|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 3401 to 3500 out of 4881 for Notch1

<< First    < Previous  |  Next >    Last >>
0.026s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
20801121 | J:178669
First Author: Ohashi S
Year: 2010
Journal: Gastroenterology
Title: NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network.
Volume: 139
Issue: 6
Pages: 2113-23
•
•
•
•
•
Publication
28475172 | J:259453
First Author: Lähdeniemi IAK
Year: 2017
Journal: Cell Death Differ
Title: Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway.
Volume: 24
Issue: 6
Pages: 984-996
•
•
•
•
•
Publication
32255245 | J:292744
First Author: Dolens AC
Year: 2020
Journal: EMBO Rep
Title: Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development.
Volume: 21
Issue: 5
Pages: e49006
•
•
•
•
•
Publication
19934324 | J:155536
First Author: Zhao L
Year: 2009
Journal: Cancer Res
Title: Srcasm inhibits Fyn-induced cutaneous carcinogenesis with modulation of Notch1 and p53.
Volume: 69
Issue: 24
Pages: 9439-47
•
•
•
•
•
Publication
26547035 | J:256881
First Author: Yoon JH
Year: 2016
Journal: Biochim Biophys Acta
Title: NOTCH1 intracellular domain negatively regulates PAK1 signaling pathway through direct interaction.
Volume: 1863
Issue: 2
Pages: 179-88
•
•
•
•
•
Publication
30042180 | J:266553
 
First Author: García-León MJ
Year: 2018
Journal: Development
Title: Dynamic regulation of NOTCH1 activation and Notch ligand expression in human thymus development.
Volume: 145
Issue: 16
•
•
•
•
•
Pathway
R-MMU-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus
•
•
•
•
•
HT Experiment
E-GEOD-8027 | Transcription profiling of mouse Dll3 and Notch1 homozygous mutant embryos to investigate craniofacial malformations of human birth defects
Series Id: GSE8027
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
Publication
29170450 | J:255959
First Author: Natsuizaka M
Year: 2017
Journal: Nat Commun
Title: Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma.
Volume: 8
Issue: 1
Pages: 1758
•
•
•
•
•
Publication
39040060 | J:352150
First Author: Qiao Y
Year: 2024
Journal: iScience
Title: The role of m6A modification in the risk prediction and Notch1 pathway of Alzheimer's disease.
Volume: 27
Issue: 7
Pages: 110235
•
•
•
•
•
Publication
20508646 | J:186350
First Author: Kim MY
Year: 2010
Journal: Cell Death Differ
Title: JIP1 binding to RBP-Jk mediates cross-talk between the Notch1 and JIP1-JNK signaling pathway.
Volume: 17
Issue: 11
Pages: 1728-38
•
•
•
•
•
Publication
15606499 | J:94643
First Author: Uyttendaele H
Year: 2004
Journal: Differentiation
Title: Activation of Notch1 in the hair follicle leads to cell-fate switch and Mohawk alopecia.
Volume: 72
Issue: 8
Pages: 396-409
•
•
•
•
•
Publication
29198941 | J:271491
First Author: Man J
Year: 2018
Journal: Cell Stem Cell
Title: Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells.
Volume: 22
Issue: 1
Pages: 104-118.e6
•
•
•
•
•
Publication
35589941 | J:325112
First Author: Sharma D
Year: 2022
Journal: Commun Biol
Title: IL-33 enhances Jagged1 mediated NOTCH1 intracellular domain (NICD) deubiquitination and pathological angiogenesis in proliferative retinopathy.
Volume: 5
Issue: 1
Pages: 479
•
•
•
•
•
Publication
39550366 | J:358763
First Author: Wang J
Year: 2024
Journal: Nat Commun
Title: NOTCH1 mitochondria localization during heart development promotes mitochondrial metabolism and the endothelial-to-mesenchymal transition in mice.
Volume: 15
Issue: 1
Pages: 9945
•
•
•
•
•
Publication
16449526 | J:108314
First Author: Reschly EJ
Year: 2006
Journal: Blood
Title: Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms.
Volume: 107
Issue: 10
Pages: 4115-21
•
•
•
•
•
DO Term
DOID:0080333 | aortic valve disease 1
•
•
•
•
•
Publication
11425854 | J:71503
First Author: Gupta-Rossi N
Year: 2001
Journal: J Biol Chem
Title: Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor.
Volume: 276
Issue: 37
Pages: 34371-8
•
•
•
•
•
Publication
27381829 | J:253760
 
First Author: Chiblak S
Year: 2016
Journal: Sci Rep
Title: K-Ras and cyclooxygenase-2 coactivation augments intraductal papillary mucinous neoplasm and Notch1 mimicking human pancreas lesions.
Volume: 6
Pages: 29455
•
•
•
•
•
Publication
25759215 | J:220689
First Author: Martin A
Year: 2015
Journal: EMBO J
Title: Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.
Volume: 34
Issue: 8
Pages: 1090-109
•
•
•
•
•
Publication
35401501 | J:323196
 
First Author: Veiga DFT
Year: 2022
Journal: Front Immunol
Title: Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia.
Volume: 13
Pages: 867443
•
•
•
•
•
Publication
38241695 | J:346078
First Author: Zhang X
Year: 2024
Journal: Cancer Res
Title: N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression.
Volume: 84
Issue: 6
Pages: 827-840
•
•
•
•
•
Publication
34222228 | J:321266
 
First Author: Ribeiro TN
Year: 2021
Journal: Front Cell Dev Biol
Title: Notch1 and Galectin-3 Modulate Cortical Reactive Astrocyte Response After Brain Injury.
Volume: 9
Pages: 649854
•
•
•
•
•
Publication
14976135 | J:90747
First Author: López-Nieva P
Year: 2004
Journal: Carcinogenesis
Title: Defective expression of Notch1 and Notch2 in connection to alterations of c-Myc and Ikaros in gamma-radiation-induced mouse thymic lymphomas.
Volume: 25
Issue: 7
Pages: 1299-304
•
•
•
•
•
Publication
36358826 | J:331090
 
First Author: Parmigiani E
Year: 2022
Journal: Cancers (Basel)
Title: Genetic Inactivation of Notch1 Synergizes with Loss of Trp53 to Induce Tumor Formation in the Adult Mouse Forebrain.
Volume: 14
Issue: 21
•
•
•
•
•
Interaction Experiment
Kurooka H (2000)
Description: Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5.
•
•
•
•
•
Interaction Experiment
Mo JS (2007)
Description: Integrin-linked kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase.
•
•
•
•
•
Interaction Experiment
Sibbe M (2009)
Description: Reelin and Notch1 cooperate in the development of the dentate gyrus.
•
•
•
•
•
Publication
22836445 | J:187392
First Author: Kuang Y
Year: 2012
Journal: Glia
Title: Dicer1 and MiR-9 are required for proper Notch1 signaling and the Bergmann glial phenotype in the developing mouse cerebellum.
Volume: 60
Issue: 11
Pages: 1734-46
•
•
•
•
•
Publication
10805726 | J:62484
First Author: Hoemann CD
Year: 2000
Journal: Mol Cell Biol
Title: Two distinct Notch1 mutant alleles are involved in the induction of T-cell leukemia in c-myc transgenic mice.
Volume: 20
Issue: 11
Pages: 3831-42
•
•
•
•
•
Publication
16887975 | J:138396
First Author: Priceputu E
Year: 2006
Journal: J Immunol
Title: Structurally distinct ligand-binding or ligand-independent Notch1 mutants are leukemogenic but affect thymocyte development, apoptosis, and metastasis differently.
Volume: 177
Issue: 4
Pages: 2153-66
•
•
•
•
•
Publication
27717825 | J:256242
First Author: Gan L
Year: 2017
Journal: Biochim Biophys Acta
Title: αMSH promotes preadipocyte proliferation by alleviating ER stress-induced leptin resistance and by activating Notch1 signal in mice.
Volume: 1863
Issue: 1
Pages: 231-238
•
•
•
•
•
Publication
34035082 | J:307931
First Author: Lee CL
Year: 2021
Journal: Cancer Res
Title: Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma.
Volume: 81
Issue: 14
Pages: 3777-3790
•
•
•
•
•
Publication
36765626 | J:333331
 
First Author: Nandi M
Year: 2023
Journal: Cancers (Basel)
Title: IL-15 Prevents the Development of T-ALL from Aberrant Thymocytes with Impaired DNA Repair Functions and Increased NOTCH1 Activation.
Volume: 15
Issue: 3
•
•
•
•
•
Publication
25723392 | J:226290
First Author: Wang WM
Year: 2015
Journal: PLoS One
Title: Epidermal growth factor receptor inhibition reduces angiogenesis via hypoxia-inducible factor-1α and Notch1 in head neck squamous cell carcinoma.
Volume: 10
Issue: 2
Pages: e0119723
•
•
•
•
•
Publication
36028880 | J:343018
First Author: Lee MJ
Year: 2022
Journal: Fluids Barriers CNS
Title: A transcriptomic analysis of cerebral microvessels reveals the involvement of Notch1 signaling in endothelial mitochondrial-dysfunction-dependent BBB disruption.
Volume: 19
Issue: 1
Pages: 64
•
•
•
•
•
Publication
16916793 | J:115981
First Author: Bhat KM
Year: 2006
Journal: Nucleic Acids Res
Title: Transcriptional regulation of human MAP2 gene in melanoma: role of neuronal bHLH factors and Notch1 signaling.
Volume: 34
Issue: 13
Pages: 3819-32
•
•
•
•
•
Publication
23408857 | J:200454
First Author: Ngondo-Mbongo RP
Year: 2013
Journal: Nucleic Acids Res
Title: Modulation of gene expression via overlapping binding sites exerted by ZNF143, Notch1 and THAP11.
Volume: 41
Issue: 7
Pages: 4000-14
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:6755491
Assay Type: Immunohistochemistry
Annotation Date: 2021-09-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6755499
Age: embryonic day 13.5
Image: 1B Notch1D/D Notch2D/D
Note: Effects were more drastic than those of Notch1 single knockout.
Specimen Label: 1B Notch1D/D Notch2D/D
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:6755491
Assay Type: Immunohistochemistry
Annotation Date: 2021-09-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691019
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6755499
Age: embryonic day 11.5
Image: 1A Notch1D/D Notch2D/D
Note: Effects were more drastic than those of Notch1 single knockout.
Specimen Label: 1A Notch1D/D Notch2D/D
Detected: true
Specimen Num: 4
•
•
•
•
•
Publication
20852131 | J:167398
First Author: Ashworth TD
Year: 2010
Journal: Blood
Title: Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.
Volume: 116
Issue: 25
Pages: 5455-64
•
•
•
•
•
Publication
28526405 | J:253814
First Author: Liu Z
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Hypoxia-inducible factor-lα mediates aggrecan and collagen Π expression via NOTCH1 signaling in nucleus pulposus cells during intervertebral disc degeneration.
Volume: 488
Issue: 3
Pages: 554-561
•
•
•
•
•
Publication
28673966 | J:246016
First Author: Yoshizaki K
Year: 2017
Journal: J Biol Chem
Title: Mediator 1 contributes to enamel mineralization as a coactivator for Notch1 signaling and stimulates transcription of the alkaline phosphatase gene.
Volume: 292
Issue: 33
Pages: 13531-13540
•
•
•
•
•
Publication
25201756 | J:230196
First Author: Hua C
Year: 2014
Journal: Exp Hematol
Title: Rictor/mammalian target of rapamycin 2 regulates the development of Notch1 induced murine T-cell acute lymphoblastic leukemia via forkhead box O3.
Volume: 42
Issue: 12
Pages: 1031-40.e1-4
•
•
•
•
•
Publication
25592291 | J:316991
 
First Author: Sriram R
Year: 2015
Journal: Breast Cancer Res
Title: Loss of periostin/OSF-2 in ErbB2/Neu-driven tumors results in androgen receptor-positive molecular apocrine-like tumors with reduced Notch1 activity.
Volume: 17
Pages: 7
•
•
•
•
•
Publication
15604248 | J:94957
First Author: Tsuji H
Year: 2004
Journal: Cancer Res
Title: Involvement of illegitimate V(D)J recombination or microhomology-mediated nonhomologous end-joining in the formation of intragenic deletions of the Notch1 gene in mouse thymic lymphomas.
Volume: 64
Issue: 24
Pages: 8882-90
•
•
•
•
•
Publication
31339573 | J:280870
First Author: Peng Z
Year: 2019
Journal: J Neurochem
Title: Inhibition of Notch1 signaling promotes neuronal differentiation and improves functional recovery in spinal cord injury through suppressing the activation of Ras homolog family member A.
Volume: 150
Issue: 6
Pages: 709-722
•
•
•
•
•
Publication
17046738 | J:117004
First Author: Lupien M
Year: 2006
Journal: Dev Biol
Title: Expression of constitutively active Notch1 in male genital tracts results in ectopic growth and blockage of efferent ducts, epididymal hyperplasia and sterility.
Volume: 300
Issue: 2
Pages: 497-511
•
•
•
•
•
Publication
16341126 | J:126298
First Author: Jang J
Year: 2006
Journal: Cell Death Differ
Title: Notch1 confers thymocytes a resistance to GC-induced apoptosis through Deltex1 by blocking the recruitment of p300 to the SRG3 promoter.
Volume: 13
Issue: 9
Pages: 1495-505
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:1267345
Assay Type: RNA in situ
Annotation Date: 1998-07-13
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1614813
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:1269967
Age: embryonic day 8.5
Image: 4C
Note: Hes-5 expression was down-regulated in Notch1 mutants, though not as dramatically as in RBP-Jkappa mutants.
Specimen Label: 4C
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:1267345
Assay Type: RNA in situ
Annotation Date: 1998-07-13
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1614013
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:1269967
Age: embryonic day 8.5
Image: 4C
Note: Hes-5 expression was down-regulated in Notch1 mutants, though not as dramatically as in RBP-Jkappa mutants.
Specimen Label: 4C
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:6755490
Assay Type: Immunohistochemistry
Annotation Date: 2021-09-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6755498
Age: embryonic day 13.5
Image: 1B Notch1D/D
Note: Elimination of Notch1 greatly reduced radial glial cells (RGC) cell number/unit area in dorsal cortex.
Specimen Label: 1B Notch1D/D
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:6755490
Assay Type: Immunohistochemistry
Annotation Date: 2021-09-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691019
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6755498
Age: embryonic day 11.5
Image: 1A Notch1D/D
Note: Elimination of Notch1 greatly reduced radial glial cells (RGC) cell number/unit area in dorsal cortex.
Specimen Label: 1A Notch1D/D
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:6755490
Assay Type: Immunohistochemistry
Annotation Date: 2021-09-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691019
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6755498
Age: embryonic day 11.5
Image: 1A Notch1D/D Notch2D/D
Note: Elimination of Notch1 greatly reduced radial glial cells (RGC) cell number/unit area in dorsal cortex.
Specimen Label: 1A Notch1D/D Notch2D/D
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:7338953
Assay Type: RNA in situ
Annotation Date: 2022-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7339025
Age: embryonic day 11.5
Image: 3BB/DD
Note: Side-by-side expression of Notch1 and Gdf7 was seen, with no apparent overlap.
Specimen Label: 3BB/DD
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:1267345
Assay Type: RNA in situ
Annotation Date: 1998-07-13
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1607213
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:1269967
Age: embryonic day 8.5
Image: 4C
Note: Hes-5 expression was down-regulated in Notch1 mutants, though not as dramatically as in RBP-Jkappa mutants.
Specimen Label: 4C
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:1267345
Assay Type: RNA in situ
Annotation Date: 1998-07-13
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1618913
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:1269967
Age: embryonic day 8.5
Image: 4C
Note: Hes-5 expression was down-regulated in Notch1 mutants, though not as dramatically as in RBP-Jkappa mutants.
Specimen Label: 4C
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:1267345
Assay Type: RNA in situ
Annotation Date: 1998-07-13
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1616413
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:1269967
Age: embryonic day 8.5
Image: 4C
Note: Hes-5 expression was down-regulated in Notch1 mutants, though not as dramatically as in RBP-Jkappa mutants.
Specimen Label: 4C
Detected: true
Specimen Num: 3
•
•
•
•
•
Protein Coding Gene
MGI:1352744 | Dtx1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1921448 | Dtx2
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein
Q61010
Organism: Mus musculus/domesticus
Length: 627  
Fragment?: false
•
•
•
•
•
Protein
Q8R3P2
Organism: Mus musculus/domesticus
Length: 619  
Fragment?: false
•
•
•
•
•
Publication
26439956 | J:350762
 
First Author: Juryńczyk M
Year: 2015
Journal: J Neuroimmunol
Title: Heat shock protein 70 (Hsp70) interacts with the Notch1 intracellular domain and contributes to the activity of Notch signaling in myelin-reactive CD4 T cells.
Volume: 287
Pages: 19-26
•
•
•
•
•
Publication
9653148 | -
First Author: Logeat F
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: The Notch1 receptor is cleaved constitutively by a furin-like convertase.
Volume: 95
Issue: 14
Pages: 8108-12
•
•
•
•
•
Publication
25700513 | -
First Author: Luca VC
Year: 2015
Journal: Science
Title: Structural biology. Structural basis for Notch1 engagement of Delta-like 4.
Volume: 347
Issue: 6224
Pages: 847-53
•
•
•
•
•
Publication
35821235 | -
First Author: Ferrante F
Year: 2022
Journal: Cell Death Dis
Title: Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics.
Volume: 13
Issue: 7
Pages: 600
•
•
•
•
•
Protein
Q6T264
Organism: Mus musculus/domesticus
Length: 1020  
Fragment?: false
•
•
•
•
•
Protein
D4QGC2
Organism: Mus musculus/domesticus
Length: 1135  
Fragment?: false
•
•
•
•
•
Protein
F6U238
Organism: Mus musculus/domesticus
Length: 1170  
Fragment?: false
•
•
•
•
•
Allele
Notch1<em1(cre/ERT2)Smoc> | MGI:6758035
Name: notch 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
•
•
•
•
•
Allele
Notch1<em3Smoc> | MGI:7265004
Name: notch 1; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Protein Coding Gene
MGI:1890504 | Maml1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
GO Term
GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex
•
•
•
•
•
GO Term
GO:0071175 | MAML2-RBP-Jkappa-ICN1 complex
•
•
•
•
•
GO Term
GO:0071179 | MAML3-RBP-Jkappa-ICN1 complex
•
•
•
•
•
Publication
22237151 | J:196546
First Author: Ntziachristos P
Year: 2012
Journal: Nat Med
Title: Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia.
Volume: 18
Issue: 2
Pages: 298-301
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5779917
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1675217
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5779949
Age: embryonic day 10.5
Image: 3E/F
Note: During phase I, when S-2 became S-1 after segmentation, pMapk1/3 expression was down-regulated and the whole Notch1 domain in S-1 was freed from pMapk1/3.
Specimen Label: 3E/F
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5779917
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1675217
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5780074
Age: embryonic day 10.5
Image: 3E/F
Note: During phase I, when S-2 became S-1 after segmentation, pMapk1/3 expression was down-regulated and the whole Notch1 domain in S-1 was freed from pMapk1/3.
Specimen Label: 3E/F
Detected: true
Specimen Num: 3
•
•
•
•
•
Protein Coding Gene
MGI:96522 | Rbpj
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
23161489 | -
First Author: Rakowski LA
Year: 2013
Journal: Cancer Res
Title: Convergence of the ZMIZ1 and NOTCH1 pathways at C-MYC in acute T lymphoblastic leukemias.
Volume: 73
Issue: 2
Pages: 930-41
•
•
•
•
•
Publication
10747963 | -
First Author: Kurooka H
Year: 2000
Journal: J Biol Chem
Title: Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5.
Volume: 275
Issue: 22
Pages: 17211-20
•
•
•
•
•
Allele
Tg(tetO-NOTCH1*)1Rwng | MGI:4431200
Name: transgene insertion 1, Rong Wang
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence
•
•
•
•
•
Allele
Gt(ROSA)26Sor<tm1(NOTCH1/GFP)Xhsu> | MGI:5430379
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Xiao-Hong Sun
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
•
•
•
•
•
Allele
Eef1a1<tm2Arge> | MGI:5491024
Name: eukaryotic translation elongation factor 1 alpha 1; targeted mutation 2, Argiris Efstratiadis
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
•
•
•
•
•
Allele
Olig1<tm1Wdr> | MGI:5629414
Name: oligodendrocyte transcription factor 1; targeted mutation 1, William D Richardson
Allele Type: Targeted
Attribute String: Null/knockout
•
•
•
•
•
Strain
MGI:6429271 | C57BL/6JSmoc-Notch1<em1(cre/ERT2)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
•
•
•
•
•
Protein Domain
IPR040797 | Zmiz1_N
Type: Domain
Description: This is the N-terminal domain found in Zmiz1 proteins (Zinc finger MIZ domain-containing protein 1). Zmiz1 is a direct Notch1 cofactor that heterogeneously regulates Notch target genes. Zmiz1 directly interacts with the RAM1 domain of Notch1 through this N-terminal tetratricopeptide repeat (TPR) domain. Furthermore, it has been shown that Zmiz1 and Notch1 cooperatively recruit each other to chromatin through direct interaction via the N-terminal TPR domain resulting in a slight increase in activating histone marks and decrease of repressive histone marks. Functional analysis indicate that the N-terminal Domain of Zmiz1 is important for driving Myc transcription and proliferation indirectly [].
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5779914
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1675217
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5779930
Age: embryonic day 10.5
Image: 2A/B/C
Note: Expressions of Notch1 and Hes7 were clearly separated in the middle to anterior. In the posterior end, expressions of Notch1 and Hes7 were intermingled, and subsets of cells even coexpressed Notch1 and Hes7.
Specimen Label: 2A/B/C
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5779914
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1675217
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5779930
Age: embryonic day 10.5
Image: 2D/E/F
Note: Expressions of Notch1 and Hes7 were clearly separated in the middle to anterior. In the posterior end, expressions of Notch1 and Hes7 were intermingled, and subsets of cells even coexpressed Notch1 and Hes7.
Specimen Label: 2D/E/F
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5779914
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1675217
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5779930
Age: embryonic day 10.5
Image: 2G/H/I
Note: Expressions of Notch1 and Hes7 were clearly separated in the middle to anterior. In the posterior end, expressions of Notch1 and Hes7 were intermingled, and subsets of cells even coexpressed Notch1 and Hes7.
Specimen Label: 2G/H/I
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5779914
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1675217
Pattern: Scattered
Stage: TS17
Assay Id: MGI:5779930
Age: embryonic day 10.5
Image: 2J/K/L
Note: In the posterior end, expressions of Notch1 and Hes7 were intermingled. Expression domains were not clearly segregated in either the S0 or S-1 region. Some cells even coexpressed Hes7 and Notch1.
Specimen Label: 2J/K/L
Detected: true
Specimen Num: 8
•
•
•
•
•
Protein Coding Gene
MGI:1098270 | Jag2
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:2389461 | Maml3
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:2389460 | Maml2
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:3045303 | Mamld1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein
Q9QYE5
Organism: Mus musculus/domesticus
Length: 1247  
Fragment?: false
•
•
•
•
•
Protein
P0C6A2
Organism: Mus musculus/domesticus
Length: 803  
Fragment?: false
•
•
•
•
•
Protein
P31266
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
•
•
•
•
•
Protein
Q01705
Organism: Mus musculus/domesticus
Length: 2531  
Fragment?: false
•
•
•
•
•
Allele
Tg(MMTV-NOTCH1*1758-2556)#Sat | MGI:3530240
Name: transgene insertion #, Spyros Artavanis Tsakonas
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom