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Search results 3701 to 3800 out of 4701 for Bcl2

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Type Details Score
Publication
17157251 | -
First Author: Moldoveanu T
Year: 2006
Journal: Mol Cell
Title: The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site.
Volume: 24
Issue: 5
Pages: 677-88
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Publication
8521816 | J:43660
First Author: Chittenden T
Year: 1995
Journal: EMBO J
Title: A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.
Volume: 14
Issue: 22
Pages: 5589-96
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Protein Domain
IPR026304 | BAX
Type: Family
Description: B cell CLL/lymphoma-2 (Bcl-2) and related proteins comprise the Bcl-2 family. Bcl-2 proteins are central regulators of caspase activation, and play a key role in cell death by regulating the integrity of the mitochondrial and endoplasmic reticulum (ER) membranes []. Though originally characterised with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis, the members of the Bcl-2 family are involved in numerous cellular pathways [].Bcl-2 and its relatives are functionally classified as either antiapoptoticor proapoptotic. All members contain at least one of four conserved motifs, termed Bcl-2 Homology (BH) domains. Antiapoptotic BCL-2 proteins contain four Bcl-2 homology domains (BH1-4). The major antiapoptotic proteins are Bcl-2-related gene A1 (A1), Bcl-2, Bcl-2-related gene, long isoform (Bcl-xL), Bcl-w, and myeloid cell leukemia 1 (MCL-1). They preserve outer mitochondrial membrane (OMM) integrity by directly inhibiting the proapoptotic Bcl-2 proteins [].The proapoptotic Bcl-2 members are divided into the effector proteins and the BH3-only proteins. The effector proteins Bcl-2 antagonist killer 1 (BAK) and Bcl-2-associated x protein (BAX) were originally described to contain only BH1-3; however, structure-based alignments revealed a conserved BH4 motif []. Upon activation BAK and BAX homo-oligomerise into proteolipid pores within the OMM to promote MOMP (mitochondrial outer membrane permeabilisation). The BH3-only proteins function in distinct cellular stress scenarios and are subdivided based on their ability to interact with the antiapoptotic or both the antiapoptotic and the effector proteins [].Bcl-2-associated x protein (BAX) is a proapoptotic member of the Bcl-2 family. It accelerates programmed cell death by binding to, and antagonising the apoptosis repressor Bcl2 [, ].
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Protein Domain
IPR026308 | BAK
Type: Family
Description: B cell CLL/lymphoma-2 (Bcl-2) and related proteins comprise the Bcl-2 family. Bcl-2 proteins are central regulators of caspase activation, and play a key role in cell death by regulating the integrity of the mitochondrial and endoplasmic reticulum (ER) membranes []. Though originally characterised with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis, the members of the Bcl-2 family are involved in numerous cellular pathways [].Bcl-2 and its relatives are functionally classified as either antiapoptoticor proapoptotic. All members contain at least one of four conserved motifs, termed Bcl-2 Homology (BH) domains. Antiapoptotic BCL-2 proteins contain four Bcl-2 homology domains (BH1-4). The major antiapoptotic proteins are Bcl-2-related gene A1 (A1), Bcl-2, Bcl-2-related gene, long isoform (Bcl-xL), Bcl-w, and myeloid cell leukemia 1 (MCL-1). They preserve outer mitochondrial membrane (OMM) integrity by directly inhibiting the proapoptotic Bcl-2 proteins [].The proapoptotic Bcl-2 members are divided into the effector proteins and the BH3-only proteins. The effector proteins Bcl-2 antagonist killer 1 (BAK) and Bcl-2-associated x protein (BAX) were originally described to contain only BH1-3;however, structure-based alignments revealed a conserved BH4 motif []. Upon activation BAK and BAX homo-oligomerise into proteolipid pores within the OMM to promote MOMP (mitochondrial outer membrane permeabilisation). The BH3-only proteins function in distinct cellular stress scenarios and are subdivided based on their ability to interact with the antiapoptotic or both the antiapoptotic and the effector proteins [].Bcl-2 homologue antagonist/killer (BAK) is a proapoptotic member of the Bcl-2 family. In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of Bcl2 or its adenovirus homologue E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis [, ].
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Protein Domain
IPR002475 | Bcl2-like
Type: Family
Description: B cell CLL/lymphoma-2 (Bcl-2) and related proteins comprise the Bcl-2 family. Bcl-2 proteins are central regulators of caspase activation, and play a key role in cell death by regulating the integrity of the mitochondrial and endoplasmic reticulum (ER) membranes []. Though originally characterised with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis, the members of the Bcl-2 family are involved in numerous cellular pathways [].Bcl-2 and its relatives are functionally classified as either antiapoptoticor proapoptotic. All members contain at least one of four conserved motifs, termed Bcl-2 Homology (BH) domains. Antiapoptotic BCL-2 proteins contain four Bcl-2 homology domains (BH1-4). The major antiapoptotic proteins are Bcl-2-related gene A1 (A1), Bcl-2, Bcl-2-related gene, long isoform (Bcl-xL), Bcl-w, and myeloid cell leukemia 1 (MCL-1). They preserve outer mitochondrial membrane (OMM) integrity by directly inhibiting the proapoptotic Bcl-2 proteins [].The proapoptotic Bcl-2 members are divided into the effector proteins and the BH3-only proteins. The effector proteins Bcl-2 antagonist killer 1 (BAK) and Bcl-2-associated x protein (BAX) were originally described to contain only BH1-3; however, structure-based alignments revealed a conserved BH4 motif []. Upon activation BAK and BAX homo-oligomerise into proteolipid pores within the OMM to promote MOMP (mitochondrial outer membrane permeabilisation). The BH3-only proteins function in distinct cellular stress scenarios and are subdivided based on their ability to interact with the antiapoptotic or both the antiapoptotic and the effector proteins [].This entry represents the Bcl2 family and related proteins, including E1B 19K protein (also known as E1B protein, small T-antigen), which is a putative adenovirus Bcl-2 homologue that inhibits E1A induced apoptosis and hence prolongs the viability of the host cell.
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Publication
10591178 | J:110760
First Author: Torres RM
Year: 1999
Journal: Immunity
Title: A negative regulatory role for Ig-alpha during B cell development.
Volume: 11
Issue: 5
Pages: 527-36
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Publication
22912588 | J:188127
First Author: Zhu X
Year: 2012
Journal: PLoS Genet
Title: Mutations in a P-type ATPase gene cause axonal degeneration.
Volume: 8
Issue: 8
Pages: e1002853
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Publication
20133598 | J:157579
First Author: Suzuki A
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs.
Volume: 107
Issue: 8
Pages: 3594-9
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Publication
17218525 | J:117301
First Author: Melichar HJ
Year: 2007
Journal: Science
Title: Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13.
Volume: 315
Issue: 5809
Pages: 230-3
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Publication
27811852 | J:242727
 
First Author: Imagawa Y
Year: 2016
Journal: Nat Commun
Title: Vital staining for cell death identifies Atg9a-dependent necrosis in developmental bone formation in mouse.
Volume: 7
Pages: 13391
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Publication
12952892 | J:85569
First Author: Shibue T
Year: 2003
Journal: Genes Dev
Title: Integral role of Noxa in p53-mediated apoptotic response.
Volume: 17
Issue: 18
Pages: 2233-8
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Publication
19168892 | J:149703
First Author: Whitney IE
Year: 2009
Journal: Invest Ophthalmol Vis Sci
Title: Multiple genes on chromosome 7 regulate dopaminergic amacrine cell number in the mouse retina.
Volume: 50
Issue: 5
Pages: 1996-2003
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Publication
33369168 | J:336944
First Author: Soria LR
Year: 2021
Journal: EMBO Mol Med
Title: Beclin-1-mediated activation of autophagy improves proximal and distal urea cycle disorders.
Volume: 13
Issue: 2
Pages: e13158
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Publication
9450996 | J:110608
First Author: Newton K
Year: 1998
Journal: EMBO J
Title: A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes.
Volume: 17
Issue: 3
Pages: 706-18
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Publication
16764695 | J:129290
First Author: Mastache EF
Year: 2006
Journal: Scand J Immunol
Title: Somatic hypermutation of Ig genes is affected differently by failures in apoptosis caused by disruption of Fas (lpr mutation) or by overexpression of Bcl-2.
Volume: 63
Issue: 6
Pages: 420-9
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Publication
20554953 | J:161936
First Author: Aït-Azzouzene D
Year: 2010
Journal: J Immunol
Title: Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice.
Volume: 185
Issue: 2
Pages: 1015-27
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Publication
16472596 | J:124922
First Author: Bernal NP
Year: 2006
Journal: Gastroenterology
Title: Epidermal growth factor receptor signaling regulates Bax and Bcl-w expression and apoptotic responses during intestinal adaptation in mice.
Volume: 130
Issue: 2
Pages: 412-23
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Publication
31019259 | J:298414
First Author: Wirasinha RC
Year: 2019
Journal: Cell Death Differ
Title: Deletion of self-reactive CCR7- thymocytes in the absence of MHC expression on thymic epithelial cells.
Volume: 26
Issue: 12
Pages: 2727-2739
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Publication
9088980 | J:110626
First Author: Kurtz BS
Year: 1997
Journal: Int Immunol
Title: Gamma 2b provides only some of the signals normally given via mu in B cell development.
Volume: 9
Issue: 3
Pages: 415-26
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Publication
10329616 | J:55778
First Author: Shibata MA
Year: 1999
Journal: EMBO J
Title: Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage.
Volume: 18
Issue: 10
Pages: 2692-701
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Publication
30304535 | J:270064
First Author: Little JN
Year: 2019
Journal: Hum Mol Genet
Title: p53 deletion rescues lethal microcephaly in a mouse model with neural stem cell abscission defects.
Volume: 28
Issue: 3
Pages: 434-447
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Publication
17218959 | J:139242
First Author: Vaughn AE
Year: 2007
Journal: Cell Death Differ
Title: Essential postmitochondrial function of p53 uncovered in DNA damage-induced apoptosis in neurons.
Volume: 14
Issue: 5
Pages: 973-81
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Publication
21385880 | J:205228
First Author: Lu X
Year: 2011
Journal: Mol Cancer Res
Title: Apoptosis is the essential target of selective pressure against p53, whereas loss of additional p53 functions facilitates carcinoma progression.
Volume: 9
Issue: 4
Pages: 430-9
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Publication
9024662 | J:38331
First Author: Yin C
Year: 1997
Journal: Nature
Title: Bax suppresses tumorigenesis and stimulates apoptosis in vivo.
Volume: 385
Issue: 6617
Pages: 637-40
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Publication
14695178 | J:87065
First Author: Chavez-Reyes A
Year: 2003
Journal: Cancer Res
Title: Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets.
Volume: 63
Issue: 24
Pages: 8664-9
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Publication
19995950 | J:155679
First Author: Isomura I
Year: 2009
Journal: J Exp Med
Title: c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells.
Volume: 206
Issue: 13
Pages: 3001-14
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Publication
15345217 | J:93602
First Author: Grumont R
Year: 2004
Journal: Immunity
Title: The mitogen-induced increase in T cell size involves PKC and NFAT activation of Rel/NF-kappaB-dependent c-myc expression.
Volume: 21
Issue: 1
Pages: 19-30
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Publication
12433363 | J:93139
First Author: Khaled AR
Year: 2002
Journal: Immunity
Title: Bax deficiency partially corrects interleukin-7 receptor alpha deficiency.
Volume: 17
Issue: 5
Pages: 561-73
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Publication
16670300 | J:131709
First Author: Van De Wiele CJ
Year: 2006
Journal: J Immunol
Title: Further differentiation of murine double-positive thymocytes is inhibited in adenosine deaminase-deficient murine fetal thymic organ culture.
Volume: 176
Issue: 10
Pages: 5925-33
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Publication
22551552 | J:188720
First Author: Wong WF
Year: 2012
Journal: J Immunol
Title: Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells.
Volume: 188
Issue: 11
Pages: 5408-20
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Publication
31775034 | J:297545
First Author: Low MSY
Year: 2019
Journal: Cell Rep
Title: IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis.
Volume: 29
Issue: 9
Pages: 2634-2645.e5
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Publication
11489972 | J:120415
First Author: Ye SK
Year: 2001
Journal: J Immunol
Title: Differential roles of cytokine receptors in the development of epidermal gamma delta T cells.
Volume: 167
Issue: 4
Pages: 1929-34
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Publication
32697991 | J:323575
First Author: Ramos CV
Year: 2020
Journal: Cell Rep
Title: Cell Competition, the Kinetics of Thymopoiesis, and Thymus Cellularity Are Regulated by Double-Negative 2 to 3 Early Thymocytes.
Volume: 32
Issue: 3
Pages: 107910
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Publication
18024075 | J:132600
First Author: Gumy LF
Year: 2008
Journal: Mol Cell Neurosci
Title: Hyperglycaemia inhibits Schwann cell proliferation and migration and restricts regeneration of axons and Schwann cells from adult murine DRG.
Volume: 37
Issue: 2
Pages: 298-311
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Publication
19734221 | J:152788
First Author: Shi M
Year: 2009
Journal: J Immunol
Title: Cell cycle progression following naive T cell activation is independent of Jak3/common gamma-chain cytokine signals.
Volume: 183
Issue: 7
Pages: 4493-501
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Publication
12741988 | J:83461
First Author: Patel TD
Year: 2003
Journal: Neuron
Title: Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents.
Volume: 38
Issue: 3
Pages: 403-16
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Publication
19196996 | J:146488
First Author: Bolitho P
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Perforin-mediated suppression of B-cell lymphoma.
Volume: 106
Issue: 8
Pages: 2723-8
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Publication
20562326 | J:165891
First Author: Signer RA
Year: 2010
Journal: Blood
Title: Immature B-cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemia.
Volume: 116
Issue: 14
Pages: 2522-30
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Publication
16365398 | J:126252
First Author: Uehara S
Year: 2006
Journal: J Immunol
Title: Premature expression of chemokine receptor CCR9 impairs T cell development.
Volume: 176
Issue: 1
Pages: 75-84
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Strain
MGI:6196543 | B6.Cg-Bok<tm1.1Ast> Bax<tm1Sjk> Bak1<tm1Thsn>
Attribute String: congenic, mutant strain, targeted mutation
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Publication
19387006 | J:150769
First Author: Schoenwaelder SM
Year: 2009
Journal: Blood
Title: Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function.
Volume: 114
Issue: 3
Pages: 663-6
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Publication
15861188 | J:111864
First Author: Lindenboim L
Year: 2005
Journal: Cell Death Differ
Title: Bak but not Bax is essential for Bcl-xS-induced apoptosis.
Volume: 12
Issue: 7
Pages: 713-23
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Publication
23744350 | J:333292
First Author: Ke F
Year: 2013
Journal: Cell Death Dis
Title: Consequences of the combined loss of BOK and BAK or BOK and BAX.
Volume: 4
Issue: 6
Pages: e650
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Publication
36253375 | J:330192
First Author: Zhao F
Year: 2022
Journal: Nat Commun
Title: Brain milieu induces early microglial maturation through the BAX-Notch axis.
Volume: 13
Issue: 1
Pages: 6117
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Publication
35292986 | J:361307
First Author: Keeley PW
Year: 2023
Journal: J Anat
Title: Cell numbers, cell ratios, and developmental plasticity in the rod pathway of the mouse retina.
Volume: 243
Issue: 2
Pages: 204-222
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Publication
22294729 | J:185011
First Author: White MJ
Year: 2012
Journal: Blood
Title: Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function.
Volume: 119
Issue: 18
Pages: 4283-90
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Publication
16645094 | J:108337
First Author: Hetz C
Year: 2006
Journal: Science
Title: Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha.
Volume: 312
Issue: 5773
Pages: 572-6
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Publication
23773998 | J:202292
First Author: Yamauchi J
Year: 2013
Journal: Hum Mol Genet
Title: Triggering regeneration and tackling apoptosis: a combinatorial approach to treating congenital muscular dystrophy type 1 A.
Volume: 22
Issue: 21
Pages: 4306-17
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Publication
15145826 | J:118568
First Author: Zong WX
Year: 2004
Journal: Genes Dev
Title: Alkylating DNA damage stimulates a regulated form of necrotic cell death.
Volume: 18
Issue: 11
Pages: 1272-82
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Publication
18252892 | J:135326
First Author: McKenzie MD
Year: 2008
Journal: Diabetes
Title: Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells.
Volume: 57
Issue: 5
Pages: 1284-92
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Publication
24292555 | J:229151
First Author: Sandow JJ
Year: 2014
Journal: Cell Death Differ
Title: ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis.
Volume: 21
Issue: 3
Pages: 475-80
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Publication
24270184 | J:207835
First Author: Suo D
Year: 2014
Journal: Nat Neurosci
Title: Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival.
Volume: 17
Issue: 1
Pages: 36-45
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Publication
22297488 | J:196753
First Author: Pelzel HR
Year: 2012
Journal: Invest Ophthalmol Vis Sci
Title: Silencing of Fem1cR3 gene expression in the DBA/2J mouse precedes retinal ganglion cell death and is associated with histone deacetylase activity.
Volume: 53
Issue: 3
Pages: 1428-35
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Publication
22227450 | J:196780
First Author: Métrailler S
Year: 2012
Journal: Exp Eye Res
Title: Early apoptosis of rod photoreceptors in Rpe65(-/-) mice is associated with the upregulated expression of lysosomal-mediated autophagic genes.
Volume: 96
Issue: 1
Pages: 70-81
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Publication
28911883 | J:261219
First Author: McWilliams TG
Year: 2017
Journal: Exp Neurol
Title: TNF superfamily member APRIL enhances midbrain dopaminergic axon growth and contributes to the nigrostriatal projection in vivo.
Volume: 298
Issue: Pt A
Pages: 97-103
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Publication
24453327 | J:206855
First Author: Tanaka T
Year: 2014
Journal: J Neurosci
Title: CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development.
Volume: 34
Issue: 4
Pages: 1370-9
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Publication
17314303 | J:141738
First Author: Shacka JJ
Year: 2007
Journal: J Neurosci
Title: Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis.
Volume: 27
Issue: 8
Pages: 2081-90
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Publication
23041929 | J:189225
First Author: Southwell DG
Year: 2012
Journal: Nature
Title: Intrinsically determined cell death of developing cortical interneurons.
Volume: 491
Issue: 7422
Pages: 109-13
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Publication
19389346 | J:149469
First Author: Cook MS
Year: 2009
Journal: Dev Biol
Title: BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice.
Volume: 328
Issue: 2
Pages: 377-83
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Publication
19672311 | J:152468
First Author: Hamann S
Year: 2009
Journal: PLoS One
Title: Bax-induced apoptosis in Leber's congenital amaurosis: a dual role in rod and cone degeneration.
Volume: 4
Issue: 8
Pages: e6616
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Publication
16893972 | J:112620
First Author: Pardo J
Year: 2006
Journal: J Cell Biol
Title: The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice.
Volume: 174
Issue: 4
Pages: 509-19
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Publication
25856413 | J:328772
First Author: Ahlers KE
Year: 2015
Journal: Glia
Title: Transient activation of microglia following acute alcohol exposure in developing mouse neocortex is primarily driven by BAX-dependent neurodegeneration.
Volume: 63
Issue: 10
Pages: 1694-713
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Publication
28663253 | J:269244
First Author: Choo HJ
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: Inner Mitochondrial Membrane Disruption Links Apoptotic and Agonist-Initiated Phosphatidylserine Externalization in Platelets.
Volume: 37
Issue: 8
Pages: 1503-1512
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Publication
29114073 | J:254378
First Author: Liu J
Year: 2017
Journal: J Neurosci
Title: Cellular and Molecular Analysis of Dendritic Morphogenesis in a Retinal Cell Type That Senses Color Contrast and Ventral Motion.
Volume: 37
Issue: 50
Pages: 12247-12262
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Publication
17192424 | J:117220
First Author: Buss RR
Year: 2006
Journal: J Neurosci
Title: Neuromuscular development in the absence of programmed cell death: phenotypic alteration of motoneurons and muscle.
Volume: 26
Issue: 52
Pages: 13413-27
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Publication
18385316 | J:133752
First Author: Jacquin MF
Year: 2008
Journal: J Neurosci
Title: In DRG11 knock-out mice, trigeminal cell death is extensive and does not account for failed brainstem patterning.
Volume: 28
Issue: 14
Pages: 3577-85
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Publication
22903063 | J:189922
First Author: Lallemend F
Year: 2012
Journal: EMBO J
Title: Positional differences of axon growth rates between sensory neurons encoded by Runx3.
Volume: 31
Issue: 18
Pages: 3718-29
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Publication
16464852 | J:108676
First Author: Dansen TB
Year: 2006
Journal: J Biol Chem
Title: Specific requirement for Bax, not Bak, in Myc-induced apoptosis and tumor suppression in vivo.
Volume: 281
Issue: 16
Pages: 10890-5
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Publication
29204649 | J:257608
First Author: Nickells RW
Year: 2017
Journal: Invest Ophthalmol Vis Sci
Title: AAV2-Mediated Transduction of the Mouse Retina After Optic Nerve Injury.
Volume: 58
Issue: 14
Pages: 6091-6104
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Publication
12244177 | J:120202
First Author: Alabyev B
Year: 2002
Journal: J Immunol
Title: Bcl-2 rescues the germinal center response but does not alter the V gene somatic hypermutation spectrum in MSH2-deficient mice.
Volume: 169
Issue: 7
Pages: 3819-24
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Publication
16103408 | J:100496
First Author: Tirosh B
Year: 2005
Journal: J Exp Med
Title: XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells.
Volume: 202
Issue: 4
Pages: 505-16
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Publication
17277100 | J:144002
First Author: Llorian M
Year: 2007
Journal: J Immunol
Title: The PI3K p110delta is required for down-regulation of RAG expression in immature B cells.
Volume: 178
Issue: 4
Pages: 1981-5
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Publication
28069569 | J:239609
First Author: Zhang J
Year: 2017
Journal: Cancer Discov
Title: The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma.
Volume: 7
Issue: 3
Pages: 322-337
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Publication
18178811 | J:130950
First Author: Janas ML
Year: 2008
Journal: J Immunol
Title: The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells.
Volume: 180
Issue: 2
Pages: 739-46
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Publication
15456877 | J:93322
First Author: Biju MP
Year: 2004
Journal: Mol Cell Biol
Title: Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes.
Volume: 24
Issue: 20
Pages: 9038-47
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Publication
39398242 | J:358085
First Author: Li X
Year: 2024
Journal: iScience
Title: A regulatory loop involving the cytochrome P450-soluble epoxide hydrolase axis and TGF-β signaling.
Volume: 27
Issue: 10
Pages: 110938
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Strain
MGI:6257022 | B6.Cg-Becn1<tm2.1Blev> Tg(APPV717F)109Ili
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Publication
22733973 | J:189192
First Author: Nakakura T
Year: 2012
Journal: Endocrinology
Title: Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion.
Volume: 153
Issue: 9
Pages: 4171-80
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26408661 | J:262271
First Author: Lu Y
Year: 2015
Journal: J Immunol
Title: PLZF Controls the Development of Fetal-Derived IL-17+Vγ6+ γδ T Cells.
Volume: 195
Issue: 9
Pages: 4273-81
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Publication
21505187 | J:185998
First Author: Yasuda T
Year: 2011
Journal: Sci Signal
Title: ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiation.
Volume: 4
Issue: 169
Pages: ra25
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Publication
33608456 | J:316343
First Author: Xie B
Year: 2021
Journal: J Immunol
Title: The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation.
Volume: 206
Issue: 7
Pages: 1515-1527
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Publication
20483771 | J:161136
First Author: Unsinger J
Year: 2010
Journal: J Immunol
Title: Sepsis-induced apoptosis leads to active suppression of delayed-type hypersensitivity by CD8+ regulatory T cells through a TRAIL-dependent mechanism.
Volume: 184
Issue: 12
Pages: 6766-72
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Publication
29167438 | J:256221
First Author: Schuler F
Year: 2017
Journal: Nat Commun
Title: Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis.
Volume: 8
Issue: 1
Pages: 1697
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Publication
38570506 | J:346861
First Author: Li J
Year: 2024
Journal: Nat Commun
Title: Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment.
Volume: 15
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Pages: 2879
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Publication
31875880 | J:299923
First Author: Zhu Y
Year: 2020
Journal: Int Immunol
Title: Intestinal epithelial cell-derived IL-15 determines local maintenance and maturation of intra-epithelial lymphocytes in the intestine.
Volume: 32
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Pages: 307-319
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Publication
20547543 | J:162091
First Author: Tani-ichi S
Year: 2010
Journal: Int Immunol
Title: Accessibility control of TCR Vγ region by STAT5.
Volume: 22
Issue: 8
Pages: 693-703
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Publication
10485656 | J:57269
First Author: Ye SK
Year: 1999
Journal: Immunity
Title: Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor.
Volume: 11
Issue: 2
Pages: 213-23
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Publication
23712827 | J:201196
First Author: Linowes BA
Year: 2013
Journal: Eur J Immunol
Title: Pim1 permits generation and survival of CD4+ T cells in the absence of γc cytokine receptor signaling.
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Publication
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Journal: Blood
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Publication
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Title: Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development.
Volume: 219
Issue: 10
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Strain
MGI:4888749 | B6.Cg-Ptprc<a> Tg(BCL2)22Wehi/WehiAnuApb
Attribute String: mutant strain, transgenic, congenic
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Publication
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Publication
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Title: Acidic environment augments FcεRI-mediated production of IL-6 and IL-13 in mast cells.
Volume: 464
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Pages: 949-55
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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