| Type |
Details |
Score |
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lubarski I |
| Year: |
2005 |
| Journal: |
J Biol Chem |
| Title: |
Interaction with the Na,K-ATPase and tissue distribution of FXYD5 (related to ion channel). |
| Volume: |
280 |
| Issue: |
45 |
| Pages: |
37717-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lubarski I |
| Year: |
2011 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
FXYD5 (dysadherin) regulates the paracellular permeability in cultured kidney collecting duct cells. |
| Volume: |
301 |
| Issue: |
6 |
| Pages: |
F1270-80 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1289514 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2003-06-16 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1610528 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:2662845 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Heart |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1289514 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2003-06-16 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689428 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:2662845 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Brain |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1289514 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2003-06-16 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1876728 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:2662845 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Spleen |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1289514 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2003-06-16 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672828 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:2662845 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Lung |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1289514 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2003-06-16 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684628 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:2662845 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Liver |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1289514 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2003-06-16 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3598828 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:2662845 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Skeletal m. |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1289514 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2003-06-16 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1737328 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:2662845 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Kidney |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1289514 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2003-06-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1797228 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:2662845 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Testis |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1289514 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2003-06-16 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603910 |
|
| Stage: |
TS10 |
| Assay Id: |
MGI:2662853 |
| Age: |
embryonic day 7.0 |
|
|
| Specimen Label: |
7 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1289514 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2003-06-16 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603918 |
|
| Stage: |
TS18 |
| Assay Id: |
MGI:2662853 |
| Age: |
embryonic day 11.0 |
|
|
| Specimen Label: |
11 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1289514 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2003-06-16 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603923 |
|
| Stage: |
TS23 |
| Assay Id: |
MGI:2662853 |
| Age: |
embryonic day 15.0 |
|
|
| Specimen Label: |
15 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1289514 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2003-06-16 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603925 |
|
| Stage: |
TS25 |
| Assay Id: |
MGI:2662853 |
| Age: |
embryonic day 17.0 |
|
|
| Specimen Label: |
17 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417777 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-03-14 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3576022 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:7444193 |
| Age: |
embryonic day 14.5 |
| Image: |
S1B |
| Note: |
Expression was detected primarily in the valve endothelium. |
| Specimen Label: |
S1B |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417777 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-03-14 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3515422 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:7444193 |
| Age: |
embryonic day 14.5 |
| Image: |
S1B |
| Note: |
Expression was detected primarily in the valve endothelium. |
| Specimen Label: |
S1B |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417777 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-04-16 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3266022 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:7621132 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
Supplementary table 2 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
185
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
78
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zuo H |
| Year: |
2018 |
| Journal: |
J Neurosci |
| Title: |
Age-Dependent Decline in Fate Switch from NG2 Cells to Astrocytes After Olig2 Deletion. |
| Volume: |
38 |
| Issue: |
9 |
| Pages: |
2359-2371 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Morrison VE |
| Year: |
2020 |
| Journal: |
eNeuro |
| Title: |
Retinoic Acid Is Required for Oligodendrocyte Precursor Cell Production and Differentiation in the Postnatal Mouse Corpus Callosum. |
| Volume: |
7 |
| Issue: |
1 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hill RA |
| Year: |
2013 |
| Journal: |
J Neurosci |
| Title: |
NG2 cells in white matter but not gray matter proliferate in response to PDGF. |
| Volume: |
33 |
| Issue: |
36 |
| Pages: |
14558-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bischof M |
| Year: |
2015 |
| Journal: |
J Neurosci |
| Title: |
Brg1-dependent chromatin remodelling is not essentially required during oligodendroglial differentiation. |
| Volume: |
35 |
| Issue: |
1 |
| Pages: |
21-35 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Boshans LL |
| Year: |
2021 |
| Journal: |
Sci Rep |
| Title: |
Direct reprogramming of oligodendrocyte precursor cells into GABAergic inhibitory neurons by a single homeodomain transcription factor Dlx2. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
3552 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ifi208/Ifi208<+> |
| Background: |
involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(CAG-Bgeo/GFP)21Lbe/? Ifi208/Ifi208<+> |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ifi208/Ifi208<+> |
| Background: |
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Topol L |
| Year: |
2003 |
| Journal: |
J Cell Biol |
| Title: |
Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. |
| Volume: |
162 |
| Issue: |
5 |
| Pages: |
899-908 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yao Y |
| Year: |
2017 |
| Journal: |
Nat Commun |
| Title: |
Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin. |
| Volume: |
8 |
|
| Pages: |
15402 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Reitmair AH |
| Year: |
1996 |
| Journal: |
Cancer Res |
| Title: |
Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice. |
| Volume: |
56 |
| Issue: |
16 |
| Pages: |
3842-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nakagawa TY |
| Year: |
1999 |
| Journal: |
Immunity |
| Title: |
Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice. |
| Volume: |
10 |
| Issue: |
2 |
| Pages: |
207-17 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Crowther RR |
| Year: |
2022 |
| Journal: |
J Immunol |
| Title: |
Cutting Edge: l-Arginine Transfer from Antigen-Presenting Cells Sustains CD4(+) T Cell Viability and Proliferation. |
| Volume: |
208 |
| Issue: |
4 |
| Pages: |
793-798 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Heit A |
| Year: |
2003 |
| Journal: |
J Immunol |
| Title: |
Cutting edge: Toll-like receptor 9 expression is not required for CpG DNA-aided cross-presentation of DNA-conjugated antigens but essential for cross-priming of CD8 T cells. |
| Volume: |
170 |
| Issue: |
6 |
| Pages: |
2802-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Periasamy P |
| Year: |
2013 |
| Journal: |
J Leukoc Biol |
| Title: |
Novel splenic antigen-presenting cells derive from a Lin(-) c-kit(lo) progenitor. |
| Volume: |
93 |
| Issue: |
1 |
| Pages: |
63-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hoyne GF |
| Year: |
2000 |
| Journal: |
Int Immunol |
| Title: |
Serrate1-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells. |
| Volume: |
12 |
| Issue: |
2 |
| Pages: |
177-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Paulsen JE |
| Year: |
2000 |
| Journal: |
Toxicol Lett |
| Title: |
Modulation by dietary factors in murine FAP models. |
| Volume: |
112-113 |
|
| Pages: |
403-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Moreira MA |
| Year: |
1997 |
| Journal: |
Cytogenet Cell Genet |
| Title: |
Assignment of TCF1, TGM1, CALM1, CKB, THBS1, B2M, and FES in Ateles paniscus chamek (Platyrrhini, Primates). |
| Volume: |
79 |
| Issue: |
1-2 |
| Pages: |
92-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chang JT |
| Year: |
2000 |
| Journal: |
J Immunol |
| Title: |
Role of costimulation in the induction of the IL-12/IL-12 receptor pathway and the development of autoimmunity. |
| Volume: |
164 |
| Issue: |
1 |
| Pages: |
100-6 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ghezzi D |
| Year: |
2011 |
| Journal: |
Nat Genet |
| Title: |
Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies. |
| Volume: |
43 |
| Issue: |
3 |
| Pages: |
259-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ayad NG |
| Year: |
2003 |
| Journal: |
Cell |
| Title: |
Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. |
| Volume: |
113 |
| Issue: |
1 |
| Pages: |
101-13 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
266
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
213
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
187
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
407
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
78
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
69
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
180
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
151
 |
| Fragment?: |
true |
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•
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•
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
171
 |
| Fragment?: |
true |
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•
•
•
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
210
 |
| Fragment?: |
false |
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•
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| Publication |
| First Author: |
Grossberger R |
| Year: |
1999 |
| Journal: |
J Biol Chem |
| Title: |
Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. |
| Volume: |
274 |
| Issue: |
20 |
| Pages: |
14500-7 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Wendt KS |
| Year: |
2001 |
| Journal: |
Nat Struct Biol |
| Title: |
Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex. |
| Volume: |
8 |
| Issue: |
9 |
| Pages: |
784-8 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Sulzenbacher G |
| Year: |
2006 |
| Journal: |
EMBO J |
| Title: |
LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis. |
| Volume: |
25 |
| Issue: |
7 |
| Pages: |
1436-44 |
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•
•
•
•
|
| Publication |
| First Author: |
Brechtel CE |
| Year: |
1998 |
| Journal: |
Biochem J |
| Title: |
4-Aminobutyrate (GABA) transporters from the amine-polyamine-choline superfamily: substrate specificity and ligand recognition profile of the 4-aminobutyrate permease from Bacillus subtilis. |
| Volume: |
333 ( Pt 3) |
|
| Pages: |
565-71 |
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•
•
•
•
|
| Publication |
| First Author: |
Hu LA |
| Year: |
1998 |
| Journal: |
J Biol Chem |
| Title: |
Functional significance of the "signature cysteine" in helix 8 of the Escherichia coli 4-aminobutyrate transporter from the amine-polyamine-choline superfamily. Restoration of Cys-300 to the Cys-less Gabp. |
| Volume: |
273 |
| Issue: |
32 |
| Pages: |
20162-7 |
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•
•
•
•
|
| Publication |
| First Author: |
Furuta T |
| Year: |
2000 |
| Journal: |
Mol Biol Cell |
| Title: |
EMB-30: an APC4 homologue required for metaphase-to-anaphase transitions during meiosis and mitosis in Caenorhabditis elegans. |
| Volume: |
11 |
| Issue: |
4 |
| Pages: |
1401-19 |
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•
•
•
•
|
| Publication |
| First Author: |
Koloteva-Levine N |
| Year: |
2004 |
| Journal: |
Mol Cell Biol |
| Title: |
The Apc5 subunit of the anaphase-promoting complex/cyclosome interacts with poly(A) binding protein and represses internal ribosome entry site-mediated translation. |
| Volume: |
24 |
| Issue: |
9 |
| Pages: |
3577-87 |
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•
•
•
•
•
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| Publication |
| First Author: |
Oosterveen T |
| Year: |
2007 |
| Journal: |
Dev Biol |
| Title: |
Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans. |
| Volume: |
308 |
| Issue: |
2 |
| Pages: |
438-48 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Willert K |
| Year: |
1999 |
| Journal: |
Development |
| Title: |
A Drosophila Axin homolog, Daxin, inhibits Wnt signaling. |
| Volume: |
126 |
| Issue: |
18 |
| Pages: |
4165-73 |
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•
•
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| Protein Domain |
| Type: |
Family |
| Description: |
This entry includes Axin-1 and Axin-2 from vertebrates and related proteins from invertebrates. Axin is a central component of the canonical Wnt signaling pathway that interacts with the adenomatous polyposis coli protein APC and the kinase GSK3beta to downregulate the effector beta-catenin []. Axin-1 (axis inhibition protein 1) is a scaffold protein that is involved in many signalling pathways, including the Wnt, transforming growth factor-beta, MAP kinase pathways, as well as p53 activation cascades [, ]. It controls many biological processes ranging from sugar intake, cell proliferation, and organ development to cell death [].Mutations in Axin-1 gene cause hepatocellular carcinoma (HCC), a primary malignant neoplasm of epithelial liver cells [], and caudal duplication anomaly (CADUA), a condition characterised by the occurrence of duplications of different organs in the caudal region [].Like its mammalian counterpart, Drosophila Axin homologue, Daxin, acts as a negative regulator of wg/Wnt signaling []. In C. elegans AXL-1 functions redundantly with its ortholog, PRY-1, in negatively regulating BAR-1/beta-catenin signaling in the developing vulva and the Q neuroblast lineage. AXL-1 also functions independently of PRY-1 in negatively regulating canonical Wnt signaling during excretory cell development []. |
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| Protein Domain |
| Type: |
Domain |
| Description: |
The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins, thereby targeting them for proteolysis by the 26S proteasome [].One of the subunits of the APC that is required for ubiquitination activity is APC10, a one-domain protein homologous to a sequence element, termed the DOC domain, found in several hypothetical proteins that may also mediate ubiquitination reactions, because they contain combinations of either RING finger (see ), cullin (see ) or HECT (see ) domains [, , ].The DOC domain consists of a β-sandwich, in which a five-stranded antiparallel β-sheet is packed on top of a three stranded antiparallel β-sheet, exhibiting a 'jellyroll' fold [, ].Proteins known to contain a DOC domain include:Eucaryotic Doc1/Apc10.Mammalian protein associated with the transcription factor Myc (PAM).Mouse runty-jerky-sterile (RJS) protein.Human HERC2, the ortholog of RJS. |
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•
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| Protein Domain |
| Type: |
Family |
| Description: |
This entry includes cell division cycle-associated protein 3 (CDCA3; also known as trigger of mitotic entry protein 1 or TOME-1), which is required for entry into mitosis. The protein is found at high levels during the G2 and M phases of mitosis, but declines rapidly during the G2 phase. Entry into mitosis requires the relocalization to the nucleus and activation of cyclin-dependent kinase 1 (cdk1) by association with cyclin B, and exit from mitosis occurs when cyclin B is degraded and the kinase activity decreases. Anaphase promoting complex (APC) is an E3 ligase active during anaphase and G1, and is required for the degradation of cyclin B. CDCA3 is a cytosolic protein and a substrate of APC. It associates with Skp-1 and is required for the degradation of the cdk1 inhibitor wee1, a tyrosine kinase. Degradation of CDCA3 leads to an accumulation of wee1 during interphase []. The CDCA3 protein contains an F-box-like region and a KEN box; the latter is required for association with the APC complex. |
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| Protein Domain |
| Type: |
Family |
| Description: |
GABA permease (gabP) catalyses the translocation of 4-aminobutyrate (GABA) across the plasma membrane, with homologues expressed in Gram-negative and Gram-positive organisms. This permease is a highly hydrophobic transmembrane protein consisting of 12 transmembrane domains with hydrophilic N- and C-terminal ends []. Induced by nitrogen-limited culture conditions in both Escherichia coli and Bacillus subtilis, gabP is an energy dependent transport system stimulated by membrane potential and has been observed adjacent and distant from other GABA degradation proteins [, ]. GabP is highly homologous to amino acid permeases from B. subtilis, E. coli, as well as to other members of the amino acid permease family (). A member of the APC (amine-polyamine-choline) transporter superfamily, GABA permease possesses a "consensus amphiphatic region"(CAR) found to be evolutionarily conserved within this transport family []. This amphiphatic region is located between helix 8 and cytoplasmic loop 8-9, forming a potential channel domain and suggested to play a significant role in ligand recognition and translocation []. Unique to GABA permeases, a conserved cysteine residue (CYS-300, E. coli) located at the beginning of the amphiphatic domain, has been determined to be critical for catalytic specificity []. |
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| Publication |
| First Author: |
Palazuelos J |
| Year: |
2015 |
| Journal: |
J Neurosci |
| Title: |
Oligodendrocyte Regeneration and CNS Remyelination Require TACE/ADAM17. |
| Volume: |
35 |
| Issue: |
35 |
| Pages: |
12241-7 |
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•
•
•
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| Publication |
| First Author: |
Guo F |
| Year: |
2012 |
| Journal: |
J Neurosci |
| Title: |
Disruption of NMDA receptors in oligodendroglial lineage cells does not alter their susceptibility to experimental autoimmune encephalomyelitis or their normal development. |
| Volume: |
32 |
| Issue: |
2 |
| Pages: |
639-45 |
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•
•
•
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| Publication |
| First Author: |
Deverman BE |
| Year: |
2012 |
| Journal: |
J Neurosci |
| Title: |
Exogenous leukemia inhibitory factor stimulates oligodendrocyte progenitor cell proliferation and enhances hippocampal remyelination. |
| Volume: |
32 |
| Issue: |
6 |
| Pages: |
2100-9 |
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•
•
•
•
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| Publication |
| First Author: |
Nguyen MV |
| Year: |
2013 |
| Journal: |
J Neurosci |
| Title: |
Oligodendrocyte lineage cells contribute unique features to Rett syndrome neuropathology. |
| Volume: |
33 |
| Issue: |
48 |
| Pages: |
18764-74 |
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•
•
•
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| Publication |
| First Author: |
Kang Z |
| Year: |
2013 |
| Journal: |
Nat Neurosci |
| Title: |
Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells. |
| Volume: |
16 |
| Issue: |
10 |
| Pages: |
1401-8 |
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•
•
•
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| Publication |
| First Author: |
Kaul A |
| Year: |
2013 |
| Journal: |
Genesis |
| Title: |
Conditional KIAA1549:BRAF mice reveal brain region- and cell type-specific effects. |
| Volume: |
51 |
| Issue: |
10 |
| Pages: |
708-16 |
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•
•
•
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| Publication |
| First Author: |
Fyffe-Maricich SL |
| Year: |
2011 |
| Journal: |
J Neurosci |
| Title: |
The ERK2 mitogen-activated protein kinase regulates the timing of oligodendrocyte differentiation. |
| Volume: |
31 |
| Issue: |
3 |
| Pages: |
843-50 |
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•
•
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| Publication |
| First Author: |
Zhang M |
| Year: |
2024 |
| Journal: |
Adv Sci (Weinh) |
| Title: |
ITPR2 Mediated Calcium Homeostasis in Oligodendrocytes is Essential for Myelination and Involved in Depressive-Like Behavior in Adolescent Mice. |
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| Pages: |
e2306498 |
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| Publication |
| First Author: |
Ishii A |
| Year: |
2012 |
| Journal: |
J Neurosci |
| Title: |
ERK1/ERK2 MAPK signaling is required to increase myelin thickness independent of oligodendrocyte differentiation and initiation of myelination. |
| Volume: |
32 |
| Issue: |
26 |
| Pages: |
8855-64 |
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