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Search results 3501 to 3600 out of 4449 for Apc

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Type Details Score
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Lubarski I
Year: 2005
Journal: J Biol Chem
Title: Interaction with the Na,K-ATPase and tissue distribution of FXYD5 (related to ion channel).
Volume: 280
Issue: 45
Pages: 37717-24
Publication
First Author: Lubarski I
Year: 2011
Journal: Am J Physiol Renal Physiol
Title: FXYD5 (dysadherin) regulates the paracellular permeability in cultured kidney collecting duct cells.
Volume: 301
Issue: 6
Pages: F1270-80
GXD Expression      
Probe: MGI:1289514
Assay Type: Northern blot
Annotation Date: 2003-06-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2662845
Age: postnatal adult
Specimen Label: Heart
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:1289514
Assay Type: Northern blot
Annotation Date: 2003-06-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2662845
Age: postnatal adult
Specimen Label: Brain
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:1289514
Assay Type: Northern blot
Annotation Date: 2003-06-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2662845
Age: postnatal adult
Specimen Label: Spleen
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:1289514
Assay Type: Northern blot
Annotation Date: 2003-06-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2662845
Age: postnatal adult
Specimen Label: Lung
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:1289514
Assay Type: Northern blot
Annotation Date: 2003-06-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2662845
Age: postnatal adult
Specimen Label: Liver
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:1289514
Assay Type: Northern blot
Annotation Date: 2003-06-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2662845
Age: postnatal adult
Specimen Label: Skeletal m.
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:1289514
Assay Type: Northern blot
Annotation Date: 2003-06-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2662845
Age: postnatal adult
Specimen Label: Kidney
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:1289514
Assay Type: Northern blot
Annotation Date: 2003-06-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2662845
Age: postnatal adult
Specimen Label: Testis
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:1289514
Assay Type: Northern blot
Annotation Date: 2003-06-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:2662853
Age: embryonic day 7.0
Specimen Label: 7
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:1289514
Assay Type: Northern blot
Annotation Date: 2003-06-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:2662853
Age: embryonic day 11.0
Specimen Label: 11
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:1289514
Assay Type: Northern blot
Annotation Date: 2003-06-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2662853
Age: embryonic day 15.0
Specimen Label: 15
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:1289514
Assay Type: Northern blot
Annotation Date: 2003-06-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2662853
Age: embryonic day 17.0
Specimen Label: 17
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:4417777
Assay Type: RNA in situ
Annotation Date: 2023-03-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3576022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7444193
Age: embryonic day 14.5
Image: S1B
Note: Expression was detected primarily in the valve endothelium.
Specimen Label: S1B
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:4417777
Assay Type: RNA in situ
Annotation Date: 2023-03-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3515422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7444193
Age: embryonic day 14.5
Image: S1B
Note: Expression was detected primarily in the valve endothelium.
Specimen Label: S1B
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4417777
Assay Type: RNA in situ
Annotation Date: 2024-04-16
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3266022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7621132
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
Protein
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: false
Publication
First Author: Zuo H
Year: 2018
Journal: J Neurosci
Title: Age-Dependent Decline in Fate Switch from NG2 Cells to Astrocytes After Olig2 Deletion.
Volume: 38
Issue: 9
Pages: 2359-2371
Publication  
First Author: Morrison VE
Year: 2020
Journal: eNeuro
Title: Retinoic Acid Is Required for Oligodendrocyte Precursor Cell Production and Differentiation in the Postnatal Mouse Corpus Callosum.
Volume: 7
Issue: 1
Publication
First Author: Hill RA
Year: 2013
Journal: J Neurosci
Title: NG2 cells in white matter but not gray matter proliferate in response to PDGF.
Volume: 33
Issue: 36
Pages: 14558-66
Publication
First Author: Bischof M
Year: 2015
Journal: J Neurosci
Title: Brg1-dependent chromatin remodelling is not essentially required during oligodendroglial differentiation.
Volume: 35
Issue: 1
Pages: 21-35
Publication
First Author: Boshans LL
Year: 2021
Journal: Sci Rep
Title: Direct reprogramming of oligodendrocyte precursor cells into GABAergic inhibitory neurons by a single homeodomain transcription factor Dlx2.
Volume: 11
Issue: 1
Pages: 3552
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ifi208/Ifi208<+>
Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tg(CAG-Bgeo/GFP)21Lbe/? Ifi208/Ifi208<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ifi208/Ifi208<+>
Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Topol L
Year: 2003
Journal: J Cell Biol
Title: Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation.
Volume: 162
Issue: 5
Pages: 899-908
Publication  
First Author: Yao Y
Year: 2017
Journal: Nat Commun
Title: Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin.
Volume: 8
Pages: 15402
Publication
First Author: Reitmair AH
Year: 1996
Journal: Cancer Res
Title: Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice.
Volume: 56
Issue: 16
Pages: 3842-9
Publication
First Author: Nakagawa TY
Year: 1999
Journal: Immunity
Title: Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice.
Volume: 10
Issue: 2
Pages: 207-17
Publication
First Author: Crowther RR
Year: 2022
Journal: J Immunol
Title: Cutting Edge: l-Arginine Transfer from Antigen-Presenting Cells Sustains CD4(+) T Cell Viability and Proliferation.
Volume: 208
Issue: 4
Pages: 793-798
Publication
First Author: Heit A
Year: 2003
Journal: J Immunol
Title: Cutting edge: Toll-like receptor 9 expression is not required for CpG DNA-aided cross-presentation of DNA-conjugated antigens but essential for cross-priming of CD8 T cells.
Volume: 170
Issue: 6
Pages: 2802-5
Publication
First Author: Periasamy P
Year: 2013
Journal: J Leukoc Biol
Title: Novel splenic antigen-presenting cells derive from a Lin(-) c-kit(lo) progenitor.
Volume: 93
Issue: 1
Pages: 63-9
Publication
First Author: Hoyne GF
Year: 2000
Journal: Int Immunol
Title: Serrate1-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells.
Volume: 12
Issue: 2
Pages: 177-85
Publication  
First Author: Paulsen JE
Year: 2000
Journal: Toxicol Lett
Title: Modulation by dietary factors in murine FAP models.
Volume: 112-113
Pages: 403-9
Publication
First Author: Moreira MA
Year: 1997
Journal: Cytogenet Cell Genet
Title: Assignment of TCF1, TGM1, CALM1, CKB, THBS1, B2M, and FES in Ateles paniscus chamek (Platyrrhini, Primates).
Volume: 79
Issue: 1-2
Pages: 92-6
Publication
First Author: Chang JT
Year: 2000
Journal: J Immunol
Title: Role of costimulation in the induction of the IL-12/IL-12 receptor pathway and the development of autoimmunity.
Volume: 164
Issue: 1
Pages: 100-6
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Ghezzi D
Year: 2011
Journal: Nat Genet
Title: Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies.
Volume: 43
Issue: 3
Pages: 259-63
Publication
First Author: Ayad NG
Year: 2003
Journal: Cell
Title: Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC.
Volume: 113
Issue: 1
Pages: 101-13
Protein
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 407  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 69  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: false
Publication
First Author: Grossberger R
Year: 1999
Journal: J Biol Chem
Title: Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex.
Volume: 274
Issue: 20
Pages: 14500-7
Publication
First Author: Wendt KS
Year: 2001
Journal: Nat Struct Biol
Title: Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex.
Volume: 8
Issue: 9
Pages: 784-8
Publication
First Author: Sulzenbacher G
Year: 2006
Journal: EMBO J
Title: LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis.
Volume: 25
Issue: 7
Pages: 1436-44
Publication  
First Author: Brechtel CE
Year: 1998
Journal: Biochem J
Title: 4-Aminobutyrate (GABA) transporters from the amine-polyamine-choline superfamily: substrate specificity and ligand recognition profile of the 4-aminobutyrate permease from Bacillus subtilis.
Volume: 333 ( Pt 3)
Pages: 565-71
Publication
First Author: Hu LA
Year: 1998
Journal: J Biol Chem
Title: Functional significance of the "signature cysteine" in helix 8 of the Escherichia coli 4-aminobutyrate transporter from the amine-polyamine-choline superfamily. Restoration of Cys-300 to the Cys-less Gabp.
Volume: 273
Issue: 32
Pages: 20162-7
Publication
First Author: Furuta T
Year: 2000
Journal: Mol Biol Cell
Title: EMB-30: an APC4 homologue required for metaphase-to-anaphase transitions during meiosis and mitosis in Caenorhabditis elegans.
Volume: 11
Issue: 4
Pages: 1401-19
Publication
First Author: Koloteva-Levine N
Year: 2004
Journal: Mol Cell Biol
Title: The Apc5 subunit of the anaphase-promoting complex/cyclosome interacts with poly(A) binding protein and represses internal ribosome entry site-mediated translation.
Volume: 24
Issue: 9
Pages: 3577-87
Publication
First Author: Oosterveen T
Year: 2007
Journal: Dev Biol
Title: Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans.
Volume: 308
Issue: 2
Pages: 438-48
Publication
First Author: Willert K
Year: 1999
Journal: Development
Title: A Drosophila Axin homolog, Daxin, inhibits Wnt signaling.
Volume: 126
Issue: 18
Pages: 4165-73
Protein Domain
Type: Family
Description: This entry includes Axin-1 and Axin-2 from vertebrates and related proteins from invertebrates. Axin is a central component of the canonical Wnt signaling pathway that interacts with the adenomatous polyposis coli protein APC and the kinase GSK3beta to downregulate the effector beta-catenin []. Axin-1 (axis inhibition protein 1) is a scaffold protein that is involved in many signalling pathways, including the Wnt, transforming growth factor-beta, MAP kinase pathways, as well as p53 activation cascades [, ]. It controls many biological processes ranging from sugar intake, cell proliferation, and organ development to cell death [].Mutations in Axin-1 gene cause hepatocellular carcinoma (HCC), a primary malignant neoplasm of epithelial liver cells [], and caudal duplication anomaly (CADUA), a condition characterised by the occurrence of duplications of different organs in the caudal region [].Like its mammalian counterpart, Drosophila Axin homologue, Daxin, acts as a negative regulator of wg/Wnt signaling []. In C. elegans AXL-1 functions redundantly with its ortholog, PRY-1, in negatively regulating BAR-1/beta-catenin signaling in the developing vulva and the Q neuroblast lineage. AXL-1 also functions independently of PRY-1 in negatively regulating canonical Wnt signaling during excretory cell development [].
Protein Domain
Type: Domain
Description: The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins, thereby targeting them for proteolysis by the 26S proteasome [].One of the subunits of the APC that is required for ubiquitination activity is APC10, a one-domain protein homologous to a sequence element, termed the DOC domain, found in several hypothetical proteins that may also mediate ubiquitination reactions, because they contain combinations of either RING finger (see ), cullin (see ) or HECT (see ) domains [, , ].The DOC domain consists of a β-sandwich, in which a five-stranded antiparallel β-sheet is packed on top of a three stranded antiparallel β-sheet, exhibiting a 'jellyroll' fold [, ].Proteins known to contain a DOC domain include:Eucaryotic Doc1/Apc10.Mammalian protein associated with the transcription factor Myc (PAM).Mouse runty-jerky-sterile (RJS) protein.Human HERC2, the ortholog of RJS.
Protein Domain
Type: Family
Description: This entry includes cell division cycle-associated protein 3 (CDCA3; also known as trigger of mitotic entry protein 1 or TOME-1), which is required for entry into mitosis. The protein is found at high levels during the G2 and M phases of mitosis, but declines rapidly during the G2 phase. Entry into mitosis requires the relocalization to the nucleus and activation of cyclin-dependent kinase 1 (cdk1) by association with cyclin B, and exit from mitosis occurs when cyclin B is degraded and the kinase activity decreases. Anaphase promoting complex (APC) is an E3 ligase active during anaphase and G1, and is required for the degradation of cyclin B. CDCA3 is a cytosolic protein and a substrate of APC. It associates with Skp-1 and is required for the degradation of the cdk1 inhibitor wee1, a tyrosine kinase. Degradation of CDCA3 leads to an accumulation of wee1 during interphase []. The CDCA3 protein contains an F-box-like region and a KEN box; the latter is required for association with the APC complex.
Protein Domain
Type: Family
Description: GABA permease (gabP) catalyses the translocation of 4-aminobutyrate (GABA) across the plasma membrane, with homologues expressed in Gram-negative and Gram-positive organisms. This permease is a highly hydrophobic transmembrane protein consisting of 12 transmembrane domains with hydrophilic N- and C-terminal ends []. Induced by nitrogen-limited culture conditions in both Escherichia coli and Bacillus subtilis, gabP is an energy dependent transport system stimulated by membrane potential and has been observed adjacent and distant from other GABA degradation proteins [, ]. GabP is highly homologous to amino acid permeases from B. subtilis, E. coli, as well as to other members of the amino acid permease family (). A member of the APC (amine-polyamine-choline) transporter superfamily, GABA permease possesses a "consensus amphiphatic region"(CAR) found to be evolutionarily conserved within this transport family []. This amphiphatic region is located between helix 8 and cytoplasmic loop 8-9, forming a potential channel domain and suggested to play a significant role in ligand recognition and translocation []. Unique to GABA permeases, a conserved cysteine residue (CYS-300, E. coli) located at the beginning of the amphiphatic domain, has been determined to be critical for catalytic specificity [].
Publication
First Author: Palazuelos J
Year: 2015
Journal: J Neurosci
Title: Oligodendrocyte Regeneration and CNS Remyelination Require TACE/ADAM17.
Volume: 35
Issue: 35
Pages: 12241-7
Publication
First Author: Guo F
Year: 2012
Journal: J Neurosci
Title: Disruption of NMDA receptors in oligodendroglial lineage cells does not alter their susceptibility to experimental autoimmune encephalomyelitis or their normal development.
Volume: 32
Issue: 2
Pages: 639-45
Publication
First Author: Deverman BE
Year: 2012
Journal: J Neurosci
Title: Exogenous leukemia inhibitory factor stimulates oligodendrocyte progenitor cell proliferation and enhances hippocampal remyelination.
Volume: 32
Issue: 6
Pages: 2100-9
Publication
First Author: Nguyen MV
Year: 2013
Journal: J Neurosci
Title: Oligodendrocyte lineage cells contribute unique features to Rett syndrome neuropathology.
Volume: 33
Issue: 48
Pages: 18764-74
Publication
First Author: Kang Z
Year: 2013
Journal: Nat Neurosci
Title: Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells.
Volume: 16
Issue: 10
Pages: 1401-8
Publication
First Author: Kaul A
Year: 2013
Journal: Genesis
Title: Conditional KIAA1549:BRAF mice reveal brain region- and cell type-specific effects.
Volume: 51
Issue: 10
Pages: 708-16
Publication
First Author: Fyffe-Maricich SL
Year: 2011
Journal: J Neurosci
Title: The ERK2 mitogen-activated protein kinase regulates the timing of oligodendrocyte differentiation.
Volume: 31
Issue: 3
Pages: 843-50
Publication    
First Author: Zhang M
Year: 2024
Journal: Adv Sci (Weinh)
Title: ITPR2 Mediated Calcium Homeostasis in Oligodendrocytes is Essential for Myelination and Involved in Depressive-Like Behavior in Adolescent Mice.
Pages: e2306498
Publication
First Author: Ishii A
Year: 2012
Journal: J Neurosci
Title: ERK1/ERK2 MAPK signaling is required to increase myelin thickness independent of oligodendrocyte differentiation and initiation of myelination.
Volume: 32
Issue: 26
Pages: 8855-64