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Search results 3501 to 3600 out of 7122 for App

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Sorl1/Sorl1
Background: either: (involves: 129/SvEmcTer * BALB/c) or (involves: 129/SvEmcTer * C57BL/6N)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dlst/Dlst<+> Tg(PRNP-APPSweInd)19959Dwst/?
Background: involves: 129S6/SvEvTac * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Eno2-PSEN2)2348Ykk/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Eno2-PSEN2*)1480Ykk/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Map2k4/Map2k4 Map2k7/Map2k7 Tg(APPswe,PSEN1dE9)85Dbo/? Tg(Camk2a-cre/ERT2)2Gsc/?
Background: involves: C3H * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Abcc1/Abcc1 Tg(Thy1-APPDutch)#Jckr/?
Background: FVB.Cg-Abcc1 Tg(Thy1-AppDutch)#Jckr
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apmap/Apmap Tg(APPswe,PSEN1dE9)85Dbo/?
Background: involves: C57BL/6J * C57BL/6N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: App/App Mapt/Mapt
Background: involves: 129S/SvEv * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
31213067 | J:277676
 
First Author: Findley CA
Year: 2019
Journal: ASN Neuro
Title: Amyloid Beta-Related Alterations to Glutamate Signaling Dynamics During Alzheimer's Disease Progression.
Volume: 11
Pages: 1759091419855541
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Publication
37028406 | J:334726
First Author: Li YD
Year: 2023
Journal: Cell Stem Cell
Title: Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer's disease.
Volume: 30
Issue: 4
Pages: 415-432.e6
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Publication
26260791 | J:225870
First Author: Satoh K
Year: 2015
Journal: J Biol Chem
Title: ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing.
Volume: 290
Issue: 40
Pages: 24152-65
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Publication
17035538 | J:113198
First Author: Cruz JC
Year: 2006
Journal: J Neurosci
Title: p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.
Volume: 26
Issue: 41
Pages: 10536-41
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Publication
12552120 | J:81843
First Author: Redwine JM
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis.
Volume: 100
Issue: 3
Pages: 1381-6
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Publication
30572184 | J:276155
 
First Author: Evans CE
Year: 2019
Journal: Neurobiol Aging
Title: Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice.
Volume: 75
Pages: 136-149
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Publication
15452128 | J:95174
First Author: Chiocco MJ
Year: 2004
Journal: J Biol Chem
Title: Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice.
Volume: 279
Issue: 50
Pages: 52535-42
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Publication
28845019 | J:273933
First Author: Hosokawa M
Year: 2018
Journal: Exp Anim
Title: Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer's disease model mice.
Volume: 67
Issue: 1
Pages: 63-70
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Publication
16597739 | J:107251
First Author: Deng Y
Year: 2006
Journal: J Neurosci
Title: Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology.
Volume: 26
Issue: 14
Pages: 3845-54
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Publication
16384682 | J:129235
First Author: Alpár A
Year: 2006
Journal: Int J Dev Neurosci
Title: The expression of wild-type human amyloid precursor protein affects the dendritic phenotype of neocortical pyramidal neurons in transgenic mice.
Volume: 24
Issue: 2-3
Pages: 133-40
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Publication
19859965 | J:284876
First Author: Perez SE
Year: 2010
Journal: J Neurosci Res
Title: DHA diet reduces AD pathology in young APPswe/PS1 Delta E9 transgenic mice: possible gender effects.
Volume: 88
Issue: 5
Pages: 1026-40
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Publication
18771817 | J:161989
First Author: Christensen DZ
Year: 2010
Journal: Neurobiol Aging
Title: Intracellular Aß triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease.
Volume: 31
Issue: 7
Pages: 1153-63
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Publication
22306812 | J:185010
First Author: Mouton-Liger F
Year: 2012
Journal: Biochim Biophys Acta
Title: Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway.
Volume: 1822
Issue: 6
Pages: 885-96
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Publication
15972962 | J:99507
First Author: Rutten BP
Year: 2005
Journal: Am J Pathol
Title: Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL/PS1M146L transgenic mice.
Volume: 167
Issue: 1
Pages: 161-73
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Publication
20493928 | J:165228
First Author: Amtul Z
Year: 2010
Journal: Neuroscience
Title: Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease.
Volume: 169
Issue: 2
Pages: 781-6
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Publication
15810906 | J:110079
First Author: Lovasic L
Year: 2005
Journal: Genes Brain Behav
Title: Working memory impairment in a transgenic amyloid precursor protein TgCRND8 mouse model of Alzheimer's disease.
Volume: 4
Issue: 3
Pages: 197-208
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Publication
24361736 | J:208010
 
First Author: Kanemoto S
Year: 2014
Journal: Neuroscience
Title: Proliferation, differentiation and amyloid-β production in neural progenitor cells isolated from TgCRND8 mice.
Volume: 261
Pages: 52-9
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Publication
15993515 | J:108864
First Author: Ambrée O
Year: 2006
Journal: Neurobiol Aging
Title: Activity changes and marked stereotypic behavior precede Abeta pathology in TgCRND8 Alzheimer mice.
Volume: 27
Issue: 7
Pages: 955-64
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Publication
15212843 | J:101683
First Author: Touma C
Year: 2004
Journal: Neurobiol Aging
Title: Age- and sex-dependent development of adrenocortical hyperactivity in a transgenic mouse model of Alzheimer's disease.
Volume: 25
Issue: 7
Pages: 893-904
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Publication
25104560 | J:218327
First Author: Tozzi A
Year: 2015
Journal: Neurobiol Aging
Title: Region- and age-dependent reductions of hippocampal long-term potentiation and NMDA to AMPA ratio in a genetic model of Alzheimer's disease.
Volume: 36
Issue: 1
Pages: 123-33
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Publication
12586549 | J:101688
First Author: Jolas T
Year: 2002
Journal: Neurobiol Dis
Title: Long-term potentiation is increased in the CA1 area of the hippocampus of APP(swe/ind) CRND8 mice.
Volume: 11
Issue: 3
Pages: 394-409
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Publication
15858047 | J:98697
First Author: Adlard PA
Year: 2005
Journal: J Neurosci
Title: Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease.
Volume: 25
Issue: 17
Pages: 4217-21
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Publication
15917101 | J:101713
First Author: Schwarze-Eicker K
Year: 2005
Journal: Neurobiol Aging
Title: Prion protein (PrPc) promotes beta-amyloid plaque formation.
Volume: 26
Issue: 8
Pages: 1177-82
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Publication
16877355 | J:111983
First Author: Ambrée O
Year: 2006
Journal: Am J Pathol
Title: Reduction of amyloid angiopathy and Abeta plaque burden after enriched housing in TgCRND8 mice: involvement of multiple pathways.
Volume: 169
Issue: 2
Pages: 544-52
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Publication
29066368 | J:268619
 
First Author: Liu M
Year: 2018
Journal: Brain Res
Title: Investigating the efficacy of a combination Aβ-targeted treatment in a mouse model of Alzheimer's disease.
Volume: 1678
Pages: 138-145
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Publication
29217476 | J:260939
 
First Author: Knock E
Year: 2018
Journal: Neurobiol Dis
Title: SUMO1 impact on Alzheimer disease pathology in an amyloid-depositing mouse model.
Volume: 110
Pages: 154-165
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Publication
21931647 | J:177694
First Author: Amtul Z
Year: 2011
Journal: PLoS One
Title: DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet?
Volume: 6
Issue: 9
Pages: e24094
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Publication
22459600 | J:191252
First Author: Durairajan SS
Year: 2012
Journal: Neurobiol Aging
Title: Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model.
Volume: 33
Issue: 12
Pages: 2903-19
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Publication
10833311 | J:129724
First Author: Masliah E
Year: 2000
Journal: Exp Neurol
Title: Abnormal glutamate transport function in mutant amyloid precursor protein transgenic mice.
Volume: 163
Issue: 2
Pages: 381-7
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Publication
15146243 | J:91112
First Author: Postina R
Year: 2004
Journal: J Clin Invest
Title: A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model.
Volume: 113
Issue: 10
Pages: 1456-64
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Publication
20493588 | J:188240
First Author: Ghosal K
Year: 2011
Journal: Neurobiol Aging
Title: Aging and excitotoxic stress exacerbate neural circuit reorganization in amyloid precursor protein intracellular domain transgenic mice.
Volume: 32
Issue: 12
Pages: 2320.e1-9
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Publication
22805202 | J:218149
First Author: Kipanyula MJ
Year: 2012
Journal: Aging Cell
Title: Ca2+ dysregulation in neurons from transgenic mice expressing mutant presenilin 2.
Volume: 11
Issue: 5
Pages: 885-93
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Protein
P70415
Organism: Mus musculus/domesticus
Length: 61  
Fragment?: true
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Protein
E0CYY8
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
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Protein
A0A087WRY7
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: true
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Protein
A0A494B8W9
Organism: Mus musculus/domesticus
Length: 57  
Fragment?: true
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Protein
E0CZA9
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: true
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Protein
E0CYJ4
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: true
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Publication
18550529 | -
First Author: Radzimanowski J
Year: 2008
Journal: J Biol Chem
Title: Crystal structure of the human Fe65-PTB1 domain.
Volume: 283
Issue: 34
Pages: 23113-20
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Publication
28323844 | -
First Author: Koistinen NA
Year: 2017
Journal: PLoS One
Title: Nuclear localization of amyloid-β precursor protein-binding protein Fe65 is dependent on regulated intramembrane proteolysis.
Volume: 12
Issue: 3
Pages: e0173888
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Publication
9461550 | -
 
First Author: Duilio A
Year: 1998
Journal: Biochem J
Title: Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein.
Volume: 330 ( Pt 1)
Pages: 513-9
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Publication
11896189 | -
First Author: Zambrano N
Year: 2002
Journal: J Cell Sci
Title: feh-1 and apl-1, the Caenorhabditis elegans orthologues of mammalian Fe65 and beta-amyloid precursor protein genes, are involved in the same pathway that controls nematode pharyngeal pumping.
Volume: 115
Issue: Pt 7
Pages: 1411-22
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Publication
28553201 | -
 
First Author: Feilen LP
Year: 2017
Journal: Front Mol Neurosci
Title: Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction.
Volume: 10
Pages: 140
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Publication
14527950 | -
First Author: Chang Y
Year: 2003
Journal: J Biol Chem
Title: Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1.
Volume: 278
Issue: 51
Pages: 51100-7
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Protein Domain
IPR039576 | APBB1/2/3
Type: Family
Description: This entry represents the FE65 family, whose members include FE65 (APBB1), FE65L1 (APBB2), and FE65L2 (APBB3). They are adaptor proteins that bind the C-terminal region of the amyloid precursor protein (APP) []. APBB1 is a neuronal adaptor protein involved in brain development, Alzheimer disease amyloid precursor protein (APP) signaling, and proteolytic processing of APP [, ]. It contains three protein-protein interaction domains, one WW domain, and two phosphotyrosine-binding domains (PTBs)[]. The C-terminal Fe65-PTB2 binds a large portion of the APP intracellular domain (AICD) including the GYENPTY internalization sequence fingerprint []. This entry also includes an Fe65 homologue from C. elegans, Feh-1. Besides binding to amyloid precursor protein, it is also involved in the same pathway that controls nematode pharyngeal pumping [].
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Publication
23283348 | J:193915
First Author: Carlo AS
Year: 2013
Journal: J Neurosci
Title: The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain.
Volume: 33
Issue: 1
Pages: 358-70
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Publication
38433923 | J:347916
First Author: Liu P
Year: 2024
Journal: iScience
Title: Aβ∗56 is a stable oligomer that impairs memory function in mice.
Volume: 27
Issue: 3
Pages: 109239
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Publication
27677309 | J:239247
First Author: Manczak M
Year: 2016
Journal: Hum Mol Genet
Title: Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
Volume: 25
Issue: 23
Pages: 5148-5166
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Publication
30728442 | J:275122
First Author: Snow AD
Year: 2019
Journal: Sci Rep
Title: The Amazon rain forest plant Uncaria tomentosa (cat's claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles.
Volume: 9
Issue: 1
Pages: 561
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Publication
25740511 | -
First Author: Hu X
Year: 2015
Journal: J Neurosci
Title: Axonal and Schwann cell BACE1 is equally required for remyelination of peripheral nerves.
Volume: 35
Issue: 9
Pages: 3806-14
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Publication
25621019 | -
First Author: Vassar R
Year: 2014
Journal: Alzheimers Res Ther
Title: BACE1 inhibitor drugs in clinical trials for Alzheimer's disease.
Volume: 6
Issue: 9
Pages: 89
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Protein Domain
IPR009120 | BACE1
Type: Family
Description: The beta-site APP cleaving enzyme-1 (BACE1), also known as Aspartyl protease 2 and memapsin-2, mediates one of the two proteolytic cleavages of beta-amyloid precursor protein (APP) to yield the amyloid β-peptide (Abeta), a key pathogenic agent in Alzheimer's disease (AD) []. Axonal and Schwann cell BACE1 is also required for remyelination of injured nerves []. BACE1 inhibitor drugs have been evaluated for AD treatment []. BACE1 is () and MEROPS identifier A01.004.
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Genotype
Genotype
Symbol: Tg(Hmgcr-PSEN1*M146L)#Lpr/? Tg(Thy1-APP)28Lpr/?
Background: involves: C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPSWE)2576Kha/? Tg(Prnp-ITM2B/APP695*42)A12Emcg/?
Background: involves: C3H * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoe/Apoe Tg(Thy1-APPSwDutIowa)BWevn/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Apoe/Apoe Tg(Thy1-APPSwDutIowa)BWevn/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: App/App Psen1/Psen1 Tg(MAPT)8cPdav/?
Background: B6.Cg-Tg(MAPT)8cPdav Psen1 App
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-APPSwInd)Dbo/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Gene
5328 | PLAU
Type: gene
Organism: human
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Publication
1482349 | J:3608
First Author: Vidal F
Year: 1992
Journal: Biochem Biophys Res Commun
Title: A murine sequence-specific DNA binding protein shows extensive local similarities to the amyloid precursor protein.
Volume: 189
Issue: 3
Pages: 1336-41
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Publication
8661100 | J:33938
First Author: Yang Y
Year: 1996
Journal: Genomics
Title: Genomic structure and chromosomal localization of the mouse CDEI-binding protein CDEBP (APLP2) gene and promoter sequences.
Volume: 35
Issue: 1
Pages: 24-9
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Publication
8300594 | J:16669
First Author: Slunt HH
Year: 1994
Journal: J Biol Chem
Title: Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).
Volume: 269
Issue: 4
Pages: 2637-44
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Publication
8220435 | J:27207
First Author: Wasco W
Year: 1993
Journal: Nat Genet
Title: Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor.
Volume: 5
Issue: 1
Pages: 95-100
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Publication
7622456 | J:26841
First Author: Thinakaran G
Year: 1995
Journal: J Biol Chem
Title: Novel regulation of chondroitin sulfate glycosaminoglycan modification of amyloid precursor protein and its homologue, APLP2.
Volume: 270
Issue: 28
Pages: 16522-5
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Publication
26528126 | J:338514
 
First Author: Tamagnini F
Year: 2015
Journal: Front Cell Neurosci
Title: Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice.
Volume: 9
Pages: 372
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Publication
20698932 | J:164692
First Author: Seo H
Year: 2010
Journal: J Neurochem
Title: The hAPP-YAC transgenic model has elevated UPS activity in the frontal cortex similar to Alzheimer's disease and Down's syndrome.
Volume: 114
Issue: 6
Pages: 1819-26
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Publication
18583063 | J:140778
First Author: Popović M
Year: 2008
Journal: Neuroscience
Title: Subfield and layer-specific depletion in calbindin-D28K, calretinin and parvalbumin immunoreactivity in the dentate gyrus of amyloid precursor protein/presenilin 1 transgenic mice.
Volume: 155
Issue: 1
Pages: 182-91
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Publication
33345400 | J:352826
First Author: Jang YN
Year: 2021
Journal: Neuropathol Appl Neurobiol
Title: RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's disease.
Volume: 47
Issue: 5
Pages: 625-639
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Publication
18378358 | J:155158
First Author: Weissman L
Year: 2009
Journal: Neurobiol Aging
Title: DNA base excision repair activities in mouse models of Alzheimer's disease.
Volume: 30
Issue: 12
Pages: 2080-1
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Genotype
Genotype
Symbol: Tg(DMD-APP*)18Neve/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPSwDutIowa)BWevn/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nos2/Nos2 Tg(Thy1-APPSwDutIowa)BWevn/?
Background: involves: C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: App/App Psen1/Psen1
Background: involves: 129 * 129S1/Sv * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(APPV717F)109Ili/? Tg(Prnp-MAPT*P301S)PS19Vle/?
Background: involves: C3H * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
12419536 | J:80485
First Author: Dodart JC
Year: 2002
Journal: Brain Res
Title: Apolipoprotein E alters the processing of the beta-amyloid precursor protein in APP(V717F) transgenic mice.
Volume: 955
Issue: 1-2
Pages: 191-9
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Publication
15312961 | J:102326
First Author: Nilsson LN
Year: 2004
Journal: Neurobiol Aging
Title: Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation.
Volume: 25
Issue: 9
Pages: 1153-67
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Publication
10718322 | J:61265
First Author: Dodart JC
Year: 2000
Journal: Neuroreport
Title: Behavioral deficits in APP(V717F) transgenic mice deficient for the apolipoprotein E gene.
Volume: 11
Issue: 3
Pages: 603-7
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Publication
24752989 | J:245024
First Author: Zhao R
Year: 2014
Journal: Hippocampus
Title: Impairments in experience-dependent scaling and stability of hippocampal place fields limit spatial learning in a mouse model of Alzheimer's disease.
Volume: 24
Issue: 8
Pages: 963-78
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Publication
20371804 | J:159623
First Author: Tomiyama T
Year: 2010
Journal: J Neurosci
Title: A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.
Volume: 30
Issue: 14
Pages: 4845-56
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Publication
18667150 | J:145474
First Author: Kuchibhotla KV
Year: 2008
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