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Type Details Score
Publication
39045105 | J:354844
First Author: Vardam-Kaur T
Year: 2024
Journal: iScience
Title: The ATP-exporting channel Pannexin 1 promotes CD8(+) T cell effector and memory responses.
Volume: 27
Issue: 7
Pages: 110290
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Publication
8415640 | J:15101
First Author: Moser AR
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.
Volume: 90
Issue: 19
Pages: 8977-81
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Protein Domain
IPR032724 | DddA-like
Type: Family
Description: Members of this family are predicted to function as toxins in bacterial polymorphic toxin systems, including DddA from Burkholderia cenocepacia []. DddA is part of the cellular contact-dependent growth inhibition (CDI) system that allows bacteria to communicate with and inhibit the growth of closely related neighbouring bacteria in a contact-dependent fashion. Its deaminase domain has double-stranded DNA cytidine deaminase activity and can be used for CRISPR-free mitochondrial base editing [].
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Protein Domain
IPR042304 | Alphavir_E2_A
Type: Homologous_superfamily
Description: Alphaviruses are enveloped RNA viruses that use arthropods such as mosquitoes for transmission to their vertebrate hosts, and include Semliki Forest and Sindbis viruses []. Alphaviruses consist of three structural proteins: the core nucleocapsid protein C, and the envelope proteins P62 and E1 () that associate as a heterodimer. The viral membrane-anchored surface glycoproteins are responsible for receptor recognition and entry into target cells through membrane fusion. The proteolytic maturation of P62 into E2 and E3 () causes a change in the viral surface. Together the E1, E2, and sometimes E3 glycoprotein "spikes"form an E1/E2 dimer or an E1/E2/E3 trimer, where E2 extends from the centre to the vertices, E1 fills the space between the vertices, and E3, if present, is at the distal end of the spike [, ]. Upon exposure of the virus to the acidity of the endosome, E1 dissociates from E2 to form an E1 homotrimer, which is necessary for the fusion step to drive the cellular and viral membranes together []. This entry represents the alphaviral E2 glycoprotein. The E2 glycoprotein functions to interact with the nucleocapsid through its cytoplasmic domain, while its ectodomain is responsible for binding a cellular receptor.The E2 glycoproteins interact with the nucleocapsid through its cytoplasmic domain, while its ectodomain is responsible for binding a cellular receptor. This is an all beta protein belonging to the immunoglobulin superfamily, with three immunoglobulin domains labelled A, B and C in amino- to carboxy-terminal order.This superfamily represents the N-terminal domain, known as domain A, of the alphavirus E2 glycoprotein and which is found at the centre of the protein [].
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Protein Domain
IPR003516 | FANCA
Type: Family
Description: Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. It is required for the monoubiquitylation of FANCD2 and FANCI heterodimer. The FA core complex consists of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCT (UBET2), FAAP100 and FAAP24 [, ].This entry represents FANCA [].
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Protein Domain
IPR027585 | Pantocin_A_RiPP_pre
Type: Family
Description: Members of this family are ribosomally-synthesised and posttranslationally-modified peptide (RiPP) precursors about 30 amino acids in length encoded in the vicinity of PaaA and PaaB homologues. Members include PaaP from Pantoea agglomerans, whose central tripeptide EEN appears to be the source of the mature product, pantocin A. Note, however, that the corresponding residues in Photobacterium sp. SKA34 and Photobacterium asymbiotica are EEK rather than EEN. This family, therefore, resembles the PQQ precursor PqqA as a peptide precursor of an extremely small mature product.
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Publication
25906749 | J:264409
First Author: Mohammed A
Year: 2015
Journal: Oncotarget
Title: Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression.
Volume: 6
Issue: 17
Pages: 15524-39
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Publication
16308421 | J:104202
First Author: Shaw RJ
Year: 2005
Journal: Science
Title: The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.
Volume: 310
Issue: 5754
Pages: 1642-6
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Publication
36706756 | J:333382
First Author: Rodrigo Albors A
Year: 2023
Journal: Dev Cell
Title: An ependymal cell census identifies heterogeneous and ongoing cell maturation in the adult mouse spinal cord that changes dynamically on injury.
Volume: 58
Issue: 3
Pages: 239-255.e10
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Publication
21949401 | J:177465
First Author: Zheng K
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: TrkB signaling in parvalbumin-positive interneurons is critical for gamma-band network synchronization in hippocampus.
Volume: 108
Issue: 41
Pages: 17201-6
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Publication
12048195 | -
First Author: Diacovich L
Year: 2002
Journal: J Biol Chem
Title: Kinetic and structural analysis of a new group of Acyl-CoA carboxylases found in Streptomyces coelicolor A3(2).
Volume: 277
Issue: 34
Pages: 31228-36
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Publication
35917179 | J:335840
 
First Author: Hwang E
Year: 2022
Journal: JCI Insight
Title: Sustained inhibition of NPY/AgRP neuronal activity by FGF1.
Volume: 7
Issue: 17
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Publication
19633196 | J:152002
First Author: Blurton-Jones M
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease.
Volume: 106
Issue: 32
Pages: 13594-9
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Publication
32316750 | J:329628
First Author: Hoyer FF
Year: 2020
Journal: Circulation
Title: Bone Marrow Endothelial Cells Regulate Myelopoiesis in Diabetes Mellitus.
Volume: 142
Issue: 3
Pages: 244-258
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Publication
29950315 | J:263851
First Author: Gage MC
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation.
Volume: 115
Issue: 28
Pages: E6556-E6565
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Publication
12540830 | -
First Author: Hartmann M
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Evolution of feedback-inhibited beta /alpha barrel isoenzymes by gene duplication and a single mutation.
Volume: 100
Issue: 3
Pages: 862-7
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Publication
18591672 | J:143954
First Author: Pastor R
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism.
Volume: 105
Issue: 26
Pages: 9070-5
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Publication
37712288 | J:342172
First Author: Pasquier A
Year: 2023
Journal: EMBO J
Title: TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression.
Volume: 42
Issue: 21
Pages: e113928
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Publication
24748112 | J:211089
First Author: Mease RA
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Cortical control of adaptation and sensory relay mode in the thalamus.
Volume: 111
Issue: 18
Pages: 6798-803
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Publication
29464061 | J:319515
First Author: Bernard V
Year: 2018
Journal: Oncotarget
Title: Natural and molecular history of prolactinoma: insights from a Prlr-/- mouse model.
Volume: 9
Issue: 5
Pages: 6144-6155
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Publication
16085792 | J:103335
First Author: Morrissey A
Year: 2005
Journal: Pediatr Res
Title: Expression of ATP-sensitive K+ channel subunits during perinatal maturation in the mouse heart.
Volume: 58
Issue: 2
Pages: 185-92
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Publication
20709958 | J:163666
First Author: Prochazka J
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Patterning by heritage in mouse molar row development.
Volume: 107
Issue: 35
Pages: 15497-502
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Publication
35472681 | J:353709
First Author: Du YQ
Year: 2022
Journal: Diabetes
Title: Endogenous Lipid-GPR120 Signaling Modulates Pancreatic Islet Homeostasis to Different Extents.
Volume: 71
Issue: 7
Pages: 1454-1471
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Publication
37891168 | J:342180
First Author: Pradhan AK
Year: 2023
Journal: Transl Psychiatry
Title: Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer's disease.
Volume: 13
Issue: 1
Pages: 332
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Publication
9806851 | J:50418
First Author: Fujita A
Year: 1998
Journal: Genomics
Title: Assignment of mouse cardiac two-pore background K+ channel gene (Kcnk4) to the proximal region of mouse chromosome 5.
Volume: 54
Issue: 1
Pages: 183-4
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Publication
28552668 | J:272682
First Author: Grassmé H
Year: 2017
Journal: Cell Host Microbe
Title: β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections.
Volume: 21
Issue: 6
Pages: 707-718.e8
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Protein Coding Gene
MGI:1915971 | Cfap68
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1924877 | Efcab6
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
21483770 | J:172232
First Author: Yang X
Year: 2011
Journal: PLoS One
Title: Spry1 is expressed in hemangioblasts and negatively regulates primitive hematopoiesis and endothelial cell function.
Volume: 6
Issue: 4
Pages: e18374
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Publication
19897731 | J:154749
First Author: Quinn BJ
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Erythrocyte scaffolding protein p55/MPP1 functions as an essential regulator of neutrophil polarity.
Volume: 106
Issue: 47
Pages: 19842-7
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Publication
28475896 | J:241497
First Author: Rialdi A
Year: 2017
Journal: Cell
Title: The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity.
Volume: 169
Issue: 4
Pages: 679-692.e14
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Publication
8600981 | J:32964
First Author: Slominski A
Year: 1996
Journal: Biochim Biophys Acta
Title: The expression of proopiomelanocortin (POMC) and of corticotropin releasing hormone receptor (CRH-R) genes in mouse skin.
Volume: 1289
Issue: 2
Pages: 247-51
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Publication
22753134 | J:186497
First Author: Flaht A
Year: 2012
Journal: Dev Dyn
Title: Cellular phenotypes and spatio-temporal patterns of lymphatic vessel development in embryonic mouse hearts.
Volume: 241
Issue: 9
Pages: 1473-86
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Publication
18077436 | J:128603
First Author: Delbono O
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45.
Volume: 104
Issue: 50
Pages: 20108-13
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Publication
25456130 | J:218754
First Author: Chatterjee A
Year: 2014
Journal: Cell Rep
Title: Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis.
Volume: 9
Issue: 4
Pages: 1333-48
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Publication
22331912 | J:182161
First Author: Kim J
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: High-grade serous ovarian cancer arises from fallopian tube in a mouse model.
Volume: 109
Issue: 10
Pages: 3921-6
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Publication
24706787 | J:208877
First Author: Chang SH
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: T helper 17 cells play a critical pathogenic role in lung cancer.
Volume: 111
Issue: 15
Pages: 5664-9
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Publication
19244212 | J:260261
First Author: Inoue A
Year: 2009
Journal: Sci Signal
Title: Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation.
Volume: 2
Issue: 59
Pages: ra7
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Publication
29400711 | J:274066
First Author: Montagne A
Year: 2018
Journal: Nat Med
Title: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system.
Volume: 24
Issue: 3
Pages: 326-337
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Publication
16849425 | J:111826
First Author: Komeima K
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Antioxidants reduce cone cell death in a model of retinitis pigmentosa.
Volume: 103
Issue: 30
Pages: 11300-5
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Publication
17242369 | J:119494
First Author: Becker M
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Stimulation of endogenous neurogenesis by anti-EFRH immunization in a transgenic mouse model of Alzheimer's disease.
Volume: 104
Issue: 5
Pages: 1691-6
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Publication
12697936 | J:83402
First Author: Reilly JF
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Amyloid deposition in the hippocampus and entorhinal cortex: quantitative analysis of a transgenic mouse model.
Volume: 100
Issue: 8
Pages: 4837-42
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Publication
18955704 | J:144070
First Author: Lee AS
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: A double dissociation revealing bidirectional competition between striatum and hippocampus during learning.
Volume: 105
Issue: 44
Pages: 17163-8
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Publication
17404210 | J:120851
First Author: Kanekiyo T
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Lipocalin-type prostaglandin D synthase/beta-trace is a major amyloid beta-chaperone in human cerebrospinal fluid.
Volume: 104
Issue: 15
Pages: 6412-7
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Publication
32041882 | J:285807
First Author: Shen W
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice.
Volume: 117
Issue: 8
Pages: 4392-4399
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Publication
10716706 | J:61202
First Author: Andrechek ER
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis.
Volume: 97
Issue: 7
Pages: 3444-9
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Publication
19429708 | J:150015
First Author: Ma Q
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma.
Volume: 106
Issue: 21
Pages: 8683-8
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Publication
18650388 | J:139017
First Author: Breault DT
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells.
Volume: 105
Issue: 30
Pages: 10420-5
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Publication
16636276 | J:109589
First Author: Franken P
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: genotype and sex interactions.
Volume: 103
Issue: 18
Pages: 7118-23
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Publication
3967899 | J:7715
First Author: Hibbs ML
Year: 1985
Journal: Immunogenetics
Title: Gm-3.2, a new granulocyte/macrophage alloantigen.
Volume: 21
Issue: 1
Pages: 61-70
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Publication
3918306 | J:19325
First Author: Yokota T
Year: 1985
Journal: Proc Natl Acad Sci U S A
Title: Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells.
Volume: 82
Issue: 1
Pages: 68-72
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Protein Coding Gene
MGI:3030517 | Or56a5
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
37533765 | J:339127
 
First Author: Jullienne A
Year: 2023
Journal: Front Aging Neurosci
Title: Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer's disease.
Volume: 15
Pages: 1220036
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Publication
32735820 | J:311914
First Author: Biswas A
Year: 2020
Journal: Stem Cell Reports
Title: The Periostin/Integrin-αv Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver.
Volume: 15
Issue: 2
Pages: 340-357
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Publication
12522149 | J:81415
First Author: Bogue CW
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Impaired B cell development and function in mice with a targeted disruption of the homeobox gene Hex.
Volume: 100
Issue: 2
Pages: 556-61
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Publication
26829053 | J:230720
First Author: Ueda T
Year: 2016
Journal: Oncogene
Title: ALK(R1275Q) perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN.
Volume: 35
Issue: 34
Pages: 4447-58
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GXD Expression
GXD Expression
Probe: MGI:5429349
Assay Type: Immunohistochemistry
Annotation Date: 2012-08-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702125
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5429962
Age: embryonic day 17.5
Image: 5B
Note: Only a few Isl1/Chromogranin A double positive cells were found.
Specimen Label: 5B
Detected: true
Specimen Num: 2
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Publication
25698744 | J:219861
First Author: de Nooij JC
Year: 2015
Journal: J Neurosci
Title: The PDZ-domain protein Whirlin facilitates mechanosensory signaling in mammalian proprioceptors.
Volume: 35
Issue: 7
Pages: 3073-84
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Publication
22826230 | J:188485
First Author: Welstead GG
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner.
Volume: 109
Issue: 32
Pages: 13004-9
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Publication
17576930 | J:122592
First Author: Ha L
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence.
Volume: 104
Issue: 26
Pages: 10968-73
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Publication
33707579 | J:304828
First Author: Muchenditsi A
Year: 2021
Journal: Sci Rep
Title: Systemic deletion of Atp7b modifies the hepatocytes' response to copper overload in the mouse models of Wilson disease.
Volume: 11
Issue: 1
Pages: 5659
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Publication
37115925 | J:335426
First Author: Butera A
Year: 2023
Journal: Sci Adv
Title: ZFP750 affects the cutaneous barrier through regulating lipid metabolism.
Volume: 9
Issue: 17
Pages: eadg5423
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Publication
21808002 | J:175610
First Author: Warthen DM
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Light enhances learned fear.
Volume: 108
Issue: 33
Pages: 13788-93
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Publication
37816355 | J:342152
First Author: Honda A
Year: 2023
Journal: Cell Rep
Title: Very-long-chain fatty acids are crucial to neuronal polarity by providing sphingolipids to lipid rafts.
Volume: 42
Issue: 10
Pages: 113195
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Publication
16461917 | J:106061
First Author: Schonhoff CM
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: S-nitrosothiol depletion in amyotrophic lateral sclerosis.
Volume: 103
Issue: 7
Pages: 2404-9
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Publication
1532662 | J:107545
First Author: Geiger T
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: T-cell responsiveness to an oncogenic peripheral protein and spontaneous autoimmunity in transgenic mice.
Volume: 89
Issue: 7
Pages: 2985-9
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Publication
31871154 | J:336847
First Author: Ng SR
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer.
Volume: 117
Issue: 1
Pages: 513-521
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Publication
15148409 | J:90666
First Author: Satoh K
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling.
Volume: 101
Issue: 21
Pages: 8017-21
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Publication
27307565 | J:234650
First Author: Saito A
Year: 2016
Journal: J Virol
Title: Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus Passage In Vivo.
Volume: 90
Issue: 15
Pages: 6918-35
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Publication
23236172 | J:193173
First Author: Sachs N
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Loss of integrin α3 prevents skin tumor formation by promoting epidermal turnover and depletion of slow-cycling cells.
Volume: 109
Issue: 52
Pages: 21468-73
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Publication
22306086 | J:181330
First Author: Sabine A
Year: 2012
Journal: Dev Cell
Title: Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation.
Volume: 22
Issue: 2
Pages: 430-45
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Publication
18487439 | J:138207
First Author: Essop MF
Year: 2008
Journal: Am J Physiol Heart Circ Physiol
Title: Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice.
Volume: 295
Issue: 1
Pages: H256-65
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Protein Coding Gene
MGI:1921072 | Tektip1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31067462 | J:276950
First Author: Coulombe P
Year: 2019
Journal: Cell Rep
Title: Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling.
Volume: 27
Issue: 6
Pages: 1769-1780.e4
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Publication
24305049 | J:207920
First Author: Rosenfeldt MT
Year: 2013
Journal: Nature
Title: p53 status determines the role of autophagy in pancreatic tumour development.
Volume: 504
Issue: 7479
Pages: 296-300
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Publication
27412785 | J:240357
First Author: Burberry A
Year: 2016
Journal: Sci Transl Med
Title: Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease.
Volume: 8
Issue: 347
Pages: 347ra93
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Publication
29581184 | J:265280
     
First Author: Tolkachov A
Year: 2018
Journal: Mol Cell Biol
Title: Loss of the hematopoietic stem cell factor GATA2 in the osteogenic lineage impairs trabecularization and mechanical strength of bone.
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Publication
27810920 | J:237521
First Author: Azagra A
Year: 2016
Journal: J Exp Med
Title: In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development.
Volume: 213
Issue: 12
Pages: 2591-2601
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Publication
30797773 | J:350392
First Author: Codina A
Year: 2019
Journal: Cell Syst
Title: Convergent Identification and Interrogation of Tumor-Intrinsic Factors that Modulate Cancer Immunity In Vivo.
Volume: 8
Issue: 2
Pages: 136-151.e7
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