| Type |
Details |
Score |
| Publication |
| First Author: |
Fang J |
| Year: |
2017 |
| Journal: |
Nat Immunol |
| Title: |
Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia. |
| Volume: |
18 |
| Issue: |
2 |
| Pages: |
236-245 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xiong Y |
| Year: |
2018 |
| Journal: |
Elife |
| Title: |
Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases. |
| Volume: |
7 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ma Q |
| Year: |
2017 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Proteasome-independent polyubiquitin linkage regulates synapse scaffolding, efficacy, and plasticity. |
| Volume: |
114 |
| Issue: |
41 |
| Pages: |
E8760-E8769 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhu Z |
| Year: |
2016 |
| Journal: |
J Immunol |
| Title: |
Cutting Edge: A Cullin-5-TRAF6 Interaction Promotes TRAF6 Polyubiquitination and Lipopolysaccharide Signaling. |
| Volume: |
197 |
| Issue: |
1 |
| Pages: |
21-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Giardino Torchia ML |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
c-IAP1 and c-IAP2 redundancy differs between T and B cells. |
| Volume: |
8 |
| Issue: |
6 |
| Pages: |
e66161 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Annibaldi A |
| Year: |
2018 |
| Journal: |
Mol Cell |
| Title: |
Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2. |
| Volume: |
69 |
| Issue: |
4 |
| Pages: |
566-580.e5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tan BM |
| Year: |
2013 |
| Journal: |
Diabetologia |
| Title: |
Baculoviral inhibitors of apoptosis repeat containing (BIRC) proteins fine-tune TNF-induced nuclear factor κB and c-Jun N-terminal kinase signalling in mouse pancreatic beta cells. |
| Volume: |
56 |
| Issue: |
3 |
| Pages: |
520-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu J |
| Year: |
2016 |
| Journal: |
Cell |
| Title: |
Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction. |
| Volume: |
167 |
| Issue: |
4 |
| Pages: |
1052-1066.e18 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jiang Y |
| Year: |
2023 |
| Journal: |
J Biol Chem |
| Title: |
c-Src regulates δ-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6. |
| Volume: |
299 |
| Issue: |
12 |
| Pages: |
105462 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mendoza FJ |
| Year: |
2005 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
MEKK1-induced apoptosis is mediated by Smac/Diablo release from the mitochondria. |
| Volume: |
331 |
| Issue: |
4 |
| Pages: |
1089-98 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kanamori M |
| Year: |
2002 |
| Journal: |
FEBS Lett |
| Title: |
NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6. |
| Volume: |
532 |
| Issue: |
1-2 |
| Pages: |
241-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ando K |
| Year: |
2010 |
| Journal: |
FEBS J |
| Title: |
Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling. |
| Volume: |
277 |
| Issue: |
9 |
| Pages: |
2051-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Martins LM |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. |
| Volume: |
277 |
| Issue: |
1 |
| Pages: |
439-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nakamura I |
| Year: |
2002 |
| Journal: |
J Immunol |
| Title: |
IL-1 regulates cytoskeletal organization in osteoclasts via TNF receptor-associated factor 6/c-Src complex. |
| Volume: |
168 |
| Issue: |
10 |
| Pages: |
5103-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cho J |
| Year: |
2005 |
| Journal: |
J Biol Chem |
| Title: |
Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals. |
| Volume: |
280 |
| Issue: |
21 |
| Pages: |
20442-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ulett GC |
| Year: |
2005 |
| Journal: |
J Immunol |
| Title: |
Mechanisms of group B streptococcal-induced apoptosis of murine macrophages. |
| Volume: |
175 |
| Issue: |
4 |
| Pages: |
2555-62 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
van Loo G |
| Year: |
2006 |
| Journal: |
Nat Immunol |
| Title: |
Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice. |
| Volume: |
7 |
| Issue: |
9 |
| Pages: |
954-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bernier M |
| Year: |
2006 |
| Journal: |
J Biol Chem |
| Title: |
Binding of manumycin A inhibits IkappaB kinase beta activity. |
| Volume: |
281 |
| Issue: |
5 |
| Pages: |
2551-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Petroski MD |
| Year: |
2007 |
| Journal: |
J Biol Chem |
| Title: |
Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme. |
| Volume: |
282 |
| Issue: |
41 |
| Pages: |
29936-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yoshimura FK |
| Year: |
2008 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Up-regulation of a cellular protein at the translational level by a retrovirus. |
| Volume: |
105 |
| Issue: |
14 |
| Pages: |
5543-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ning S |
| Year: |
2008 |
| Journal: |
Mol Cell Biol |
| Title: |
TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1. |
| Volume: |
28 |
| Issue: |
20 |
| Pages: |
6536-46 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mace PD |
| Year: |
2008 |
| Journal: |
J Biol Chem |
| Title: |
Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment. |
| Volume: |
283 |
| Issue: |
46 |
| Pages: |
31633-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marabese M |
| Year: |
2008 |
| Journal: |
Cell Death Differ |
| Title: |
HtrA2 enhances the apoptotic functions of p73 on bax. |
| Volume: |
15 |
| Issue: |
5 |
| Pages: |
849-58 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chang J |
| Year: |
2009 |
| Journal: |
Nat Med |
| Title: |
Inhibition of osteoblastic bone formation by nuclear factor-kappaB. |
| Volume: |
15 |
| Issue: |
6 |
| Pages: |
682-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Park HM |
| Year: |
2009 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
The serine protease HtrA2/Omi cleaves Parkin and irreversibly inactivates its E3 ubiquitin ligase activity. |
| Volume: |
387 |
| Issue: |
3 |
| Pages: |
537-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rabizadeh S |
| Year: |
2003 |
| Journal: |
Cytokine Growth Factor Rev |
| Title: |
Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR). |
| Volume: |
14 |
| Issue: |
3-4 |
| Pages: |
225-39 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kieper N |
| Year: |
2010 |
| Journal: |
Exp Cell Res |
| Title: |
Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1. |
| Volume: |
316 |
| Issue: |
7 |
| Pages: |
1213-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nykjaer A |
| Year: |
2005 |
| Journal: |
Curr Opin Neurobiol |
| Title: |
p75NTR--live or let die. |
| Volume: |
15 |
| Issue: |
1 |
| Pages: |
49-57 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kenneth NS |
| Year: |
2010 |
| Journal: |
EMBO J |
| Title: |
IKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function. |
| Volume: |
29 |
| Issue: |
17 |
| Pages: |
2966-78 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wysong A |
| Year: |
2011 |
| Journal: |
Am J Pathol |
| Title: |
NF-κB inhibition protects against tumor-induced cardiac atrophy in vivo. |
| Volume: |
178 |
| Issue: |
3 |
| Pages: |
1059-68 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Oberoi TK |
| Year: |
2012 |
| Journal: |
EMBO J |
| Title: |
IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. |
| Volume: |
31 |
| Issue: |
1 |
| Pages: |
14-28 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cheng J |
| Year: |
2011 |
| Journal: |
Am J Hum Genet |
| Title: |
Functional mutation of SMAC/DIABLO, encoding a mitochondrial proapoptotic protein, causes human progressive hearing loss DFNA64. |
| Volume: |
89 |
| Issue: |
1 |
| Pages: |
56-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang P |
| Year: |
2013 |
| Journal: |
J Immunol |
| Title: |
Protein tyrosine phosphatase with proline-glutamine-serine-threonine-rich motifs negatively regulates TLR-triggered innate responses by selectively inhibiting IκB kinase β/NF-κB activation. |
| Volume: |
190 |
| Issue: |
4 |
| Pages: |
1685-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cheng KK |
| Year: |
2013 |
| Journal: |
Biochem J |
| Title: |
TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt. |
| Volume: |
455 |
| Issue: |
2 |
| Pages: |
207-16 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fitzgerald JC |
| Year: |
2012 |
| Journal: |
Cell Death Differ |
| Title: |
Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function. |
| Volume: |
19 |
| Issue: |
2 |
| Pages: |
257-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee JY |
| Year: |
2014 |
| Journal: |
Am J Pathol |
| Title: |
Matrix metalloproteinase-3 promotes early blood-spinal cord barrier disruption and hemorrhage and impairs long-term neurological recovery after spinal cord injury. |
| Volume: |
184 |
| Issue: |
11 |
| Pages: |
2985-3000 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mei ZZ |
| Year: |
2016 |
| Journal: |
J Biol Chem |
| Title: |
Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively. |
| Volume: |
291 |
| Issue: |
35 |
| Pages: |
18176-89 |
|
•
•
•
•
•
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| Publication |
| First Author: |
Peng SJ |
| Year: |
2019 |
| Journal: |
J Immunol |
| Title: |
UBL4A Augments Innate Immunity by Promoting the K63-Linked Ubiquitination of TRAF6. |
| Volume: |
203 |
| Issue: |
7 |
| Pages: |
1943-1951 |
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•
•
•
•
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| Publication |
| First Author: |
Wan X |
| Year: |
2015 |
| Journal: |
Dis Model Mech |
| Title: |
IKKα is involved in kidney recovery and regeneration of acute ischemia/reperfusion injury in mice through IL10-producing regulatory T cells. |
| Volume: |
8 |
| Issue: |
7 |
| Pages: |
733-42 |
|
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•
•
•
•
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| Publication |
| First Author: |
Rothe M |
| Year: |
1995 |
| Journal: |
Cell |
| Title: |
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. |
| Volume: |
83 |
| Issue: |
7 |
| Pages: |
1243-52 |
|
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•
•
•
•
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| Publication |
| First Author: |
Häcker H |
| Year: |
2006 |
| Journal: |
Nature |
| Title: |
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. |
| Volume: |
439 |
| Issue: |
7073 |
| Pages: |
204-7 |
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•
•
•
•
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| Publication |
| First Author: |
Gardam S |
| Year: |
2008 |
| Journal: |
Immunity |
| Title: |
TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. |
| Volume: |
28 |
| Issue: |
3 |
| Pages: |
391-401 |
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•
•
•
•
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| Publication |
| First Author: |
Zarnegar BJ |
| Year: |
2008 |
| Journal: |
Nat Immunol |
| Title: |
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. |
| Volume: |
9 |
| Issue: |
12 |
| Pages: |
1371-8 |
|
•
•
•
•
•
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| Publication |
| First Author: |
Gomez-Diaz C |
| Year: |
2021 |
| Journal: |
iScience |
| Title: |
The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains. |
| Volume: |
24 |
| Issue: |
11 |
| Pages: |
103241 |
|
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•
•
•
•
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| Publication |
| First Author: |
Mambetsariev N |
| Year: |
2016 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Nuclear TRAF3 is a negative regulator of CREB in B cells. |
| Volume: |
113 |
| Issue: |
4 |
| Pages: |
1032-7 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Schneider AT |
| Year: |
2017 |
| Journal: |
Cancer Cell |
| Title: |
RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer. |
| Volume: |
31 |
| Issue: |
1 |
| Pages: |
94-109 |
|
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•
•
•
•
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| Publication |
| First Author: |
Sun D |
| Year: |
2011 |
| Journal: |
Nat Immunol |
| Title: |
Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF). |
| Volume: |
12 |
| Issue: |
9 |
| Pages: |
853-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nakano H |
| Year: |
1997 |
| Journal: |
Genomics |
| Title: |
Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32. |
| Volume: |
42 |
| Issue: |
1 |
| Pages: |
26-32 |
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•
•
•
•
|
| Publication |
| First Author: |
Etemadi N |
| Year: |
2013 |
| Journal: |
FEBS J |
| Title: |
Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor. |
| Volume: |
280 |
| Issue: |
21 |
| Pages: |
5283-97 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim EK |
| Year: |
2017 |
| Journal: |
Biochim Biophys Acta |
| Title: |
SMN1 functions as a novel inhibitor for TRAF6-mediated NF-κB signaling. |
| Volume: |
1864 |
| Issue: |
5 |
| Pages: |
760-770 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
239
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
235
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
279
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1547
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
202
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
306
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
219
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
235
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
239
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
202
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
306
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
279
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
304
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
185
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
219
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
231
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
324
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
279
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
138
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
279
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tokunaga F |
| Year: |
2009 |
| Journal: |
Nat Cell Biol |
| Title: |
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. |
| Volume: |
11 |
| Issue: |
2 |
| Pages: |
123-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mikkelsen SS |
| Year: |
2009 |
| Journal: |
J Biol Chem |
| Title: |
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1. |
| Volume: |
284 |
| Issue: |
16 |
| Pages: |
10774-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vucur M |
| Year: |
2023 |
| Journal: |
Immunity |
| Title: |
Sublethal necroptosis signaling promotes inflammation and liver cancer. |
| Volume: |
56 |
| Issue: |
7 |
| Pages: |
1578-1595.e8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fujita H |
| Year: |
2014 |
| Journal: |
Mol Cell Biol |
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