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Type Details Score
Publication
First Author: Ruland J
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101.
Volume: 98
Issue: 4
Pages: 1859-64
Publication
First Author: Millay DP
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism.
Volume: 106
Issue: 45
Pages: 19023-8
Publication
First Author: Laubach KN
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: p73α1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1.
Volume: 119
Issue: 22
Pages: e2123202119
Publication
First Author: Cai J
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: DARPP32, a target of hyperactive mTORC1 in the retinal pigment epithelium.
Volume: 119
Issue: 33
Pages: e2207489119
Publication
First Author: Vu TTM
Year: 2020
Journal: Biochemistry
Title: The ATF3 Transcription Factor Is a Short-Lived Substrate of the Arg/N-Degron Pathway.
Volume: 59
Issue: 30
Pages: 2796-2812
Publication
First Author: Niwa-Kawakita M
Year: 2017
Journal: J Exp Med
Title: PML is a ROS sensor activating p53 upon oxidative stress.
Volume: 214
Issue: 11
Pages: 3197-3206
Publication
First Author: Angelillo-Scherrer A
Year: 2005
Journal: J Clin Invest
Title: Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy.
Volume: 115
Issue: 2
Pages: 237-46
Publication
First Author: Chaudhari A
Year: 2015
Journal: Mol Cell Biol
Title: p110α Hot Spot Mutations E545K and H1047R Exert Metabolic Reprogramming Independently of p110α Kinase Activity.
Volume: 35
Issue: 19
Pages: 3258-73
Publication
First Author: Fantozzi A
Year: 2014
Journal: Cancer Res
Title: VEGF-mediated angiogenesis links EMT-induced cancer stemness to tumor initiation.
Volume: 74
Issue: 5
Pages: 1566-75
Publication
First Author: Zivkovic A
Year: 2011
Journal: J Immunol
Title: TLR 2 and CD14 mediate innate immunity and lung inflammation to staphylococcal Panton-Valentine leukocidin in vivo.
Volume: 186
Issue: 3
Pages: 1608-17
Publication
First Author: Greenfield A
Year: 1998
Journal: Hum Mol Genet
Title: The UTX gene escapes X inactivation in mice and humans.
Volume: 7
Issue: 4
Pages: 737-42
Publication
First Author: Zeng A
Year: 2013
Journal: J Cell Biol
Title: Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells.
Volume: 201
Issue: 3
Pages: 409-25
Publication
First Author: Bickford JS
Year: 2013
Journal: J Cyst Fibros
Title: Effect of allergy and inflammation on eicosanoid gene expression in CFTR deficiency.
Volume: 12
Issue: 3
Pages: 258-65
Publication
First Author: Dupuy AJ
Year: 2001
Journal: Genesis
Title: Transposition and gene disruption in the male germline of the mouse.
Volume: 30
Issue: 2
Pages: 82-8
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication  
First Author: Oni-Orisan A
Year: 2013
Journal: Prostaglandins Other Lipid Mediat
Title: Dual modulation of cyclooxygenase and CYP epoxygenase metabolism and acute vascular inflammation in mice.
Volume: 104-105
Pages: 67-73
Publication
First Author: Kuroda A
Year: 2017
Journal: Respir Res
Title: Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung.
Volume: 18
Issue: 1
Pages: 69
Publication
First Author: Tikidji-Hamburyan A
Year: 2017
Journal: Nat Commun
Title: Rods progressively escape saturation to drive visual responses in daylight conditions.
Volume: 8
Issue: 1
Pages: 1813
Publication
First Author: Abramsson A
Year: 2007
Journal: Genes Dev
Title: Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development.
Volume: 21
Issue: 3
Pages: 316-31
Publication
First Author: Chamberlain CE
Year: 2014
Journal: J Clin Invest
Title: Menin determines K-RAS proliferative outputs in endocrine cells.
Volume: 124
Issue: 9
Pages: 4093-101
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Menigoz A
Year: 2016
Journal: Pflugers Arch
Title: TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons.
Volume: 468
Issue: 4
Pages: 593-607
Publication  
First Author: Ajith A
Year: 2023
Journal: J Clin Invest
Title: Targeting TREM1 augments antitumor T cell immunity by inhibiting myeloid-derived suppressor cells and restraining anti-PD-1 resistance.
Volume: 133
Issue: 21
Publication
First Author: Méndez-Lucas A
Year: 2017
Journal: Cancer Res
Title: Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities.
Volume: 77
Issue: 16
Pages: 4355-4364
Publication
First Author: Shibata A
Year: 2011
Journal: EMBO J
Title: Factors determining DNA double-strand break repair pathway choice in G2 phase.
Volume: 30
Issue: 6
Pages: 1079-92
Publication
First Author: Sohni A
Year: 2015
Journal: Mol Cell Biol
Title: Dynamic switching of active promoter and enhancer domains regulates Tet1 and Tet2 expression during cell state transitions between pluripotency and differentiation.
Volume: 35
Issue: 6
Pages: 1026-42
Publication
First Author: Weng Z
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M.
Volume: 95
Issue: 21
Pages: 12334-9
Publication
First Author: Bryan JH
Year: 1977
Journal: Virchows Arch A Pathol Anat Histol
Title: Brain development in hydrocephalic-polydactyl, a recessive pleiotropic mutant in the mouse.
Volume: 374
Issue: 3
Pages: 205-14
Publication
First Author: Conboy J
Year: 1986
Journal: Proc Natl Acad Sci U S A
Title: Molecular cloning of protein 4.1, a major structural element of the human erythrocyte membrane skeleton.
Volume: 83
Issue: 24
Pages: 9512-6
Publication
First Author: Bufe B
Year: 2019
Journal: Nat Commun
Title: Bacterial MgrB peptide activates chemoreceptor Fpr3 in mouse accessory olfactory system and drives avoidance behaviour.
Volume: 10
Issue: 1
Pages: 4889
Publication
First Author: Sweet DT
Year: 2013
Journal: Circ Res
Title: Endothelial Shc regulates arteriogenesis through dual control of arterial specification and inflammation via the notch and nuclear factor-κ-light-chain-enhancer of activated B-cell pathways.
Volume: 113
Issue: 1
Pages: 32-39
Publication
First Author: Abravanel DL
Year: 2015
Journal: J Clin Invest
Title: Notch promotes recurrence of dormant tumor cells following HER2/neu-targeted therapy.
Volume: 125
Issue: 6
Pages: 2484-96
Publication
First Author: Dhingra A
Year: 2000
Journal: J Neurosci
Title: The light response of ON bipolar neurons requires G[alpha]o.
Volume: 20
Issue: 24
Pages: 9053-8
Publication
First Author: Khan A
Year: 2021
Journal: Reprod Biol
Title: The evolutionarily conserved gene, Fam114a2, is dispensable for fertility in mouse.
Volume: 21
Issue: 3
Pages: 100531
Publication
First Author: Tanaka A
Year: 2010
Journal: Blood
Title: Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis.
Volume: 115
Issue: 20
Pages: 4138-47
Publication
First Author: Saxena A
Year: 2013
Journal: Int J Colorectal Dis
Title: Mucus and adiponectin deficiency: role in chronic inflammation-induced colon cancer.
Volume: 28
Issue: 9
Pages: 1267-79
Publication
First Author: Ito A
Year: 2007
Journal: J Neuroimmunol
Title: Involvement of the SgIGSF/Necl-2 adhesion molecule in degranulation of mesenteric mast cells.
Volume: 184
Issue: 1-2
Pages: 209-13
Publication
First Author: Joetham A
Year: 2008
Journal: J Immunol
Title: Plasticity of regulatory T cells: subversion of suppressive function and conversion to enhancement of lung allergic responses.
Volume: 180
Issue: 11
Pages: 7117-24
Publication
First Author: Falkenham A
Year: 2013
Journal: Am J Pathol
Title: Early fibroblast progenitor cell migration to the AngII-exposed myocardium is not CXCL12 or CCL2 dependent as previously thought.
Volume: 183
Issue: 2
Pages: 459-69
Publication
First Author: Bosak A
Year: 2013
Journal: Arch Biochem Biophys
Title: Peripheral site and acyl pocket define selective inhibition of mouse butyrylcholinesterase by two biscarbamates.
Volume: 529
Issue: 2
Pages: 140-5
Publication
First Author: Contractor A
Year: 2002
Journal: Science
Title: Trans-synaptic Eph receptor-ephrin signaling in hippocampal mossy fiber LTP.
Volume: 296
Issue: 5574
Pages: 1864-9
Publication
First Author: Castellanos-Rubio A
Year: 2017
Journal: J Immunol
Title: Cytoplasmic Form of Carlr lncRNA Facilitates Inflammatory Gene Expression upon NF-κB Activation.
Volume: 199
Issue: 2
Pages: 581-588
Publication
First Author: Prokhortchouk A
Year: 2006
Journal: Mol Cell Biol
Title: Kaiso-deficient mice show resistance to intestinal cancer.
Volume: 26
Issue: 1
Pages: 199-208
Publication
First Author: Marazioti A
Year: 2018
Journal: Nat Commun
Title: Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion.
Volume: 9
Issue: 1
Pages: 672
Publication
First Author: Ravi A
Year: 2021
Journal: Dev Cell
Title: PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay.
Volume: 56
Issue: 11
Pages: 1661-1676.e10
Publication
First Author: Soro-Paavonen A
Year: 2008
Journal: Diabetes
Title: Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes.
Volume: 57
Issue: 9
Pages: 2461-9
Publication  
First Author: Domokos A
Year: 2023
Journal: Front Immunol
Title: The transcriptional control of the VEGFA-VEGFR1 (FLT1) axis in alternatively polarized murine and human macrophages.
Volume: 14
Pages: 1168635
Publication
First Author: Carrer A
Year: 2019
Journal: Cancer Discov
Title: Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis.
Volume: 9
Issue: 3
Pages: 416-435
Publication
First Author: Zhang W
Year: 2012
Journal: PLoS One
Title: Lymphoma-like T cell infiltration in liver is associated with increased copy number of dominant negative form of TGFβ receptor II.
Volume: 7
Issue: 11
Pages: e49413
Allele
Name: transgene insertion 1, Lothar Hennighausen
Allele Type: Transgenic
Attribute String: Recombinase
Publication
First Author: Erazo-Oliveras A
Year: 2023
Journal: Nat Commun
Title: Mutant APC reshapes Wnt signaling plasma membrane nanodomains by altering cholesterol levels via oncogenic β-catenin.
Volume: 14
Issue: 1
Pages: 4342
GO Term
GO Term
GO Term
Allele
Name: BTB domain containing 3; endonuclease-mediated mutation 1, Stephanie C Dulawa
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready
Publication  
First Author: Burke SJ
Year: 2018
Journal: Mol Metab
Title: Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation.
Volume: 14
Pages: 95-107
Publication
First Author: Holtzman DA
Year: 1987
Journal: Proc Natl Acad Sci U S A
Title: Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells.
Volume: 84
Issue: 23
Pages: 8325-9
Publication
First Author: Tang Y
Year: 2010
Journal: Genesis
Title: The contribution of the Tie2+ lineage to primitive and definitive hematopoietic cells.
Volume: 48
Issue: 9
Pages: 563-7
Publication
First Author: Barros CC
Year: 2012
Journal: PLoS One
Title: Altered glucose homeostasis and hepatic function in obese mice deficient for both kinin receptor genes.
Volume: 7
Issue: 7
Pages: e40573
Publication
First Author: Mao H
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: LRP1 Regulates Retinal Angiogenesis by Inhibiting PARP-1 Activity and Endothelial Cell Proliferation.
Volume: 36
Issue: 2
Pages: 350-60
Publication  
First Author: Mutchler SM
Year: 2021
Journal: Int J Mol Sci
Title: Deletion of the Gamma Subunit of ENaC in Endothelial Cells Does Not Protect against Renal Ischemia Reperfusion Injury.
Volume: 22
Issue: 20
Publication
First Author: Hakozaki A
Year: 2010
Journal: J Immunol
Title: Receptor activator of NF-kappaB (RANK) ligand induces ectodomain shedding of RANK in murine RAW264.7 macrophages.
Volume: 184
Issue: 5
Pages: 2442-8
Publication
First Author: Hall A
Year: 2020
Journal: Skelet Muscle
Title: Tetraspanin CD82 is necessary for muscle stem cell activation and supports dystrophic muscle function.
Volume: 10
Issue: 1
Pages: 34
Publication
First Author: Jacobs JP
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: IL-17-producing T cells can augment autoantibody-induced arthritis.
Volume: 106
Issue: 51
Pages: 21789-94
Publication
First Author: Esplugues E
Year: 2011
Journal: Nature
Title: Control of TH17 cells occurs in the small intestine.
Volume: 475
Issue: 7357
Pages: 514-8
Publication
First Author: Cariou B
Year: 2006
Journal: J Biol Chem
Title: The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice.
Volume: 281
Issue: 16
Pages: 11039-49
Publication
First Author: Abdelkarim M
Year: 2010
Journal: J Biol Chem
Title: The farnesoid X receptor regulates adipocyte differentiation and function by promoting peroxisome proliferator-activated receptor-gamma and interfering with the Wnt/beta-catenin pathways.
Volume: 285
Issue: 47
Pages: 36759-67
Protein Domain
Type: Family
Description: Ribose 5-phosphate isomerase, also known as phosphoriboisomerase, catalyses the reversible conversion of D-ribose 5-phosphate to D-ribulose 5-phosphate, the first step in the non-oxidative branch of the pentose phosphate pathway []. This reaction enables ribose to be synthesized from sugars, as well as the recycling of sugars during the degradation of nucleotides. There are two unrelated types of ribose 5-phosphate isomerases: type A (RpiA) is the most common and is found in most organisms, while type B (RpiB) is restricted to specific eukaryotic and prokaryotic species. Escherichia coli produces both RpiA and RpiB (also known as AlsB), although RpiA accounts for 99% of total RPI enzymes []. This entry represents type A (RpiA) enzymes found in eukaryotes (plants, Metazoa and fungi), bacteria and archaea.
Protein Domain
Type: Family
Description: Curli are extracellular functional amyloids that are assembled by enteric bacteria during biofilm formation and host colonization. The csg (curli specific gene) operon encodes major structural and accessory proteins that are required for curli production. The csgBAC operon encodes the major and minor curli fibre components, CsgA and CsgB, respectively. CsgA is secreted to the extracellular milieu as an unfolded protein and forms amyloid polymers upon interacting with the CsgB nucleator []. CsgA is comprised of five imperfect repeating units with highly conserved glutamine and asparagine residues that are important for amyloid formation. Each repeating unit is predicted to form a strand-loop-strand motif []. In vitro, CsgC inhibits CsgA amyloid formation at substoichiometric concentrations and maintains CsgA in a non-β-sheet rich conformation, making CsgC an efficient and selective amyloid inhibitor [].
Publication
First Author: Kask K
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: The AMPA receptor subunit GluR-B in its Q/R site-unedited form is not essential for brain development and function.
Volume: 95
Issue: 23
Pages: 13777-82
Publication
First Author: Brennand K
Year: 2007
Journal: PLoS Biol
Title: All beta cells contribute equally to islet growth and maintenance.
Volume: 5
Issue: 7
Pages: e163
Protein
Organism: Mus musculus/domesticus
Length: 1461  
Fragment?: false
Publication
First Author: Longabaugh WJR
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Bcl11b and combinatorial resolution of cell fate in the T-cell gene regulatory network.
Volume: 114
Issue: 23
Pages: 5800-5807
Publication
First Author: Gong B
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses.
Volume: 110
Issue: 48
Pages: 19615-20
Publication
First Author: Davis RE
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: A knockin mouse model of the Bardet-Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity.
Volume: 104
Issue: 49
Pages: 19422-7
Publication
First Author: Singh A
Year: 2009
Journal: Free Radic Biol Med
Title: Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs.
Volume: 46
Issue: 3
Pages: 376-86
Publication  
First Author: Queck A
Year: 2020
Journal: Front Immunol
Title: Alox12/15 Deficiency Exacerbates, While Lipoxin A4 Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis.
Volume: 11
Pages: 1447
Publication
First Author: Kirabo A
Year: 2011
Journal: Neoplasia
Title: The Jak2 inhibitor, G6, alleviates Jak2-V617F-mediated myeloproliferative neoplasia by providing significant therapeutic efficacy to the bone marrow.
Volume: 13
Issue: 11
Pages: 1058-68
Publication
First Author: Takaki A
Year: 2008
Journal: J Exp Med
Title: Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice.
Volume: 205
Issue: 9
Pages: 2053-63
Publication
First Author: Ackermann M
Year: 2018
Journal: Nat Commun
Title: Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections.
Volume: 9
Issue: 1
Pages: 5088
Publication
First Author: Brown WE
Year: 1995
Journal: Genomics
Title: The mouse angiogenin gene family: structures of an angiogenin-related protein gene and two pseudogenes.
Volume: 29
Issue: 1
Pages: 200-6
Publication
First Author: El Malki K
Year: 2013
Journal: J Invest Dermatol
Title: An alternative pathway of imiquimod-induced psoriasis-like skin inflammation in the absence of interleukin-17 receptor a signaling.
Volume: 133
Issue: 2
Pages: 441-51
Publication
First Author: Jenke A
Year: 2014
Journal: Basic Res Cardiol
Title: Adiponectin promotes coxsackievirus B3 myocarditis by suppression of acute anti-viral immune responses.
Volume: 109
Issue: 3
Pages: 408
Publication
First Author: Wang X
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: IL-17 constrains natural killer cell activity by restraining IL-15-driven cell maturation via SOCS3.
Volume: 116
Issue: 35
Pages: 17409-17418
Publication
First Author: Ackermann Misfeldt A
Year: 2008
Journal: Diabetes
Title: Beta-cell proliferation, but not neogenesis, following 60% partial pancreatectomy is impaired in the absence of FoxM1.
Volume: 57
Issue: 11
Pages: 3069-77
Publication  
First Author: Burdick LN
Year: 2024
Journal: Biomolecules
Title: Sex as a Critical Variable in Basic and Pre-Clinical Studies of Fibrodysplasia Ossificans Progressiva.
Volume: 14
Issue: 2
Publication    
First Author: Liu Z
Year: 2022
Journal: Elife
Title: Discovery and functional assessment of a novel adipocyte population driven by intracellular Wnt/β-catenin signaling in mammals.
Volume: 11
Publication
First Author: Robichaux MA
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Defining the layers of a sensory cilium with STORM and cryoelectron nanoscopy.
Volume: 116
Issue: 47
Pages: 23562-23572
Publication
First Author: Delaunay A
Year: 2008
Journal: PLoS One
Title: The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositis.
Volume: 3
Issue: 2
Pages: e1609
Publication
First Author: Tagawa A
Year: 2016
Journal: Diabetes
Title: Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy.
Volume: 65
Issue: 3
Pages: 755-67
Publication
First Author: Lehoczky JA
Year: 2013
Journal: PLoS Genet
Title: A novel intergenic ETnII-β insertion mutation causes multiple malformations in polypodia mice.
Volume: 9
Issue: 12
Pages: e1003967
Publication
First Author: Gupta S
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation.
Volume: 117
Issue: 39
Pages: 24316-24325
Publication
First Author: Bouldin CM
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning.
Volume: 107
Issue: 12
Pages: 5489-94
Publication
First Author: Li Y
Year: 2007
Journal: Cancer Res
Title: Activation of the signal transducers and activators of the transcription 3 pathway in alveolar epithelial cells induces inflammation and adenocarcinomas in mouse lung.
Volume: 67
Issue: 18
Pages: 8494-503
Publication
First Author: Pilz A
Year: 2009
Journal: J Immunol
Title: Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL.
Volume: 183
Issue: 4
Pages: 2286-93
Publication
First Author: Gerbitz A
Year: 2012
Journal: PLoS One
Title: Stromal interferon-γ signaling and cross-presentation are required to eliminate antigen-loss variants of B cell lymphomas in mice.
Volume: 7
Issue: 3
Pages: e34552
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Moss A Jr
Year: 1994
Journal: Transplant Proc
Title: Analysis of the human anti-pig cellular immune response using the Hu-scid mouse-porcine skin graft model.
Volume: 26
Issue: 3
Pages: 1209
Publication
First Author: Chédotal A
Year: 1998
Journal: Development
Title: Semaphorins III and IV repel hippocampal axons via two distinct receptors.
Volume: 125
Issue: 21
Pages: 4313-23
Publication
First Author: Elahi-Gedwillo KY
Year: 2019
Journal: Cancer Res
Title: Antifibrotic Therapy Disrupts Stromal Barriers and Modulates the Immune Landscape in Pancreatic Ductal Adenocarcinoma.
Volume: 79
Issue: 2
Pages: 372-386