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Search results 3601 to 3700 out of 4881 for Notch1

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Type Details Score
HT Experiment
E-GEOD-67889 | Sequential Notch activation regulates ventricular chamber development
Series Id: GSE67889
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE69227 | Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B-cell progenitors
Series Id: E-GEOD-69227
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
26876172 | J:235693
First Author: Tesone AJ
Year: 2016
Journal: Cell Rep
Title: Satb1 Overexpression Drives Tumor-Promoting Activities in Cancer-Associated Dendritic Cells.
Volume: 14
Issue: 7
Pages: 1774-1786
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Publication
25301628 | J:217437
First Author: Magnusson JP
Year: 2014
Journal: Science
Title: A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse.
Volume: 346
Issue: 6206
Pages: 237-41
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Publication
33774049 | J:304930
   
First Author: Canalis E
Year: 2021
Journal: J Biol Chem
Title: Activation of Notch3 in osteoblasts/osteocytes causes compartment-specific changes in bone remodeling.
Pages: 100583
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Publication
32908186 | J:306657
First Author: López-López S
Year: 2020
Journal: Sci Rep
Title: NOTCH3 signaling is essential for NF-κB activation in TLR-activated macrophages.
Volume: 10
Issue: 1
Pages: 14839
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Publication
25164209 | J:317772
First Author: Rusanescu G
Year: 2014
Journal: J Cell Mol Med
Title: Notch3 is necessary for neuronal differentiation and maturation in the adult spinal cord.
Volume: 18
Issue: 10
Pages: 2103-16
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Publication
18250475 | J:131973
First Author: Jurynczyk M
Year: 2008
Journal: J Immunol
Title: Notch3 inhibition in myelin-reactive T cells down-regulates protein kinase C theta and attenuates experimental autoimmune encephalomyelitis.
Volume: 180
Issue: 4
Pages: 2634-40
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HT Experiment
E-GEOD-40527 | Expression Analysis of Whole Thymus and Thymic Tumors on the Sdl Mouse Model
Series Id: GSE40527
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE190330 | single cell RNA sequencing of adult (P60) vomeronasal organ
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
28321121 | J:249414
First Author: Kramer AC
Year: 2017
Journal: Leukemia
Title: Dnmt3a regulates T-cell development and suppresses T-ALL transformation.
Volume: 31
Issue: 11
Pages: 2479-2490
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Publication
25658374 | J:244950
First Author: Verhein KC
Year: 2015
Journal: Environ Health Perspect
Title: Novel Roles for Notch3 and Notch4 Receptors in Gene Expression and Susceptibility to Ozone-Induced Lung Inflammation in Mice.
Volume: 123
Issue: 8
Pages: 799-805
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Publication
33665264 | J:307609
 
First Author: Sharma M
Year: 2021
Journal: Data Brief
Title: Transcriptomic data showing differentially expressed genes between Notch3 and Notch4 deleted mice.
Volume: 35
Pages: 106873
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Protein
Q7TPU6
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
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Publication
16530044 | -
First Author: Nam Y
Year: 2006
Journal: Cell
Title: Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
Volume: 124
Issue: 5
Pages: 973-83
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Publication
18758478 | -
First Author: Kovall RA
Year: 2008
Journal: Oncogene
Title: More complicated than it looks: assembly of Notch pathway transcription complexes.
Volume: 27
Issue: 38
Pages: 5099-109
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Publication
18758483 | J:141198
First Author: McElhinny AS
Year: 2008
Journal: Oncogene
Title: Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways.
Volume: 27
Issue: 38
Pages: 5138-47
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Publication
16510869 | J:106711
First Author: Shen H
Year: 2006
Journal: Genes Dev
Title: The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.
Volume: 20
Issue: 6
Pages: 675-88
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Publication
17317671 | -
First Author: Zhao Y
Year: 2007
Journal: J Biol Chem
Title: The notch regulator MAML1 interacts with p53 and functions as a coactivator.
Volume: 282
Issue: 16
Pages: 11969-81
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Publication
17875709 | -
First Author: Alves-Guerra MC
Year: 2007
Journal: Cancer Res
Title: Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival.
Volume: 67
Issue: 18
Pages: 8690-8
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Publication
16880534 | -
First Author: Chiang MY
Year: 2006
Journal: Mol Cell Biol
Title: Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1.
Volume: 26
Issue: 16
Pages: 6261-71
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Publication
19150886 | -
First Author: Liu H
Year: 2009
Journal: Circ Res
Title: NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1.
Volume: 104
Issue: 4
Pages: 466-75
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Publication
15961999 | -
First Author: Wu L
Year: 2005
Journal: EMBO J
Title: Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation.
Volume: 24
Issue: 13
Pages: 2391-402
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Publication
15546612 | -
First Author: Fryer CJ
Year: 2004
Journal: Mol Cell
Title: Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.
Volume: 16
Issue: 4
Pages: 509-20
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Publication
26318021 | J:226412
First Author: Biehl MJ
Year: 2015
Journal: Dev Biol
Title: Rbpj-κ mediated Notch signaling plays a critical role in development of hypothalamic Kisspeptin neurons.
Volume: 406
Issue: 2
Pages: 235-46
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Publication
3119223 | -
First Author: Kelley MR
Year: 1987
Journal: Cell
Title: Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus.
Volume: 51
Issue: 4
Pages: 539-48
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Publication
7697721 | -
First Author: Lindsell CE
Year: 1995
Journal: Cell
Title: Jagged: a mammalian ligand that activates Notch1.
Volume: 80
Issue: 6
Pages: 909-17
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Publication
36356552 | J:360070
 
First Author: Ren K
Year: 2022
Journal: J Autoimmun
Title: Notch signaling dependent monocyte conversion alleviates immune-mediated neuropathies by regulating RBP-J/NR4A1 axis.
Volume: 133
Pages: 102945
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Publication
33609440 | J:309291
First Author: Machado L
Year: 2021
Journal: Cell Stem Cell
Title: Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation.
Volume: 28
Issue: 6
Pages: 1125-1135.e7
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Publication
27993983 | J:238419
First Author: Wang C
Year: 2017
Journal: Development
Title: Ascl2 inhibits myogenesis by antagonizing the transcriptional activity of myogenic regulatory factors.
Volume: 144
Issue: 2
Pages: 235-247
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Publication
21781958 | J:176609
First Author: Goldberg LB
Year: 2011
Journal: Dev Biol
Title: Persistent expression of activated Notch inhibits corticotrope and melanotrope differentiation and results in dysfunction of the HPA axis.
Volume: 358
Issue: 1
Pages: 23-32
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Strain
MGI:3703350 | STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
Attribute String: transgenic, mutant stock
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Publication
- | J:119129
     
First Author: Liu J
Year: 2007
Journal: MGI Direct Data Submission
Title: Constitutive notch signaling in adult transgenic mice inhibits bFGF-induced angiogenesis and blocks ovarian follicle development
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Genotype
Genotype
Symbol: Hey1/Hey1 Mesp1/Mesp1<+> Tg(CAG-cat,-Notch1)1Ysa/?
Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Shh/Shh<+>
Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Pdx1-cre/Esr1*)35.10Dam/?
Background: involves: 129S4/SvJae * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Neurog3-cre/Esr1*)1Dam/?
Background: involves: 129S4/SvJae * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Mx1-cre)1Cgn/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Hes1/Hes1<+>
Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Notch1/Notch1
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Wt1-cre)#Jbeb/?
Background: involves: 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Six2/Six2<+>
Background: involves: 129S4/SvJaeSor * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Neurog3-cre/ERT2)1Able/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Col1a1-cre)1Kry/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Six3-cre)69Frty/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Protein Coding Gene
MGI:1098280 | Crebbp
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P45481
Organism: Mus musculus/domesticus
Length: 2441  
Fragment?: false
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Publication
23477786 | J:196361
First Author: Cappellari O
Year: 2013
Journal: Dev Cell
Title: Dll4 and PDGF-BB convert committed skeletal myoblasts to pericytes without erasing their myogenic memory.
Volume: 24
Issue: 6
Pages: 586-99
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Publication
29101245 | J:251141
First Author: Kawai H
Year: 2017
Journal: J Neurosci
Title: Area-Specific Regulation of Quiescent Neural Stem Cells by Notch3 in the Adult Mouse Subependymal Zone.
Volume: 37
Issue: 49
Pages: 11867-11880
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Protein
E9Q6E8
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Protein
Q69Z97
Organism: Mus musculus/domesticus
Length: 826  
Fragment?: true
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Protein
F6UY95
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: true
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Protein
Q8BMG4
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
Q5U409
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
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Protein
Q6ZPH8
Organism: Mus musculus/domesticus
Length: 443  
Fragment?: true
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Protein
Q3TZA9
Organism: Mus musculus/domesticus
Length: 500  
Fragment?: true
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Protein
Q810L0
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
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Protein
E9Q7L5
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Publication
12050117 | -
First Author: Fryer CJ
Year: 2002
Journal: Genes Dev
Title: Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex.
Volume: 16
Issue: 11
Pages: 1397-411
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Protein Domain
IPR000800 | Notch_dom
Type: Domain
Description: The Notch domain is also called the 'DSL' domain or the Lin-12/Notch repeat (LNR). The LNR region is present only in Notch related proteins C-terminal to EGF repeats. The lin-12/Notch proteins act as transmembrane receptors for intercellular signals that specify cell fates during animal development. In response to a ligand, proteolytic cleavages release the intracellular domain of Notch, which then gains access to the nucleus and acts as a transcriptional co-activator []. The LNR region is supposed to negatively regulate the Lin-12/Notch proteins activity. It is a triplication of an around 35-40 amino acids module present on the extracellular part of the protein [, ]. Each module contains six cysteine residues engaged in three disulphide bonds and three conserved aspartate and asparagine residues []. The biochemical characterisation of a recombinantly expressed LIN-12.1 module from the human Notch1 receptor indicate that the disulphide bonds are formed between the firstand fifth, second and fourth, and third and sixth cysteines. The formation of this particular disulphide isomer is favored by the presence of Ca2+,which is also required to maintain the structural integrity of the rLIN-12.1 module. The conserved aspartate and asparagine residues are likely to be important for Ca2+binding, and thereby contribute to the native fold.
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Protein Domain
IPR046370 | MAML_N_sf
Type: Homologous_superfamily
Description: This entry represents the N-terminal domain found in a family of neurogenic mastermind-like proteins (MAMLs), which act as critical transcriptional co-activators for Notch signaling [, , ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.The N-terminal domain of MAML proteins adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors []. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
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Protein Domain
IPR046369 | MAML1-3
Type: Family
Description: This family includes the neurogenic mastermind-like proteins 1-3 (MAML1-3) from chordates, which act as critical transcriptional co-activators for Notch signaling [, ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.They consist of an N-terminal domain which adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors [, ]]. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
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Protein Domain
IPR019082 | Mastermind-like_N
Type: Domain
Description: This entry represents the N-terminal domain found in a family of neurogenic mastermind-like proteins (MAMLs), which act as critical transcriptional co-activators for Notch signaling [, , ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.The N-terminal domain of MAML proteins adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors []. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
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Protein Domain
IPR035993 | Notch-like_dom_sf
Type: Homologous_superfamily
Description: The Notch domain is also called the 'DSL' domain or the Lin-12/Notch repeat (LNR). The LNR region is present only in Notch related proteins C-terminal to EGF repeats. The lin-12/Notch proteins act as transmembrane receptors for intercellular signals that specify cell fates during animal development. In response to a ligand, proteolytic cleavages release the intracellular domain of Notch, which then gains access to the nucleus and acts as a transcriptional co-activator []. The LNR region is supposed to negatively regulate the Lin-12/Notch proteins activity. It is a triplication of an around 35-40 amino acids module present on the extracellular part of the protein [, ]. Each module contains six cysteine residues engaged in three disulphide bonds and three conserved aspartate and asparagine residues []. The biochemical characterisation of a recombinantly expressed LIN-12.1 module from the human Notch1 receptor indicate that the disulphide bonds are formed between the firstand fifth, second and fourth, and third and sixth cysteines. The formation of this particular disulphide isomer is favored by the presence of Ca2+, which is also required to maintain the structural integrity of the rLIN-12.1 module. The conserved aspartate and asparagine residues are likely to be important for Ca2+binding, and thereby contribute to the native fold.
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HT Experiment
GSE110614 | Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
20960513 | J:168858
First Author: Kitamoto T
Year: 2010
Journal: Stem Cells
Title: Notch3 null mutation in mice causes muscle hyperplasia by repetitive muscle regeneration.
Volume: 28
Issue: 12
Pages: 2205-16
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Publication
18927153 | J:143587
First Author: Tang H
Year: 2008
Journal: Development
Title: Notch signaling maintains Leydig progenitor cells in the mouse testis.
Volume: 135
Issue: 22
Pages: 3745-53
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Publication
29780306 | J:264391
 
First Author: McGovern MM
Year: 2018
Journal: Front Cell Neurosci
Title: Spontaneous Hair Cell Regeneration Is Prevented by Increased Notch Signaling in Supporting Cells.
Volume: 12
Pages: 120
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Publication
28215940 | J:241013
First Author: Grassmeyer J
Year: 2017
Journal: Dev Biol
Title: Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression.
Volume: 424
Issue: 1
Pages: 77-89
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Publication
18676808 | J:139492
First Author: Jeon HM
Year: 2008
Journal: Genes Dev
Title: Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling.
Volume: 22
Issue: 15
Pages: 2028-33
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Publication
12753744 | J:83476
First Author: Saito T
Year: 2003
Journal: Immunity
Title: Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development.
Volume: 18
Issue: 5
Pages: 675-85
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Publication
8573724 | J:29516
First Author: Mallo M
Year: 1995
Journal: Dev Dyn
Title: Protein characterization and targeted disruption of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex.
Volume: 204
Issue: 3
Pages: 338-47
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Publication
21478879 | J:172130
First Author: Rathinam C
Year: 2011
Journal: Nat Immunol
Title: The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells.
Volume: 12
Issue: 5
Pages: 399-407
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Publication
15288263 | J:92119
First Author: Lefort K
Year: 2004
Journal: Semin Cancer Biol
Title: Notch signaling in the integrated control of keratinocyte growth/differentiation and tumor suppression.
Volume: 14
Issue: 5
Pages: 374-86
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Publication
16612405 | J:114914
First Author: Grabher C
Year: 2006
Journal: Nat Rev Cancer
Title: Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia.
Volume: 6
Issue: 5
Pages: 347-59
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Publication
25564622 | J:238903
First Author: Mori M
Year: 2015
Journal: Development
Title: Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors.
Volume: 142
Issue: 2
Pages: 258-67
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Protein Coding Gene
MGI:1276116 | Ep300
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
B2RWS6
Organism: Mus musculus/domesticus
Length: 2412  
Fragment?: false
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Publication
8139658 | -
First Author: Tax FE
Year: 1994
Journal: Nature
Title: Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila.
Volume: 368
Issue: 6467
Pages: 150-4
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Allele
Notch4<tm1Grid> | MGI:1929139
 
Name: notch 4; targeted mutation 1, Tom Gridley
Allele Type: Targeted
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Publication
29085372 | J:360068
 
First Author: Huang F
Year: 2017
Journal: Front Immunol
Title: miR-148a-3p Mediates Notch Signaling to Promote the Differentiation and M1 Activation of Macrophages.
Volume: 8
Pages: 1327
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Publication
29644573 | J:326307
First Author: Jiang Y
Year: 2019
Journal: Protein Cell
Title: Myeloid-specific targeting of Notch ameliorates murine renal fibrosis via reduced infiltration and activation of bone marrow-derived macrophage.
Volume: 10
Issue: 3
Pages: 196-210
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Publication
30105024 | J:278727
 
First Author: Lin Y
Year: 2018
Journal: Front Immunol
Title: Notch Signaling Modulates Macrophage Polarization and Phagocytosis Through Direct Suppression of Signal Regulatory Protein α Expression.
Volume: 9
Pages: 1744
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Publication
25429074 | J:230688
First Author: Nakamura M
Year: 2015
Journal: J Immunol
Title: A genome-wide analysis identifies a notch-RBP-Jκ-IL-7Rα axis that controls IL-17-producing γδ T cell homeostasis in mice.
Volume: 194
Issue: 1
Pages: 243-51
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Strain
MGI:3044664 | B6.Cg-Tg(Nes-cre)1Kln Tg(ACTB-NOTCH1)1Shn
Attribute String: congenic, mutant stock, transgenic
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Publication
22991339 | J:233259
First Author: Chen S
Year: 2013
Journal: J Bone Miner Res
Title: Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression of Sox9.
Volume: 28
Issue: 3
Pages: 649-59
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Publication
23520387 | J:195278
First Author: Yanger K
Year: 2013
Journal: Genes Dev
Title: Robust cellular reprogramming occurs spontaneously during liver regeneration.
Volume: 27
Issue: 7
Pages: 719-24
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Publication
20299358 | J:185844
First Author: Fujimura S
Year: 2010
Journal: J Am Soc Nephrol
Title: Notch2 activation in the embryonic kidney depletes nephron progenitors.
Volume: 21
Issue: 5
Pages: 803-10
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Publication
23748444 | J:204568
First Author: Maddaluno L
Year: 2013
Journal: Nature
Title: EndMT contributes to the onset and progression of cerebral cavernous malformations.
Volume: 498
Issue: 7455
Pages: 492-6
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Allele
Gt(ROSA)26Sor<tm9(CAG-mEYFP*,-tdTomato*,-Notch1*,-mKate2*,-Rbpj*)Ben> | MGI:6761546
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 9, Rui Benedito
Allele Type: Targeted
Attribute String: Conditional ready, Epitope tag, Inserted expressed sequence, Reporter
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Allele
Gt(ROSA)26Sor<tm8(CAG-EYFP*,-mCherry*,-EGFP*,-Maml1*,-mCerulean*,-Notch1*)Ben> | MGI:6761439
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 8, Rui Benedito
Allele Type: Targeted
Attribute String: Conditional ready, Epitope tag, Inserted expressed sequence, Reporter
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Pdx1-cre)89.1Dam/?
Background: involves: 129S4/SvJae * C57BL/6 * ICR
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Nes-cre)1Kln/? Tg(ACTB-NOTCH1)1Shn/?
Background: B6.Cg-Tg(Nes-cre)1Kln Tg(ACTB-NOTCH1)1Shn
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Actb-NOTCH1)2Shn/? Tg(Nes-cre)1Kln/?
Background: involves: C57BL/6J * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(ACTB-NOTCH1)1Shn/? Tg(Syn1-cre)671Jxm/?
Background: involves: C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(ACTB-NOTCH1)1Shn/? Tg(Nes-cre/Esr1*)4Ynj/?
Background: involves: C57BL/6 * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mesp1/Mesp1<+> Rbpj/Rbpj Tg(CAG-cat,-Notch1)1Ysa/?
Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mesp1/Mesp1<+> Pofut1/Pofut1 Tg(CAG-cat,-Notch1)1Ysa/?
Background: involves: C3H * C57BL/6 * CBA * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kras/Kras Tg(Pdx1-cre/Esr1*)35.10Dam/?
Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kras/Kras Tg(Cela1-cre/ERT)1Dam/?
Background: involves: 129S4/SvJae * 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
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