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Search results 3201 to 3300 out of 3383 for Pdx1

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Type Details Score
Publication
32200350 | J:288996
First Author: Muthalagu N
Year: 2020
Journal: Cancer Discov
Title: Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma.
Volume: 10
Issue: 6
Pages: 872-887
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Publication
26880805 | J:231612
First Author: Yan Y
Year: 2016
Journal: Cancer Res
Title: KLF4-Mediated Suppression of CD44 Signaling Negatively Impacts Pancreatic Cancer Stemness and Metastasis.
Volume: 76
Issue: 8
Pages: 2419-31
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Publication
26560028 | J:244297
First Author: Zheng X
Year: 2015
Journal: Nature
Title: Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.
Volume: 527
Issue: 7579
Pages: 525-530
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Publication
35216965 | J:350085
First Author: Garcia Garcia CJ
Year: 2022
Journal: Gastroenterology
Title: Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment.
Volume: 162
Issue: 7
Pages: 2018-2031
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Publication
30100261 | J:270527
First Author: Li C
Year: 2018
Journal: Dev Cell
Title: PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism.
Volume: 46
Issue: 4
Pages: 441-455.e8
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Publication
31063757 | J:281276
First Author: Michael IP
Year: 2019
Journal: Dev Cell
Title: ALK7 Signaling Manifests a Homeostatic Tissue Barrier That Is Abrogated during Tumorigenesis and Metastasis.
Volume: 49
Issue: 3
Pages: 409-424.e6
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Publication
22628411 | J:193065
First Author: Collisson EA
Year: 2012
Journal: Cancer Discov
Title: A central role for RAF?MEK?ERK signaling in the genesis of pancreatic ductal adenocarcinoma.
Volume: 2
Issue: 8
Pages: 685-93
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Publication
38872370 | J:350483
First Author: Yamaguchi J
Year: 2024
Journal: Cancer Med
Title: Trefoil factor 1 suppresses stemness and enhances chemosensitivity of pancreatic cancer.
Volume: 13
Issue: 11
Pages: e7395
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Publication
30705405 | J:278756
First Author: Nishikawa Y
Year: 2019
Journal: Oncogene
Title: Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis.
Volume: 38
Issue: 22
Pages: 4283-4296
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Publication
31268604 | J:387156
First Author: Parajuli P
Year: 2019
Journal: EMBO J
Title: TGIF1 functions as a tumor suppressor in pancreatic ductal adenocarcinoma.
Volume: 38
Issue: 13
Pages: e101067
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Publication
40588523 | J:370341
First Author: Antonucci L
Year: 2025
Journal: Nat Cancer
Title: Self-amplifying NRF2-EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer.
Volume: 6
Issue: 7
Pages: 1263-1282
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Publication
24395249 | J:205582
First Author: Saborowski M
Year: 2014
Journal: Genes Dev
Title: A modular and flexible ESC-based mouse model of pancreatic cancer.
Volume: 28
Issue: 1
Pages: 85-97
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Publication
30401713 | J:270055
First Author: Elahi-Gedwillo KY
Year: 2019
Journal: Cancer Res
Title: Antifibrotic Therapy Disrupts Stromal Barriers and Modulates the Immune Landscape in Pancreatic Ductal Adenocarcinoma.
Volume: 79
Issue: 2
Pages: 372-386
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Publication
42102213 | J:385754
First Author: Mart??nez-Bosch N
Year: 2026
Journal: Sci Adv
Title: PARP2 deficiency impairs pancreatic cancer progression by promoting genomic instability and antitumor immunity.
Volume: 12
Issue: 19
Pages: eadu8849
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Publication
23958541 | J:324563
First Author: Philip B
Year: 2013
Journal: Gastroenterology
Title: A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice.
Volume: 145
Issue: 6
Pages: 1449-58
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Publication
28414315 | J:241507
First Author: Krebs AM
Year: 2017
Journal: Nat Cell Biol
Title: The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer.
Volume: 19
Issue: 5
Pages: 518-529
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Publication
40408246 | J:367790
First Author: Valenti G
Year: 2025
Journal: Cell Rep
Title: Regulatory network analysis of Dclk1 gene expression reveals a tuft cell-ILC2 axis that inhibits pancreatic tumor progression.
Volume: 44
Issue: 6
Pages: 115734
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Publication
22421440 | J:183391
First Author: Mann KM
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma.
Volume: 109
Issue: 16
Pages: 5934-41
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Publication
39342278 | J:357744
First Author: Sozzi S
Year: 2024
Journal: J Exp Clin Cancer Res
Title: Inactivation of HIPK2 attenuates KRAS(G12D) activity and prevents pancreatic tumorigenesis.
Volume: 43
Issue: 1
Pages: 265
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Publication
26359451 | J:226787
First Author: Dosch JS
Year: 2015
Journal: Cancer Res
Title: Cancer stem cell marker phenotypes are reversible and functionally homogeneous in a preclinical model of pancreatic cancer.
Volume: 75
Issue: 21
Pages: 4582-92
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Publication
41198969 | J:380907
First Author: Han J
Year: 2026
Journal: Nat Cancer
Title: Spatiotemporal control of SMARCA5 by a MAPK-RUNX1 axis distinguishes mutant KRAS-driven pancreatic malignancy from tissue regeneration.
Volume: 7
Issue: 1
Pages: 43-59
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Publication
41709591 | J:385473
First Author: Mearns H
Year: 2026
Journal: Mol Oncol
Title: Identification of serum protein biomarkers for pre-cancerous lesions associated with pancreatic ductal adenocarcinoma.
Volume: 20
Issue: 6
Pages: 1473-1493
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Publication
35868307 | J:327235
First Author: Chen Y
Year: 2022
Journal: Cancer Cell
Title: Oncogenic collagen I homotrimers from cancer cells bind to ?3?1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer.
Volume: 40
Issue: 8
Pages: 818-834.e9
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Publication
38355776 | J:361131
First Author: Astuti Y
Year: 2024
Journal: Nat Cancer
Title: Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis.
Volume: 5
Issue: 5
Pages: 774-790
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Publication
30877201 | J:277840
First Author: Corsa CAS
Year: 2019
Journal: J Biol Chem
Title: The E3 ubiquitin ligase parkin is dispensable for metabolic homeostasis in murine pancreatic ? cells and adipocytes.
Volume: 294
Issue: 18
Pages: 7296-7307
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Publication
41887801 | J:389709
First Author: Unger L
Year: 2026
Journal: Genes Dev
Title: Defective HNF1A hinders GLI3 processing favoring duodenal versus pancreatic fate, thus leading to intestinal elongation in vivo.
Volume: 40
Issue: 11-12
Pages: 805-831
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Publication
26153246 | J:263296
First Author: Oropeza D
Year: 2015
Journal: Diabetes
Title: Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone.
Volume: 64
Issue: 11
Pages: 3798-807
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Publication
18442046 | J:136227
First Author: Elghazi L
Year: 2008
Journal: Genesis
Title: Generation of a reporter mouse line expressing Akt and EGFP upon Cre-mediated recombination.
Volume: 46
Issue: 5
Pages: 256-64
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Publication
38724194 | J:347978
 
First Author: Zheng D
Year: 2024
Journal: Life Sci Alliance
Title: Brd4::Nutm1 fusion gene initiates NUT carcinoma in vivo.
Volume: 7
Issue: 7
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Publication
41266112 | J:375424
 
First Author: Luo C
Year: 2026
Journal: Life Sci Alliance
Title: SOX2 is a dispensable modulator of NUT carcinoma oncogenesis in mice.
Volume: 9
Issue: 2
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Publication
41827915 | J:382700
 
First Author: Zalucha EM
Year: 2026
Journal: Cells
Title: The Role of Pancreatic Preproglucagon in Regulating Local Inflammation in Mice.
Volume: 15
Issue: 5
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Publication
31619587 | J:298249
 
First Author: Kim KS
Year: 2019
Journal: JCI Insight
Title: Glycemic effect of pancreatic preproglucagon in mouse sleeve gastrectomy.
Volume: 4
Issue: 20
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Publication
30361701 | J:268101
First Author: Cigliola V
Year: 2018
Journal: Nat Cell Biol
Title: Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon(+) ?-cells.
Volume: 20
Issue: 11
Pages: 1267-1277
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Publication
40138419 | J:364195
First Author: Yang L
Year: 2025
Journal: Sci Adv
Title: The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation.
Volume: 11
Issue: 13
Pages: eadt4770
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Publication
26203139 | J:225811
First Author: Kim ER
Year: 2015
Journal: J Neurosci
Title: Hypothalamic Non-AgRP, Non-POMC GABAergic Neurons Are Required for Postweaning Feeding and NPY Hyperphagia.
Volume: 35
Issue: 29
Pages: 10440-50
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Publication
32821827 | J:312564
First Author: Wasylishen AR
Year: 2020
Journal: Sci Adv
Title: Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo.
Volume: 6
Issue: 32
Pages: eaba8415
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Publication
40810739 | J:373684
First Author: Luo C
Year: 2025
Journal: Adv Sci (Weinh)
Title: Deficiency of Leucine-Rich Repeat Containing G Protein-Coupled Receptor 4 in Pancreas Reduces ? Cell Mass.
Volume: 12
Issue: 41
Pages: e08858
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Publication
32467243 | J:290417
 
First Author: Lorberbaum DS
Year: 2020
Journal: Development
Title: Retinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human ? cell specification.
Volume: 147
Issue: 12
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Hmga2/Hmga2<+> Kras/Kras<+> Tg(Pdx1-cre)6Tuv/? Trp53/Trp53<+>
Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd9/Cd9<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kras/Kras<+> Tg(Pdx1-cre)6Tuv/? Trp53/Trp53
Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd9/Cd9 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kras/Kras<+> Tg(Pdx1-cre)6Tuv/? Trp53/Trp53<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd9/Cd9 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kras/Kras<+> Tg(Pdx1-cre)6Tuv/? Trp53/Trp53
Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd9/Cd9<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kras/Kras<+> Tg(Pdx1-cre)6Tuv/? Trp53/Trp53<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kras/Kras<+> Tg(Pdx1-cre)89.1Dam/? Trim29/Trim29 Trp53/Trp53<+>
Background: involves: 129 * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kras/Kras<+> Tg(Pdx1-cre)89.1Dam/? Trim29/Trim29
Background: involves: 129 * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kras/Kras<+> Tg(Pdx1-cre)89.1Dam/? Trim29/Trim29<+> Trp53/Trp53<+>
Background: involves: 129 * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gata4/Gata4<+> Gata6/Gata6<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Pdx1-cre)6Tuv/?
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gata4/Gata4 Gata6/Gata6 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Pdx1-cre)6Tuv/?
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gata4/Gata4<+> Gata6/Gata6<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Pdx1-cre)6Tuv/?
Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gata4/Gata4 Gata6/Gata6 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Pdx1-cre)6Tuv/?
Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Pdx1-flpo)#Ybi/?
Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
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Publication
38206362 | J:358305
First Author: Baumel-Alterzon S
Year: 2024
Journal: Diabetologia
Title: NRF2 is required for neonatal mouse beta cell growth by maintaining redox balance and promoting mitochondrial biogenesis and function.
Volume: 67
Issue: 3
Pages: 547-560
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Protein
Q70KY4
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Protein
Q8BMF4
Organism: Mus musculus/domesticus
Length: 642  
Fragment?: false
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Protein
Q9R1E0
Organism: Mus musculus/domesticus
Length: 652  
Fragment?: false
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Protein
Q9WVH3
Organism: Mus musculus/domesticus
Length: 505  
Fragment?: false
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Protein
Q8BKZ9
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Protein
B1AUT3
Organism: Mus musculus/domesticus
Length: 505  
Fragment?: false
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Protein
Q9WVH5
Organism: Mus musculus/domesticus
Length: 652  
Fragment?: false
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Protein
Q5RJI9
Organism: Mus musculus/domesticus
Length: 640  
Fragment?: false
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Publication
20562852 | J:162641
First Author: Marcheva B
Year: 2010
Journal: Nature
Title: Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes.
Volume: 466
Issue: 7306
Pages: 627-31
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Publication
24085033 | J:204991
First Author: Pasek RC
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Advancements and challenges in generating accurate animal models of gestational diabetes mellitus.
Volume: 305
Issue: 11
Pages: E1327-38
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Publication
38512414 | J:350675
First Author: Yu V
Year: 2024
Journal: Diabetologia
Title: Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity.
Volume: 67
Issue: 6
Pages: 1079-1094
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Publication
33285301 | J:300481
 
First Author: Collier JJ
Year: 2021
Journal: Mol Metab
Title: Pancreatic, but not myeloid-cell, expression of interleukin-1alpha is required for maintenance of insulin secretion and whole body glucose homeostasis.
Volume: 44
Pages: 101140
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Publication
29069604 | J:254840
First Author: Ferreira RMM
Year: 2017
Journal: Cell Rep
Title: Duct- and Acinar-Derived Pancreatic Ductal Adenocarcinomas Show Distinct Tumor Progression and Marker Expression.
Volume: 21
Issue: 4
Pages: 966-978
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Publication
25774850 | J:228179
First Author: Marquard J
Year: 2015
Journal: Nat Med
Title: Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.
Volume: 21
Issue: 4
Pages: 363-72
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Publication
33393460 | J:308021
   
First Author: Maruno T
Year: 2021
Journal: Elife
Title: Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging.
Volume: 10
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Publication
29153842 | J:252273
First Author: Todoric J
Year: 2017
Journal: Cancer Cell
Title: Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.
Volume: 32
Issue: 6
Pages: 824-839.e8
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Publication
39473974 | J:357851
First Author: Ma Y
Year: 2024
Journal: iScience
Title: Tumor-infiltrating mast cells confer resistance to immunotherapy in pancreatic cancer.
Volume: 27
Issue: 11
Pages: 111085
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Publication
38632714 | J:371583
First Author: Arneson-Wissink PC
Year: 2024
Journal: J Cachexia Sarcopenia Muscle
Title: Hepatic signal transducer and activator of transcription-3 signalling drives early-stage pancreatic cancer cachexia via suppressed ketogenesis.
Volume: 15
Issue: 3
Pages: 975-988
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Publication
30842658 | J:274344
First Author: Lee JW
Year: 2019
Journal: Nature
Title: Hepatocytes direct the formation of a pro-metastatic niche in the liver.
Volume: 567
Issue: 7747
Pages: 249-252
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Publication
29808009 | J:336458
First Author: Ruess DA
Year: 2018
Journal: Nat Med
Title: Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.
Volume: 24
Issue: 7
Pages: 954-960
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Publication
27569912 | J:236387
First Author: Daley D
Year: 2016
Journal: Cell
Title: ?? T Cells Support Pancreatic Oncogenesis by Restraining ?? T Cell Activation.
Volume: 166
Issue: 6
Pages: 1485-1499.e15
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Publication
28049824 | J:239540
First Author: Zhang G
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: p53 pathway is involved in cell competition during mouse embryogenesis.
Volume: 114
Issue: 3
Pages: 498-503
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Publication
42053430 | J:390783
     
First Author: Ruiz CF
Year: 2026
Journal: Cancer Discov
Title: Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas.
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Publication
16397221 | J:105031
First Author: Hruban RH
Year: 2006
Journal: Cancer Res
Title: Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations.
Volume: 66
Issue: 1
Pages: 95-106
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Publication
28425994 | J:254425
First Author: Maddocks ODK
Year: 2017
Journal: Nature
Title: Modulating the therapeutic response of tumours to dietary serine and glycine starvation.
Volume: 544
Issue: 7650
Pages: 372-376
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Publication
40676699 | J:370462
First Author: Hetzel S
Year: 2025
Journal: Genome Biol
Title: Direct genetic transformation bypasses tumor-associated DNA methylation alterations.
Volume: 26
Issue: 1
Pages: 212
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Publication
35590198 | J:339062
First Author: O'Connor MN
Year: 2021
Journal: Med
Title: LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency.
Volume: 2
Issue: 11
Pages: 1231-1252.e10
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Publication
31048544 | J:289183
First Author: Wang L
Year: 2019
Journal: Genes Dev
Title: ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis.
Volume: 33
Issue: 11-12
Pages: 641-655
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Publication
30952657 | J:276349
First Author: Poulin EJ
Year: 2019
Journal: Cancer Discov
Title: Tissue-Specific Oncogenic Activity of KRAS(A146T).
Volume: 9
Issue: 6
Pages: 738-755
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Publication
38733589 | J:348743
First Author: Tomi? G
Year: 2024
Journal: Cell Rep
Title: Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis.
Volume: 43
Issue: 5
Pages: 114224
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Publication
32541668 | J:291708
First Author: Perkail S
Year: 2020
Journal: Nat Commun
Title: BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice.
Volume: 11
Issue: 1
Pages: 3018
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Publication
37341148 | J:338218
First Author: Tsuyama T
Year: 2023
Journal: EMBO Rep
Title: Hypoxia causes pancreatic ?-cell dysfunction and impairs insulin secretion by activating the transcriptional repressor BHLHE40.
Volume: 24
Issue: 8
Pages: e56227
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Publication
19939939 | J:166881
First Author: Kim I
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