-dependent reduction of hepatic steatosis in a bile salt deficient mouse model.
Volume: 1842
Issue: 5
Pages: 739-46
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Publication
27222476 | J:236118
First Author: Sinclair A
Year: 2016
Journal: Blood
Title: CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.
Volume: 128
Issue: 3
Pages: 371-83
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Publication
33526437 | J:345380
First Author: Olazagoitia-Garmendia A
Year: 2022
Journal: Gut
Title: Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells.
Volume: 71
Issue: 1
Pages: 68-76
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Publication
30905411 | J:291131
First Author: Kasamatsu A
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Deficiency of lysyl hydroxylase 2 in mice causes systemic endoplasmic reticulum stress leading to early embryonic lethality.
Volume: 512
Issue: 3
Pages: 486-491
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Publication
31856641 | J:337420
First Author: Nakashima A
Year: 2020
Journal: Autophagy
Title: Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia.
Volume: 16
Issue: 10
Pages: 1771-1785
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Publication
12727874 | -
First Author: Balguerie A
Year: 2003
Journal: EMBO J
Title: Domain organization and structure-function relationship of the HET-s prion protein of Podospora anserina.
Volume: 22
Issue: 9
Pages: 2071-81
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Publication
8622955 | J:35115
First Author: Wang Q
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.
Volume: 93
Issue: 8
Pages: 3444-9
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Publication
1423603 | J:3019
First Author: Burgoyne PS
Year: 1992
Journal: Cell
Title: Fertility in mice requires X-Y pairing and a Y-chromosomal "spermiogenesis" gene mapping to the long arm.
Volume: 71
Issue: 3
Pages: 391-8
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Publication
11991715 | J:73797
First Author: Doudney K
Year: 2002
Journal: Genomics
Title: Cloning and characterization of Igsf9 in mouse and human: a new member of the immunoglobulin superfamily expressed in the developing nervous system.
Volume: 79
Issue: 5
Pages: 663-70
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Publication
20427744 | J:160293
First Author: Fröhlich LF
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Targeted deletion of the Nesp55 DMR defines another Gnas imprinting control region and provides a mouse model of autosomal dominant PHP-Ib.
Volume: 107
Issue: 20
Pages: 9275-80
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GO Term
GO:0052816 | long-chain fatty acyl-CoA hydrolase activity
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GO Term
GO:0016509 | long-chain-3-hydroxyacyl-CoA dehydrogenase activity
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GO Term
GO:0004466 | long-chain fatty acyl-CoA dehydrogenase activity
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GO Term
GO:0052815 | medium-chain fatty acyl-CoA hydrolase activity
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Publication
30541894 | J:268121
First Author: Bayraktar EC
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo.
Volume: 116
Issue: 1
Pages: 303-312
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Publication
8678984 | J:34784
First Author: Levy N
Year: 1996
Journal: Mamm Genome
Title: Molecular analysis of an isoYq chromosome in a sterile male mouse.
Volume: 7
Issue: 8
Pages: 608-9
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Publication
16710301 | -
First Author: Jensen AM
Year: 2006
Journal: EMBO J
Title: Modulatory and catalytic modes of ATP binding by the calcium pump.
Volume: 25
Issue: 11
Pages: 2305-14
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Publication
18075584 | -
First Author: Olesen C
Year: 2007
Journal: Nature
Title: The structural basis of calcium transport by the calcium pump.
Volume: 450
Issue: 7172
Pages: 1036-42
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Publication
18930923 | -
First Author: Clausen JD
Year: 2008
Journal: J Biol Chem
Title: Critical interaction of actuator domain residues arginine 174, isoleucine 188, and lysine 205 with modulatory nucleotide in sarcoplasmic reticulum Ca2+-ATPase.
Volume: 283
Issue: 51
Pages: 35703-14
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Protein Domain
IPR005725 | ATPase_V1-cplx_asu
Type: Family
Description: Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. There are several different types of transmembrane ATPases,which can differ in function (ATP hydrolysis and/or synthesis), structure (e.g., F-, V- and A-ATPases, which contain rotary motors) and in the type of ions they transport [, ]. The different types include:F-ATPases (ATP synthases, F1F0-ATPases), which are found in mitochondria, chloroplasts and bacterial plasma membranes where they are the prime producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases), which are primarily found in eukaryotes and they function as proton pumps that acidify intracellular compartments and, in some cases, transport protons across the plasma membrane []. They are also found in bacteria [].A-ATPases (A1A0-ATPases), which are found in Archaea and function like F-ATPases, though with respect to their structure and some inhibitor responses, A-ATPases are more closely related to the V-ATPases [, ].P-ATPases (E1E2-ATPases), which are found in bacteria and in eukaryotic plasma membranes and organelles, and function to transport a variety of different ions across membranes.E-ATPases, which are cell-surface enzymes that hydrolyse a range of NTPs, including extracellular ATP.V-ATPases (also known as V1V0-ATPase or vacuolar ATPase) are found in the eukaryotic endomembrane system, and in the plasma membrane of prokaryotes and certain specialised eukaryotic cells. V-ATPases hydrolyse ATP to drive a proton pump, and are involved in a variety of vital intra- and inter-cellular processes such as receptor mediated endocytosis, protein trafficking, active transport of metabolites, homeostasis and neurotransmitter release []. V-ATPases are composed of two linked complexes: the V1 complex (subunits A-H) contains the catalytic core that hydrolyses ATP, while the V0 complex (subunits a, c, c', c'', d) forms the membrane-spanning pore. V-ATPases may have an additional role in membrane fusion through binding to t-SNARE proteins [].This entry represents subunit A from the V1 complex of V-ATPases. There are three copies each of subunits A and B (), both of which participate in nucleotide binding. However, only subunit A is catalytic, functioning in ATP hydrolysis to drive the rotation of the D and F subunits of V1, as well as the V0 complex c-ring rotor subunit for proton translocation [, ].
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Protein Domain
IPR008250 | ATPase_P-typ_transduc_dom_A_sf
Type: Homologous_superfamily
Description: Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. There are several different types of transmembrane ATPases, which can differ in function (ATP hydrolysis and/or synthesis), structure (e.g., F-, V- and A-ATPases, which contain rotary motors) and in the type of ions they transport [, ]. The different types include:F-ATPases (ATP synthases, F1F0-ATPases), which are found in mitochondria, chloroplasts and bacterial plasma membranes where they are the prime producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases), which are primarily found in eukaryotes and they function as proton pumps that acidify intracellular compartments and, in some cases, transport protons across the plasma membrane []. They are also found in bacteria [].A-ATPases (A1A0-ATPases), which are found in Archaea and function like F-ATPases, though with respect to their structure and some inhibitor responses, A-ATPases are more closely related to the V-ATPases [, ].P-ATPases (E1E2-ATPases), which are found in bacteria and in eukaryotic plasma membranes and organelles, and function to transport a variety of different ions across membranes.E-ATPases, which are cell-surface enzymes that hydrolyse a range of NTPs, including extracellular ATP.P-ATPases (also known as E1-E2 ATPases) ([intenz:3.6.3.-]) are found in bacteria and in a number of eukaryotic plasma membranes and organelles []. P-ATPases function to transport a variety of different compounds, including ions and phospholipids, across a membrane using ATP hydrolysis for energy. There are many different classes of P-ATPases, which transport specific types of ion: H+, Na+, K+, Mg2+, Ca2+, Ag+and Ag2+, Zn2+, Co2+, Pb2+, Ni2+, Cd2+, Cu+and Cu2+. P-ATPases can be composed of one or two polypeptides, and can usually assume two main conformations called E1 and E2.This superfamily represents the actuator (A) domain, and some transmembrane helices found in P-type ATPases []. It contains the TGES-loop which is essential for the metal ion binding which results in tight association between the A and P (phosphorylation) domains []. It does not contain the phosphorylation site. It is thought that the large movement of the actuator domain, which is transmitted to the transmembrane helices, is essential to the long distance coupling between formation/decomposition of the acyl phosphate in the cytoplasmic P-domain and the changes in the ion-binding sites buried deep in the membranous region []. This domain has a modulatory effect on the phosphoenzyme processing steps through its nucleotide binding [, ].
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Publication
20410265 | J:198335
First Author: Hirai A
Year: 2010
Journal: J Virol
Title: Role of mouse hepatitis virus (MHV) receptor murine CEACAM1 in the resistance of mice to MHV infection: studies of mice with chimeric mCEACAM1a and mCEACAM1b.
Volume: 84
Issue: 13
Pages: 6654-66
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Publication
33707780 | J:305472
First Author: Prados A
Year: 2021
Journal: Nat Immunol
Title: Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity.
Volume: 22
Issue: 4
Pages: 510-519
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Publication
32591500 | J:292080
First Author: Miao K
Year: 2020
Journal: Nat Commun
Title: NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation.
Volume: 11
Issue: 1
Pages: 3256
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Publication
18252823 | J:143961
First Author: Johansson F
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Genotype
Genotype
Symbol: Aldh1a2/Aldh1a2 Tg(Dll1-cre)1Gos/?
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
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