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Search results 3601 to 3700 out of 7122 for App

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Type Details Score
Publication
23226497 | J:195687
First Author: Nabar NR
Year: 2012
Journal: PLoS One
Title: Cell therapy: a safe and efficacious therapeutic treatment for Alzheimer's disease in APP+PS1 mice.
Volume: 7
Issue: 12
Pages: e49468
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Publication
25698614 | J:221052
 
First Author: Kanamaru T
Year: 2015
Journal: Brain Res
Title: Intravenous transplantation of bone marrow-derived mononuclear cells prevents memory impairment in transgenic mouse models of Alzheimer's disease.
Volume: 1605
Pages: 49-58
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Publication
15158158 | J:90576
First Author: Arendash GW
Year: 2004
Journal: Brain Res
Title: Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain.
Volume: 1012
Issue: 1-2
Pages: 29-41
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Publication
23595759 | J:196964
First Author: Corbett BF
Year: 2013
Journal: J Neurosci
Title: Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease.
Volume: 33
Issue: 16
Pages: 7020-6
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Publication
25529196 | J:219346
 
First Author: Kanamaru T
Year: 2015
Journal: Neurosci Lett
Title: Oxidative stress accelerates amyloid deposition and memory impairment in a double-transgenic mouse model of Alzheimer's disease.
Volume: 587
Pages: 126-31
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Publication
19705461 | J:159344
First Author: Mori T
Year: 2010
Journal: Glia
Title: Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease.
Volume: 58
Issue: 3
Pages: 300-14
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Publication
20368278 | J:160440
First Author: Chakrabarty P
Year: 2010
Journal: J Immunol
Title: IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice.
Volume: 184
Issue: 9
Pages: 5333-43
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Publication
17714960 | J:128849
First Author: Cracchiolo JR
Year: 2007
Journal: Neurobiol Learn Mem
Title: Enhanced cognitive activity--over and above social or physical activity--is required to protect Alzheimer's mice against cognitive impairment, reduce Abeta deposition, and increase synaptic immunoreactivity.
Volume: 88
Issue: 3
Pages: 277-94
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Publication
19825975 | J:156612
First Author: Chakrabarty P
Year: 2010
Journal: FASEB J
Title: Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition.
Volume: 24
Issue: 2
Pages: 548-59
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Publication
22042871 | J:180222
First Author: Kiyota T
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders.
Volume: 108
Issue: 49
Pages: E1339-48
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Publication
18687920 | J:168867
First Author: Abramowski D
Year: 2008
Journal: J Pharmacol Exp Ther
Title: Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition.
Volume: 327
Issue: 2
Pages: 411-24
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Publication
16806588 | J:121939
First Author: Li G
Year: 2007
Journal: Neurobiol Aging
Title: Neuroprotective effect of Coenzyme Q10 on ischemic hemisphere in aged mice with mutations in the amyloid precursor protein.
Volume: 28
Issue: 6
Pages: 877-82
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Publication
33283891 | J:303680
First Author: Sanchez-Mico MV
Year: 2021
Journal: Glia
Title: Amyloid-β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease.
Volume: 69
Issue: 4
Pages: 997-1011
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Publication
22563077 | J:188380
First Author: Maesako M
Year: 2012
Journal: J Biol Chem
Title: Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice.
Volume: 287
Issue: 27
Pages: 23024-33
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Publication
20433905 | J:165238
First Author: Masliah E
Year: 2010
Journal: Neuroscience
Title: Genetic deletion of Nogo/Rtn4 ameliorates behavioral and neuropathological outcomes in amyloid precursor protein transgenic mice.
Volume: 169
Issue: 1
Pages: 488-94
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Publication
26500157 | J:229404
First Author: Rönnbäck A
Year: 2016
Journal: J Neurochem
Title: Mitochondrial dysfunction in a transgenic mouse model expressing human amyloid precursor protein (APP) with the Arctic mutation.
Volume: 136
Issue: 3
Pages: 497-502
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Publication
24305500 | J:286212
First Author: Reinert J
Year: 2014
Journal: J Alzheimers Dis
Title: Aβ38 in the brains of patients with sporadic and familial Alzheimer's disease and transgenic mouse models.
Volume: 39
Issue: 4
Pages: 871-81
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Publication
38776461 | J:360710
First Author: Kong Y
Year: 2024
Journal: ACS Chem Neurosci
Title: Increased Cerebral Level of P2X7R in a Tauopathy Mouse Model by PET Using [(18)F]GSK1482160.
Volume: 15
Issue: 11
Pages: 2112-2120
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Publication
18276079 | J:135294
First Author: Clement AB
Year: 2008
Journal: Neuroscience
Title: Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress.
Volume: 152
Issue: 2
Pages: 459-68
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Protein Coding Gene
MGI:1100500 | Flot1
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Psen1<tm2Shn> | MGI:2449304
Name: presenilin 1; targeted mutation 2, Jie Shen
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Psen1<tm1Vln> | MGI:2684616
Name: presenilin 1; targeted mutation 1, Fred Van Leuven
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Transgene
MGI:3057141 | Tg(PDGFB-APP)5Lms
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:3603944 | Tg(Eno2-APPSwe)1223-3Ykk
Type: transgene
Organism: mouse, laboratory
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Allele
Tg(tetO-APPSwInd)885Dbo | MGI:3639702
Name: transgene insertion 885, David R Borchelt
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence
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Transgene
MGI:3709064 | Tg(tetO-APPSwInd)18Dbo
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:3720793 | Tg(Ckm-APPSw)A2Lfa
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:3720794 | Tg(Ckm-APPSw)A6Lfa
Type: transgene
Organism: mouse, laboratory
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Allele
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr | MGI:3765351
Name: transgene insertion 21, Mathias Jucker
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Transgene
MGI:5491621 | Tg(Thy1-APPSweLon)41Ema
Type: transgene
Organism: mouse, laboratory
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Allele
App<tm2.1Tcs> | MGI:5637816
Name: amyloid beta precursor protein; targeted mutation 2.1, Takaomi C Saido
Allele Type: Targeted
Attribute String: Humanized sequence
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Allele
App<tm3.1Tcs> | MGI:5637817
Name: amyloid beta precursor protein; targeted mutation 3.1, Takaomi C Saido
Allele Type: Targeted
Attribute String: Humanized sequence
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Genotype
Genotype
Symbol: Tg(APPswe,PSEN1dE9)85Dbo/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(PDGFB-APP)5Lms/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Zbtb20/?
Background: B6.Cg-Zbtb20
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPDutch)#Jckr/? Tg(Thy1-PSEN1*G384A)45Jckr/?
Background: involves: C57BL/6 * C57BL/6J * DBA/2
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Flot1/Flot1
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: C3/C3 Zbtb20/?
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: App/App Cast/Cast
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hc<1>/Hc<1> Tg(APPswe,PSEN1dE9)85Dbo/?
Background: D2.Cg-Tg(APPswe,PSEN1dE9)85Dbo
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/? Trem2/Trem2<+>
Background: involves: C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/? Trem2/Trem2<+>
Background: involves: C57BL/6J * C57BL/6NTac
Zygosity: cx
Has Mutant Allele: true
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HT Experiment
E-GEOD-22009 | Hepatic acute phase proteins control innate immune responses during infection by promoting myeloid derived suppressor cell function
Series Id: GSE22009
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-27888 | Comparative transcriptome analysis of APPs alpha-DM and APLP2-KO brains
Series Id: GSE27888
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Genotype
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(tetO-APPSwInd)107Dbo/?
Background: involves: C3H/HeJ * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Publication
10547924 | J:58092
First Author: Holcomb LA
Year: 1999
Journal: Behav Genet
Title: Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.
Volume: 29
Issue: 3
Pages: 177-85
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Publication
13678670 | J:132063
First Author: Kurt MA
Year: 2003
Journal: Neurobiol Dis
Title: Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes.
Volume: 14
Issue: 1
Pages: 89-97
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Publication
22305478 | J:191171
First Author: Rijal Upadhaya A
Year: 2012
Journal: Neurobiol Aging
Title: Dispersible amyloid β-protein oligomers, protofibrils, and fibrils represent diffusible but not soluble aggregates: their role in neurodegeneration in amyloid precursor protein (APP) transgenic mice.
Volume: 33
Issue: 11
Pages: 2641-60
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Publication
35897046 | J:330620
First Author: Ibanez KR
Year: 2022
Journal: Alzheimers Res Ther
Title: Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways.
Volume: 14
Issue: 1
Pages: 104
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Publication
36361598 | J:331443
 
First Author: Raïch I
Year: 2022
Journal: Int J Mol Sci
Title: Antagonization of OX(1) Receptor Potentiates CB(2) Receptor Function in Microglia from APP(Sw/Ind) Mice Model.
Volume: 23
Issue: 21
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Publication
24489866 | J:212692
First Author: Sasaoka N
Year: 2014
Journal: PLoS One
Title: Long-term oral administration of hop flower extracts mitigates Alzheimer phenotypes in mice.
Volume: 9
Issue: 1
Pages: e87185
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Publication
25533482 | J:219343
First Author: Lian H
Year: 2015
Journal: Neuron
Title: NFκB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease.
Volume: 85
Issue: 1
Pages: 101-15
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Publication
20828568 | J:164422
First Author: Singh TD
Year: 2010
Journal: FEBS Lett
Title: MEGF10 functions as a receptor for the uptake of amyloid-β.
Volume: 584
Issue: 18
Pages: 3936-42
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Strain
MGI:3606153 | FVB/N-Tg(APP)6209Kha
Attribute String: mutant strain, transgenic, coisogenic
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Publication
15193286 | J:91135
First Author: Colas D
Year: 2004
Journal: Neurobiol Dis
Title: Sleep-wake architecture in mouse models for Down syndrome.
Volume: 16
Issue: 2
Pages: 291-9
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Strain
MGI:3722380 | FVB.Cg-Tg(APPSWE)2576Kha
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:4838841 | B6;SJL-Tg(APPSWE)2576Kha/Tac
Attribute String: transgenic, mutant stock
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Strain
MGI:3604894 | FVB/N-Tg(APPSWE)2576Kha
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:4838309 | 129S6.Cg-Tg(APPSWE)2576Kha/Tac
Attribute String: congenic, mutant strain, transgenic
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Publication
30273829 | J:271623
 
First Author: Cattaud V
Year: 2018
Journal: Neurobiol Aging
Title: Early disruption of parvalbumin expression and perineuronal nets in the hippocampus of the Tg2576 mouse model of Alzheimer's disease can be rescued by enriched environment.
Volume: 72
Pages: 147-158
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Publication
28934394 | J:249677
First Author: Kumar S
Year: 2017
Journal: Hum Mol Genet
Title: MicroRNA-455-3p as a potential peripheral biomarker for Alzheimer's disease.
Volume: 26
Issue: 19
Pages: 3808-3822
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Publication
16125396 | J:104629
First Author: Ribé EM
Year: 2005
Journal: Neurobiol Dis
Title: Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice.
Volume: 20
Issue: 3
Pages: 814-22
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Publication
31611836 | J:283431
 
First Author: Michael N
Year: 2019
Journal: Front Neurol
Title: Effects of Dabigatran in Mouse Models of Aging and Cerebral Amyloid Angiopathy.
Volume: 10
Pages: 966
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Publication
21103342 | J:166988
First Author: Parachikova A
Year: 2010
Journal: PLoS One
Title: Formulation of a medical food cocktail for Alzheimer's disease: beneficial effects on cognition and neuropathology in a mouse model of the disease.
Volume: 5
Issue: 11
Pages: e14015
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Publication
23465714 | J:211749
First Author: Williams PA
Year: 2013
Journal: Neurobiol Aging
Title: Retinal ganglion cell dendritic degeneration in a mouse model of Alzheimer's disease.
Volume: 34
Issue: 7
Pages: 1799-806
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Publication
20427654 | J:159830
First Author: Kurup P
Year: 2010
Journal: J Neurosci
Title: Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61.
Volume: 30
Issue: 17
Pages: 5948-57
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Publication
18505838 | J:136392
First Author: Cacucci F
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model.
Volume: 105
Issue: 22
Pages: 7863-8
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Publication
36330340 | J:331078
 
First Author: Borgstedt L
Year: 2022
Journal: Front Neurosci
Title: Isoflurane has no effect on cognitive or behavioral performance in a mouse model of early-stage Alzheimer's disease.
Volume: 16
Pages: 1033729
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Publication
22343315 | J:182361
First Author: Kameshima N
Year: 2012
Journal: Neurosci Lett
Title: Correlation of Aβ deposition in the nasal cavity with the formation of senile plaques in the brain of a transgenic mouse model of Alzheimer's disease.
Volume: 513
Issue: 2
Pages: 166-9
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Publication
23623603 | J:211731
First Author: Kim KS
Year: 2013
Journal: Neurobiol Aging
Title: Long-term immunomodulatory effect of amniotic stem cells in an Alzheimer's disease model.
Volume: 34
Issue: 10
Pages: 2408-20
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Publication
20384814 | J:159858
First Author: Zhang XM
Year: 2010
Journal: Eur J Neurosci
Title: Functional deprivation promotes amyloid plaque pathogenesis in Tg2576 mouse olfactory bulb and piriform cortex.
Volume: 31
Issue: 4
Pages: 710-21
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Publication
28390823 | J:244231
 
First Author: Boscia F
Year: 2017
Journal: Neurobiol Aging
Title: The expression and activity of KV3.4 channel subunits are precociously upregulated in astrocytes exposed to Aβ oligomers and in astrocytes of Alzheimer's disease Tg2576 mice.
Volume: 54
Pages: 187-198
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Publication
23582659 | J:211737
First Author: Lithner CU
Year: 2013
Journal: Neurobiol Aging
Title: Disruption of neocortical histone H3 homeostasis by soluble Aβ: implications for Alzheimer's disease.
Volume: 34
Issue: 9
Pages: 2081-90
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Publication
23582662 | J:211736
First Author: Perez-Gonzalez R
Year: 2013
Journal: Neurobiol Aging
Title: Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease.
Volume: 34
Issue: 9
Pages: 2133-45
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Publication
34955845 | J:324370
 
First Author: Piccialli I
Year: 2021
Journal: Front Pharmacol
Title: The Na+/Ca2+ Exchanger 3 Is Functionally Coupled With the NaV1.6 Voltage-Gated Channel and Promotes an Endoplasmic Reticulum Ca2+ Refilling in a Transgenic Model of Alzheimer's Disease.
Volume: 12
Pages: 775271
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Publication
11432979 | J:71332
First Author: Pappolla MA
Year: 2001
Journal: J Neurochem
Title: Induction of NADPH cytochrome P450 reductase by the Alzheimer beta-protein. Amyloid as a "foreign body".
Volume: 78
Issue: 1
Pages: 121-8
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Publication
12551918 | J:82959
First Author: Parvathenani LK
Year: 2003
Journal: J Biol Chem
Title: P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease.
Volume: 278
Issue: 15
Pages: 13309-17
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Publication
26808326 | J:249713
First Author: Wolf A
Year: 2016
Journal: PLoS One
Title: A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice.
Volume: 11
Issue: 1
Pages: e0147733
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Publication
12788511 | J:83981
First Author: Lalonde R
Year: 2003
Journal: Brain Res
Title: Transgenic mice expressing the betaAPP695SWE mutation: effects on exploratory activity, anxiety, and motor coordination.
Volume: 977
Issue: 1
Pages: 38-45
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Publication
11814407 | J:74582
First Author: King DL
Year: 2002
Journal: Brain Res
Title: Maintained synaptophysin immunoreactivity in Tg2576 transgenic mice during aging: correlations with cognitive impairment.
Volume: 926
Issue: 1-2
Pages: 58-68
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Publication
28887195 | J:249717
 
First Author: Cui Y
Year: 2018
Journal: Behav Brain Res
Title: Pharmacological activation of the Nrf2 pathway by 3H-1, 2-dithiole-3-thione is neuroprotective in a mouse model of Alzheimer disease.
Volume: 336
Pages: 219-226
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Publication
16423498 | J:128239
First Author: Kouznetsova E
Year: 2006
Journal: Int J Dev Neurosci
Title: Developmental and amyloid plaque-related changes in cerebral cortical capillaries in transgenic Tg2576 Alzheimer mice.
Volume: 24
Issue: 2-3
Pages: 187-93
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Publication
32019603 | J:299918
First Author: Ikezu S
Year: 2020
Journal: Acta Neuropathol Commun
Title: Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models.
Volume: 8
Issue: 1
Pages: 12
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Publication
25454795 | J:220906
 
First Author: Bi Oh S
Year: 2015
Journal: Brain Res
Title: Impacts of aging and amyloid-β deposition on plasminogen activators and plasminogen activator inhibitor-1 in the Tg2576 mouse model of Alzheimer's disease.
Volume: 1597
Pages: 159-67
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Publication
30618634 | J:310597
 
First Author: Latina V
Year: 2018
Journal: Front Cell Neurosci
Title: NGF-Dependent Changes in Ubiquitin Homeostasis Trigger Early Cholinergic Degeneration in Cellular and Animal AD-Model.
Volume: 12
Pages: 487
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Publication
25453257 | J:220764
First Author: Maioli S
Year: 2015
Journal: Aging Cell
Title: Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer's disease.
Volume: 14
Issue: 1
Pages: 122-9
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Publication
18155846 | J:135460
First Author: Lesné S
Year: 2008
Journal: Neuroscience
Title: Plaque-bearing mice with reduced levels of oligomeric amyloid-beta assemblies have intact memory function.
Volume: 151
Issue: 3
Pages: 745-9
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Publication
23276639 | J:197645
 
First Author: Takano M
Year: 2013
Journal: Neurosci Lett
Title: Proteomic analysis of the hippocampus in Alzheimer's disease model mice by using two-dimensional fluorescence difference in gel electrophoresis.
Volume: 534
Pages: 85-9
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Publication
22727275 | J:191605
First Author: Verret L
Year: 2013
Journal: Neurobiol Aging
Title: Transient enriched housing before amyloidosis onset sustains cognitive improvement in Tg2576 mice.
Volume: 34
Issue: 1
Pages: 211-25
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Publication
21873260 | J:296286
First Author: Calkins MJ
Year: 2011
Journal: Hum Mol Genet
Title: Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease.
Volume: 20
Issue: 23
Pages: 4515-29
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Publication
12196559 | J:78748
First Author: Stein TD
Year: 2002
Journal: J Neurosci
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