| Type |
Details |
Score |
| Genotype |
| Symbol: |
Tg(Fabp4-Apol6)#Hsul/? |
| Background: |
C57BL/6J-Tg(Fabp4-Apol6)#Hsul |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Zfp574/Zfp574 Tg(IghMyc)22Bri/? |
| Background: |
B6.Cg-Zfp574 Tg(IghMyc)22Bri |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(BCL2)36Wehi/? Tg(IghMyc)22Bri/? |
| Background: |
B6.Cg-Tg(BCL2)36Wehi Tg(IghMyc)22Bri |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Agrp/Agrp<+> |
| Background: |
involves: 129S6/SvEvTac * C57BL/6NCrl |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Neurog2/Neurog2 |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Calca/? |
| Background: |
involves: 129S6/SvEvTac * C57BL/6NCrl |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Tubb3-EGFP)1Wbh/? |
| Background: |
involves: C57BL/6JOlaHsd |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Grimes JA |
| Year: |
2000 |
| Journal: |
J Biol Chem |
| Title: |
The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex. |
| Volume: |
275 |
| Issue: |
13 |
| Pages: |
9461-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Laherty CD |
| Year: |
1998 |
| Journal: |
Mol Cell |
| Title: |
SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. |
| Volume: |
2 |
| Issue: |
1 |
| Pages: |
33-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Duong HA |
| Year: |
2011 |
| Journal: |
Science |
| Title: |
A molecular mechanism for circadian clock negative feedback. |
| Volume: |
332 |
| Issue: |
6036 |
| Pages: |
1436-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shi X |
| Year: |
2012 |
| Journal: |
Mol Cell Biochem |
| Title: |
Sin3 interacts with Foxk1 and regulates myogenic progenitors. |
| Volume: |
366 |
| Issue: |
1-2 |
| Pages: |
251-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pinnell N |
| Year: |
2015 |
| Journal: |
Immunity |
| Title: |
The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia. |
| Volume: |
43 |
| Issue: |
5 |
| Pages: |
870-83 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
126
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Washkowitz AJ |
| Year: |
2015 |
| Journal: |
Development |
| Title: |
Mga is essential for the survival of pluripotent cells during peri-implantation development. |
| Volume: |
142 |
| Issue: |
1 |
| Pages: |
31-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu Y |
| Year: |
2017 |
| Journal: |
Dev Cell |
| Title: |
PWP1 Mediates Nutrient-Dependent Growth Control through Nucleolar Regulation of Ribosomal Gene Expression. |
| Volume: |
43 |
| Issue: |
2 |
| Pages: |
240-252.e5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Casper AL |
| Year: |
2011 |
| Journal: |
Development |
| Title: |
no child left behind encodes a novel chromatin factor required for germline stem cell maintenance in males but not females. |
| Volume: |
138 |
| Issue: |
16 |
| Pages: |
3357-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fernández-Calvo P |
| Year: |
2011 |
| Journal: |
Plant Cell |
| Title: |
The Arabidopsis bHLH transcription factors MYC3 and MYC4 are targets of JAZ repressors and act additively with MYC2 in the activation of jasmonate responses. |
| Volume: |
23 |
| Issue: |
2 |
| Pages: |
701-15 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li H |
| Year: |
2007 |
| Journal: |
Plant Mol Biol |
| Title: |
The bHLH-type transcription factor AtAIB positively regulates ABA response in Arabidopsis. |
| Volume: |
65 |
| Issue: |
5 |
| Pages: |
655-65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen Q |
| Year: |
2011 |
| Journal: |
Plant Cell |
| Title: |
The basic helix-loop-helix transcription factor MYC2 directly represses PLETHORA expression during jasmonate-mediated modulation of the root stem cell niche in Arabidopsis. |
| Volume: |
23 |
| Issue: |
9 |
| Pages: |
3335-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yadav V |
| Year: |
2005 |
| Journal: |
Plant Cell |
| Title: |
A basic helix-loop-helix transcription factor in Arabidopsis, MYC2, acts as a repressor of blue light-mediated photomorphogenic growth. |
| Volume: |
17 |
| Issue: |
7 |
| Pages: |
1953-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kazan K |
| Year: |
2013 |
| Journal: |
Mol Plant |
| Title: |
MYC2: the master in action. |
| Volume: |
6 |
| Issue: |
3 |
| Pages: |
686-703 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aleman F |
| Year: |
2016 |
| Journal: |
Sci Rep |
| Title: |
An ABA-increased interaction of the PYL6 ABA receptor with MYC2 Transcription Factor: A putative link of ABA and JA signaling. |
| Volume: |
6 |
|
| Pages: |
28941 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cheng Z |
| Year: |
2011 |
| Journal: |
Mol Plant |
| Title: |
The bHLH transcription factor MYC3 interacts with the Jasmonate ZIM-domain proteins to mediate jasmonate response in Arabidopsis. |
| Volume: |
4 |
| Issue: |
2 |
| Pages: |
279-88 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schweizer F |
| Year: |
2013 |
| Journal: |
Plant Cell |
| Title: |
Arabidopsis basic helix-loop-helix transcription factors MYC2, MYC3, and MYC4 regulate glucosinolate biosynthesis, insect performance, and feeding behavior. |
| Volume: |
25 |
| Issue: |
8 |
| Pages: |
3117-32 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Proteins included in this entry have an N-terminal RanBP2-type zinc finger and a Yaf2/RYBP C-terminal binding motif. Proteins with these regions include Yaf2 and RYBP proteins, which are homologous parts of the PRC1 complex [].RYBP is a zinc finger protein with an essential role during embryonic development, which binds transcriptional factors, Polycomb products, and mediators of apoptosisis []. RYBP also binds ubiquitin and Cbx proteins via the C-terminal docking module [, ]. RYBP is natively unstructured until it binds to the C-terminal region of the Polycomb protein Ring1B or to DNA []. Yaf2 binds to MYC and inhibits MYC-mediated transactivation []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This domain can be found in the MAX gene-associated protein (Mga), which is a dual-specificity transcription factor that contains both a bHLHZip domain and a T-box domain and is able to bind to and regulate transcriptional targets through both E-box sites as well as T-box-binding elements (TBEs) []. MAX gene-associated protein (MGA) is a dual-specificity transcription factor, acting as a repressor or an activator and binding to 5'-AATTTCACACCTAGGTGTGAAATT-3'. MGA regulates genes targeted by MYC-MAX, suppressing transcriptional activation by MYC and inhibiting MYC-dependent cell transformation. MGA binds DNA via a T-Box []. MGA is a component of the MLL1 complex []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This family represents the periodic tryptophan protein 1 (PWP1), a chromatin-associated factor that regulates transcription during developmental growth as part of the TORC1 and Myc signaling pathway in response to nutrients. It regulates Pol I-mediated rRNA biogenesis and the epigenetic status of rDNA []. Drosophila melanogaster PWP1, also known as Protein no child left behind (nclb), is required in males for both germline stem cell (GSC) maintenance and early stages of germ cell differentiation of germ cell cysts []. In females it is necessary to regulate germ cell differentiation and egg chamber development []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Sin3a is a transcriptional repressor and a homologue of the SIN3 repressor from yeast. Sin3a associates with the strong repressive isoform of Mxi1, a helix-loop-helix leucone zipper that associates with Max to antagonize Myc oncogenic activities []. Unlike Mxi1 and Myc, expression of Sin3a does not vary during development []. Sin3a is a component of several complexes, including the REST-CoREST repressor complex [], the PER complex which maintains circadian rhythm []and the Sin3 HDAC complex []. Sin3a also interacts with FOXK1 to regulate cell cycle progression []. Sin3a has three PAH domains by which it interacts with HCFC1, REST and SAP30 [, ]. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This is the N-terminal domain found in Zmiz1 proteins (Zinc finger MIZ domain-containing protein 1). Zmiz1 is a direct Notch1 cofactor that heterogeneously regulates Notch target genes. Zmiz1 directly interacts with the RAM1 domain of Notch1 through this N-terminal tetratricopeptide repeat (TPR) domain. Furthermore, it has been shown that Zmiz1 and Notch1 cooperatively recruit each other to chromatin through direct interaction via the N-terminal TPR domain resulting in a slight increase in activating histone marks and decrease of repressive histone marks. Functional analysis indicate that the N-terminal Domain of Zmiz1 is important for driving Myc transcription and proliferation indirectly []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry includes several bHLH transcription factors from plants, such as AIB and MYC proteins (MYC2, MYC3 and MYC4). AIB, also termed AtbHLH17, or EN 35, is a transcription activator that regulates positively abscisic acid (ABA) response []. MYC2, also termed protein jasmonate insensitive 1, is a transcriptional activator involved in abscisic acid (ABA), jasmonic acid (JA), and light signaling pathways [, , , ]. MYC3 is a transcription factor involved in tryptophan, jasmonic acid (JA) and other stress-responsive gene regulation []. MYC4 is a transcription factor involved in jasmonic acid (JA) gene regulation. MYC2, together with MYC3 and MYC4, controls additively subsets of JA-dependent responses [, ]. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Conserved_site |
| Description: |
This motif is found in the C-terminal region of the Yaf2 and RYBP proteins, which are homologous parts of the PRC1 complex [].RYBP is a zinc finger protein with an essential role during embryonic development, which binds transcriptional factors, Polycomb products, and mediators of apoptosisis []. RYBP also binds ubiquitin and Cbx proteins via the C-terminal docking module [, ]. RYBP is natively unstructured until it binds to the C-terminal region of the Polycomb protein Ring1B or to DNA []. Yaf2 binds to MYC and inhibits MYC-mediated transactivation []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Maddocks ODK |
| Year: |
2017 |
| Journal: |
Nature |
| Title: |
Modulating the therapeutic response of tumours to dietary serine and glycine starvation. |
| Volume: |
544 |
| Issue: |
7650 |
| Pages: |
372-376 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schreiber-Agus N |
| Year: |
1998 |
| Journal: |
Nature |
| Title: |
Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth. |
| Volume: |
393 |
| Issue: |
6684 |
| Pages: |
483-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ingvarsson S |
| Year: |
1988 |
| Journal: |
Oncogene |
| Title: |
Chromosome localization and expression pattern of Lmyc and Bmyc in murine embryonal carcinoma cells. |
| Volume: |
3 |
| Issue: |
6 |
| Pages: |
679-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Arrigoni R |
| Year: |
2006 |
| Journal: |
FEBS Lett |
| Title: |
The Polycomb-associated protein Rybp is a ubiquitin binding protein. |
| Volume: |
580 |
| Issue: |
26 |
| Pages: |
6233-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Neira JL |
| Year: |
2009 |
| Journal: |
Biochemistry |
| Title: |
The transcriptional repressor RYBP is a natively unfolded protein which folds upon binding to DNA. |
| Volume: |
48 |
| Issue: |
6 |
| Pages: |
1348-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang R |
| Year: |
2010 |
| Journal: |
Structure |
| Title: |
Polycomb group targeting through different binding partners of RING1B C-terminal domain. |
| Volume: |
18 |
| Issue: |
8 |
| Pages: |
966-75 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry includes CDCA7 and CDA7L.Cell division cycle-associated protein 7 (CDCA7/JPO1) is a transcription regulator whose expression is activated by c-Myc and by E2F1 []. CDCA7 can associate with Myc in a phosphorylation-dependent manner. CDCA7 phosphorylation by AKT leads to loss of its association with Myc []. This interaction affects Myc-dependent apoptosis and transformation [, , ]. CDCA7 has also been identified as a Notch target involved in hematopoietic stem cell emergence [].Cell division cycle-associated 7-like protein (CDCA7L/JPO2/R1) is closely related to CDCA7/JPO1; and like CDCA7, it plays a role in transcriptional regulation and interacts with c-Myc []. JPO2 overexpression induces metastasis in medulloblastoma []. JPO2 can interact directly and dynamically with chromatin, the dynamics of JPO2 chromatin binding being decelerated upon interaction with LEDGF/p75, which binds and tethers JPO2 to chromatin [, ].JPO2 inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter []. JPO2 and MAOA act upstream of cyclin D1 and E2F1, and are involved in apoptotic signalling pathways []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nakahara M |
| Year: |
2013 |
| Journal: |
Mamm Genome |
| Title: |
Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. |
| Volume: |
24 |
| Issue: |
5-6 |
| Pages: |
228-39 |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE19225 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
Baseline |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Publication |
| First Author: |
King A |
| Year: |
2017 |
| Journal: |
PLoS Genet |
| Title: |
Dynein light chain regulates adaptive and innate B cell development by distinctive genetic mechanisms. |
| Volume: |
13 |
| Issue: |
9 |
| Pages: |
e1007010 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li Z |
| Year: |
2014 |
| Journal: |
Mol Cell |
| Title: |
CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity. |
| Volume: |
54 |
| Issue: |
5 |
| Pages: |
805-19 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Inoue K |
| Year: |
2001 |
| Journal: |
Genes Dev |
| Title: |
Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas. |
| Volume: |
15 |
| Issue: |
22 |
| Pages: |
2934-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wodarczyk C |
| Year: |
2010 |
| Journal: |
PLoS One |
| Title: |
Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals. |
| Volume: |
5 |
| Issue: |
9 |
| Pages: |
e12719 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Miluzio A |
| Year: |
2011 |
| Journal: |
Cancer Cell |
| Title: |
Impairment of cytoplasmic eIF6 activity restricts lymphomagenesis and tumor progression without affecting normal growth. |
| Volume: |
19 |
| Issue: |
6 |
| Pages: |
765-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fog CK |
| Year: |
2015 |
| Journal: |
Blood |
| Title: |
Loss of PRDM11 promotes MYC-driven lymphomagenesis. |
| Volume: |
125 |
| Issue: |
8 |
| Pages: |
1272-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Scott CL |
| Year: |
2007 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Role of the chromobox protein CBX7 in lymphomagenesis. |
| Volume: |
104 |
| Issue: |
13 |
| Pages: |
5389-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Y |
| Year: |
2016 |
| Journal: |
Aging Cell |
| Title: |
Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation. |
| Volume: |
15 |
| Issue: |
4 |
| Pages: |
646-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nemajerova A |
| Year: |
2010 |
| Journal: |
J Clin Invest |
| Title: |
Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice. |
| Volume: |
120 |
| Issue: |
6 |
| Pages: |
2070-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Alt JR |
| Year: |
2003 |
| Journal: |
EMBO J |
| Title: |
Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis. |
| Volume: |
22 |
| Issue: |
6 |
| Pages: |
1442-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Suthaus J |
| Year: |
2012 |
| Journal: |
Blood |
| Title: |
HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice. |
| Volume: |
119 |
| Issue: |
22 |
| Pages: |
5173-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Keller U |
| Year: |
2005 |
| Journal: |
Oncogene |
| Title: |
Nfkb 1 is dispensable for Myc-induced lymphomagenesis. |
| Volume: |
24 |
| Issue: |
41 |
| Pages: |
6231-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kollek M |
| Year: |
2017 |
| Journal: |
J Exp Med |
| Title: |
Transient apoptosis inhibition in donor stem cells improves hematopoietic stem cell transplantation. |
| Volume: |
214 |
| Issue: |
10 |
| Pages: |
2967-2983 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Janssen E |
| Year: |
2004 |
| Journal: |
J Immunol |
| Title: |
Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding. |
| Volume: |
172 |
| Issue: |
11 |
| Pages: |
6810-9 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, transgenic, targeted mutation, congenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Walczynski J |
| Year: |
2014 |
| Journal: |
Oncogene |
| Title: |
Sensitisation of c-MYC-induced B-lymphoma cells to apoptosis by ATF2. |
| Volume: |
33 |
| Issue: |
8 |
| Pages: |
1027-36 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Momken I |
| Year: |
2017 |
| Journal: |
Biochem J |
| Title: |
A new leptin-mediated mechanism for stimulating fatty acid oxidation: a pivotal role for sarcolemmal FAT/CD36. |
| Volume: |
474 |
| Issue: |
1 |
| Pages: |
149-162 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Haklai-Topper L |
| Year: |
2010 |
| Journal: |
EMBO J |
| Title: |
Cis interaction between Semaphorin6A and Plexin-A4 modulates the repulsive response to Sema6A. |
| Volume: |
29 |
| Issue: |
15 |
| Pages: |
2635-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hastings KT |
| Year: |
2006 |
| Journal: |
J Immunol |
| Title: |
Functional requirements for the lysosomal thiol reductase GILT in MHC class II-restricted antigen processing. |
| Volume: |
177 |
| Issue: |
12 |
| Pages: |
8569-77 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Phipps-Yonas H |
| Year: |
2013 |
| Journal: |
Eur J Immunol |
| Title: |
GILT expression in B cells diminishes cathepsin S steady-state protein expression and activity. |
| Volume: |
43 |
| Issue: |
1 |
| Pages: |
65-74 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wen R |
| Year: |
2006 |
| Journal: |
Mol Cell Biol |
| Title: |
Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis. |
| Volume: |
26 |
| Issue: |
24 |
| Pages: |
9364-76 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, transgenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hara J |
| Year: |
2001 |
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Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. |
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30 |
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2013 |
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PLoS One |
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Sellayah D |
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Orexin receptor-1 mediates brown fat developmental differentiation. |
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Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice. |
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Toyama S |
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Respir Physiol Neurobiol |
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Zhang W |
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2009 |
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Brain Res |
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Orexin neurons in the hypothalamus mediate cardiorespiratory responses induced by disinhibition of the amygdala and bed nucleus of the stria terminalis. |
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Kelz MB |
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2008 |
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Proc Natl Acad Sci U S A |
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An essential role for orexins in emergence from general anesthesia. |
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Mieda M |
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2004 |
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Proc Natl Acad Sci U S A |
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Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice. |
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101 |
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13 |
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Yang L |
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2013 |
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J Neurosci |
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Hypocretin/orexin neurons contribute to hippocampus-dependent social memory and synaptic plasticity in mice. |
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33 |
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12 |
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Akiyama M |
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2004 |
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Eur J Neurosci |
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Reduced food anticipatory activity in genetically orexin (hypocretin) neuron-ablated mice. |
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20 |
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11 |
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Mieda M |
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2004 |
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J Neurosci |
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Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness. |
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46 |
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2025 |
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Sci Rep |
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Utility of complexity analysis in electroencephalography and electromyography for automated classification of sleep-wake states in mice. |
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15 |
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2014 |
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Exp Neurol |
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261 |
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J Physiol |
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| Allele |
| Name: |
transgene insertion 1348D, Gerard Evan |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
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Dörr JR |
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Nature |
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501 |
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| Strain |
| Attribute String: |
congenic, targeted mutation, transgenic |
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| Attribute String: |
congenic, endonuclease-mediated mutation, mutant strain, transgenic |
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2008 |
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J Clin Invest |
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TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis. |
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2020 |
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PLoS One |
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2023 |
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Nat Med |
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2017 |
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Sci Rep |
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J Immunol |
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Exp Hematol |
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Proc Natl Acad Sci U S A |
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52 |
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•
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| Allele |
| Name: |
transgene insertion 147-9b, Philip Leder |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
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•
•
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Podrini C |
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2018 |
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Commun Biol |
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Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways. |
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1 |
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Hand R |
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2005 |
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Neuron |
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Phosphorylation of Neurogenin2 specifies the migration properties and the dendritic morphology of pyramidal neurons in the neocortex. |
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2006 |
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J Carcinog |
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Characterization of pancreatic lesions from MT-tgf alpha, Ela-myc and MT-tgf alpha/Ela-myc single and double transgenic mice. |
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5 |
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19 |
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•
•
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| Allele |
| Name: |
immunoglobulin heavy constant alpha; targeted mutation 1, Siegfried Janz |
| Allele Type: |
Targeted |
| Attribute String: |
Inserted expressed sequence |
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•
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•
•
•
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| Strain |
| Attribute String: |
coisogenic, transgenic |
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