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Search results 3701 to 3800 out of 8814 for Clock

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Type Details Score
Publication
First Author: Mouri A
Year: 2013
Journal: Rev Neurosci
Title: The roles of MAGE-D1 in the neuronal functions and pathology of the central nervous system.
Volume: 24
Issue: 1
Pages: 61-70
Publication
First Author: Dardente H
Year: 2009
Journal: Comp Biochem Physiol A Mol Integr Physiol
Title: Transcriptional feedback loops in the ovine circadian clock.
Volume: 153
Issue: 4
Pages: 391-8
Publication
First Author: Wang W
Year: 2011
Journal: J Exp Bot
Title: EFO1 and EFO2, encoding putative WD-domain proteins, have overlapping and distinct roles in the regulation of vegetative development and flowering of Arabidopsis.
Volume: 62
Issue: 3
Pages: 1077-88
Publication
First Author: Li X
Year: 2016
Journal: Plant Cell
Title: Blue Light- and Low Temperature-Regulated COR27 and COR28 Play Roles in the Arabidopsis Circadian Clock.
Volume: 28
Issue: 11
Pages: 2755-2769
Publication
First Author: Song YH
Year: 2012
Journal: Plant J
Title: CONSTANS and ASYMMETRIC LEAVES 1 complex is involved in the induction of FLOWERING LOCUS T in photoperiodic flowering in Arabidopsis.
Volume: 69
Issue: 2
Pages: 332-42
Publication
First Author: An H
Year: 2004
Journal: Development
Title: CONSTANS acts in the phloem to regulate a systemic signal that induces photoperiodic flowering of Arabidopsis.
Volume: 131
Issue: 15
Pages: 3615-26
Publication
First Author: Hori K
Year: 2013
Journal: Plant J
Title: Hd16, a gene for casein kinase I, is involved in the control of rice flowering time by modulating the day-length response.
Volume: 76
Issue: 1
Pages: 36-46
Publication
First Author: Kim SK
Year: 2008
Journal: Planta
Title: OsCO3, a CONSTANS-LIKE gene, controls flowering by negatively regulating the expression of FT-like genes under SD conditions in rice.
Volume: 228
Issue: 2
Pages: 355-65
Protein Domain
Type: Family
Description: Circadian-associated transcriptional repressor (Ciart or Chrono) is a negative regulatory component of the circadian clock [, , ]. It functions as a transcriptional repressor, modulating BMAL1-CLOCK activity. It also regulates metabolic pathways such as the glucocorticoid response triggered by behavioral stress [].
Protein Domain
Type: Domain
Description: Nuclear receptor-interacting protein 1 (also known as nuclear factor RIP140) modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1 []. It also modulates transcriptional repression by nuclear hormone receptors []and clock gene expression []. It consists of four distinct autonomous repression domains [].This domain is the fourth (C-terminal) repression domain of nuclear receptor-interacting protein 1 [, ].
Protein Domain
Type: Family
Description: Nuclear receptor-interacting protein 1 (also known as nuclear factor RIP140) modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1 []. It also modulates transcriptional repression by nuclear hormone receptors []and clock gene expression []. It consists of four distinct autonomous repression domains [].This domain is the third repression domain of nuclear receptor-interacting protein 1 [, ].
Protein Domain
Type: Domain
Description: Nuclear receptor-interacting protein 1 (also known as nuclear factor RIP140) modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1 []. It also modulates transcriptional repression by nuclear hormone receptors []and clock gene expression []. It consists of four distinct autonomous repression domains [].This domain is the second repression domain of nuclear receptor-interacting protein 1 [, ].
Protein Domain
Type: Domain
Description: Nuclear receptor-interacting protein 1 (also known as nuclear factor RIP140) modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1 []. It also modulates transcriptional repression by nuclear hormone receptors []and clock gene expression []. It consists of four distinct autonomous repression domains [].This domain is the first (N-terminal) repression domain of nuclear receptor-interacting protein 1 [, ].
Protein Domain
Type: Family
Description: Clock-interacting pacemaker or clock-interacting circadian protein (CIPC) is an additional negative-feedback regulator of the circadian clock, through inhibition of CLOCK-BMAL1 activity [, , ]. Studies in knockout mice suggest that it may not be critically required for basic clock function [].
Protein Domain
Type: Family
Description: ENOX proteins are growth-related cell surface proteins that catalyse both hydroquinone or NADH oxidation and protein disulfide-thiol interchange []. The two enzymatic activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock [, ]. ENOX proteins may play roles in cancer, cellular time-keeping, growth, aging and neurodegenerative diseases [].
Protein Domain
Type: Family
Description: These proteins are found in a wide range of eukaryotes. They are nuclear proteins, suggested to play a role in the spliceosome complex []. XAP5 from Arabidopsis thaliana has been shown to be involved in light regulation of the circadian clock and photomorphogenesis [].
Protein Domain
Type: Domain
Description: This entry represents a conserved domain found in a group of proteins called telomere-length regulation TEL2, or clock abnormal protein-2, which are conserved from plants to humans. These proteins regulate telomere length and contribute to silencing of sub-telomeric regions []. Tel2 acts at an early step of the TEL1/ATM pathway of DNA damage signaling []. In vitro the protein binds to telomeric DNA repeats.
Protein Domain
Type: Family
Description: This entry represents a group of plant WD repeat-containing proteins, including RUP1/2 (or EFO1/2) from Arabidopsis. EFO2 acts as a floral repressor, while EFO1 may not be directly involved in flowering, however, they have overlapping roles in regulating other developmental processes. Moreover, both EFO1/2 genes are regulated by the circadian clock [].
Protein Domain
Type: Family
Description: UBE3A (also known as E6-AP) is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. It regulates cell proliferation by promoting proteasomal degradation of p27 []. It can also serve as a molecular circadian clock through regulating the BMAL1 transcription factor [].
Protein Domain
Type: Family
Description: Cold-regulated proteins 27 and 28 are regulated by low temperature and light. They are involved in central circadian clock regulation and in flowering promotion, by binding to the chromatin of clock-associated evening genes TOC1, PRR5, ELF4 and cold-responsive genes in order to repress their transcription [, ]. They are also involved in freezing tolerance regulation.
Protein Domain
Type: Family
Description: The melanoma antigen (MAGE) protein family contains more than 25 members that share a conserved MAGE homology domain (MHD). MAGED1 plays a role in anti-tumorigenesis in a variety of cell types and is involved in regulating circadian clock functions [, ]. It also plays important roles in the central nervous system in both developmental and adult stages [].
Protein Domain
Type: Family
Description: This entry represents a group of plant zinc finger proteins, including CONSTANS and related proteins. CONSTANS is a transcription factor that acts in the long day flowering pathway and may mediate between the circadian clock and the control of flowering [, ]. This entry also includes rice Ghd7 and CO3, which also control rice flowering [, ].
HT Experiment
Series Id: GSE38365
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE46356
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE59941
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE43071
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 840  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 647  
Fragment?: true
Publication
First Author: Bénard C
Year: 2001
Journal: Development
Title: The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length.
Volume: 128
Issue: 20
Pages: 4045-55
Publication
First Author: Anderson CM
Year: 2008
Journal: Genes Dev
Title: Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.
Volume: 22
Issue: 7
Pages: 854-9
Publication
First Author: Jiang Z
Year: 2008
Journal: Biochemistry
Title: Molecular cloning and characterization of a candidate human growth-related and time-keeping constitutive cell surface hydroquinone (NADH) oxidase.
Volume: 47
Issue: 52
Pages: 14028-38
Publication
First Author: Tang X
Year: 2010
Journal: J Bioenerg Biomembr
Title: Essential role of copper in the activity and regular periodicity of a recombinant, tumor-associated, cell surface, growth-related and time-keeping hydroquinone (NADH) oxidase with protein disulfide-thiol interchange activity (ENOX2).
Volume: 42
Issue: 5
Pages: 355-60
Publication
First Author: Morré DJ
Year: 2003
Journal: Free Radic Res
Title: Cell surface NADH oxidases (ECTO-NOX proteins) with roles in cancer, cellular time-keeping, growth, aging and neurodegenerative diseases.
Volume: 37
Issue: 8
Pages: 795-808
Publication
First Author: Stubblefield JJ
Year: 2018
Journal: Cell Rep
Title: Temporal Control of Metabolic Amplitude by Nocturnin.
Volume: 22
Issue: 5
Pages: 1225-1235
Protein Domain
Type: Family
Description: Nocturnin is a poly(A)-specific 3' exonuclease that specifically degrades the 3' poly(A) tail of RNA in a process known as deadenylation. Nocturnin is expressed in the cytoplasm of Xenopus laevis retinal photoreceptor cells in a rhythmic fashion, and it has been proposed that it participates in posttranscriptional regulation of the circadian clock or its outputs, and that the mRNA target(s) of this deadenylase are circadian clock-related []. In mouse, the nocturnin gene, mNoc, is expressed in a circadian pattern in a range of tissues including retina, spleen, heart, kidney, and liver. It is highly expressed in bone-marrow stromal cells, adipocytes and hepatocytes []. In mammals, nocturnin plays a role in regulating mesenchymal stem-cell lineage allocation, perhaps through regulating PPAR-gamma (peroxisome proliferator-activated receptor-gamma) nuclear translocation []. Nocturnin expression depends on the circadian clock and nutrient status. Loss of this activity results in increased metabolic flux and reduced obesity [].
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE48758
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment
Series Id: GSE73552
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Lachner M
Year: 2001
Journal: Nature
Title: Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
Volume: 410
Issue: 6824
Pages: 116-20
Publication
First Author: Sparrow DB
Year: 2008
Journal: Hum Mol Genet
Title: Mutation of Hairy-and-Enhancer-of-Split-7 in humans causes spondylocostal dysostosis.
Volume: 17
Issue: 23
Pages: 3761-6
Protein
Organism: Mus musculus/domesticus
Length: 1161  
Fragment?: false
Publication
First Author: Cavaillès V
Year: 1995
Journal: EMBO J
Title: Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.
Volume: 14
Issue: 15
Pages: 3741-51
Publication
First Author: Iwasaki H
Year: 2000
Journal: Cell
Title: A kaiC-interacting sensory histidine kinase, SasA, necessary to sustain robust circadian oscillation in cyanobacteria.
Volume: 101
Issue: 2
Pages: 223-33
Publication
First Author: Katayama M
Year: 2003
Journal: J Bacteriol
Title: ldpA encodes an iron-sulfur protein involved in light-dependent modulation of the circadian period in the cyanobacterium Synechococcus elongatus PCC 7942.
Volume: 185
Issue: 4
Pages: 1415-22
Publication
First Author: Subramaniam N
Year: 1999
Journal: J Biol Chem
Title: Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids.
Volume: 274
Issue: 25
Pages: 18121-7
Publication
First Author: Obuse C
Year: 2004
Journal: Nat Cell Biol
Title: A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1.
Volume: 6
Issue: 11
Pages: 1135-41
Publication
First Author: Bot C
Year: 2017
Journal: J Cell Sci
Title: Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage.
Volume: 130
Issue: 6
Pages: 1134-1146
Publication
First Author: Hazen SP
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: LUX ARRHYTHMO encodes a Myb domain protein essential for circadian rhythms.
Volume: 102
Issue: 29
Pages: 10387-92
Publication
First Author: Dai S
Year: 2011
Journal: Plant Cell
Title: BROTHER OF LUX ARRHYTHMO is a component of the Arabidopsis circadian clock.
Volume: 23
Issue: 3
Pages: 961-72
Publication
First Author: Zhai H
Year: 2010
Journal: Biochem Biophys Res Commun
Title: A single-repeat R3-MYB transcription factor MYBC1 negatively regulates freezing tolerance in Arabidopsis.
Volume: 394
Issue: 4
Pages: 1018-23
Protein Domain
Type: Conserved_site
Description: The short CCT (CO, COL, TOC1) motif is found in a number of plant proteins, including Constans (CO), Constans-like (COL) and TOC1. The CCT motif is about 45 amino acids long and contains a putative nuclear localisation signal within the second half of the CCT motif []. The CCT motif is found in the Arabidopsis circadian rhythm protein TOC1, an autoregulatory response regulator homologue the controls the photoperiodic flowering through its clock function [].
Protein Domain
Type: Family
Description: Chromobox protein homologue 3 (CBX3, also known as HP1 gamma) is a component of heterochromatin that binds histone H3 tails methylated at 'Lys-9' which leads to epigenetic repression []. By interacting with MIS12 complex, it is involved in the formation of a functional kinetochore []. It recruits NIPBL to sites of DNA damage at double-strand breaks []. It is a component of the E2F6.com-1 []and PER []complexes. The PER complex controls the circadian clock [].
Protein Domain
Type: Domain
Description: This entry represents the conserved RNA recognition motif (RRM) in ECTO-NOX proteins (ENOX). ENOX proteins are growth-related cell surface proteins that catalyse both hydroquinone or NADH oxidation and protein disulfide-thiol interchange []. The two enzymatic activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock [, ]. ENOX proteins may play roles in cancer, cellular time-keeping, growth, aging and neurodegenerative diseases [].
Protein Domain
Type: Domain
Description: This entry represents the C-terminal domain of the Nck-associated protein 5 (NCKAP5), also known as the Peripheral clock protein. NCKAP5 interacts with the SH3-containing region of the adaptor protein Nck. Nck is a protein that interacts with receptor tyrosine kinases and guanine nucleotide exchange factor Sos. The role of Nck can be thought of as similar to Grb2. The role of NCKAP5 is to assist Nck with its adaptor protein role [].
Protein Domain
Type: Family
Description: This entry represents a group of plant Myb domain proteins, including LUX, BOA and MYBC1 from Arabidopsis. LUX and BOA are transcription factors and critical components of the regulatory circuit of the circadian clock [, ]. LUX also binds toELF3 and associates with ELF4 in a diurnal complex which is required for the expression of the growth-promoting transcription factors PIF4 and PIF5 and subsequent hypocotyl growth in the early evening []. MYBC1 has been shown to negatively regulate freezing tolerance in Arabidopsis [].
Protein Domain
Type: Family
Description: HES-7 is a bHLH-type repressor that is both a direct target of the Notch signalling pathway, and part of a negative feedback mechanism required to attenuate Notch signalling [, ]. It can bind to its own promoter, thereby inhibiting its own transcription. In mouse its 3'UTR is essential for somite segmentation clock []. Mutations in the HES-7 gene cause spondylocostal dysostosis, an inherited disorder characterised by the presence of extensive hemivertebrae, truncal shortening and abnormally aligned ribs [].
Protein Domain
Type: Homologous_superfamily
Description: This entry represents the repeats found in dinoflagellate luciferases.Luciferase is involved in catalysing the light emitting reaction in bioluminescence, and luciferin binding protein (LBP) is known to bind to luciferin (the substrate for luciferase) to stop it reacting with the enzyme and therefore switching off the bioluminescence function. The expression of these two proteins is controlled by a circadian clock at the translational level, with synthesis and degradation occurring on a daily basis [].
Protein Domain
Type: Domain
Description: This entry represents the C-terminal region of the iron-sulphur protein LdpA (Light dependent period), which is found in phototropic organisms. LdpA was originally identified in cyanobacteria where it is involved in light-dependent modulation of the circadian clock. The presence of iron-sulphur clusters on LdpA suggests that it may modulate the circadian clock as an indirect function of light intensity by sensing changes in cellular physiology [].
Publication  
First Author: Ota W
Year: 2018
Journal: iScience
Title: Impaired Circadian Photoentrainment in Opn5-Null Mice.
Volume: 6
Pages: 299-305
Publication
First Author: Thompson CL
Year: 2002
Journal: Oncogene
Title: Photolyase/cryptochrome blue-light photoreceptors use photon energy to repair DNA and reset the circadian clock.
Volume: 21
Issue: 58
Pages: 9043-56
Publication
First Author: Yamaguchi S
Year: 2003
Journal: Science
Title: Synchronization of cellular clocks in the suprachiasmatic nucleus.
Volume: 302
Issue: 5649
Pages: 1408-12
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Labialle S
Year: 2008
Journal: Hum Mol Genet
Title: Coordinated diurnal regulation of genes from the Dlk1-Dio3 imprinted domain: implications for regulation of clusters of non-paralogous genes.
Volume: 17
Issue: 1
Pages: 15-26
Publication
First Author: Mrosovsky N
Year: 1999
Journal: J Comp Physiol A
Title: Thresholds for masking responses to light in three strains of retinally degenerate mice.
Volume: 184
Issue: 4
Pages: 423-8
Publication
First Author: Yoshimura T
Year: 1996
Journal: J Comp Physiol A
Title: Spectral sensitivity of photoreceptors mediating phase-shifts of circadian rhythms in retinally degenerate CBA/J (rd/rd) and normal CBA/N (+/+)mice.
Volume: 178
Issue: 6
Pages: 797-802
Publication
First Author: Jagannath A
Year: 2013
Journal: Cell
Title: The CRTC1-SIK1 pathway regulates entrainment of the circadian clock.
Volume: 154
Issue: 5
Pages: 1100-11
Publication
First Author: Schmutz I
Year: 2011
Journal: PLoS One
Title: Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.
Volume: 6
Issue: 6
Pages: e21325
Publication
First Author: Keers R
Year: 2012
Journal: PLoS One
Title: Reduced anxiety and depression-like behaviours in the circadian period mutant mouse afterhours.
Volume: 7
Issue: 6
Pages: e38263
Publication
First Author: Maggi S
Year: 2017
Journal: Sci Rep
Title: The after-hours circadian mutant has reduced phenotypic plasticity in behaviors at multiple timescales and in sleep homeostasis.
Volume: 7
Issue: 1
Pages: 17765
Publication
First Author: Guilding C
Year: 2013
Journal: J Physiol
Title: Suppressed cellular oscillations in after-hours mutant mice are associated with enhanced circadian phase-resetting.
Volume: 591
Issue: 4
Pages: 1063-80
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment
Series Id: GSE59486
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
Publication  
First Author: Wang Y
Year: 2001
Journal: BMC Dev Biol
Title: Rhythmic expression of Nocturnin mRNA in multiple tissues of the mouse.
Volume: 1
Pages: 9
Publication
First Author: Kawai M
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation.
Volume: 107
Issue: 23
Pages: 10508-13
Publication
First Author: Baggs JE
Year: 2003
Journal: Curr Biol
Title: Nocturnin, a deadenylase in Xenopus laevis retina: a mechanism for posttranscriptional control of circadian-related mRNA.
Volume: 13
Issue: 3
Pages: 189-98
Publication
First Author: Tu DC
Year: 2005
Journal: Neuron
Title: Physiologic diversity and development of intrinsically photosensitive retinal ganglion cells.
Volume: 48
Issue: 6
Pages: 987-99
Publication
First Author: van der Horst GT
Year: 1999
Journal: Nature
Title: Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms.
Volume: 398
Issue: 6728
Pages: 627-30
Publication
First Author: Wang J
Year: 2017
Journal: Cell Metab
Title: Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver.
Volume: 25
Issue: 1
Pages: 102-117
Publication
First Author: Cheng HY
Year: 2007
Journal: Neuron
Title: microRNA modulation of circadian-clock period and entrainment.
Volume: 54
Issue: 5
Pages: 813-29
Publication
First Author: Wang CY
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Circadian rhythm of RNA N6-methyladenosine and the role of cryptochrome.
Volume: 465
Issue: 1
Pages: 88-94
Publication
First Author: Kang TH
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Circadian oscillation of nucleotide excision repair in mammalian brain.
Volume: 106
Issue: 8
Pages: 2864-7
Publication
First Author: Pollack BP
Year: 1999
Journal: J Biol Chem
Title: The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity.
Volume: 274
Issue: 44
Pages: 31531-42
Publication
First Author: Takai H
Year: 2010
Journal: Genes Dev
Title: Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.
Volume: 24
Issue: 18
Pages: 2019-30
Protein
Organism: Mus musculus/domesticus
Length: 1323  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 338  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1909  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 922  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false