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Score |
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Jain A |
| Year: |
2024 |
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Nat Immunol |
| Title: |
Nociceptor-immune interactomes reveal insult-specific immune signatures of pain. |
| Volume: |
25 |
| Issue: |
7 |
| Pages: |
1296-1305 |
|
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•
•
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| First Author: |
González C |
| Year: |
2000 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Bacteriocin AS-48, a microbial cyclic polypeptide structurally and functionally related to mammalian NK-lysin. |
| Volume: |
97 |
| Issue: |
21 |
| Pages: |
11221-6 |
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•
•
•
•
|
| Publication |
| First Author: |
Mócsai A |
| Year: |
2006 |
| Journal: |
Nat Immunol |
| Title: |
Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. |
| Volume: |
7 |
| Issue: |
12 |
| Pages: |
1326-33 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Dikeakos JD |
| Year: |
2009 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease. |
| Volume: |
106 |
| Issue: |
18 |
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7408-13 |
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•
•
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| First Author: |
Novikov A |
| Year: |
2019 |
| Journal: |
Am J Physiol Renal Physiol |
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SGLT2 inhibition and renal urate excretion: role of luminal glucose, GLUT9, and URAT1. |
| Volume: |
316 |
| Issue: |
1 |
| Pages: |
F173-F185 |
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•
•
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| First Author: |
Bukovsky A |
| Year: |
2003 |
| Journal: |
Reprod Biol Endocrinol |
| Title: |
Multiple luteinizing hormone receptor (LHR) protein variants, interspecies reactivity of anti-LHR mAb clone 3B5, subcellular localization of LHR in human placenta, pelvic floor and brain, and possible role for LHR in the development of abnormal pregnancy, pelvic floor disorders and Alzheimer's disease. |
| Volume: |
1 |
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| Pages: |
46 |
|
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•
•
•
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| First Author: |
Inanobe A |
| Year: |
1999 |
| Journal: |
J Neurosci |
| Title: |
Characterization of G-protein-gated K+ channels composed of Kir3.2 subunits in dopaminergic neurons of the substantia nigra. |
| Volume: |
19 |
| Issue: |
3 |
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1006-17 |
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•
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| First Author: |
Bergo A |
| Year: |
2015 |
| Journal: |
J Biol Chem |
| Title: |
Methyl-CpG binding protein 2 (MeCP2) localizes at the centrosome and is required for proper mitotic spindle organization. |
| Volume: |
290 |
| Issue: |
6 |
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| First Author: |
Espinosa A |
| Year: |
2006 |
| Journal: |
J Immunol |
| Title: |
The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death. |
| Volume: |
176 |
| Issue: |
10 |
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6277-85 |
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•
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| First Author: |
Rajagopal A |
| Year: |
2008 |
| Journal: |
Nature |
| Title: |
Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. |
| Volume: |
453 |
| Issue: |
7198 |
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1127-31 |
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| First Author: |
Ahmady E |
| Year: |
2011 |
| Journal: |
J Biol Chem |
| Title: |
Identification of a novel muscle A-type lamin-interacting protein (MLIP). |
| Volume: |
286 |
| Issue: |
22 |
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•
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| First Author: |
Yamauchi A |
| Year: |
2014 |
| Journal: |
J Mol Cell Cardiol |
| Title: |
Functional differentiation of RAMP2 and RAMP3 in their regulation of the vascular system. |
| Volume: |
77 |
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Osman A |
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2023 |
| Journal: |
Brain Behav Immun |
| Title: |
Acetate supplementation rescues social deficits and alters transcriptional regulation in prefrontal cortex of Shank3 deficient mice. |
| Volume: |
114 |
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311-324 |
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| First Author: |
Will WM |
| Year: |
2006 |
| Journal: |
J Immunol |
| Title: |
Attenuation of IL-7 receptor signaling is not required for allelic exclusion. |
| Volume: |
176 |
| Issue: |
6 |
| Pages: |
3350-5 |
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| First Author: |
Avelar AJ |
| Year: |
2019 |
| Journal: |
Neuropharmacology |
| Title: |
Why flavored vape products may be attractive: Green apple tobacco flavor elicits reward-related behavior, upregulates nAChRs on VTA dopamine neurons, and alters midbrain dopamine and GABA neuron function. |
| Volume: |
158 |
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•
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| First Author: |
Gunn BG |
| Year: |
2013 |
| Journal: |
J Neurosci |
| Title: |
Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic transmission in a mouse model of early-life adversity: relevance to neurosteroids and programming of the stress response. |
| Volume: |
33 |
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50 |
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| First Author: |
Mikami N |
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2020 |
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Proc Natl Acad Sci U S A |
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Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation. |
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Zhao L |
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| Journal: |
Genesis |
| Title: |
Hypomorphic phenotype in mice with pituitary-specific knockout of steroidogenic factor 1. |
| Volume: |
30 |
| Issue: |
2 |
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| First Author: |
Babicky ML |
| Year: |
2019 |
| Journal: |
Oncogene |
| Title: |
MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages. |
| Volume: |
38 |
| Issue: |
28 |
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Schoeps B |
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2021 |
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Cancer Res |
| Title: |
TIMP1 Triggers Neutrophil Extracellular Trap Formation in Pancreatic Cancer. |
| Volume: |
81 |
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Horiguchi M |
| Year: |
2019 |
| Journal: |
FEBS Lett |
| Title: |
Senescence caused by inactivation of the homeodomain transcription factor Pdx1 in adult pancreatic acinar cells in mice. |
| Volume: |
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| First Author: |
Nan C |
| Year: |
2010 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Deficiency of methionine sulfoxide reductase A causes cellular dysfunction and mitochondrial damage in cardiac myocytes under physical and oxidative stresses. |
| Volume: |
402 |
| Issue: |
4 |
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| First Author: |
Kazakov A |
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2013 |
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Cardiovasc Res |
| Title: |
Inhibition of endothelial nitric oxide synthase induces and enhances myocardial fibrosis. |
| Volume: |
100 |
| Issue: |
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| First Author: |
Fredericks GJ |
| Year: |
2014 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex. |
| Volume: |
111 |
| Issue: |
46 |
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16478-83 |
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| First Author: |
Popescu IR |
| Year: |
2010 |
| Journal: |
FEBS Lett |
| Title: |
The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity. |
| Volume: |
584 |
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Derish I |
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2020 |
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PLoS One |
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Differential role of planar cell polarity gene Vangl2 in embryonic and adult mammalian kidneys. |
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Chen C |
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J Clin Invest |
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Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing. |
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Wang CJ |
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Proc Natl Acad Sci U S A |
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CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement. |
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Luzzio A |
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Mamm Genome |
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The spontaneous mouse mutant low set ears (Lse) is caused by tandem duplication of Fgf3 and Fgf4. |
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34 |
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Sci Rep |
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IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity. |
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Neuropsychopharmacology |
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Antihyperalgesia by α2-GABAA receptors occurs via a genuine spinal action and does not involve supraspinal sites. |
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A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. |
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In vivo suppressor mutations correct a murine model of hereditary tyrosinemia type I. |
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Proc Natl Acad Sci U S A |
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Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. |
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Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers. |
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Serotonin (5-HT) neuron-specific inactivation of Cadherin-13 impacts 5-HT system formation and cognitive function. |
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Nature |
| Title: |
SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation. |
| Volume: |
584 |
| Issue: |
7822 |
| Pages: |
635-639 |
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| Publication |
| First Author: |
Langsdorf A |
| Year: |
2007 |
| Journal: |
Dev Biol |
| Title: |
Sulfs are regulators of growth factor signaling for satellite cell differentiation and muscle regeneration. |
| Volume: |
311 |
| Issue: |
2 |
| Pages: |
464-77 |
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| Publication |
| First Author: |
Kanazawa A |
| Year: |
2005 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Wnt5b partially inhibits canonical Wnt/beta-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes. |
| Volume: |
330 |
| Issue: |
2 |
| Pages: |
505-10 |
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•
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| Publication |
| First Author: |
Bai S |
| Year: |
2005 |
| Journal: |
J Clin Invest |
| Title: |
FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner. |
| Volume: |
115 |
| Issue: |
10 |
| Pages: |
2742-51 |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
86
 |
| Fragment?: |
true |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
166
 |
| Fragment?: |
true |
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| Protein Domain |
| Type: |
Domain |
| Description: |
This domain is found in Propionyl-coenzyme A carboxylase (PCC), present in Roseobacter denitrificans. PCC is a mitochondrial biotin-dependent enzyme that is essential for the catabolism of certain amino acids, cholesterol, and fatty acids with an odd number of carbon atoms. Since this domain mediates biotin carboxylase-carboxyltransferase interactions it is referred to as the BT domain. The BT domain is located between biotin carboxylase and the biotin carboxyl carrier protein domains. The BT domain shares some structural similarity with the pyruvate carboxylase tetramerization domain of pyruvate carboxylase []. |
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| Protein Domain |
| Type: |
Family |
| Description: |
This group of serine peptidases belong to MEROPS peptidase family S11 (D-Ala-D-Ala carboxypeptidase A family, clan SE). The protein fold of the peptidase domain for members of this family resembles that of D-Ala-D-Ala-carboxypeptidase B, the type example for clan SE.Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes []. They include a wide range of peptidase activity, including exopeptidase, endo-peptidase, oligopeptidase and omega-peptidase activity. Over 20 families (denoted S1 - S27) of serine protease have been identified, these being grouped into 6 clans (SA, SB, SC, SE, SF and SG) on the basis of structural similarity and other functional evidence. Structures are known for four of the clans (SA, SB, SC and SE): these appear to be totally unrelated, suggesting at least four evolutionary origins of serine peptidases and possibly many more [].Not with standing their different evolutionary origins, there are similarities in the reaction mechanisms of several peptidases. Chymotrypsin, subtilisin and carboxypeptidase C clans have a catalytic triad of serine, aspartate and histidine in common: serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base []. The geometric orientations of the catalytic residues are similar between families, despite different protein folds. The linear arrangements of the catalytic residues commonly reflect clan relationships. For example the catalytic triad in the chymotrypsin clan (SA) is ordered HDS, but is ordered DHS in the subtilisin clan (SB) and SDH in the carboxypeptidase clan (SC) [, ].Bacterial cell walls are complex structures containing amino acids and amino sugars, with alternating chains of N-acetylglucosamine and N-acetyl-muramic acid units linked by short peptides []: the link peptide in Escherichia coli is L-alanyl-D-isoglutamyl-L-meso-diaminopimelyl-D-alanine. The chains are usually cross-linked between the carboxyl of D-alanine and the free amino group of diaminopimelate. During the synthesis of peptidoglycan, the precursor has the described tetramer sequence with an added C-terminal D-alanine [].D-Ala-D-Ala carboxypeptidase A is involved in the metabolism of cell components []; it is synthesised with a leader peptide to target it to the cell membrane []. After cleavage of the leader peptide, the enzyme is retained in the membrane by a C-terminal anchor. There are three families of serine-type D-Ala-D-Ala peptidase, which are also known as low molecular weight penicillin-binding proteins.Family S11 contains only D-Ala-D-Ala peptidases, unlike families S12 and S13, which contain other enzymes, such as class C beta-lactamases and D-amino-peptidases []. Although these enzymes are serine proteases, some members of family S11 are partially inhibited by thiol-blocking agents []. |
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| Publication |
| First Author: |
Biever A |
| Year: |
2015 |
| Journal: |
J Neurosci |
| Title: |
PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spiny neurons. |
| Volume: |
35 |
| Issue: |
10 |
| Pages: |
4113-30 |
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| Publication |
| First Author: |
Zwijsen A |
| Year: |
2000 |
| Journal: |
Dev Dyn |
| Title: |
Expression of the inhibitory Smad7 in early mouse development and upregulation during embryonic vasculogenesis. |
| Volume: |
218 |
| Issue: |
4 |
| Pages: |
663-70 |
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•
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| Publication |
| First Author: |
George A |
| Year: |
1996 |
| Journal: |
J Biol Chem |
| Title: |
The carboxyl-terminal domain of phosphophoryn contains unique extended triplet amino acid repeat sequences forming ordered carboxyl-phosphate interaction ridges that may be essential in the biomineralization process. |
| Volume: |
271 |
| Issue: |
51 |
| Pages: |
32869-73 |
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| Publication |
| First Author: |
Bosco A |
| Year: |
2018 |
| Journal: |
Mol Ther |
| Title: |
Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma. |
| Volume: |
26 |
| Issue: |
10 |
| Pages: |
2379-2396 |
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•
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| Publication |
| First Author: |
Celen C |
| Year: |
2022 |
| Journal: |
Cell Rep |
| Title: |
Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling. |
| Volume: |
41 |
| Issue: |
5 |
| Pages: |
111581 |
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•
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| Publication |
| First Author: |
Bebee TW |
| Year: |
2015 |
| Journal: |
Elife |
| Title: |
The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. |
| Volume: |
4 |
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•
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| Publication |
| First Author: |
Lima-Junior DS |
| Year: |
2017 |
| Journal: |
J Immunol |
| Title: |
Dectin-1 Activation during Leishmania amazonensis Phagocytosis Prompts Syk-Dependent Reactive Oxygen Species Production To Trigger Inflammasome Assembly and Restriction of Parasite Replication. |
| Volume: |
199 |
| Issue: |
6 |
| Pages: |
2055-2068 |
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| Publication |
| First Author: |
Sims-Robinson C |
| Year: |
2016 |
| Journal: |
Exp Neurol |
| Title: |
The role of endoplasmic reticulum stress in hippocampal insulin resistance. |
| Volume: |
277 |
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| Pages: |
261-267 |
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| Publication |
| First Author: |
Zheng H |
| Year: |
2015 |
| Journal: |
Antioxid Redox Signal |
| Title: |
CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion. |
| Volume: |
22 |
| Issue: |
10 |
| Pages: |
819-31 |
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| First Author: |
Liot S |
| Year: |
2021 |
| Journal: |
Sci Rep |
| Title: |
Development of thymic tumor in [LSL:KrasG12D; Pdx1-CRE] mice, an adverse effect associated with accelerated pancreatic carcinogenesis. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
15075 |
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| Publication |
| First Author: |
Benchoua A |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
Active caspase-8 translocates into the nucleus of apoptotic cells to inactivate poly(ADP-ribose) polymerase-2. |
| Volume: |
277 |
| Issue: |
37 |
| Pages: |
34217-22 |
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| First Author: |
Maruyama A |
| Year: |
2008 |
| Journal: |
Arch Biochem Biophys |
| Title: |
Nrf2 regulates the alternative first exons of CD36 in macrophages through specific antioxidant response elements. |
| Volume: |
477 |
| Issue: |
1 |
| Pages: |
139-45 |
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| Publication |
| First Author: |
Longo-Guess CM |
| Year: |
2005 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice. |
| Volume: |
102 |
| Issue: |
22 |
| Pages: |
7894-9 |
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| Publication |
| First Author: |
Selathurai A |
| Year: |
2015 |
| Journal: |
Cell Metab |
| Title: |
The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity. |
| Volume: |
21 |
| Issue: |
5 |
| Pages: |
718-30 |
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| Publication |
| First Author: |
Everard A |
| Year: |
2019 |
| Journal: |
Nat Commun |
| Title: |
Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
457 |
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| Publication |
| First Author: |
Geng A |
| Year: |
2018 |
| Journal: |
Nat Commun |
| Title: |
KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
2707 |
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| Publication |
| First Author: |
Dobrzyn P |
| Year: |
2010 |
| Journal: |
J Lipid Res |
| Title: |
Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice. |
| Volume: |
51 |
| Issue: |
8 |
| Pages: |
2202-10 |
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| Publication |
| First Author: |
Gitton Y |
| Year: |
1999 |
| Journal: |
Cereb Cortex |
| Title: |
Role of thalamic axons in the expression of H-2Z1, a mouse somatosensory cortex specific marker. |
| Volume: |
9 |
| Issue: |
6 |
| Pages: |
611-20 |
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| Publication |
| First Author: |
Tworak A |
| Year: |
2023 |
| Journal: |
Cell Rep |
| Title: |
Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia. |
| Volume: |
42 |
| Issue: |
8 |
| Pages: |
112982 |
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| Publication |
| First Author: |
Miyamoto S |
| Year: |
2012 |
| Journal: |
Diabetes |
| Title: |
Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophage: anti-inflammatory effect of cholecystokinin. |
| Volume: |
61 |
| Issue: |
4 |
| Pages: |
897-907 |
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| Publication |
| First Author: |
Grizenkova J |
| Year: |
2012 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice. |
| Volume: |
109 |
| Issue: |
34 |
| Pages: |
13722-7 |
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•
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| Publication |
| First Author: |
Gay D |
| Year: |
2013 |
| Journal: |
Nat Med |
| Title: |
Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding. |
| Volume: |
19 |
| Issue: |
7 |
| Pages: |
916-23 |
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•
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| Publication |
| First Author: |
Beechey C |
| Year: |
1997 |
| Journal: |
Mouse Genome |
| Title: |
Brachyrrine, BR, a mouse craniofacial mutant, maps to distal Chromosome 17 and is a candidate model for midline cleft syndrome |
| Volume: |
95 |
| Issue: |
3 |
| Pages: |
692-694 |
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•
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| Publication |
| First Author: |
Ren A |
| Year: |
2012 |
| Journal: |
J Physiol |
| Title: |
Regulation of hippocampus-dependent memory by the zinc finger protein Zbtb20 in mature CA1 neurons. |
| Volume: |
590 |
| Issue: |
19 |
| Pages: |
4917-32 |
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| Publication |
| First Author: |
Blumenthal A |
| Year: |
2012 |
| Journal: |
PLoS One |
| Title: |
M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. |
| Volume: |
7 |
| Issue: |
5 |
| Pages: |
e37314 |
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| Publication |
| First Author: |
Gabitova-Cornell L |
| Year: |
2020 |
| Journal: |
Cancer Cell |
| Title: |
Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer. |
| Volume: |
38 |
| Issue: |
4 |
| Pages: |
567-583.e11 |
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| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
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| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
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