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Search results 3501 to 3600 out of 3880 for Wt1

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Strain
MGI:7524629 | B6.Cg-Nr5a1<tm1Klp> Wt1<tm1Jae>
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Pax2<1Neu>/Pax2<+> Wt1/Wt1<+>
Background: involves: 102 * 129S4/SvJae * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Wt1/Wt1 Tg(GATA5-cre)1Krc/?
Background: involves: 129P2/OlaHsd * 129S2/SvPas
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dis3l2/Dis3l2 Wt1/Wt1<+>
Background: involves: 129S4/SvJae * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Drosha/Drosha Wt1/Wt1<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJae
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Adm/Adm Wt1/Wt1<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJae
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nrg1/Nrg1 Wt1/Wt1<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Wt1/Wt1 Pax8/Pax8<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ucp1/Ucp1<+> Wtap/Wtap
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
24376653 | J:211125
First Author: Xiao Z
Year: 2013
Journal: PLoS One
Title: Wtip- and gadd45a-interacting protein dendrin is not crucial for the development or maintenance of the glomerular filtration barrier.
Volume: 8
Issue: 12
Pages: e83133
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Publication
34660602 | J:312373
 
First Author: Xie SJ
Year: 2021
Journal: Front Cell Dev Biol
Title: Dynamic m6A mRNA Methylation Reveals the Role of METTL3/14-m6A-MNK2-ERK Signaling Axis in Skeletal Muscle Differentiation and Regeneration.
Volume: 9
Pages: 744171
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Publication
26258302 | J:225789
First Author: Durst R
Year: 2015
Journal: Nature
Title: Mutations in DCHS1 cause mitral valve prolapse.
Volume: 525
Issue: 7567
Pages: 109-13
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Allele
Ewsr1<tm1Sblee> | MGI:3713772
Name: Ewing sarcoma breakpoint region 1; targeted mutation 1, Sean Lee
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, Null/knockout
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Publication
17415412 | J:122058
First Author: Li H
Year: 2007
Journal: J Clin Invest
Title: Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development.
Volume: 117
Issue: 5
Pages: 1314-23
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Publication
25918410 | J:221663
First Author: Park JH
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Inactivation of EWS reduces PGC-1α protein stability and mitochondrial homeostasis.
Volume: 112
Issue: 19
Pages: 6074-9
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Publication
33006225 | J:301541
First Author: Lee SG
Year: 2020
Journal: EMBO Rep
Title: Ewing sarcoma protein promotes dissociation of poly(ADP-ribose) polymerase 1 from chromatin.
Volume: 21
Issue: 11
Pages: e48676
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Publication
37709831 | J:341344
First Author: Jung JW
Year: 2023
Journal: Sci Rep
Title: In-depth proteome analysis of brain tissue from Ewsr1 knockout mouse by multiplexed isobaric tandem mass tag labeling.
Volume: 13
Issue: 1
Pages: 15261
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Publication
23987512 | J:204551
First Author: Park JH
Year: 2013
Journal: Dev Cell
Title: A multifunctional protein, EWS, is essential for early brown fat lineage determination.
Volume: 26
Issue: 4
Pages: 393-404
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Publication
21030557 | J:177806
First Author: Cho J
Year: 2011
Journal: Blood
Title: Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence.
Volume: 117
Issue: 4
Pages: 1156-66
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Publication
29731676 | J:343817
First Author: Yoon Y
Year: 2018
Journal: Exp Neurobiol
Title: Genetic Ablation of EWS RNA Binding Protein 1 (EWSR1) Leads to Neuroanatomical Changes and Motor Dysfunction in Mice.
Volume: 27
Issue: 2
Pages: 103-111
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Publication
22910415 | J:188129
First Author: Sohn EJ
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Accumulation of pre-let-7g and downregulation of mature let-7g with the depletion of EWS.
Volume: 426
Issue: 1
Pages: 89-93
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Strain
MGI:5008581 | FVB-Tg(LRRK2)WT1Mjfa
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:4460777 | B6.FVB-Tg(LRRK2)WT1Mjfa/J
Attribute String: congenic, mutant strain, transgenic
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Publication
- | J:161656
     
First Author: Farrer MJ
Year: 2010
Journal: MGI Direct Data Submission
Title: LRRK2 WT BAC transgenic strain.
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Genotype
Genotype
Symbol: Ewsr1/Ewsr1
Background: involves: 129S6/SvEvTac * Black Swiss
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Axin2/Axin2<+> Tg(Wt1-Sox9)92Asc/?
Background: involves: 129 * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(LRRK2)WT1Mjfa/?
Background: FVB-Tg(LRRK2)WT1Mjfa
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ewsr1/Ewsr1
Background: involves: 129S6/SvEvTac
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sox9/Sox9 Tg(Wt1-cre)#Jbeb/?
Background: involves: 129S7/SvEvBrd * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Plekha5/Plekha5<+> Wt1/Wt1
Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Wt1/Wt1<+> Zfpm2/Zfpm2
Background: involves: 129S1/Sv * 129S4/SvJae * 129S7/SvEvBrd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tbx18/Tbx18<+> Wt1/Wt1
Background: involves: 129S4/SvJae
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nr5a1/Nr5a1<+> Wt1/Wt1<+>
Background: B6.Cg-Nr5a1 Wt1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Wnt4/Wnt4<+> Wt1/Wt1<+>
Background: B6.Cg-Wt1 Wnt4 Chr Y
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Plekha5/? Wt1/Wt1
Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sry/? Sry/? Wt1/Wt1<+>
Background: B6.Cg-Wt1 Chr Y
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Wt1/Wt1<+>
Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Wt1/Wt1<+>
Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Wt1/Wt1<+>
Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Wt1/?
Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Wt1/Wt1 Wnt4/Wnt4<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
10869550 | -
First Author: Shimizu H
Year: 2000
Journal: FEBS Lett
Title: Identification of an optimal Ncx binding sequence required for transcriptional activation.
Volume: 475
Issue: 3
Pages: 170-4
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Publication
19697050 | -
First Author: Kato Y
Year: 2009
Journal: Pediatr Surg Int
Title: Immature enteric neurons in Ncx/Hox11L.1 deficient intestinal neuronal dysplasia model mice.
Volume: 25
Issue: 11
Pages: 961-5
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Protein
Q3UWE8
Organism: Mus musculus/domesticus
Length: 51  
Fragment?: true
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Publication
11585763 | -
First Author: Chakraborty M
Year: 2001
Journal: Cancer Res
Title: Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression.
Volume: 61
Issue: 19
Pages: 7255-63
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Publication
8943350 | -
First Author: Johnstone RW
Year: 1996
Journal: Mol Cell Biol
Title: A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1.
Volume: 16
Issue: 12
Pages: 6945-56
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Publication
15671026 | -
First Author: Xie J
Year: 2005
Journal: J Biol Chem
Title: PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein.
Volume: 280
Issue: 14
Pages: 13824-32
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Publication
15064766 | J:90585
First Author: Cheng L
Year: 2004
Journal: Nat Neurosci
Title: Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates.
Volume: 7
Issue: 5
Pages: 510-7
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Publication
22723691 | J:185665
First Author: Guo Z
Year: 2012
Journal: J Neurosci
Title: Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.
Volume: 32
Issue: 25
Pages: 8509-20
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Protein Domain
IPR026117 | Par-4
Type: Family
Description: Prostate apoptosis response 4 (Par-4) induced apoptosis of selective prostate cancer cells PC-3, DU-145, and TSU-Pr and caused tumor regression by inhibition of NF-kappaB activity and cell membrane trafficking of Fas and FasL that leads to the activation of the Fas-Fas-associated death domain-caspase-8 pro-death pathway []. It modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1. It down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1 []. Par-4 also regulates the amyloid precursor protein (APP) cleavage activity of BACE1 [].
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Protein Domain
IPR042247 | TLX1/2/3
Type: Family
Description: This entry represents a group of homeobox proteins, including Tlx1/2/3. They are transcription factors that belong to the to the Hox11 family. In general, they bind to the DNA sequence 5'-CGGTAATTGG-3' []. Tlx1 and Tlx3 are required for fate determination of glutamatergic and GABAergic neurons in the dorsal spinal cord [, ]. Tlx1, also known as Hox11, is required to maintain normal Wt1 mRNA levels in the developing spleen in mice []. Tlx2, also known as Ncx/Hox11L.1, is required for the adequate development of enteric neurons in mice [].
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Publication
27930302 | J:239076
First Author: Quinn TA
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Electrotonic coupling of excitable and nonexcitable cells in the heart revealed by optogenetics.
Volume: 113
Issue: 51
Pages: 14852-14857
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Publication
23418471 | J:199341
First Author: Carmona R
Year: 2013
Journal: PLoS One
Title: Cells derived from the coelomic epithelium contribute to multiple gastrointestinal tissues in mouse embryos.
Volume: 8
Issue: 2
Pages: e55890
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Publication
25343991 | J:219227
First Author: Beccano-Kelly DA
Year: 2015
Journal: Hum Mol Genet
Title: LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory.
Volume: 24
Issue: 5
Pages: 1336-49
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Genotype
Genotype
Symbol: Notch1/Notch1 Tg(Wt1-cre)#Jbeb/?
Background: involves: 129
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Wt1-cre)#Jbeb/?
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Wt1-cre)#Jbeb/?
Background: involves: 129 * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
30771308 | J:276074
 
First Author: Quijada P
Year: 2019
Journal: J Mol Cell Cardiol
Title: Pre-existing fibroblasts of epicardial origin are the primary source of pathological fibrosis in cardiac ischemia and aging.
Volume: 129
Pages: 92-104
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HT Experiment
GSE207712 | Pd1 regulates proliferation and differentiation of neural progenitors during brain development
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
18331720 | J:183217
First Author: Langer EM
Year: 2008
Journal: Dev Cell
Title: Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus.
Volume: 14
Issue: 3
Pages: 424-36
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Publication
29547716 | J:261823
First Author: Wen J
Year: 2018
Journal: Mol Cell
Title: Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Volume: 69
Issue: 6
Pages: 1028-1038.e6
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Publication
29507755 | J:319950
 
First Author: Yue Y
Year: 2018
Journal: Cell Discov
Title: VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation.
Volume: 4
Pages: 10
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Wt1/Wt1<+> Zfpm2/Zfpm2
Background: involves: 129S1/Sv * 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Col1a1/Col1a1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Wt1/Wt1<+>
Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Col1a1/Col1a1 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Wt1/Wt1<+>
Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
30285093 | J:276812
First Author: Ortega EA
Year: 2019
Journal: Biol Reprod
Title: Alterations of sex determination pathways in the genital ridges of males with limited Y chromosome genes†.
Volume: 100
Issue: 3
Pages: 810-823
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Publication
20659558 | J:163737
First Author: Melrose HL
Year: 2010
Journal: Neurobiol Dis
Title: Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice.
Volume: 40
Issue: 3
Pages: 503-17
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Publication
25309331 | J:242269
 
First Author: Beccano-Kelly DA
Year: 2014
Journal: Front Cell Neurosci
Title: Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice.
Volume: 8
Pages: 301
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Wt1-cre)#Jbeb/?
Background: involves: 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Pgk1-lacZ)13Vmel/? Tg(WT1-cre)1Asc/?
Background: involves: 129S2/SvPas * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Protein
P22561
Organism: Mus musculus/domesticus
Length: 449  
Fragment?: false
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Protein
Q199A7
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
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Protein
A2A404
Organism: Mus musculus/domesticus
Length: 288  
Fragment?: false
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Protein
A2A400
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: true
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Protein
F6VXG5
Organism: Mus musculus/domesticus
Length: 360  
Fragment?: true
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Protein
F6Y2T6
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: false
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Protein
A2A405
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: false
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Protein
A2A401
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: true
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HT Experiment
E-GEOD-9124 | Transcription profiling of mouse heart from E12.5 wildtype- and Sp3 animals
Series Id: GSE9124
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
26823431 | J:229445
First Author: Yamauchi Y
Year: 2016
Journal: Science
Title: Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction.
Volume: 351
Issue: 6272
Pages: 514-6
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Publication
28339606 | J:244947
First Author: Ruthig VA
Year: 2017
Journal: Biol Reprod
Title: Testicular abnormalities in mice with Y chromosome deficiencies.
Volume: 96
Issue: 3
Pages: 694-706
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Publication
17989236 | J:127444
First Author: Zamora M
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Epicardium-derived progenitor cells require beta-catenin for coronary artery formation.
Volume: 104
Issue: 46
Pages: 18109-14
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Publication
20965161 | J:167078
First Author: Gregoire EP
Year: 2011
Journal: Dev Biol
Title: Transient development of ovotestes in XX Sox9 transgenic mice.
Volume: 349
Issue: 1
Pages: 65-77
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Publication
33000003 | J:354989
First Author: Forte E
Year: 2020
Journal: STAR Protoc
Title: Protocol for Isolation of Cardiac Interstitial Cells from Adult Murine Hearts for Unbiased Single Cell Profiling.
Volume: 1
Issue: 2
Pages: 100077
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Genotype
Genotype
Symbol: Ewsr1/Ewsr1<+> Tg(CAG-cre/Esr1*)5Amc/?
Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Wt1-cre)#Jbeb/?
Background: involves: 129S7/SvEvBrd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Wt1-cre)#Jbeb/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Wt1-cre)#Jbeb/?
Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Wt1-cre)#Jbeb/?
Background: involves: 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
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Publication
26839965 | J:236757
First Author: West DB
Year: 2016
Journal: PLoS Genet
Title: Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression.
Volume: 12
Issue: 2
Pages: e1005691
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Publication
21224394 | J:182886
First Author: Moik DV
Year: 2011
Journal: J Cell Sci
Title: Loss of migfilin expression has no overt consequences on murine development and homeostasis.
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HT Experiment
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