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Search results 3501 to 3600 out of 4881 for Notch1

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Hits by Pathway

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Hits by Strain

Type Details Score
Allele
Pax3<tm7(Notch1*)Buck> | MGI:5636809
Name: paired box 3; targeted mutation 7, Margaret E Buckingham
Allele Type: Targeted
Attribute String: Conditional ready, Constitutively active, Inserted expressed sequence, Reporter
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Allele
Tg(tetO-Notch1*)1Dam | MGI:6151073
Name: transgene insertion 1, Douglas A Melton
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
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Allele
Notch1<em2Smoc> | MGI:7265003
Name: notch 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Tg(Rr382-GFP)#Licai | MGI:7439359
Name: transgene insertion, Li Cai
Allele Type: Transgenic
Attribute String: Reporter
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Genotype
Genotype
Symbol: Olig1/Olig1
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
21931869 | J:177688
First Author: Suliman S
Year: 2011
Journal: PLoS One
Title: Notch3 is dispensable for thymocyte β-selection and Notch1-induced T cell leukemogenesis.
Volume: 6
Issue: 9
Pages: e24937
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Allele
Tg(Notch1)A5Rko | MGI:1926630
Name: transgene insertion A5, Raphael Kopan
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Notch1)A7Rko | MGI:1926633
Name: transgene insertion A7, Raphael Kopan
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Notch1)A3Rko | MGI:1926625
Name: transgene insertion A3, Raphael Kopan
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Notch1)A4Rko | MGI:1926629
Name: transgene insertion A4, Raphael Kopan
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Mesp2<tm5(Notch1)Ysa> | MGI:2386850
Name: mesoderm posterior 2; targeted mutation 5, Yumiko Saga
Allele Type: Targeted
Attribute String: Constitutively active, Inserted expressed sequence, Null/knockout
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Protein Coding Gene
MGI:2672905 | Dtx4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q6PDK8
Organism: Mus musculus/domesticus
Length: 616  
Fragment?: false
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Publication
15994223 | J:99859
First Author: Carlson TR
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice.
Volume: 102
Issue: 28
Pages: 9884-9
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HT Experiment
GSE15232 | A Regulatory Pathway Involving Notch1/beta-Catenin/Isl1 Determines Cardiac Progenitor Cell Fate
Series Id: E-GEOD-15232
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Publication
22974708 | J:207644
First Author: Villanueva A
Year: 2012
Journal: Gastroenterology
Title: Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice.
Volume: 143
Issue: 6
Pages: 1660-1669.e7
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Protein Coding Gene
MGI:1343101 | Kat2a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913604 | Snw1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9JHD2
Organism: Mus musculus/domesticus
Length: 830  
Fragment?: false
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Protein
Q9CSN1
Organism: Mus musculus/domesticus
Length: 536  
Fragment?: false
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Allele
Tg(Notch1)1Anc | MGI:1926638
Name: transgene insertion 1, Angela M Christiano
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:6144644 | ICR.Cg-Mesp2<tm5(Notch1)Ysa>/YsaRbrc
Attribute String: mutant strain, congenic, targeted mutation
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Allele
Tg(CAG-cat,-Notch1)1Ysa | MGI:3702441
Name: transgene insertion 1, Yumiko Saga
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
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Allele
Notch1<tm4(cre)Rko> | MGI:5009236
Name: notch 1; targeted mutation 4, Raphael Kopan
Allele Type: Targeted
Attribute String: Recombinase
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Allele
Gt(ROSA)26Sor<tm2Iaai> | MGI:5496402
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Iannis Aifantis
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Strain
MGI:6770990 | C57BL/6JSmoc-Notch1<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Tg(CAG-Notch1)#Guiq | MGI:7311996
Name: transgene insertion, Guiquan Chen
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(Notch1)A3Rko/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Notch1)A4Rko/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Notch1)A5Rko/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Notch1)A7Rko/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mesp2/Mesp2
Background: involves: C57BL/6 * CBA
Zygosity: hm
Has Mutant Allele: true
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Publication
17699740 | J:149110
First Author: Wu L
Year: 2007
Journal: Blood
Title: The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development.
Volume: 110
Issue: 10
Pages: 3618-23
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Publication
26209882 | J:227032
 
First Author: Tateya T
Year: 2015
Journal: Hear Res
Title: In vivo overactivation of the Notch signaling pathway in the developing cochlear epithelium.
Volume: 327
Pages: 209-17
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Publication
28019674 | J:274523
First Author: Canalis E
Year: 2017
Journal: J Cell Biochem
Title: Hairy and Enhancer of Split-Related With YRPW Motif-Like (HeyL) Is Dispensable for Bone Remodeling in Mice.
Volume: 118
Issue: 7
Pages: 1819-1826
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HT Experiment
E-GEOD-71912 | Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy
Series Id: GSE71912
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE159187 | Transcriptomic analysis of myocardium-specific Creld1 knockout mice at E13.5 and P3
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein Coding Gene
MGI:1343094 | Kat2b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9JHD1
Organism: Mus musculus/domesticus
Length: 813  
Fragment?: false
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Publication
20499347 | J:233131
First Author: Tao J
Year: 2010
Journal: J Bone Miner Res
Title: Osteosclerosis owing to Notch gain of function is solely Rbpj-dependent.
Volume: 25
Issue: 10
Pages: 2175-83
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Publication
26578715 | J:235906
First Author: Canalis E
Year: 2016
Journal: Am J Physiol Endocrinol Metab
Title: Canonical Notch activation in osteocytes causes osteopetrosis.
Volume: 310
Issue: 2
Pages: E171-82
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Publication
27125305 | J:236122
First Author: Gekas C
Year: 2016
Journal: Leukemia
Title: β-Catenin is required for T-cell leukemia initiation and MYC transcription downstream of Notch1.
Volume: 30
Issue: 10
Pages: 2002-2010
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Publication
28094257 | J:244565
 
First Author: Yue F
Year: 2017
Journal: Nat Commun
Title: Pten is necessary for the quiescence and maintenance of adult muscle stem cells.
Volume: 8
Pages: 14328
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Publication
25295490 | J:225340
 
First Author: Chanrion M
Year: 2014
Journal: Nat Commun
Title: Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut.
Volume: 5
Pages: 5005
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Publication
32961023 | J:326593
First Author: Bi HR
Year: 2021
Journal: CNS Neurosci Ther
Title: Neuron-specific deletion of presenilin enhancer2 causes progressive astrogliosis and age-related neurodegeneration in the cortex independent of the Notch signaling.
Volume: 27
Issue: 2
Pages: 174-185
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Publication
15277242 | J:91518
First Author: Kiaris H
Year: 2004
Journal: Am J Pathol
Title: Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium.
Volume: 165
Issue: 2
Pages: 695-705
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Publication
37454290 | J:339293
First Author: Jannaway M
Year: 2023
Journal: Cell Rep
Title: VEGFR3 is required for button junction formation in lymphatic vessels.
Volume: 42
Issue: 7
Pages: 112777
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HT Experiment
E-GEOD-58712 | Cyclin C-CDK3/8/19 kinases play a tumor-suppressive role in vivo
Series Id: GSE58712
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Strain
MGI:5432151 | B6.Cg-Gt(ROSA)26Sor<tm1(NOTCH1/GFP)Xhsu> Tg(Lck-cre)548Jxm
Attribute String: transgenic, mutant strain, congenic
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Allele
Gt(ROSA)26Sor<tm1(Notch1)Dam> | MGI:2684314
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Douglas A Melton
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
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Strain
MGI:3767657 | STOCK Gt(ROSA)26Sor<tm1(Notch1)Dam>/J
Attribute String: mutant stock, targeted mutation
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Publication
23954701 | J:328408
First Author: Zanotti S
Year: 2013
Journal: Osteoarthritis Cartilage
Title: Interleukin 6 mediates selected effects of Notch in chondrocytes.
Volume: 21
Issue: 11
Pages: 1766-73
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Allele
Tg(ACTB-NOTCH1)1Shn | MGI:3044583
Name: transgene insertion 1, Jie Shen
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Actb-NOTCH1)2Shn | MGI:3044584
Name: transgene insertion 2, Jie Shen
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Notch2<tm1Bmc> | MGI:3621957
Name: notch 2; targeted mutation 1, Brent McCright
Allele Type: Targeted
Attribute String: Inserted expressed sequence
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Strain
MGI:6144570 | ICR.Cg-Tg(CAG-cat,-Notch1)1Ysa/YsaRbrc
Attribute String: mutant strain, congenic, transgenic
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Strain
MGI:5634566 | STOCK Notch1<tm4(cre)Rko>/J
Attribute String: mutant stock, targeted mutation
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Allele
Notch1<tm6.1Rko> | MGI:5523515
Name: notch 1; targeted mutation 6.1, Raphael Kopan
Allele Type: Targeted
Attribute String: Inserted expressed sequence
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Allele
Notch2<tm3.1Rko> | MGI:5523517
Name: notch 2; targeted mutation 3.1, Raphael Kopan
Allele Type: Targeted
Attribute String: Inserted expressed sequence
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Allele
Tg(KRT14-Notch*/ESR1)CA4Fmw | MGI:5824128
Name: transgene insertion CA4, Fiona M Watt
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
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Allele
Tg(RNU6-gRNA:Notch1,KRT14-cas9)2Kesa | MGI:6394107
Name: transgene insertion 2, Kei Sakamoto
Allele Type: Transgenic
Attribute String: Endonuclease, Null/knockout
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Allele
Tg(RNU6-gRNA:Notch1,KRT14-cas9)1Kesa | MGI:6394115
Name: transgene insertion 1, Kei Sakamoto
Allele Type: Transgenic
Attribute String: Endonuclease, Null/knockout
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Notch1)1Anc/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Notch2/Notch2
Background: involves: 129S1/Sv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Lck-cre)548Jxm/?
Background: B6.Cg-Gt(ROSA)26Sor Tg(Lck-cre)548Jxm
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Eef1a1/Eef1a1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: C57BL/6 * C57BL/6NTac
Zygosity: cn
Has Mutant Allele: true
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Publication
24485662 | J:315873
First Author: Weisberg SP
Year: 2014
Journal: Cell Rep
Title: ZFX controls propagation and prevents differentiation of acute T-lymphoblastic and myeloid leukemia.
Volume: 6
Issue: 3
Pages: 528-40
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Publication
35451473 | J:325723
 
First Author: Duvall K
Year: 2022
Journal: Development
Title: Revisiting the role of Notch in nephron segmentation confirms a role for proximal fate selection during mouse and human nephrogenesis.
Volume: 149
Issue: 10
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Publication
31526760 | J:279349
First Author: Jackstadt R
Year: 2019
Journal: Cancer Cell
Title: Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis.
Volume: 36
Issue: 3
Pages: 319-336.e7
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Publication
18758477 | J:140988
First Author: Bellavia D
Year: 2008
Journal: Oncogene
Title: Notch3: from subtle structural differences to functional diversity.
Volume: 27
Issue: 38
Pages: 5092-8
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Publication
19536265 | J:197167
First Author: Buonamici S
Year: 2009
Journal: Nature
Title: CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia.
Volume: 459
Issue: 7249
Pages: 1000-4
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Publication
25264928 | J:223490
First Author: Savoy-Burke G
Year: 2014
Journal: PLoS One
Title: Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells.
Volume: 9
Issue: 9
Pages: e108160
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Publication
24817584 | J:213585
First Author: Liu J
Year: 2014
Journal: Genesis
Title: Constitutive notch signaling in adult transgenic mice inhibits bFGF-induced angiogenesis and blocks ovarian follicle development.
Volume: 52
Issue: 9
Pages: 809-16
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Publication
36503993 | J:338389
First Author: Belyea BC
Year: 2023
Journal: Clin Sci (Lond)
Title: Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype.
Volume: 137
Issue: 1
Pages: 35-45
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Publication
29664186 | J:268206
First Author: Dai Q
Year: 2018
Journal: Stem Cells
Title: Notch Signaling Regulates Lgr5+ Olfactory Epithelium Progenitor/Stem Cell Turnover and Mediates Recovery of Lesioned Olfactory Epithelium in Mouse Model.
Volume: 36
Issue: 8
Pages: 1259-1272
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Publication
18588871 | J:138714
First Author: Rowan S
Year: 2008
Journal: Dev Biol
Title: Notch signaling regulates growth and differentiation in the mammalian lens.
Volume: 321
Issue: 1
Pages: 111-22
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Publication
23752615 | J:204823
First Author: Zhang P
Year: 2013
Journal: J Immunol
Title: Notch-regulated periphery B cell differentiation involves suppression of E protein function.
Volume: 191
Issue: 2
Pages: 726-36
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Publication
31797926 | J:285635
First Author: Shu Y
Year: 2019
Journal: Nat Commun
Title: Renewed proliferation in adult mouse cochlea and regeneration of hair cells.
Volume: 10
Issue: 1
Pages: 5530
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Protein Coding Gene
MGI:1202301 | Itch
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8C863
Organism: Mus musculus/domesticus
Length: 864  
Fragment?: false
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Publication
39529885 | J:358439
 
First Author: Šisl D
Year: 2024
Journal: Front Pharmacol
Title: Modulation of Notch signaling pathway in activated hepatic stellate cells does not ameliorate the outcome of liver fibrosis in carbon tetrachloride and DDC-feeding models.
Volume: 15
Pages: 1440236
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Publication
23727022 | J:199099
First Author: Zender S
Year: 2013
Journal: Cancer Cell
Title: A critical role for notch signaling in the formation of cholangiocellular carcinomas.
Volume: 23
Issue: 6
Pages: 784-95
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Publication
24423059 | J:210099
 
First Author: Paes de Faria J
Year: 2014
Journal: BMC Neurosci
Title: New Olig1 null mice confirm a non-essential role for Olig1 in oligodendrocyte development.
Volume: 15
Pages: 12
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Publication
22493066 | J:185821
First Author: Wen Y
Year: 2012
Journal: Mol Cell Biol
Title: Constitutive Notch activation upregulates Pax7 and promotes the self-renewal of skeletal muscle satellite cells.
Volume: 32
Issue: 12
Pages: 2300-11
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Publication
16103066 | J:100770
First Author: Beverly LJ
Year: 2005
Journal: Cancer Res
Title: Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regression.
Volume: 65
Issue: 16
Pages: 7159-68
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Strain
MGI:3687998 | C57BL/6J-Tg(ACTB-NOTCH1)1Shn/J
Attribute String: coisogenic, mutant strain, transgenic
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Allele
Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe | MGI:3703057
Name: transgene insertion 1, Corinne G Lobe
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
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Genotype
Genotype
Symbol: Mesp1/Mesp1<+> Tg(CAG-cat,-Notch1)1Ysa/?
Background: involves: C3H * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mesp2/Mesp2 Psen1/Psen1
Background: involves: C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Eef1a1/Eef1a1<+> Tg(Mx1-cre)1Cgn/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Notch2/Notch2
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Notch1/Notch1<+>
Background: involves: C57BL/6NTac
Zygosity: ht
Has Mutant Allele: true
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Publication
20733081 | J:164383
First Author: Pan W
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Notch signaling is required for the generation of hair cells and supporting cells in the mammalian inner ear.
Volume: 107
Issue: 36
Pages: 15798-803
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Publication
33512383 | J:307793
First Author: Tardivon D
Year: 2021
Journal: Blood
Title: Notch signaling promotes disease initiation and progression in murine chronic lymphocytic leukemia.
Volume: 137
Issue: 22
Pages: 3079-3092
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Publication
37310065 | J:359038
First Author: Namikawa M
Year: 2023
Journal: J Pathol
Title: Simultaneous activation of Kras-Akt and Notch pathways induces extrahepatic biliary cancer via the mTORC1 pathway.
Volume: 260
Issue: 4
Pages: 478-492
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Publication
18818392 | J:143346
First Author: Kim YW
Year: 2008
Journal: Blood
Title: Defective Notch activation in microenvironment leads to myeloproliferative disease.
Volume: 112
Issue: 12
Pages: 4628-38
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Publication
22354878 | J:181633
First Author: Liu Z
Year: 2012
Journal: Dev Dyn
Title: In vivo Notch reactivation in differentiating cochlear hair cells induces Sox2 and Prox1 expression but does not disrupt hair cell maturation.
Volume: 241
Issue: 4
Pages: 684-96
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Publication
32213630 | J:288582
 
First Author: Peired AJ
Year: 2020
Journal: Sci Transl Med
Title: Acute kidney injury promotes development of papillary renal cell adenoma and carcinoma from renal progenitor cells.
Volume: 12
Issue: 536
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HT Experiment
E-GEOD-54976 | Gene expression in thymi of Tcf1 -/-, Tcf +/- or Tcf1 -/- mice with tumor
Series Id: GSE54976
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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