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Type Details Score
Publication
10666455 | -
First Author: Yehudai-Resheff S
Year: 2000
Journal: Nucleic Acids Res
Title: Characterization of the E.coli poly(A) polymerase: nucleotide specificity, RNA-binding affinities and RNA structure dependence.
Volume: 28
Issue: 5
Pages: 1139-44
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Publication
1634528 | -
First Author: Chen JY
Year: 1992
Journal: J Biol Chem
Title: Cytoplasmic and mitochondrial tRNA nucleotidyltransferase activities are derived from the same gene in the yeast Saccharomyces cerevisiae.
Volume: 267
Issue: 21
Pages: 14879-83
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Protein Domain
IPR004165 | CoA_trans_fam_I
Type: Family
Description: Coenzyme A (CoA) transferases belong to an evolutionary conserved [, ]family of enzymes catalyzing the reversible transfer of CoA from one carboxylic acid to another. They have been identified in many prokaryotes and in mammalian tissues. The bacterial enzymes are heterodimer of two subunits (A and B) of about 25 Kd each while eukaryotic SCOT consist of a single chain which is colinear with the two bacterial subunits.CoA-transferases are found in organisms from all kingdoms of life. They catalyse reversible transfer reactions of coenzyme A groups from CoA-thioesters to free acids. There are at least three families of CoA-transferases, which differ in sequence and reaction mechanism:Family I consists of CoA-transferases for 3-oxoacids (, ), short-chain fatty acids (, ) and glutaconate (). Most use succinyl-CoA or acetyl-CoA as CoA donors.Family II consists of the homodimeric alpha-subunits of citrate lyase and citramalate lyase (, ). These enzymes catalyse the transfer of acyl carrier protein (ACP) with a covalently bound CoA derivative, but can accept free CoA thioesters as well.Family III consists of formyl-CoA:oxalate CoA-transferase [], succinyl-CoA:(R)-benzylsuccinate CoA-transferase [], (E)-cinnamoyl-CoA:(R)-phenyllactate CoA-transferase [], succinyl-CoA:mesaconate CoA-transferase []and butyrobetainyl-CoA:(R)-carnitine CoA-transferase []. These CoA-transferases occur in prokaryotes and eukaryotes, and catalyse CoA-transfer reactions in a highly substrate- and stereo-specific manner [].This family consists of 3-oxoacid CoA-transferases and related CoA-transferases from family I.
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Protein Domain
IPR036126 | TBCA_sf
Type: Homologous_superfamily
Description: The tubulin heterodimer consists of one alpha- and one beta-tubulin polypeptide. In humans, five tubulin-specific chaperones termed TBCA/B/C/D/E are essential for bring the alpha- and beta-tubulin subunits together into a tightly associated heterodimer. Following the generation of quasi-native beta- and alpha-tubulin polypeptides (via multiple rounds of ATP-dependent interaction with the cytosolic chaperonin), TBCA and TBCB bind to and stabilise newly synthesised beta- and alpha-tubulin, respectively. The exchange of beta-tubulin between TBCA and TBCD, and of alpha-tubulin between TBCB and TBCE, resulting in the formation of TBCD/beta and TBCE/alpha. These two complexes then interact with each other and form a supercomplex (TBCE/alpha/TBCD/beta). Interaction of the supercomplex with TBCC causes the disassembly of the supercomplex and the release of E-site GDP-bound alpha/beta tubulin heterodimer, which becomes polymerization competent following spontaneous exchange with GTP [].This entry represents tubulin binding cofactor A (TBCA) from animal, plants and fungi. Human TBCA functions as a molecular chaperone for beta-tubulin []. Budding yeast TBCA, also known as Rbl2, may bind transiently to free beta-tubulin, which then passes into an aggregated form that is not toxic []. The sequence identity of Rbl2 and human TBCA is only 32%, they appear to be structurally distinct and may interact with beta-tubulin by different mechanisms []. The structure of TBCA has three helices forming a bundle closed fold with left-handed twist topology going up-and-down.
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Protein Domain
IPR002646 | PolA_pol_head_dom
Type: Domain
Description: This group includes nucleic acid independent RNA polymerases, such as polynucleotide adenylyltransferase (), which adds the poly (A) tail to mRNA. This group also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA ().CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)]., one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction [, ]. This Class II group is comprised mainly of eubacterial and eukaryotic enzymes and includes Bacillus stearothermophilus CCAase [], Escherichia coli poly(A) polymerase I [, ], human mitochondrial CCAase [, ], and Saccharomyces cerevisiae CCAase (CCA1) [, , ]. CCA-adding enzymes have a single catalytic pocket, which recognizes both ATP and CTP substrates [, ]. This family belongs to the Pol beta-like NT superfamily [, ]. Escherichia coli CCAase is related to this group but has not been included in this alignment as this enzyme lacks the N-terminal helix conserved in the remainder of the NT superfamily.In the Pol beta-like NT superfamily [, ], the majority of enzymes have two carboxylates, Dx[D/E], together with a third more distal carboxylate, which coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are fairly well conserved in this family.
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Protein Domain
IPR000590 | HMG_CoA_synt_AS
Type: Active_site
Description: Hydroxymethylglutaryl-CoA synthase () catalyses the condensation of acetyl-CoA with acetoacetyl-CoA to produce HMG-CoA and CoA, the second reaction in the mevalonate-dependent isoprenoid biosynthesis pathway. HMG-CoA synthase contains an important catalytic cysteine residue that acts as a nucleophile in the first step of the reaction: the acetylation of the enzyme by acetyl-CoA (its first substrate) to produce an acetyl-enzyme thioester, releasing the reduced coenzyme A. The subsequent nucleophilic attack on acetoacetyl-CoA (its second substrate) leads to the formation of HMG-CoA [].HMG-CoA synthase occurs in eukaryotes, archaea and certain bacteria []. In vertebrates, there are two isozymes located in different subcellular compartments: a cytosolic form that is the starting point of the mevalonate pathway (leads to cholesterol and other sterolic and isoprenoid compounds), and a mitochondrial form responsible for ketone body biosynthesis. HMG-CoA is also found in other eukaryotes such as insects, plants and fungi []. In bacteria, isoprenoid precursors are generally synthesised via an alternative, non-mevalonate pathway, however a number of Gram-positive pathogens utilise a mevalonate pathway involving HMG-CoA synthase that is parallel to that found in eukaryotes [, ].This entry represents the sequence surrounding the catalytic cysteine required for nucleophilic attack in the first step of the reaction, the acetylation of the enzyme by acetyl-CoA.
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Protein Domain
IPR013746 | HMG_CoA_synt_C_dom
Type: Domain
Description: Hydroxymethylglutaryl-CoA synthase () catalyses the condensation of acetyl-CoA with acetoacetyl-CoA to produce HMG-CoA and CoA, the second reaction in the mevalonate-dependent isoprenoid biosynthesis pathway. HMG-CoA synthase contains an important catalytic cysteine residue that acts as a nucleophile in the first step of the reaction: the acetylation of the enzyme by acetyl-CoA (its first substrate) to produce an acetyl-enzyme thioester, releasing the reduced coenzyme A. The subsequent nucleophilic attack on acetoacetyl-CoA (its second substrate) leads to the formation of HMG-CoA [].HMG-CoA synthase occurs in eukaryotes, archaea and certain bacteria []. In vertebrates, there are two isozymes located in different subcellular compartments: a cytosolic form that is the starting point of the mevalonate pathway (leads to cholesterol and other sterolic and isoprenoid compounds), and a mitochondrial form responsible for ketone body biosynthesis. HMG-CoA is also found in other eukaryotes such as insects, plants and fungi []. In bacteria, isoprenoid precursors are generally synthesised via an alternative, non-mevalonate pathway, however a number of Gram-positive pathogens utilise a mevalonate pathway involving HMG-CoA synthase that is parallel to that found in eukaryotes [, ].This entry represents the C-terminal domain of HMG-CoA synthase enzymes from both eukaryotes and prokaryotes.
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Publication
38297077 | J:345656
First Author: Thakur A
Year: 2024
Journal: Commun Biol
Title: HNF4A guides the MLL4 complex to establish and maintain H3K4me1 at gene regulatory elements.
Volume: 7
Issue: 1
Pages: 144
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Publication
20861447 | J:165411
First Author: Pan F
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile X syndrome.
Volume: 107
Issue: 41
Pages: 17768-73
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Publication
26212662 | J:253121
First Author: Gresset A
Year: 2015
Journal: Stem Cell Reports
Title: Boundary Caps Give Rise to Neurogenic Stem Cells and Terminal Glia in the Skin.
Volume: 5
Issue: 2
Pages: 278-90
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Publication
14602678 | J:87226
First Author: Liu A
Year: 2003
Journal: Development
Title: FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors.
Volume: 130
Issue: 25
Pages: 6175-85
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Publication
28636954 | J:259205
First Author: Ersching J
Year: 2017
Journal: Immunity
Title: Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase.
Volume: 46
Issue: 6
Pages: 1045-1058.e6
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ncRNA Gene
MGI:5784924 | Betalinc1
Type: lincRNA_gene
Organism: mouse, laboratory
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Publication
19855845 | J:154035
First Author: Rangel A
Year: 2009
Journal: PLoS One
Title: Regulation of GABA(A) and glutamate receptor expression, synaptic facilitation and long-term potentiation in the hippocampus of prion mutant mice.
Volume: 4
Issue: 10
Pages: e7592
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Publication
10655586 | J:60189
First Author: Cano A
Year: 2000
Journal: Nat Cell Biol
Title: The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression.
Volume: 2
Issue: 2
Pages: 76-83
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Publication
24958103 | J:224268
First Author: Kurbegovic A
Year: 2014
Journal: Mol Cell Biol
Title: Novel functional complexity of polycystin-1 by GPS cleavage in vivo: role in polycystic kidney disease.
Volume: 34
Issue: 17
Pages: 3341-53
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Publication
11397946 | J:70452
First Author: Grupe A
Year: 2001
Journal: Science
Title: In silico mapping of complex disease-related traits in mice.
Volume: 292
Issue: 5523
Pages: 1915-8
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Publication
25066922 | J:320010
First Author: Ji H
Year: 2014
Journal: Hepatology
Title: T-cell immunoglobulin and mucin domain 4 (TIM-4) signaling in innate immune-mediated liver ischemia-reperfusion injury.
Volume: 60
Issue: 6
Pages: 2052-2064
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Publication
20713697 | J:163751
First Author: Kuroda J
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart.
Volume: 107
Issue: 35
Pages: 15565-70
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Publication
24946806 | J:212182
First Author: Hynes AM
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Murine Joubert syndrome reveals Hedgehog signaling defects as a potential therapeutic target for nephronophthisis.
Volume: 111
Issue: 27
Pages: 9893-8
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Publication
17122055 | J:116180
First Author: Wallén-Mackenzie A
Year: 2006
Journal: J Neurosci
Title: Vesicular glutamate transporter 2 is required for central respiratory rhythm generation but not for locomotor central pattern generation.
Volume: 26
Issue: 47
Pages: 12294-307
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Publication
34262084 | J:321288
First Author: Babcock MC
Year: 2021
Journal: Sci Rep
Title: Substrate reduction therapy for Krabbe disease and metachromatic leukodystrophy using a novel ceramide galactosyltransferase inhibitor.
Volume: 11
Issue: 1
Pages: 14486
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Protein Coding Gene
MGI:3030269 | Or2a51
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3030268 | Or2a20
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12370428 | J:126711
First Author: Weihua Z
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth.
Volume: 99
Issue: 21
Pages: 13589-94
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Publication
3162231 | J:9065
First Author: Reckelhoff JF
Year: 1988
Journal: Immunogenetics
Title: Mep-1, the gene regulating meprin activity, maps between Pgk-2 and Ce-2 on mouse chromosome 17.
Volume: 27
Issue: 4
Pages: 298-300
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Publication
23204224 | J:194376
First Author: Shakya R
Year: 2013
Journal: Cancer Res
Title: Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.
Volume: 73
Issue: 2
Pages: 885-96
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Publication
22225874 | J:182324
First Author: Guerci A
Year: 2012
Journal: Cell Metab
Title: Srf-dependent paracrine signals produced by myofibers control satellite cell-mediated skeletal muscle hypertrophy.
Volume: 15
Issue: 1
Pages: 25-37
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Publication
25816987 | J:239288
First Author: Eisner A
Year: 2015
Journal: Dev Cell
Title: The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis.
Volume: 33
Issue: 1
Pages: 22-35
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Publication
28860566 | J:256487
First Author: Sallese A
Year: 2017
Journal: Sci Rep
Title: Targeting cholesterol homeostasis in lung diseases.
Volume: 7
Issue: 1
Pages: 10211
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Publication
19829704 | J:154094
First Author: Oyagi A
Year: 2009
Journal: PLoS One
Title: Generation and characterization of conditional heparin-binding EGF-like growth factor knockout mice.
Volume: 4
Issue: 10
Pages: e7461
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Publication
29606579 | J:261691
First Author: Mitra A
Year: 2018
Journal: Neuron
Title: Spontaneous Infra-slow Brain Activity Has Unique Spatiotemporal Dynamics and Laminar Structure.
Volume: 98
Issue: 2
Pages: 297-305.e6
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Publication
16847256 | J:111824
First Author: Xin M
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: A threshold of GATA4 and GATA6 expression is required for cardiovascular development.
Volume: 103
Issue: 30
Pages: 11189-94
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Publication
21339332 | J:170997
First Author: Tsun A
Year: 2011
Journal: J Cell Biol
Title: Centrosome docking at the immunological synapse is controlled by Lck signaling.
Volume: 192
Issue: 4
Pages: 663-74
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Publication
14687553 | J:87180
First Author: Kolleker A
Year: 2003
Journal: Neuron
Title: Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptors.
Volume: 40
Issue: 6
Pages: 1199-212
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Publication
38714644 | J:347983
First Author: Hurtado A
Year: 2024
Journal: Nat Commun
Title: Complete male-to-female sex reversal in XY mice lacking the miR-17~92 cluster.
Volume: 15
Issue: 1
Pages: 3809
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Publication
8870704 | J:35618
First Author: Marchant A
Year: 1996
Journal: Clin Exp Immunol
Title: Methylprednisolone differentially regulates IL-10 and tumour necrosis factor (TNF) production during murine endotoxaemia.
Volume: 106
Issue: 1
Pages: 91-6
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Publication
18765640 | J:141176
First Author: Perilhou A
Year: 2008
Journal: Mol Cell Biol
Title: The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathways.
Volume: 28
Issue: 21
Pages: 6568-79
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Publication
18794533 | J:142584
First Author: Martel G
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Stathmin reveals dissociable roles of the basolateral amygdala in parental and social behaviors.
Volume: 105
Issue: 38
Pages: 14620-5
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Protein Coding Gene
MGI:1922028 | Rrp7a
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12114623 | J:107879
First Author: Cohen P
Year: 2002
Journal: Science
Title: Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss.
Volume: 297
Issue: 5579
Pages: 240-3
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Publication
30944222 | J:274277
First Author: Motwani M
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Hierarchy of clinical manifestations in SAVI N153S and V154M mouse models.
Volume: 116
Issue: 16
Pages: 7941-7950
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Publication
19917889 | J:168130
First Author: Hu X
Year: 2009
Journal: Circulation
Title: Vascular endothelial-specific dimethylarginine dimethylaminohydrolase-1-deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine.
Volume: 120
Issue: 22
Pages: 2222-9
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Publication
21242957 | J:170625
First Author: Choi D
Year: 2011
Journal: Lab Invest
Title: Vhl is required for normal pancreatic β cell function and the maintenance of β cell mass with age in mice.
Volume: 91
Issue: 4
Pages: 527-38
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Publication
29456534 | J:309772
 
First Author: Freudenberg K
Year: 2018
Journal: Front Immunol
Title: Critical Role of TGF-β and IL-2 Receptor Signaling in Foxp3 Induction by an Inhibitor of DNA Methylation.
Volume: 9
Pages: 125
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Publication
27486508 | J:240342
 
First Author: Harfmann BD
Year: 2016
Journal: Skelet Muscle
Title: Muscle-specific loss of Bmal1 leads to disrupted tissue glucose metabolism and systemic glucose homeostasis.
Volume: 6
Pages: 12
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Publication
29688896 | J:265435
First Author: Emmerson A
Year: 2018
Journal: J Clin Invest
Title: Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling.
Volume: 128
Issue: 7
Pages: 3088-3101
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Publication
20232379 | J:166571
First Author: Masset A
Year: 2011
Journal: Int J Cancer
Title: Unimpeded skin carcinogenesis in K14-HPV16 transgenic mice deficient for plasminogen activator inhibitor.
Volume: 128
Issue: 2
Pages: 283-93
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Publication
39088537 | J:358139
First Author: Kot A
Year: 2024
Journal: J Bone Miner Res
Title: Loss of the long form of Plod2 phenocopies contractures of Bruck syndrome-osteogenesis imperfecta.
Volume: 39
Issue: 9
Pages: 1240-1252
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Publication
23389032 | J:197853
First Author: Sanbe A
Year: 2013
Journal: J Biol Chem
Title: Phenotype of cardiomyopathy in cardiac-specific heat shock protein B8 K141N transgenic mouse.
Volume: 288
Issue: 13
Pages: 8910-21
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Publication
28620275 | J:268569
 
First Author: Sakai A
Year: 2017
Journal: Front Neurosci
Title: Genome-Wide Target Analyses of Otx2 Homeoprotein in Postnatal Cortex.
Volume: 11
Pages: 307
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Publication
32747500 | J:300373
First Author: Astori A
Year: 2020
Journal: J Immunol
Title: ARID1a Associates with Lymphoid-Restricted Transcription Factors and Has an Essential Role in T Cell Development.
Volume: 205
Issue: 5
Pages: 1419-1432
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Publication
34380733 | J:309467
 
First Author: Yang D
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Increased plasmin-mediated proteolysis of L1CAM in a mouse model of idiopathic normal pressure hydrocephalus.
Volume: 118
Issue: 33
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Publication
27565439 | J:235939
First Author: Jurek A
Year: 2016
Journal: Exp Cell Res
Title: Eph receptor interclass cooperation is required for the regulation of cell proliferation.
Volume: 348
Issue: 1
Pages: 10-22
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Publication
21706006 | J:174437
First Author: Woodfin A
Year: 2011
Journal: Nat Immunol
Title: The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo.
Volume: 12
Issue: 8
Pages: 761-9
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Publication
35176204 | J:329406
First Author: Stathopoulou K
Year: 2022
Journal: FEBS J
Title: CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes.
Volume: 289
Issue: 15
Pages: 4622-4645
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Publication
24469034 | J:218635
First Author: Savar A
Year: 2015
Journal: Oncogene
Title: Loss of epithelial p53 and αv integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment.
Volume: 34
Issue: 4
Pages: 516-24
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Publication
31242080 | J:313181
First Author: Donde A
Year: 2020
Journal: Autophagy
Title: Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43.
Volume: 16
Issue: 4
Pages: 672-682
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Publication
12563036 | J:81969
First Author: Vermot J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice.
Volume: 100
Issue: 4
Pages: 1763-8
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Publication
32805188 | J:304129
First Author: Coste Pradas J
Year: 2020
Journal: J Am Heart Assoc
Title: Identification of Genes and Pathways Regulated by Lamin A in Heart.
Volume: 9
Issue: 16
Pages: e015690
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Publication
38697008 | J:348435
 
First Author: Suzuki A
Year: 2024
Journal: J Reprod Immunol
Title: Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice.
Volume: 163
Pages: 104252
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Publication
24043760 | J:204070
First Author: Soler A
Year: 2013
Journal: J Exp Med
Title: Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis.
Volume: 210
Issue: 10
Pages: 1937-45
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Publication
28731407 | J:256682
   
First Author: Madi A
Year: 2017
Journal: Elife
Title: T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences.
Volume: 6
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Publication
23019586 | J:190314
First Author: Wang L
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Epidermal growth factor receptor is a preferred target for treating amyloid-β-induced memory loss.
Volume: 109
Issue: 41
Pages: 16743-8
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Publication
23630294 | J:197324
First Author: Stratinaki M
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Regulator of G protein signaling 4 [corrected] is a crucial modulator of antidepressant drug action in depression and neuropathic pain models.
Volume: 110
Issue: 20
Pages: 8254-9
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Publication
22291039 | J:185076
First Author: Ivanovic A
Year: 2012
Journal: J Cell Biol
Title: The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves.
Volume: 196
Issue: 3
Pages: 337-44
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Publication
28526034 | J:267803
First Author: Thiriot A
Year: 2017
Journal: BMC Biol
Title: Differential DARC/ACKR1 expression distinguishes venular from non-venular endothelial cells in murine tissues.
Volume: 15
Issue: 1
Pages: 45
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Publication
18276789 | J:132271
First Author: Billon A
Year: 2008
Journal: Am J Pathol
Title: The estrogen effects on endothelial repair and mitogen-activated protein kinase activation are abolished in endothelial nitric-oxide (NO) synthase knockout mice, but not by NO synthase inhibition by N-nitro-L-arginine methyl ester.
Volume: 172
Issue: 3
Pages: 830-8
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Publication
32205425 | J:291178
First Author: Bogoslowski A
Year: 2020
Journal: J Immunol
Title: Neutrophils Recirculate through Lymph Nodes to Survey Tissues for Pathogens.
Volume: 204
Issue: 9
Pages: 2552-2561
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Publication
23839064 | J:331840
First Author: Bonnegarde-Bernard A
Year: 2014
Journal: Mucosal Immunol
Title: IKKβ in intestinal epithelial cells regulates allergen-specific IgA and allergic inflammation at distant mucosal sites.
Volume: 7
Issue: 2
Pages: 257-67
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Publication
29781812 | J:265434
First Author: Daenthanasanmak A
Year: 2018
Journal: J Clin Invest
Title: PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity.
Volume: 128
Issue: 7
Pages: 2787-2801
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30723302 | J:293285
First Author: Pieper A
Year: 2019
Journal: Sci Rep
Title: NeuroD2 controls inhibitory circuit formation in the molecular layer of the cerebellum.
Volume: 9
Issue: 1
Pages: 1448
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Publication
25512522 | J:216930
First Author: Johnson BP
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase.
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Pages: 18757-62
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Publication
32376682 | J:290315
 
First Author: Cheong A
Year: 2020
Journal: Development
Title: Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation.
Volume: 147
Issue: 10
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•
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Publication
33268499 | J:299741
First Author: Gudmundsson KO
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Prdm16 is a critical regulator of adult long-term hematopoietic stem cell quiescence.
Volume: 117
Issue: 50
Pages: 31945-31953
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Publication
26070485 | J:260545
First Author: Conde P
Year: 2015
Journal: Immunity
Title: DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance.
Volume: 42
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Publication
18055814 | J:132501
First Author: De Maria A
Year: 2007
Journal: Invest Ophthalmol Vis Sci
Title: DNase IIbeta distribution and activity in the mouse lens.
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Issue: 12
Pages: 5638-46
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Publication
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First Author: Labarca C
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety.
Volume: 98
Issue: 5
Pages: 2786-91
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Publication
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First Author: Jones TI
Year: 2020
Journal: Skelet Muscle
Title: Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severity.
Volume: 10
Issue: 1
Pages: 8
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Publication
16577489 | J:15010
First Author: Clark FH
Year: 1932
Journal: Proc Natl Acad Sci U S A
Title: Hydrocephalus, a Hereditary Character in the House Mouse.
Volume: 18
Issue: 11
Pages: 654-6
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Publication
26881968 | J:229594
First Author: Buniello A
Year: 2016
Journal: EMBO Mol Med
Title: Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing.
Volume: 8
Issue: 3
Pages: 191-207
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Publication
28324005 | J:246874
First Author: Ghosh A
Year: 2017
Journal: Endocrinology
Title: Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice.
Volume: 158
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Publication
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First Author: Antoury L
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Journal: Nat Commun
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Year: 2019
Journal: Sci Rep
Title: The role of membrane excitability in pancreatic β-cell glucotoxicity.
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Pages: 6952
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Genotype
Genotype
Symbol: Tg(Scgb1a1-rtTA)1Jaw/? Tg(tetO-EGFR*)#Kkw/?
Background: involves: 129 * C57BL/6 * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Publication
28799208 | J:245231
First Author: Lebrun A
Year: 2017
Journal: J Pathol
Title: CCR2+ monocytic myeloid-derived suppressor cells (M-MDSCs) inhibit collagen degradation and promote lung fibrosis by producing transforming growth factor-β1.
Volume: 243
Issue: 3
Pages: 320-330
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Publication
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First Author: Volk A
Year: 2014
Journal: J Exp Med
Title: Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML.
Volume: 211
Issue: 6
Pages: 1093-108
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Publication
30185526 | J:266136
 
First Author: Abbasi F
Year: 2018
Journal: J Cell Sci
Title: RSPH6A is required for sperm flagellum formation and male fertility in mice.
Volume: 131
Issue: 19
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Publication
26121749 | J:224537
First Author: Baek JH
Year: 2015
Journal: J Clin Invest
Title: IL-34 mediates acute kidney injury and worsens subsequent chronic kidney disease.
Volume: 125
Issue: 8
Pages: 3198-214
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•
•
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Genotype
Genotype
Symbol: Tg(ACTB-THRB*)#Syc/?
Background: involves: CD-1
Zygosity: ot
Has Mutant Allele: true
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Publication
25237043 | J:311015
First Author: Sun A
Year: 2014
Journal: J Am Heart Assoc
Title: Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK/p53 pathway in mice.
Volume: 3
Issue: 5
Pages: e000779
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Publication
19786552 | J:153820
First Author: Montfort A
Year: 2009
Journal: J Immunol
Title: FAN stimulates TNF(alpha)-induced gene expression, leukocyte recruitment, and humoral response.
Volume: 183
Issue: 8
Pages: 5369-78
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Publication
20368175 | J:167887
First Author: Castaño AP
Year: 2009
Journal: Sci Transl Med
Title: Serum amyloid P inhibits fibrosis through Fc gamma R-dependent monocyte-macrophage regulation in vivo.
Volume: 1
Issue: 5
Pages: 5ra13
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Publication
27768893 | J:238087
First Author: Chatterjee A
Year: 2016
Journal: Cell
Title: MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria.
Volume: 167
Issue: 3
Pages: 722-738.e23
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Publication
37944529 | J:358291
First Author: Tsitsou-Kampeli A
Year: 2023
Journal: Cell Rep Med
Title: Cholesterol 24-hydroxylase at the choroid plexus contributes to brain immune homeostasis.
Volume: 4
Issue: 11
Pages: 101278
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Publication
10919290 | J:65566
First Author: Hellani A
Year: 2000
Journal: Endocrinology
Title: Developmental and hormonal regulation of the expression of oligodendrocyte-specific protein/claudin 11 in mouse testis.
Volume: 141
Issue: 8
Pages: 3012-9
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Publication
34706220 | J:325344
First Author: Lipstein N
Year: 2021
Journal: Neuron
Title: Munc13-1 is a Ca2+-phospholipid-dependent vesicle priming hub that shapes synaptic short-term plasticity and enables sustained neurotransmission.
Volume: 109
Issue: 24
Pages: 3980-4000.e7
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Publication
25806541 | J:229178
First Author: Hardy AB
Year: 2015
Journal: PLoS One
Title: Zip4 mediated zinc influx stimulates insulin secretion in pancreatic beta cells.
Volume: 10
Issue: 3
Pages: e0119136
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Publication
35644115 | J:327507
 
First Author: Wu Y
Year: 2022
Journal: Biomed Pharmacother
Title: Endothelium-targeted delivery of PPARδ by adeno-associated virus serotype 1 ameliorates vascular injury induced by hindlimb ischemia in obese mice.
Volume: 151
Pages: 113172
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Publication
19604493 | J:151576
First Author: Tinoco R
Year: 2009
Journal: Immunity
Title: Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo.
Volume: 31
Issue: 1
Pages: 145-57
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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