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Search results 3601 to 3700 out of 8321 for Src

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Hits by Pathway

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Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Shc1/Shc1
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shc1/Shc1
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shc1/Shc1
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shc1/Shc1
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shc1/Shc1
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shb/Shb
Background: B6.129X1-Shb
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shb/Shb
Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: involves: 129S4/SvJae
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: involves: 129S1/Sv
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fgr/Fgr
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: B6.129S4-Lyn
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fgr/Fgr
Background: B6.129S7-Fgr
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: involves: 129S4/SvJaeSor
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: B6.129P2-Lyn
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fgr/Fgr
Background: involves: 129S7/SvEvBrd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: involves: 129S4/SvJaeSor * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: C57BL/6JAnu-Lyn
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: C57B/6JAnu-Lyn/AnuApb
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Srcin1/Srcin1
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: C57BL/6N-Lyn/H
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Srcin1/Srcin1<+>
Background: C57BL/6N-Srcin1/J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Stac/Stac
Background: C57BL/6NJ-Stac/Mmjax
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Srcin1/Srcin1 Tg(dlx5a-cre)1Mekk/?
Background: involves: CD-1
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn
Background: involves: 129S4/SvJaeSor * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Publication
12709437 | -
First Author: Maeno K
Year: 2003
Journal: J Biol Chem
Title: Adaptor protein 3BP2 is a potential ligand of Src homology 2 and 3 domains of Lyn protein-tyrosine kinase.
Volume: 278
Issue: 27
Pages: 24912-20
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Publication
15297464 | -
First Author: Rohde CM
Year: 2004
Journal: J Biol Chem
Title: A juxtamembrane tyrosine in the colony stimulating factor-1 receptor regulates ligand-induced Src association, receptor kinase function, and down-regulation.
Volume: 279
Issue: 42
Pages: 43448-61
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Publication
11698646 | -
First Author: Okazaki T
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine.
Volume: 98
Issue: 24
Pages: 13866-71
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Publication
8530369 | -
First Author: Sotirellis N
Year: 1995
Journal: J Biol Chem
Title: Autophosphorylation induces autoactivation and a decrease in the Src homology 2 domain accessibility of the Lyn protein kinase.
Volume: 270
Issue: 50
Pages: 29773-80
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Publication
21296879 | -
First Author: von Holleben M
Year: 2011
Journal: J Biol Chem
Title: Immunoinhibitory adapter protein Src homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading.
Volume: 286
Issue: 15
Pages: 13489-501
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Publication
15919751 | -
First Author: Trevaskis J
Year: 2005
Journal: Endocrinology
Title: Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance.
Volume: 146
Issue: 9
Pages: 3757-64
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Publication
16857672 | -
First Author: Li X
Year: 2006
Journal: J Biol Chem
Title: Structural basis of Robo proline-rich motif recognition by the srGAP1 Src homology 3 domain in the Slit-Robo signaling pathway.
Volume: 281
Issue: 38
Pages: 28430-7
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Publication
13129930 | -
First Author: Kaneko T
Year: 2003
Journal: J Biol Chem
Title: Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain.
Volume: 278
Issue: 48
Pages: 48162-8
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Publication
17409413 | -
First Author: Fagiani E
Year: 2007
Journal: Cancer Res
Title: RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas.
Volume: 67
Issue: 7
Pages: 3064-73
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Publication
16326715 | -
First Author: Ogura K
Year: 2006
Journal: J Biol Chem
Title: NMR solution structure of the tandem Src homology 3 domains of p47phox complexed with a p22phox-derived proline-rich peptide.
Volume: 281
Issue: 6
Pages: 3660-8
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Publication
21505067 | -
First Author: Yamamoto H
Year: 2011
Journal: Plant Cell
Title: An Src homology 3 domain-like fold protein forms a ferredoxin binding site for the chloroplast NADH dehydrogenase-like complex in Arabidopsis.
Volume: 23
Issue: 4
Pages: 1480-93
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Publication
20457612 | -
First Author: Sugden C
Year: 2010
Journal: J Biol Chem
Title: Two novel Src homology 2 domain proteins interact to regulate dictyostelium gene expression during growth and early development.
Volume: 285
Issue: 30
Pages: 22927-35
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Publication
10781592 | -
First Author: Lim RW
Year: 2000
Journal: J Biol Chem
Title: Regulated association of microtubule-associated protein 2 (MAP2) with Src and Grb2: evidence for MAP2 as a scaffolding protein.
Volume: 275
Issue: 27
Pages: 20578-87
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Publication
15834155 | -
First Author: Solomaha E
Year: 2005
Journal: J Biol Chem
Title: Kinetics of Src homology 3 domain association with the proline-rich domain of dynamins: specificity, occlusion, and the effects of phosphorylation.
Volume: 280
Issue: 24
Pages: 23147-56
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Publication
15007077 | -
First Author: Hori T
Year: 2004
Journal: J Biol Chem
Title: Structural basis of leukotriene B4 12-hydroxydehydrogenase/15-Oxo-prostaglandin 13-reductase catalytic mechanism and a possible Src homology 3 domain binding loop.
Volume: 279
Issue: 21
Pages: 22615-23
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Publication
11279199 | -
First Author: Chang BY
Year: 2001
Journal: J Biol Chem
Title: The interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1.
Volume: 276
Issue: 23
Pages: 20346-56
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Publication
9750131 | -
First Author: Ohba T
Year: 1998
Journal: Anal Biochem
Title: Dot far-western blot analysis of relative binding affinities of the Src homology 3 domains of Efs and its related proteins.
Volume: 262
Issue: 2
Pages: 185-92
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Publication
11369760 | -
First Author: Li R
Year: 2001
Journal: J Biol Chem
Title: CD44-initiated cell spreading induces Pyk2 phosphorylation, is mediated by Src family kinases, and is negatively regulated by CD45.
Volume: 276
Issue: 31
Pages: 28767-73
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Publication
11805080 | -
First Author: Cao H
Year: 2002
Journal: J Biol Chem
Title: A phosphotyrosine-dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: recruitment of C-terminal Src kinase.
Volume: 277
Issue: 11
Pages: 8771-4
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Publication
19746159 | -
First Author: Quack T
Year: 2009
Journal: PLoS One
Title: The formin-homology protein SmDia interacts with the Src kinase SmTK and the GTPase SmRho1 in the gonads of Schistosoma mansoni.
Volume: 4
Issue: 9
Pages: e6998
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Publication
16628251 | J:108942
First Author: Huber TB
Year: 2006
Journal: J Clin Invest
Title: Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin.
Volume: 116
Issue: 5
Pages: 1337-45
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Publication
34010642 | J:339733
First Author: Okubo K
Year: 2021
Journal: Cell Rep
Title: Inhibitory affinity modulation of FcγRIIA ligand binding by glycosphingolipids by inside-out signaling.
Volume: 35
Issue: 7
Pages: 109142
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Publication
10611342 | J:119839
First Author: Ho LH
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B.
Volume: 96
Issue: 26
Pages: 15086-90
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Publication
7499277 | J:29834
First Author: Katagiri T
Year: 1995
Journal: J Biol Chem
Title: Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells.
Volume: 270
Issue: 47
Pages: 27987-90
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Publication
20004975 | J:158448
First Author: Kettner A
Year: 2010
Journal: Mol Immunol
Title: Insulin potentiates FcepsilonRI-mediated signaling in mouse bone marrow-derived mast cells.
Volume: 47
Issue: 5
Pages: 1039-46
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Publication
22262902 | J:179886
First Author: Chen YK
Year: 2012
Journal: J Neurosci
Title: Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance.
Volume: 32
Issue: 3
Pages: 1043-55
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Publication
31320558 | J:283622
 
First Author: Wang L
Year: 2019
Journal: Science
Title: Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses.
Volume: 365
Issue: 6454
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Publication
30495987 | J:283722
First Author: Shi Y
Year: 2018
Journal: FASEB J
Title: Elevating ATP-binding cassette transporter G1 improves re-endothelialization function of endothelial progenitor cells via Lyn/Akt/eNOS in diabetic mice.
Volume: 32
Issue: 12
Pages: 6525-6536
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Publication
14698816 | J:87700
First Author: Liang H
Year: 2003
Journal: Exp Gerontol
Title: Genetic mouse models of extended lifespan.
Volume: 38
Issue: 11-12
Pages: 1353-64
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Protein Coding Gene
MGI:96756 | Lck
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
8812416 | J:34242
First Author: Sun DS
Year: 1996
Journal: Genomics
Title: Identification, molecular characterization, and chromosomal localization of the cDNA encoding a novel leucine zipper motif-containing protein.
Volume: 36
Issue: 1
Pages: 54-62
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Publication
9261404 | J:42241
First Author: Valk PJ
Year: 1997
Journal: J Virol
Title: The genes encoding the peripheral cannabinoid receptor and alpha-L-fucosidase are located near a newly identified common virus integration site, Evi11.
Volume: 71
Issue: 9
Pages: 6796-804
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Publication
15467833 | J:93419
First Author: Abou-Rjaily GA
Year: 2004
Journal: J Clin Invest
Title: CEACAM1 modulates epidermal growth factor receptor--mediated cell proliferation.
Volume: 114
Issue: 7
Pages: 944-52
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Publication
11756549 | J:76630
First Author: Feng Q
Year: 2002
Journal: Mol Cell Biol
Title: Identification and functional characterization of the p66/p68 components of the MeCP1 complex.
Volume: 22
Issue: 2
Pages: 536-46
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Publication
10068665 | J:127946
First Author: Lucas DM
Year: 1999
Journal: Blood
Title: A novel spliced form of SH2-containing inositol phosphatase is expressed during myeloid development.
Volume: 93
Issue: 6
Pages: 1922-33
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Publication
10086341 | J:53892
First Author: Schmandt R
Year: 1999
Journal: Oncogene
Title: Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells.
Volume: 18
Issue: 10
Pages: 1867-79
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Publication
27789474 | J:249234
First Author: Li Q
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1.
Volume: 36
Issue: 12
Pages: 2394-2403
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Publication
28641114 | J:253234
First Author: Li MY
Year: 2017
Journal: Neuron
Title: A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex.
Volume: 94
Issue: 6
Pages: 1155-1172.e8
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Publication
31207271 | J:279032
 
First Author: Jiang W
Year: 2019
Journal: Mol Cell Endocrinol
Title: Klotho inhibits PKCα/p66SHC-mediated podocyte injury in diabetic nephropathy.
Volume: 494
Pages: 110490
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Publication
25153088 | J:212898
First Author: Buckley MW
Year: 2014
Journal: PLoS One
Title: Unexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation.
Volume: 9
Issue: 8
Pages: e105576
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Publication
20824186 | J:165021
 
First Author: Königsberger S
Year: 2010
Journal: PLoS One
Title: HPK1 associates with SKAP-HOM to negatively regulate Rap1-mediated B-lymphocyte adhesion.
Volume: 5
Issue: 9
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Publication
9199344 | J:326666
First Author: Harmer SL
Year: 1997
Journal: Mol Cell Biol
Title: Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes.
Volume: 17
Issue: 7
Pages: 4087-95
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Publication
8776723 | J:327403
First Author: Dey BR
Year: 1996
Journal: Mol Endocrinol
Title: Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10.
Volume: 10
Issue: 6
Pages: 631-41
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Publication
14502564 | J:85624
First Author: Gagnon A
Year: 2003
Journal: J Cell Physiol
Title: Regulation of endogenous SH2 domain-containing inositol 5-phosphatase (SHIP2) in 3T3-L1 and human preadipocytes.
Volume: 197
Issue: 2
Pages: 243-50
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Publication
11259577 | J:277874
First Author: Valverde AM
Year: 2001
Journal: Mol Cell Biol
Title: Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis.
Volume: 21
Issue: 7
Pages: 2269-80
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Publication
7529871 | J:200360
First Author: Ravichandran KS
Year: 1995
Journal: Mol Cell Biol
Title: Interaction of Shc with Grb2 regulates association of Grb2 with mSOS.
Volume: 15
Issue: 2
Pages: 593-600
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Publication
8101647 | J:13198
First Author: Segatto O
Year: 1993
Journal: Oncogene
Title: Shc products are substrates of erbB-2 kinase.
Volume: 8
Issue: 8
Pages: 2105-12
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Publication
15837797 | J:98081
First Author: Smith WW
Year: 2005
Journal: J Cell Biol
Title: Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity.
Volume: 169
Issue: 2
Pages: 331-9
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Publication
10486198 | J:304002
First Author: Yuen EC
Year: 1999
Journal: Exp Neurol
Title: Early BDNF, NT-3, and NT-4 signaling events.
Volume: 159
Issue: 1
Pages: 297-308
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Publication
23832324 | J:315504
First Author: Xiong Y
Year: 2013
Journal: J Am Heart Assoc
Title: Arginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability.
Volume: 2
Issue: 4
Pages: e000096
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Publication
25147340 | J:318252
First Author: Vikram A
Year: 2014
Journal: Arterioscler Thromb Vasc Biol
Title: Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species.
Volume: 34
Issue: 10
Pages: 2301-9
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Publication
27385725 | J:321237
First Author: Edwards NA
Year: 2016
Journal: Mol Hum Reprod
Title: P66Shc, a key regulator of metabolism and mitochondrial ROS production, is dysregulated by mouse embryo culture.
Volume: 22
Issue: 9
Pages: 634-47
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Publication
8890164 | J:169817
First Author: Cloutier JF
Year: 1996
Journal: EMBO J
Title: Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.
Volume: 15
Issue: 18
Pages: 4909-18
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Publication
11707404 | J:73038
First Author: Ong SH
Year: 2001
Journal: EMBO J
Title: ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation.
Volume: 20
Issue: 22
Pages: 6327-36
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Publication
19798056 | J:154710
First Author: Liu NS
Year: 2009
Journal: EMBO J
Title: Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor.
Volume: 28
Issue: 22
Pages: 3485-99
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Publication
16872848 | J:113463
First Author: Hirahashi J
Year: 2006
Journal: Immunity
Title: Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy.
Volume: 25
Issue: 2
Pages: 271-83
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Publication
10428862 | J:56679
First Author: Lock P
Year: 1999
Journal: J Biol Chem
Title: Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck.
Volume: 274
Issue: 32
Pages: 22775-84
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Strain
MGI:6331748 | B6;129-Lyn<tm1Ard> Tg(IghelMD4)4Ccg/AnuApb
Attribute String: mutant strain, targeted mutation, transgenic
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Genotype
Genotype
Symbol: Fyn/Fyn Yes1/Yes1
Background: involves: 129S7/SvEvBrd
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Il5ra/Il5ra Lyn/Lyn
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shc1/Shc1 Tg(Nes-cre)1Kln/?
Background: involves: 129 * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shc1/Shc1 Tg(Lck-cre)1Cwi/?
Background: involves: 129 * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn Tg(IghelMD4)4Ccg/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Src/Src Yes1/Yes1
Background: involves: 129S7/SvEvBrd
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shc1/Shc1 Tg(MMTV-PyVT)634Mul/?
Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shc1/Shc1 Tg(MMTV-PyVT)634Mul/?
Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shc1/Shc1 Tg(MMTV-Erbb2*,-cre)1Mul/?
Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kit/Kit Lyn/Lyn
Background: involves: 101 * 129P2/OlaHsd * C3H/HeH
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Il4/Il4 Lyn/Lyn
Background: involves: 129P2/OlaHsd * 129S2/SvPas
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd19/Cd19 Lyn/Lyn
Background: involves: 129S4/SvJaeSor * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn Tg(Itgax-cre)1-1Reiz/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn<+>
Background: C57BL/6J-Lyn
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lyn/Lyn<+>
Background: C57BL/6J-Lyn
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Srcin1/Srcin1<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Skap2/Skap2<+>
Background: involves: C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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